MX336940B - Uso de compuestos mejoradores de señal en deteccion de electroquimioluminiscencia. - Google Patents

Uso de compuestos mejoradores de señal en deteccion de electroquimioluminiscencia.

Info

Publication number
MX336940B
MX336940B MX2013004230A MX2013004230A MX336940B MX 336940 B MX336940 B MX 336940B MX 2013004230 A MX2013004230 A MX 2013004230A MX 2013004230 A MX2013004230 A MX 2013004230A MX 336940 B MX336940 B MX 336940B
Authority
MX
Mexico
Prior art keywords
signal enhancing
enhancing compounds
electrochemiluminescence
electrochemiluminescence detection
detection
Prior art date
Application number
MX2013004230A
Other languages
English (en)
Other versions
MX2013004230A (es
Inventor
Johannes Stoeckel
Michaela Windfuhr
Andreas Finke
Bernhard Hauptmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013004230A publication Critical patent/MX2013004230A/es
Publication of MX336940B publication Critical patent/MX336940B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/10—Modification of an amino radical directly attached in position 6
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Plasma & Fusion (AREA)
  • Fluid Mechanics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La invención se refiere a métodos para la detección de un analito en una muestra por electroquimioluminiscencia usando nuevas composiciones de reactivo. Se describen nuevas composiciones de reactivos, kits de reactivos para medir electroquimioluminiscencia (ECL) y métodos de detección de electroquimioluminiscencia usando las nuevas composiciones de reactivos. En particular, la invención se refiere al uso de nuevas combinaciones de compuestos que se pueden usar en estas mediciones para proporcionar desempeño mejorado a ensayo.
MX2013004230A 2010-10-25 2011-10-24 Uso de compuestos mejoradores de señal en deteccion de electroquimioluminiscencia. MX336940B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10188716 2010-10-25
EP10192106 2010-11-22
PCT/EP2011/068540 WO2012055815A1 (en) 2010-10-25 2011-10-24 Use of signal enhancing compounds in electrochemiluminescence detection

Publications (2)

Publication Number Publication Date
MX2013004230A MX2013004230A (es) 2013-05-30
MX336940B true MX336940B (es) 2016-02-08

Family

ID=44860372

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004230A MX336940B (es) 2010-10-25 2011-10-24 Uso de compuestos mejoradores de señal en deteccion de electroquimioluminiscencia.

Country Status (15)

Country Link
US (1) US9341575B2 (es)
EP (1) EP2633289B1 (es)
JP (1) JP5824523B2 (es)
KR (1) KR101789356B1 (es)
CN (1) CN103443614B (es)
AU (1) AU2011322704B2 (es)
BR (1) BR112013007614B1 (es)
CA (1) CA2813089C (es)
DK (1) DK2633289T3 (es)
ES (1) ES2581553T3 (es)
HU (1) HUE029030T2 (es)
MX (1) MX336940B (es)
PL (1) PL2633289T3 (es)
SG (1) SG189113A1 (es)
WO (1) WO2012055815A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106153953A (zh) * 2015-04-03 2016-11-23 盐城拜明生物技术有限公司 一种用于检测血清样品中叶酸含量的叶酸释放剂
EP3426398B1 (en) 2016-03-11 2024-01-24 Roche Diagnostics GmbH Branched-chain amines in electrochemiluminescence detection
CN106124753B (zh) * 2016-07-08 2018-03-06 广州东林生物科技有限公司 电化学发光缓冲液及清洗液
CN108375571B (zh) * 2018-02-05 2019-11-26 苏州长光华医生物医学工程有限公司 一种用于化学发光免疫检测的磁颗粒试剂及试剂盒
WO2020142313A1 (en) * 2019-01-03 2020-07-09 Meso Scale Technologies, Llc Compositions and methods for carrying out assay measurements
WO2021019732A1 (ja) * 2019-07-31 2021-02-04 株式会社日立ハイテク 生体分子分析方法および生体分子分析装置
CN115518417B (zh) * 2022-09-01 2024-09-06 天津鸿宇泰生物科技有限公司 用于化学发光检测试剂的消泡剂组合物、使用方法和应用
CN115494232B (zh) * 2022-10-31 2023-10-27 江苏三联生物工程股份有限公司 4,4-二甲基噁唑啉在制备含辣根过氧化物酶的试剂中的应用

