CA2802407C - Treatment of gout and hyperuricemia - Google Patents
Treatment of gout and hyperuricemia Download PDFInfo
- Publication number
- CA2802407C CA2802407C CA2802407A CA2802407A CA2802407C CA 2802407 C CA2802407 C CA 2802407C CA 2802407 A CA2802407 A CA 2802407A CA 2802407 A CA2802407 A CA 2802407A CA 2802407 C CA2802407 C CA 2802407C
- Authority
- CA
- Canada
- Prior art keywords
- gout
- ylthio
- bromo
- triazol
- cyclopropylnaphthalen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
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Landscapes
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Applications Claiming Priority (9)
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| US35500410P | 2010-06-15 | 2010-06-15 | |
| US61/355,004 | 2010-06-15 | ||
| US41144910P | 2010-11-08 | 2010-11-08 | |
| US61/411,449 | 2010-11-08 | ||
| US201161430522P | 2011-01-06 | 2011-01-06 | |
| US61/430,522 | 2011-01-06 | ||
| US201161489420P | 2011-05-24 | 2011-05-24 | |
| US61/489,420 | 2011-05-24 | ||
| PCT/US2011/040398 WO2011159732A1 (en) | 2010-06-15 | 2011-06-14 | Treatment of gout and hyperuricemia |
Publications (2)
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| CA2802407A1 CA2802407A1 (en) | 2011-12-22 |
| CA2802407C true CA2802407C (en) | 2018-01-23 |
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| CA2802407A Expired - Fee Related CA2802407C (en) | 2010-06-15 | 2011-06-14 | Treatment of gout and hyperuricemia |
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| SI (1) | SI2582683T1 (enExample) |
| SM (1) | SMT201800266T1 (enExample) |
| TR (1) | TR201806828T4 (enExample) |
| WO (1) | WO2011159732A1 (enExample) |
| ZA (1) | ZA201300055B (enExample) |
Families Citing this family (19)
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| CA2794798C (en) | 2010-03-30 | 2017-05-30 | Ardea Biosciences, Inc. | Treatment of gout |
| PT2582683T (pt) * | 2010-06-15 | 2018-05-25 | Ardea Biosciences Inc | Tratamento da gota e de hiperuricemia |
| CA2852490A1 (en) * | 2011-11-03 | 2013-05-10 | Ardea Biosciences, Inc. | 3,4-di-substituted pyridine compound to reduce serum uric acid levels |
| AR091651A1 (es) | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
| US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
| CN103613552A (zh) * | 2013-12-02 | 2014-03-05 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸钠的新晶型及其制备方法 |
| CN103755651A (zh) * | 2013-12-23 | 2014-04-30 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸的盐的新晶型及其制备方法 |
| US9969701B2 (en) | 2013-12-20 | 2018-05-15 | Crystal Pharmatech Co., Ltd. | Salts and co-crystals of lesinurad |
| JP2015160847A (ja) * | 2014-02-28 | 2015-09-07 | ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ | 小分子のキサンチンオキシダーゼ阻害剤および使用方法 |
| CN105622531A (zh) | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
| WO2016203436A1 (en) * | 2015-06-19 | 2016-12-22 | Dr. Reddy's Laboratories Limited | Amorphous and amorphous solid dispersion of lesinurad and their preparation |
| EP3112334A1 (en) | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Process for manufacturing 1-cyclopropyl-naphthalenes |
| JP6976946B2 (ja) * | 2015-12-08 | 2021-12-08 | アーディア・バイオサイエンシーズ・インコーポレイテッドArdea Biosciences, Inc. | 生理活性の強い、ｕｒａｔ１のインヒビターを含む医薬組成物 |
| US11447916B2 (en) | 2018-10-26 | 2022-09-20 | The Procter & Gamble Company | Paper towel rolls |
| CA3060211C (en) | 2018-10-26 | 2025-05-13 | The Procter & Gamble Company | TOILET PAPER ROLLS |
| US11633076B2 (en) | 2018-10-26 | 2023-04-25 | The Procter & Gamble Company | Sanitary tissue product rolls |
| US11700979B2 (en) | 2018-10-26 | 2023-07-18 | The Procter & Gamble Company | Sanitary tissue product rolls |
| US20220288038A1 (en) * | 2019-08-21 | 2022-09-15 | The University Of Tokyo | Abcc11 inhibitor |
| CN110824067B (zh) * | 2019-12-11 | 2024-12-27 | 天津药物研究院有限公司 | 一种非布司他中基因毒性杂质的检测方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005063788A1 (ja) | 2003-12-26 | 2005-07-14 | Kissei Pharmaceutical Co., Ltd. | ベンズイミダゾール誘導体及びその医薬用途 |
| US20060189811A1 (en) | 2004-07-23 | 2006-08-24 | Fujiyakuhin Co., Ltd. | Process for producing 1,2,4-triazole compound and intermediate therefor |
| EA015846B1 (ru) | 2004-08-25 | 2011-12-30 | Ардеа Байосайенсиз, Инк. | 2-[5-бром-4-(4-циклопропилнафталин-1-ил)-4н-[1,2,4]триазол-3-илсульфанил]уксусная кислота и ее метиловый эфир |
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| US20090042887A1 (en) | 2007-01-19 | 2009-02-12 | Tap Pharmaceutical Products, Inc. | Methods for Preventing or Reducing the Number of Gout Flares Using Xanthine Oxidoreductase Inhibitors and Anti-Inflammatory Agents |
