JP2013528650A5 - - Google Patents
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- Publication number
- JP2013528650A5 JP2013528650A5 JP2013515459A JP2013515459A JP2013528650A5 JP 2013528650 A5 JP2013528650 A5 JP 2013528650A5 JP 2013515459 A JP2013515459 A JP 2013515459A JP 2013515459 A JP2013515459 A JP 2013515459A JP 2013528650 A5 JP2013528650 A5 JP 2013528650A5
- Authority
- JP
- Japan
- Prior art keywords
- ylthio
- bromo
- triazol
- acetic acid
- cyclopropylnaphthalen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 51
- -1 4-cyclopropylnaphthalen-1-yl Chemical group 0.000 claims 20
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 7
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 7
- 229960003459 allopurinol Drugs 0.000 claims 7
- 229940116269 uric acid Drugs 0.000 claims 7
- 201000005569 Gout Diseases 0.000 claims 6
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 210000002966 serum Anatomy 0.000 claims 5
- 241000282412 Homo Species 0.000 claims 4
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 claims 3
- BQSJTQLCZDPROO-UHFFFAOYSA-N febuxostat Chemical compound C1=C(C#N)C(OCC(C)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 BQSJTQLCZDPROO-UHFFFAOYSA-N 0.000 claims 3
- 229960005101 febuxostat Drugs 0.000 claims 3
- FGQFOYHRJSUHMR-UHFFFAOYSA-N lesinurad Chemical compound OC(=O)CSC1=NN=C(Br)N1C(C1=CC=CC=C11)=CC=C1C1CC1 FGQFOYHRJSUHMR-UHFFFAOYSA-N 0.000 claims 3
- 239000003064 xanthine oxidase inhibitor Substances 0.000 claims 3
- 201000001431 Hyperuricemia Diseases 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 1
- 229960000583 acetic acid Drugs 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35500410P | 2010-06-15 | 2010-06-15 | |
| US61/355,004 | 2010-06-15 | ||
| US41144910P | 2010-11-08 | 2010-11-08 | |
| US61/411,449 | 2010-11-08 | ||
| US201161430522P | 2011-01-06 | 2011-01-06 | |
| US61/430,522 | 2011-01-06 | ||
| US201161489420P | 2011-05-24 | 2011-05-24 | |
| US61/489,420 | 2011-05-24 | ||
| PCT/US2011/040398 WO2011159732A1 (en) | 2010-06-15 | 2011-06-14 | Treatment of gout and hyperuricemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013528650A JP2013528650A (ja) | 2013-07-11 |
| JP2013528650A5 true JP2013528650A5 (enExample) | 2014-06-05 |
| JP5964821B2 JP5964821B2 (ja) | 2016-08-03 |
Family
ID=45348529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515459A Expired - Fee Related JP5964821B2 (ja) | 2010-06-15 | 2011-06-14 | 痛風と高尿酸血症の処置 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9216179B2 (enExample) |
| EP (1) | EP2582683B1 (enExample) |
| JP (1) | JP5964821B2 (enExample) |
| CA (1) | CA2802407C (enExample) |
| CY (1) | CY1120473T1 (enExample) |
| DK (1) | DK2582683T3 (enExample) |
| ES (1) | ES2670700T3 (enExample) |
| HR (1) | HRP20180780T1 (enExample) |
| HU (1) | HUE038265T2 (enExample) |
| LT (1) | LT2582683T (enExample) |
| NO (1) | NO2019008I1 (enExample) |
| PL (1) | PL2582683T3 (enExample) |
| PT (1) | PT2582683T (enExample) |
| RS (1) | RS57275B1 (enExample) |
| SI (1) | SI2582683T1 (enExample) |
| SM (1) | SMT201800266T1 (enExample) |
| TR (1) | TR201806828T4 (enExample) |
| WO (1) | WO2011159732A1 (enExample) |
| ZA (1) | ZA201300055B (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9402827B2 (en) | 2010-03-30 | 2016-08-02 | Ardea Biosciences, Inc. | Treatment of gout |
| ES2670700T3 (es) * | 2010-06-15 | 2018-05-31 | Ardea Biosciences, Inc. | Tratamiento de gota e hiperuricemia |
| UA114304C2 (uk) * | 2011-11-03 | 2017-05-25 | Ардеа Біосайєнсіс, Інк. | Спосіб зниження сироваткових рівнів сечової кислоти у людини |
| AR091651A1 (es) | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| CN103613552A (zh) * | 2013-12-02 | 2014-03-05 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸钠的新晶型及其制备方法 |
| CN103755651A (zh) * | 2013-12-23 | 2014-04-30 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的盐的新晶型及其制备方法 |
| WO2015095703A1 (en) | 2013-12-20 | 2015-06-25 | Crystal Pharmatech, Inc. | Novel salts and co-crystals of lesinurad |
| JP2015160847A (ja) * | 2014-02-28 | 2015-09-07 | ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ | 小分子のキサンチンオキシダーゼ阻害剤および使用方法 |
| CN105622531A (zh) | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
| WO2016203436A1 (en) * | 2015-06-19 | 2016-12-22 | Dr. Reddy's Laboratories Limited | Amorphous and amorphous solid dispersion of lesinurad and their preparation |
| EP3112334A1 (en) | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Process for manufacturing 1-cyclopropyl-naphthalenes |
| CN108289848A (zh) * | 2015-12-08 | 2018-07-17 | 阿迪亚生命科学公司 | 包含urat1的有效抑制剂的药物组合物 |