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL178647C (nl) * 1974-03-08 1986-05-01 Duphar Int Res Werkwijze ter bereiding van een de plantengroei bevorderende vloeibare samenstelling.
US4628037A (en) 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
US4554088A (en) 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4695393A (en) 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4698302A (en) 1983-05-12 1987-10-06 Advanced Magnetics, Inc. Enzymatic reactions using magnetic particles
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
US5591581A (en) 1986-04-30 1997-01-07 Igen, Inc. Electrochemiluminescent rhenium moieties and methods for their use
US6165729A (en) 1986-04-30 2000-12-26 Hyperion Catalysis International, Inc. Electrochemiluminescent reaction utilizing amine-derived reductant
US6316607B1 (en) 1986-04-30 2001-11-13 Igen International, Inc. Electrochemiluminescent assays
US4965392A (en) 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
US5935779A (en) 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5308754A (en) 1988-03-21 1994-05-03 Kankare Jouko J Electrogenerated luminescence in solution
US5093268A (en) 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
CA2002083C (en) 1988-11-03 2001-01-09 Haresh P. Shah Enhanced electrochemiluminescence
US5779976A (en) * 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5705402A (en) 1988-11-03 1998-01-06 Igen International, Inc. Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
US5324457A (en) 1989-10-02 1994-06-28 Board Of Regents, The University Of Tx System Devices and methods for generating electrogenerated chemiluminescence
JPH0534345A (ja) 1991-02-19 1993-02-09 Tdk Corp 化学発光を利用する抗原・抗体の測定方法
ZA929351B (en) 1991-12-11 1993-06-04 Igen Inc Electrochemiluminescent label for DNA assays.
JP3541047B2 (ja) * 1993-02-18 2004-07-07 日本化薬株式会社 バイオリアクターの防腐剤および測定法
DE4401577A1 (de) * 1993-05-03 1994-11-10 Boehringer Mannheim Gmbh Elektrochemilumineszenzverfahren
WO1994025853A1 (de) * 1993-05-03 1994-11-10 Boehringer Mannheim Gmbh Elektrochemilumineszenzverfahren
US5466416A (en) 1993-05-14 1995-11-14 Ghaed; Ali Apparatus and methods for carrying out electrochemiluminescence test measurements
EP0720614B1 (de) 1994-07-25 2000-05-24 Roche Diagnostics GmbH Metallkomplexe mit geladenem linker
US5786141A (en) 1994-08-26 1998-07-28 Bard; Allen J. Electrogenerated chemiluminescence labels for analysis and/or referencing
US5866434A (en) 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US5641623A (en) 1995-01-04 1997-06-24 Martin; Mark T. Electrochemiluminescence assay
US20010003647A1 (en) 1995-06-07 2001-06-14 Ji Sun Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same
US5643713A (en) 1995-06-07 1997-07-01 Liang; Pam Electrochemiluminescent monitoring of compounds
WO1996028538A1 (en) 1995-03-10 1996-09-19 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6140045A (en) 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6207369B1 (en) 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US5679519A (en) 1995-05-09 1997-10-21 Oprandy; John J. Multi-label complex for enhanced sensitivity in electrochemiluminescence assay
US6099760A (en) 1995-06-07 2000-08-08 Igen, Inc. Hydrogen peroxide based ECL
GB9606850D0 (en) 1996-04-01 1996-06-05 Univ Liverpool An assay system and novel labelled compounds for use therwith
