JP2013528650A5 - - Google Patents
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- Publication number
- JP2013528650A5 JP2013528650A5 JP2013515459A JP2013515459A JP2013528650A5 JP 2013528650 A5 JP2013528650 A5 JP 2013528650A5 JP 2013515459 A JP2013515459 A JP 2013515459A JP 2013515459 A JP2013515459 A JP 2013515459A JP 2013528650 A5 JP2013528650 A5 JP 2013528650A5
- Authority
- JP
- Japan
- Prior art keywords
- ylthio
- bromo
- triazol
- acetic acid
- cyclopropylnaphthalen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 51
- -1 4-cyclopropylnaphthalen-1-yl Chemical group 0.000 claims 20
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 7
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 7
- 229960003459 allopurinol Drugs 0.000 claims 7
- 229940116269 uric acid Drugs 0.000 claims 7
- 201000005569 Gout Diseases 0.000 claims 6
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 5
- 241000282412 Homo Species 0.000 claims 4
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 claims 3
- BQSJTQLCZDPROO-UHFFFAOYSA-N febuxostat Chemical compound C1=C(C#N)C(OCC(C)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 BQSJTQLCZDPROO-UHFFFAOYSA-N 0.000 claims 3
- 229960005101 febuxostat Drugs 0.000 claims 3
- FGQFOYHRJSUHMR-UHFFFAOYSA-N lesinurad Chemical compound OC(=O)CSC1=NN=C(Br)N1C(C1=CC=CC=C11)=CC=C1C1CC1 FGQFOYHRJSUHMR-UHFFFAOYSA-N 0.000 claims 3
- 239000003064 xanthine oxidase inhibitor Substances 0.000 claims 3
- 201000001431 Hyperuricemia Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 1
- 229960000583 acetic acid Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35500410P | 2010-06-15 | 2010-06-15 | |
| US61/355,004 | 2010-06-15 | ||
| US41144910P | 2010-11-08 | 2010-11-08 | |
| US61/411,449 | 2010-11-08 | ||
| US201161430522P | 2011-01-06 | 2011-01-06 | |
| US61/430,522 | 2011-01-06 | ||
| US201161489420P | 2011-05-24 | 2011-05-24 | |
| US61/489,420 | 2011-05-24 | ||
| PCT/US2011/040398 WO2011159732A1 (en) | 2010-06-15 | 2011-06-14 | Treatment of gout and hyperuricemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013528650A JP2013528650A (ja) | 2013-07-11 |
| JP2013528650A5 true JP2013528650A5 (enExample) | 2014-06-05 |
| JP5964821B2 JP5964821B2 (ja) | 2016-08-03 |
Family
ID=45348529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515459A Expired - Fee Related JP5964821B2 (ja) | 2010-06-15 | 2011-06-14 | 痛風と高尿酸血症の処置 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9216179B2 (enExample) |
| EP (1) | EP2582683B1 (enExample) |
| JP (1) | JP5964821B2 (enExample) |
| CA (1) | CA2802407C (enExample) |
| CY (1) | CY1120473T1 (enExample) |
| DK (1) | DK2582683T3 (enExample) |
| ES (1) | ES2670700T3 (enExample) |
| HR (1) | HRP20180780T1 (enExample) |
| HU (1) | HUE038265T2 (enExample) |
| LT (1) | LT2582683T (enExample) |
| NO (1) | NO2019008I1 (enExample) |
| PL (1) | PL2582683T3 (enExample) |
| PT (1) | PT2582683T (enExample) |
| RS (1) | RS57275B1 (enExample) |
| SI (1) | SI2582683T1 (enExample) |
| SM (1) | SMT201800266T1 (enExample) |
| TR (1) | TR201806828T4 (enExample) |
| WO (1) | WO2011159732A1 (enExample) |
| ZA (1) | ZA201300055B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2560642A4 (en) | 2010-03-30 | 2013-12-18 | Ardea Biosciences Inc | TREATMENT OF GICHT |
| EP2582683B1 (en) * | 2010-06-15 | 2018-03-21 | Ardea Biosciences, Inc. | Treatment of gout and hyperuricemia |
| EP3501520A1 (en) | 2011-11-03 | 2019-06-26 | Ardea Biosciences, Inc. | 3,4-di-substituted pyridine compound, methods of using and compositions comprising the same |
| AR091651A1 (es) | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| CN103613552A (zh) * | 2013-12-02 | 2014-03-05 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸钠的新晶型及其制备方法 |
| CN103755651A (zh) * | 2013-12-23 | 2014-04-30 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的盐的新晶型及其制备方法 |
| US9969701B2 (en) | 2013-12-20 | 2018-05-15 | Crystal Pharmatech Co., Ltd. | Salts and co-crystals of lesinurad |
| JP2015160847A (ja) * | 2014-02-28 | 2015-09-07 | ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ | 小分子のキサンチンオキシダーゼ阻害剤および使用方法 |
| CN105622531A (zh) | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
| WO2016203436A1 (en) * | 2015-06-19 | 2016-12-22 | Dr. Reddy's Laboratories Limited | Amorphous and amorphous solid dispersion of lesinurad and their preparation |
| EP3112334A1 (en) | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Process for manufacturing 1-cyclopropyl-naphthalenes |
