AR124985A1 - Nuevas formas de sal de un inhibidor de cyp11a1 estructurado en 4h-piran-4-ona - Google Patents
Nuevas formas de sal de un inhibidor de cyp11a1 estructurado en 4h-piran-4-onaInfo
- Publication number
- AR124985A1 AR124985A1 ARP220100427A ARP220100427A AR124985A1 AR 124985 A1 AR124985 A1 AR 124985A1 AR P220100427 A ARP220100427 A AR P220100427A AR P220100427 A ARP220100427 A AR P220100427A AR 124985 A1 AR124985 A1 AR 124985A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- cyp11a1
- inhibitor
- piran
- ona
- Prior art date
Links
- 150000003839 salts Chemical group 0.000 title abstract 5
- 108010084976 Cholesterol Side-Chain Cleavage Enzyme Proteins 0.000 title abstract 2
- 102100027516 Cholesterol side-chain cleavage enzyme, mitochondrial Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 3
- LHVKCOBGLZGRQZ-UHFFFAOYSA-N 2-(1,3-dihydroisoindol-2-ylmethyl)-5-[(1-methylsulfonylpiperidin-4-yl)methoxy]pyran-4-one Chemical compound C1N(CC2=CC=CC=C12)CC=1OC=C(C(C=1)=O)OCC1CCN(CC1)S(=O)(=O)C LHVKCOBGLZGRQZ-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- XTEGVFVZDVNBPF-UHFFFAOYSA-N naphthalene-1,5-disulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1S(O)(=O)=O XTEGVFVZDVNBPF-UHFFFAOYSA-N 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 abstract 1
- 229940092714 benzenesulfonic acid Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 crystalline salts Chemical class 0.000 abstract 1
- AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical compound OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 abstract 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000011976 maleic acid Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 235000006408 oxalic acid Nutrition 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a sales nuevas, particularmente sales cristalinas, de 2-(isoindolin-2-ilmetil)-5-((1-(metilsulfonil)piperidin-4-il)metoxi)-4H-piran-4-ona (I) que son particularmente adecuadas para su uso en la fabricación de composiciones farmacéuticas. Además, la invención se refiere a composiciones farmacéuticas que comprenden dichas sales nuevas. El compuesto (I) es un inhibidor selectivo de la enzima CYP11A1 y es útil en el tratamiento de cánceres regulados por hormonas, tal como el cáncer de próstata y el cáncer de mama. Reivindicación 1: Una sal de 2-(isoindolin-2-ilmetil)-5-((1-(metilsulfonil)piperidin-4-il)metoxi)-4H-piran-4-ona (I) con un ácido seleccionado del grupo caracterizada porque consiste en ácido p-toluenosulfónico, ácido 2-naftalenosulfónico, ácido 1,5-naftalenodisulfónico, ácido bromhídrico, ácido nítrico, ácido bencenosulfónico, ácido clorhídrico, ácido maleico, ácido 1,2-etanodisulfónico, ácido oxálico, ácido etanosulfónico, ácido sulfúrico y ácido metanosulfónico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20215217 | 2021-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR124985A1 true AR124985A1 (es) | 2023-05-24 |
Family
ID=80685169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP220100427A AR124985A1 (es) | 2021-03-01 | 2022-02-25 | Nuevas formas de sal de un inhibidor de cyp11a1 estructurado en 4h-piran-4-ona |
Country Status (16)
Country | Link |
---|---|
US (1) | US20240158377A1 (es) |
EP (1) | EP4301750A1 (es) |
JP (1) | JP2024511297A (es) |
KR (1) | KR20230165775A (es) |
CN (1) | CN117242069A (es) |
AR (1) | AR124985A1 (es) |
AU (1) | AU2022230234A1 (es) |
BR (1) | BR112023017416A2 (es) |
CA (1) | CA3210592A1 (es) |
CL (1) | CL2023002588A1 (es) |
CO (1) | CO2023011532A2 (es) |
IL (1) | IL305517A (es) |
MX (1) | MX2023010268A (es) |
PE (1) | PE20240084A1 (es) |
TW (1) | TW202302578A (es) |
WO (1) | WO2022184978A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023139312A1 (en) * | 2022-01-20 | 2023-07-27 | Orion Corporation | Pharmaceutical composition of a cyp11a1 inhibitor |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR110412A1 (es) | 2016-12-22 | 2019-03-27 | Orion Corp | Inhibidores de la cyp11a1 |
-
2022
- 2022-02-25 AR ARP220100427A patent/AR124985A1/es unknown
- 2022-02-28 JP JP2023553469A patent/JP2024511297A/ja active Pending
- 2022-02-28 BR BR112023017416A patent/BR112023017416A2/pt unknown
- 2022-02-28 PE PE2023002472A patent/PE20240084A1/es unknown
- 2022-02-28 EP EP22709342.4A patent/EP4301750A1/en active Pending
- 2022-02-28 CN CN202280032282.6A patent/CN117242069A/zh active Pending
- 2022-02-28 IL IL305517A patent/IL305517A/en unknown
- 2022-02-28 AU AU2022230234A patent/AU2022230234A1/en active Pending
- 2022-02-28 CA CA3210592A patent/CA3210592A1/en active Pending
- 2022-02-28 WO PCT/FI2022/050130 patent/WO2022184978A1/en active Application Filing
- 2022-02-28 KR KR1020237033636A patent/KR20230165775A/ko unknown
- 2022-02-28 US US18/548,487 patent/US20240158377A1/en active Pending
- 2022-02-28 MX MX2023010268A patent/MX2023010268A/es unknown
- 2022-03-01 TW TW111107384A patent/TW202302578A/zh unknown
-
2023
- 2023-08-30 CO CONC2023/0011532A patent/CO2023011532A2/es unknown
- 2023-08-31 CL CL2023002588A patent/CL2023002588A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN117242069A (zh) | 2023-12-15 |
EP4301750A1 (en) | 2024-01-10 |
BR112023017416A2 (pt) | 2023-09-26 |
JP2024511297A (ja) | 2024-03-13 |
CO2023011532A2 (es) | 2023-11-20 |
AU2022230234A1 (en) | 2023-09-07 |
PE20240084A1 (es) | 2024-01-16 |
KR20230165775A (ko) | 2023-12-05 |
CL2023002588A1 (es) | 2024-02-02 |
US20240158377A1 (en) | 2024-05-16 |
CA3210592A1 (en) | 2022-09-09 |
WO2022184978A1 (en) | 2022-09-09 |
IL305517A (en) | 2023-10-01 |
MX2023010268A (es) | 2023-11-14 |
TW202302578A (zh) | 2023-01-16 |
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