FI970593L (fi) * 1997-02-12 1998-08-13 Sakari Mikael Kulmala Pinnoitettujen johteiden käyttö analyyttisiin tarkoituksiin
FR2764381A1 (fr) 1997-06-09 1998-12-11 Univ De Neuchatel Detecteur electrochimioluminescent
US6413783B1 (en) 1997-09-18 2002-07-02 Meso Scale Technologies, Llc Assay sonication apparatus and methodology
DE19803528A1 (de) 1998-01-30 1999-08-05 Roche Diagnostics Gmbh Verfahren zur Analyse einer Probe mittels eines Elektrochemolumineszenz-Bindungsreaktion-Tests
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
EP0962773A1 (en) 1998-06-03 1999-12-08 Mark Howard Jones Electrochemical based assay processes instrument and labels
GB9815042D0 (en) 1998-07-10 1998-09-09 Imperial College Detector
US6136268A (en) 1999-08-17 2000-10-24 Orion Diagnostica Method for luminescence measurements
US6994971B1 (en) * 1999-10-08 2006-02-07 University Of Utah Research Foundation Particle analysis assay for biomolecular quantification
US7897404B2 (en) 2000-09-29 2011-03-01 Roche Diagnostics Operations, Inc. Conjugates of defined stoichiometry
DK1412487T3 (da) 2001-07-30 2010-08-30 Meso Scale Technologies Llc Assayelektroder der har immobiliserede lipid/proteinlag og fremgangsmåder til at fremstille og anvende disse
CA2932756C (en) * 2001-09-10 2020-07-07 Meso Scale Technologies, Llc Assay buffer, compositions containing the same, and methods of using the same
CA2511389C (en) * 2002-12-26 2016-10-18 Meso Scale Technologies, Llc. Assay cartridges and methods of using the same
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
FI119894B (fi) * 2005-03-30 2009-04-30 Labmaster Oy Elektrokemiluminesenssiin perustuva analyysimenetelmä ja siinä käytettävä laite
WO2007002580A2 (en) * 2005-06-23 2007-01-04 Bioveris Corporation Diagnostic as say system with multi -well reagent container
EP1963853B1 (en) 2005-12-21 2016-03-09 Meso Scale Technologies, LLC Assay modules having assay reagents and methods of making and using same
ATE530895T1 (de) 2006-08-25 2011-11-15 Hoffmann La Roche Zelle zur durchführung elektrochemilumineszenter messungen
CN101246125A (zh) * 2008-03-14 2008-08-20 华南师范大学 基于纳米/微米粒子放大信号的非pcr扩增的快速检测转基因产品的电化学发光方法
JP2010237020A (ja) * 2009-03-31 2010-10-21 Japan Aerospace Exploration Agency 生体分子検出装置及び生体分子検出方法
FI20100246L (fi) * 2010-06-11 2011-12-12 Sakari Kulmala Menetelmät ja laitteet luminesenssin tuottamiseksi integroiduista elektrodisiruista katodisten ja bipolaaristen pulssien avulla

Also Published As

Publication number Publication date
MX2013004230A (es) 2013-05-30
PL2633289T3 (pl) 2016-12-30
CA2813089C (en) 2018-02-20
AU2011322704B2 (en) 2014-12-11
JP5824523B2 (ja) 2015-11-25
US20130224758A1 (en) 2013-08-29
BR112013007614A2 (pt) 2018-05-02
US9341575B2 (en) 2016-05-17
HUE029030T2 (en) 2017-01-30
KR101789356B1 (ko) 2017-10-23
EP2633289A1 (en) 2013-09-04
KR20140012940A (ko) 2014-02-04
CN103443614B (zh) 2015-07-22
HK1188826A1 (en) 2014-05-16
EP2633289B1 (en) 2016-04-20
CN103443614A (zh) 2013-12-11
CA2813089A1 (en) 2012-05-03
BR112013007614B1 (pt) 2020-12-29
DK2633289T3 (en) 2016-06-06
SG189113A1 (en) 2013-05-31
JP2013542436A (ja) 2013-11-21
AU2011322704A1 (en) 2013-03-21
WO2012055815A1 (en) 2012-05-03
ES2581553T3 (es) 2016-09-06

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