| PE20181521A1 (es) * | 2015-12-08 | 2018-09-24 | Ardea Biosciences Inc | Composicion farmaceutica que comprende un potente inhibidor de urat1 |
| US11700979B2 (en) | 2018-10-26 | 2023-07-18 | The Procter & Gamble Company | Sanitary tissue product rolls |
| CA3060211C (en) | 2018-10-26 | 2025-05-13 | The Procter & Gamble Company | TOILET PAPER ROLLS |
| CA3060193C (en) | 2018-10-26 | 2023-05-09 | The Procter & Gamble Company | Paper towel rolls |
| US11633076B2 (en) | 2018-10-26 | 2023-04-25 | The Procter & Gamble Company | Sanitary tissue product rolls |
| US20220288038A1 (en) * | 2019-08-21 | 2022-09-15 | The University Of Tokyo | Abcc11 inhibitor |
| CN110824067B (zh) * | 2019-12-11 | 2024-12-27 | 天津药物研究院有限公司 | 一种非布司他中基因毒性杂质的检测方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005063788A1 (ja) | 2003-12-26 | 2005-07-14 | Kissei Pharmaceutical Co., Ltd. | ベンズイミダゾール誘導体及びその医薬用途 |
| US20060189811A1 (en) | 2004-07-23 | 2006-08-24 | Fujiyakuhin Co., Ltd. | Process for producing 1,2,4-triazole compound and intermediate therefor |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| DK2135608T3 (da) | 2004-08-25 | 2012-01-23 | Ardea Biosciences Inc | S-triazolyl-alfa-mercaptoacetanilider som inhibitorer for HIV-revers transkriptase |
| CN101646440A (zh) | 2007-01-19 | 2010-02-10 | 武田制药北美公司 | 使用黄嘌呤氧化还原酶抑制剂和抗炎剂预防痛风突发或减少痛风突发次数的方法 |
| ME01294B (me) | 2007-11-27 | 2013-06-20 | Ardea Biosciences Inc | Nova jedinjenja i kompozicije i metode upotrebe |
| US8242154B2 (en) * | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US8173690B2 (en) * | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| CA2736117C (en) | 2008-09-04 | 2013-11-19 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US20100160351A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| EP2432774A4 (en) * | 2009-05-20 | 2013-01-02 | Ardea Biosciences Inc | COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING URIC ACID RATES |
| EP2266966A1 (en) | 2009-06-11 | 2010-12-29 | Chemo Ibérica, S.A. | A process for the preparation of febuxostat |
| MX2012007925A (es) | 2010-01-08 | 2012-08-03 | Ardea Biosciences Inc | Formas polimorficas, cristalinas y de mesofase de 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-ilti o)acetato de sodio, y usos de las mismas. |
| EP2560642A4 (en) | 2010-03-30 | 2013-12-18 | Ardea Biosciences Inc | TREATMENT OF GICHT |
| EP2582683B1 (en) * | 2010-06-15 | 2018-03-21 | Ardea Biosciences, Inc. | Treatment of gout and hyperuricemia |
| ES2706066T3 (es) * | 2010-07-02 | 2019-03-27 | Univ Health Network | Procedimiento dirigido a enfermedades mutantes con PTEN y composiciones para las mismas |
| US20130296345A1 (en) * | 2010-10-15 | 2013-11-07 | Ardea Biosciences, Inc. | Methods for treating hyperuricemia and related diseases |
| LT2658846T (lt) | 2010-12-30 | 2017-02-27 | Ardea Biosciences, Inc. | 2-(5-brom-4-(4-ciklopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acto rūgšties polimorfinės formos ir jų panaudojimas |
| ES2633762T3 (es) | 2011-05-24 | 2017-09-25 | Ardea Biosciences, Inc. | Hipertensión e hiperuricemia |
-
2011
- 2011-06-14 EP EP11796324.9A patent/EP2582683B1/en not_active Revoked
- 2011-06-14 SM SM20180266T patent/SMT201800266T1/it unknown
- 2011-06-14 PT PT117963249T patent/PT2582683T/pt unknown
- 2011-06-14 ES ES11796324.9T patent/ES2670700T3/es active Active
- 2011-06-14 TR TR2018/06828T patent/TR201806828T4/tr unknown
- 2011-06-14 US US13/704,192 patent/US9216179B2/en active Active
- 2011-06-14 RS RS20180571A patent/RS57275B1/sr unknown
- 2011-06-14 WO PCT/US2011/040398 patent/WO2011159732A1/en not_active Ceased
- 2011-06-14 SI SI201131474T patent/SI2582683T1/en unknown
- 2011-06-14 DK DK11796324.9T patent/DK2582683T3/en active
- 2011-06-14 JP JP2013515459A patent/JP5964821B2/ja not_active Expired - Fee Related
- 2011-06-14 HU HUE11796324A patent/HUE038265T2/hu unknown
- 2011-06-14 CA CA2802407A patent/CA2802407C/en not_active Expired - Fee Related
- 2011-06-14 LT LTEP11796324.9T patent/LT2582683T/lt unknown
- 2011-06-14 HR HRP20180780TT patent/HRP20180780T1/hr unknown
- 2011-06-14 PL PL11796324T patent/PL2582683T3/pl unknown
-
2013
- 2013-01-03 ZA ZA2013/00055A patent/ZA201300055B/en unknown
-
2015
- 2015-11-12 US US14/939,963 patent/US20160143889A1/en not_active Abandoned
-
2018
- 2018-05-18 CY CY20181100520T patent/CY1120473T1/el unknown
- 2018-09-19 US US16/135,153 patent/US20190015392A1/en not_active Abandoned
-
2019
- 2019-02-19 NO NO2019008C patent/NO2019008I1/no unknown
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