| NZ595035A (en) | 2007-11-27 | 2012-11-30 | Ardea Biosciences Inc | Substituted diazole and triazole compounds and compositions and methods of use |
| US8173690B2 (en) * | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| MX2011002450A (es) | 2008-09-04 | 2011-05-25 | Ardea Biosciences Inc | Compuestos, composiciones y métodos para utilizar los mismos para modular niveles de ácido úrico. |
| US8242154B2 (en) * | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US20100160351A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| EP2432774A4 (en) * | 2009-05-20 | 2013-01-02 | Ardea Biosciences Inc | COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING URIC ACID RATES |
| EP2266966A1 (en) | 2009-06-11 | 2010-12-29 | Chemo Ibérica, S.A. | A process for the preparation of febuxostat |
| MY161482A (en) | 2010-01-08 | 2017-04-14 | Ardea Biosciences Inc | Polymorphic, crystalline and mesophase forms of sodium 2-(5-bromo-4-(4-cyclopropylnapthalen-1-yl)-4h-1,2,4-triazol-3-ylthio)acetate, and uses thereof |
| CA2794798C (en) | 2010-03-30 | 2017-05-30 | Ardea Biosciences, Inc. | Treatment of gout |
| PT2582683T (pt) * | 2010-06-15 | 2018-05-25 | Ardea Biosciences Inc | Tratamento da gota e de hiperuricemia |
| US8933070B2 (en) * | 2010-07-02 | 2015-01-13 | University Health Network | Methods of targeting PTEN mutant diseases and compositions therefor |
| US20130296345A1 (en) * | 2010-10-15 | 2013-11-07 | Ardea Biosciences, Inc. | Methods for treating hyperuricemia and related diseases |
| AU2011352129B2 (en) * | 2010-12-30 | 2015-01-22 | Ardea Biosciences, Inc. | Polymorphic forms of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid and uses thereof |
| MX348281B (es) | 2011-05-24 | 2017-06-02 | Ardea Biosciences Inc * | Hipertension e hiperuricemia. |
-
2011
- 2011-06-14 PT PT117963249T patent/PT2582683T/pt unknown
- 2011-06-14 WO PCT/US2011/040398 patent/WO2011159732A1/en not_active Ceased
- 2011-06-14 PL PL11796324T patent/PL2582683T3/pl unknown
- 2011-06-14 LT LTEP11796324.9T patent/LT2582683T/lt unknown
- 2011-06-14 ES ES11796324.9T patent/ES2670700T3/es active Active
- 2011-06-14 US US13/704,192 patent/US9216179B2/en active Active
- 2011-06-14 HU HUE11796324A patent/HUE038265T2/hu unknown
- 2011-06-14 EP EP11796324.9A patent/EP2582683B1/en not_active Revoked
- 2011-06-14 TR TR2018/06828T patent/TR201806828T4/tr unknown
- 2011-06-14 SM SM20180266T patent/SMT201800266T1/it unknown
- 2011-06-14 RS RS20180571A patent/RS57275B1/sr unknown
- 2011-06-14 HR HRP20180780TT patent/HRP20180780T1/hr unknown
- 2011-06-14 JP JP2013515459A patent/JP5964821B2/ja not_active Expired - Fee Related
- 2011-06-14 CA CA2802407A patent/CA2802407C/en not_active Expired - Fee Related
- 2011-06-14 DK DK11796324.9T patent/DK2582683T3/en active
- 2011-06-14 SI SI201131474T patent/SI2582683T1/en unknown
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2013
- 2013-01-03 ZA ZA2013/00055A patent/ZA201300055B/en unknown
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2015
- 2015-11-12 US US14/939,963 patent/US20160143889A1/en not_active Abandoned
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2018
- 2018-05-18 CY CY20181100520T patent/CY1120473T1/el unknown
- 2018-09-19 US US16/135,153 patent/US20190015392A1/en not_active Abandoned
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2019
- 2019-02-19 NO NO2019008C patent/NO2019008I1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1120473T1 (el) | 2019-07-10 |
| WO2011159732A1 (en) | 2011-12-22 |
| RS57275B1 (sr) | 2018-08-31 |
| LT2582683T (lt) | 2018-06-11 |
| US20130178484A1 (en) | 2013-07-11 |
| TR201806828T4 (tr) | 2018-06-21 |
| JP5964821B2 (ja) | 2016-08-03 |
| JP2013528650A (ja) | 2013-07-11 |
| HRP20180780T1 (hr) | 2018-07-13 |
| ES2670700T3 (es) | 2018-05-31 |
| EP2582683A1 (en) | 2013-04-24 |
| PT2582683T (pt) | 2018-05-25 |
| SI2582683T1 (en) | 2018-07-31 |
| EP2582683A4 (en) | 2014-04-30 |
| US20190015392A1 (en) | 2019-01-17 |
| US9216179B2 (en) | 2015-12-22 |
| HUE038265T2 (hu) | 2018-10-29 |
| EP2582683B1 (en) | 2018-03-21 |
| US20160143889A1 (en) | 2016-05-26 |
| PL2582683T3 (pl) | 2018-08-31 |
| SMT201800266T1 (it) | 2018-07-17 |
| CA2802407A1 (en) | 2011-12-22 |
| ZA201300055B (en) | 2018-05-30 |
| DK2582683T3 (en) | 2018-06-06 |
| NO2019008I1 (no) | 2019-02-19 |
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