| CA3060185A1 (en) | 2018-10-26 | 2020-04-26 | The Procter & Gamble Company | Sanitary tissue product rolls |
| US11447916B2 (en) | 2018-10-26 | 2022-09-20 | The Procter & Gamble Company | Paper towel rolls |
| US12152347B2 (en) | 2018-10-26 | 2024-11-26 | The Procter & Gamble Company | Sanitary tissue product rolls |
| CA3060180A1 (en) | 2018-10-26 | 2020-04-26 | The Procter & Gamble Company | Sanitary tissue product rolls |
| JP7440934B2 (ja) * | 2019-08-21 | 2024-02-29 | 国立大学法人 東京大学 | Ａｂｃｃ１１阻害剤 |
| CN110824067B (zh) * | 2019-12-11 | 2024-12-27 | 天津药物研究院有限公司 | 一种非布司他中基因毒性杂质的检测方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4914611B2 (ja) | 2003-12-26 | 2012-04-11 | キッセイ薬品工業株式会社 | ベンズイミダゾール誘導体及びその医薬用途 |
| US20060189811A1 (en) | 2004-07-23 | 2006-08-24 | Fujiyakuhin Co., Ltd. | Process for producing 1,2,4-triazole compound and intermediate therefor |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| EP2402011B1 (en) | 2004-08-25 | 2012-11-14 | Ardea Biosciences, Inc. | S-triazolyl alpha-mercaptoacetanilides as inhibitors of HIV reverse transcriptase |
| EP2120956A4 (en) | 2007-01-19 | 2010-01-20 | Takeda Pharmaceuticals North A | METHODS FOR PREVENTING OR REDUCING THE NUMBER OF DROUGHT ERYTHEMES USING XANTHINE OXYDOREDUCTASE INHIBITORS AND INFLAMMATORY AGENTS |
| EA201270666A1 (ru) | 2007-11-27 | 2012-12-28 | Ардеа Биосайнсиз Инк. | Соединения и фармацевтические композиции для снижения уровня мочевой кислоты |
| JP2012502050A (ja) | 2008-09-04 | 2012-01-26 | アルディア バイオサイエンス，インク． | 尿酸値を調節するための化合物、組成物及びそれを使用する方法。 |
| US8242154B2 (en) * | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US8173690B2 (en) * | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US20100160351A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| EP2432774A4 (en) * | 2009-05-20 | 2013-01-02 | Ardea Biosciences Inc | COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING URIC ACID RATES |
| EP2266966A1 (en) | 2009-06-11 | 2010-12-29 | Chemo Ibérica, S.A. | A process for the preparation of febuxostat |
| MX2012007925A (es) | 2010-01-08 | 2012-08-03 | Ardea Biosciences Inc | Formas polimorficas, cristalinas y de mesofase de 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-ilti o)acetato de sodio, y usos de las mismas. |
| US9402827B2 (en) * | 2010-03-30 | 2016-08-02 | Ardea Biosciences, Inc. | Treatment of gout |
| ES2670700T3 (es) * | 2010-06-15 | 2018-05-31 | Ardea Biosciences, Inc. | Tratamiento de gota e hiperuricemia |
| WO2012000103A1 (en) * | 2010-07-02 | 2012-01-05 | University Health Network | Methods of targeting pten mutant diseases and compositions therefor |
| EP2627331A4 (en) * | 2010-10-15 | 2014-03-12 | Ardea Biosciences Inc | METHODS OF TREATING HYPERURICEMIA AND RELATED DISEASES |
| MX2013007505A (es) | 2010-12-30 | 2013-08-01 | Ardea Biosciences Inc | Formas polimorficas de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1 -il)-4h-1,2,4-triazol-3-iltio)acetico y usos de los mismos. |
| US20140171424A1 (en) | 2011-05-24 | 2014-06-19 | Ardea Biosciences, Inc. | Hypertension and hyperuricemia |
-
2011
- 2011-06-14 ES ES11796324.9T patent/ES2670700T3/es active Active
- 2011-06-14 PT PT117963249T patent/PT2582683T/pt unknown
- 2011-06-14 TR TR2018/06828T patent/TR201806828T4/tr unknown
- 2011-06-14 DK DK11796324.9T patent/DK2582683T3/en active
- 2011-06-14 HU HUE11796324A patent/HUE038265T2/hu unknown
- 2011-06-14 US US13/704,192 patent/US9216179B2/en active Active
- 2011-06-14 JP JP2013515459A patent/JP5964821B2/ja not_active Expired - Fee Related
- 2011-06-14 HR HRP20180780TT patent/HRP20180780T1/hr unknown
- 2011-06-14 SM SM20180266T patent/SMT201800266T1/it unknown
- 2011-06-14 RS RS20180571A patent/RS57275B1/sr unknown
- 2011-06-14 LT LTEP11796324.9T patent/LT2582683T/lt unknown
- 2011-06-14 WO PCT/US2011/040398 patent/WO2011159732A1/en not_active Ceased
- 2011-06-14 SI SI201131474T patent/SI2582683T1/en unknown
- 2011-06-14 PL PL11796324T patent/PL2582683T3/pl unknown
- 2011-06-14 CA CA2802407A patent/CA2802407C/en not_active Expired - Fee Related
- 2011-06-14 EP EP11796324.9A patent/EP2582683B1/en not_active Revoked
-
2013
- 2013-01-03 ZA ZA2013/00055A patent/ZA201300055B/en unknown
-
2015
- 2015-11-12 US US14/939,963 patent/US20160143889A1/en not_active Abandoned
-
2018
- 2018-05-18 CY CY20181100520T patent/CY1120473T1/el unknown
- 2018-09-19 US US16/135,153 patent/US20190015392A1/en not_active Abandoned
-
2019
- 2019-02-19 NO NO2019008C patent/NO2019008I1/no unknown
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