PE20141069A1 - Marcadores de enfermedad tromboembolica - Google Patents

Marcadores de enfermedad tromboembolica

Info

Publication number
PE20141069A1
PE20141069A1 PE2013002819A PE2013002819A PE20141069A1 PE 20141069 A1 PE20141069 A1 PE 20141069A1 PE 2013002819 A PE2013002819 A PE 2013002819A PE 2013002819 A PE2013002819 A PE 2013002819A PE 20141069 A1 PE20141069 A1 PE 20141069A1
Authority
PE
Peru
Prior art keywords
factor
serpin
risk
subject
event
Prior art date
Application number
PE2013002819A
Other languages
English (en)
Inventor
Eduardo Salas
Jose Manuel Soria
Miroslava Ogorelkova
Roberto Elosua
Joan S Vila
Sergio Castillo
Original Assignee
Gendiag Exe Sl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46320920&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141069(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gendiag Exe Sl filed Critical Gendiag Exe Sl
Publication of PE20141069A1 publication Critical patent/PE20141069A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA LA EVALUACION DEL RIESGO DE UN EVENTO TROMBOEMBOLICO EN UN SUJETO QUE COMPRENDE DETERMINAR EN UNA MUESTRA AISLADA TAL COMO SALIVA, ORINA O SANGRE DE DICHO SUJETO LA PRESENCIA DE SERPIN A10 (INHIBIDOR DE LA PROTEINA Z), Arg67Stop (RS2232698), SERPIN C1 (ANTITROMBINA), FACTOR XII C46T (RS1801020), FACTOR XIII VAL34LEU (RS5985), FACTOR II (PROTROMBINA) G20210A (RS1799963), ENTRE OTROS, QUE ES INDICATIVO DE UN RIESGO DE TENER UN ACONTECIMIENTO TROMBOEMBOLICO TAL COMO INFARTO DE MIOCARDIO, ACCIDENTE CEREBROVASCULAR, ATAQUES ISQUEMICOS TRANSITORIOS, TROMBOSIS VENOSA PROFUNDA, EMBOLIA PULMONAR; EN DONDE LA PRESENCIA O AUSENCIA DEL POLINUCLEOTIDO SE IDENTIFICA POR HIBRIDACION CON SONDAS ESPECIFICAS DE SEC ID N� 1 A 24 APLICADAS COMO MANCHAS EN UN MICROCONJUNTO
PE2013002819A 2011-06-16 2012-06-13 Marcadores de enfermedad tromboembolica PE20141069A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11170235.3A EP2535424B1 (en) 2011-06-16 2011-06-16 SNPs associated with thromboemoblic disease

Publications (1)

Publication Number Publication Date
PE20141069A1 true PE20141069A1 (es) 2014-09-06

Family

ID=46320920

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013002819A PE20141069A1 (es) 2011-06-16 2012-06-13 Marcadores de enfermedad tromboembolica

Country Status (16)

