JP6712275B2 - 拡張型心筋症（ｄｃｍ）の処置のための４−メチルスルホニル置換ピペリジンウレア化合物 - Google Patents

拡張型心筋症（ｄｃｍ）の処置のための４−メチルスルホニル置換ピペリジンウレア化合物 Download PDF

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JP6712275B2
JP6712275B2 JP2017538593A JP2017538593A JP6712275B2 JP 6712275 B2 JP6712275 B2 JP 6712275B2 JP 2017538593 A JP2017538593 A JP 2017538593A JP 2017538593 A JP2017538593 A JP 2017538593A JP 6712275 B2 JP6712275 B2 JP 6712275B2
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pharmaceutically acceptable
acceptable salt
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piperidine
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JP2018502883A (ja
JP2018502883A5 (enExample
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ジョハン・オスロブ
ダニエル・オーベル
ジェイ・キム
ロバート・マクドウェル
ヨンホン・ソン
アーヴィンダー・シュラン
ミン・ヂョン
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マイオカーディア，インク
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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JP2017538593A 2015-01-22 2016-01-21 拡張型心筋症（ｄｃｍ）の処置のための４−メチルスルホニル置換ピペリジンウレア化合物 Active JP6712275B2 (ja)

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US201562106571P 2015-01-22 2015-01-22
US62/106,571 2015-01-22
PCT/US2016/014365 WO2016118774A1 (en) 2015-01-22 2016-01-21 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm)

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JP2018502883A5 JP2018502883A5 (enExample) 2019-02-28
JP6712275B2 true JP6712275B2 (ja) 2020-06-17

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GB201813312D0 (en) 2018-08-15 2018-09-26 Modern Biosciences Ltd Compounds and their therapeutic use
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GB201905520D0 (en) 2019-04-18 2019-06-05 Modern Biosciences Ltd Compounds and their therapeutic use
CA3138080A1 (en) * 2019-05-19 2020-11-26 Jean-Francois TAMBY Treatment of systolic dysfunction and heart failure with reduced ejection fraction with the compound(r)-4-(1-((3-(difluoromethyl)-1-methyl-1h-pyrazol-4-yl)sulfonyl)-1-fluoroethyl) n-(isoxazol-3-yl)piperidine-1-carboxamid
TW202116765A (zh) 2019-07-16 2021-05-01 美商邁奧卡迪亞公司 (r)-4-(1-((3-(二氟甲基)-1-甲基-1h-吡唑-4-基)磺醯基)-1-氟乙基)-n-(異噁唑-3-基)哌啶-1-甲醯胺之多晶型物形式
CN110407744A (zh) * 2019-08-13 2019-11-05 上海毕得医药科技有限公司 一种1-(4-氨基吡啶-2-基)乙酮的合成方法
PE20230608A1 (es) 2020-05-05 2023-04-13 Nuvalent Inc Quimioterapicos de eter macrociclico heteroaromatico
EP4146205A4 (en) 2020-05-05 2024-05-29 Nuvalent, Inc. HETEROAROMATIC MACROCYCLIC ETHERS AS CHEMOTHERAPEUTIC AGENTS
BR112022025551A2 (pt) * 2020-06-15 2023-03-07 Myokardia Inc Tratamento de disfunção atrial
KR102541297B1 (ko) 2020-08-18 2023-06-09 가톨릭대학교 산학협력단 확장성 심근병 모델 및 이의 제조방법
JP2024508526A (ja) 2021-03-04 2024-02-27 サイトキネティックス， インコーポレイテッド 心筋サルコメア阻害剤
CN118234725A (zh) 2021-10-01 2024-06-21 纽威伦特公司 杂芳族大环醚化合物的固体形式、药物组合物及制备
CN116082326B (zh) * 2022-12-16 2024-12-27 药康众拓(江苏)医药科技有限公司北京分公司 一种氘代吡唑磺酰甲基-哌啶异噁唑脲类化合物及其用途
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PH12017501279B1 (en) 2023-06-16
CR20170370A (es) 2017-10-20
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JP2018502883A (ja) 2018-02-01
PE20212253A1 (es) 2021-11-24
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CL2017001871A1 (es) 2018-04-13
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MY203427A (en) 2024-06-27
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GT201700163A (es) 2018-10-18
US20160243100A1 (en) 2016-08-25
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IL279247A (en) 2021-01-31
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IL286369A (en) 2021-10-31
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KR20230145504A (ko) 2023-10-17
ECSP17054181A (es) 2019-02-28
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AU2016209200A1 (en) 2017-08-10
CA2974370C (en) 2023-10-31
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CO2017008398A2 (es) 2017-10-31
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HK1246775A1 (en) 2018-09-14
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