Country Link
US (2) US9518297B2 (es)
EP (3) EP2535424B1 (es)
AR (1) AR086734A1 (es)
AU (1) AU2012269112B2 (es)
BR (1) BR112013032352A2 (es)
CA (1) CA2839368C (es)
CL (1) CL2013003605A1 (es)
DK (2) DK2535424T3 (es)
DO (1) DOP2013000296A (es)
ES (2) ES2547075T3 (es)
MX (2) MX349347B (es)
NO (1) NO2721172T3 (es)
PE (1) PE20141069A1 (es)
PT (2) PT2535424E (es)
RU (1) RU2606758C2 (es)
WO (1) WO2012171949A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10557170B2 (en) 2011-06-16 2020-02-11 Gendiag.Exe, S.L. Thromboembolic disease markers
EP2535424B1 (en) 2011-06-16 2015-08-05 Gendiag.exe, S.L. SNPs associated with thromboemoblic disease
JP2016522679A (ja) 2013-04-04 2016-08-04 プレジデント アンド フェローズ オブ ハーバード カレッジ ＣＲＩＳＰＲ／Ｃａｓ系を用いたゲノム編集の治療的使用
AU2016243583B2 (en) 2015-03-27 2022-03-10 President And Fellows Of Harvard College Modified T cells and methods of making and using the same
WO2017097854A1 (en) * 2015-12-08 2017-06-15 Umc Utrecht Holding B.V. Extracellular vesicle markers for stable angina and unstable angina
EP3551762B1 (en) * 2016-12-09 2022-01-26 Gene Gender S.R.L. Method and kit for predicting the risk of deep vein thrombosis and pulmonary embolism
US11377692B2 (en) 2016-12-09 2022-07-05 Gene Gender S.R.L. Method for predicting the risk of deep vein thrombosis and pulmonary embolism associated with hormonal preparations and hormone levels
WO2018195129A1 (en) 2017-04-17 2018-10-25 University Of Maryland, College Park Embryonic cell cultures and methods of using the same
WO2018215590A1 (en) * 2017-05-24 2018-11-29 Gendiag.Exe, S.L. Cancer-associated venous thromboembolic events
EP3749783A1 (en) * 2018-02-09 2020-12-16 Genincode UK, Ltd. Prediction of pregnancy loss
CN108642163B (zh) * 2018-05-16 2021-10-22 江苏中济万泰生物医药有限公司 一种人类红细胞abo血型基因分型引物组及应用
RU2710213C1 (ru) * 2018-12-17 2019-12-25 Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ) Способ определения вероятности церебральной и нецеребральной тромбоэмболии артерий большого круга кровообращения
EA038901B1 (ru) * 2019-09-27 2021-11-03 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр гематологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ гематологии" Минздрава России) Способ прогнозирования тромбоэмболических осложнений у женщин при носительстве мутаций гена протромбина [f2(20210)ga]
RU2722986C1 (ru) * 2019-12-24 2020-06-05 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр терапии и профилактической медицины" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТПМ" Минздрава России) Способ прогнозирования дополнительного риска тромбоэмболических осложнений у пациентов старческого возраста с фибрилляцией предсердий
CN114410766A (zh) * 2021-11-24 2022-04-29 广州知力医学诊断技术有限公司 一种血栓与出凝血性疾病检测panel及其应用
EP4194568A1 (en) * 2021-12-10 2023-06-14 Genincode Uk Limited Covid-19-associated venous thromboembolism
CN114214402B (zh) * 2021-12-29 2024-02-09 江苏意诺飞生物科技有限公司 血液高凝或静脉血栓风险基因多态性检测引物组、试剂盒及检测方法和应用
CN114937473B (zh) * 2022-07-20 2022-11-18 中日友好医院(中日友好临床医学研究所) 基于多基因突变的vte风险评估模型、构建方法及应用

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US1975A (en) 1841-02-12 Manner of constructing corn-shellers
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EP2535424B1 (en) 2011-06-16 2015-08-05 Gendiag.exe, S.L. SNPs associated with thromboemoblic disease

Also Published As

Publication number Publication date
EP2535424B1 (en) 2015-08-05
NO2721172T3 (es) 2018-06-09
RU2606758C2 (ru) 2017-01-10
WO2012171949A3 (en) 2013-02-21
EP2721172A2 (en) 2014-04-23
DK2535424T3 (en) 2015-09-14
DOP2013000296A (es) 2014-03-31
CL2013003605A1 (es) 2014-08-08
WO2012171949A2 (en) 2012-12-20
US20160102355A1 (en) 2016-04-14
US10023914B2 (en) 2018-07-17
AU2012269112B2 (en) 2015-09-03
PT2535424E (pt) 2015-10-29
AU2012269112A1 (en) 2014-01-30
ES2547075T3 (es) 2015-10-01
BR112013032352A2 (pt) 2018-10-30
MX2013014622A (es) 2014-03-27
DK2721172T5 (en) 2018-02-26
CA2839368A1 (en) 2012-12-20
PT2721172T (pt) 2018-02-21
RU2014101169A (ru) 2015-07-27
ES2663943T3 (es) 2018-04-17
EP2721172B1 (en) 2018-01-10
EP2799556A2 (en) 2014-11-05
MX360663B (es) 2018-11-13
DK2721172T3 (en) 2018-02-19
CA2839368C (en) 2018-12-04
US9518297B2 (en) 2016-12-13
MX349347B (es) 2017-07-25
EP2799556A3 (en) 2015-04-08
US20140221230A1 (en) 2014-08-07
EP2535424A1 (en) 2012-12-19
AR086734A1 (es) 2014-01-22

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