WO2013167727A3 - Method for determining arthritis relapse risk - Google Patents

Method for determining arthritis relapse risk Download PDF

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Publication number
WO2013167727A3
WO2013167727A3 PCT/EP2013/059707 EP2013059707W WO2013167727A3 WO 2013167727 A3 WO2013167727 A3 WO 2013167727A3 EP 2013059707 W EP2013059707 W EP 2013059707W WO 2013167727 A3 WO2013167727 A3 WO 2013167727A3
Authority
WO
WIPO (PCT)
Prior art keywords
arthritis
determining
risk
patient
relapse risk
Prior art date
Application number
PCT/EP2013/059707
Other languages
French (fr)
Other versions
WO2013167727A2 (en
Inventor
Johannes Roth
Dirk FOELL
Original Assignee
Westfaelische Wilhelms-Universitaet Muenster
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Westfaelische Wilhelms-Universitaet Muenster filed Critical Westfaelische Wilhelms-Universitaet Muenster
Publication of WO2013167727A2 publication Critical patent/WO2013167727A2/en
Publication of WO2013167727A3 publication Critical patent/WO2013167727A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4727—Calcium binding proteins, e.g. calmodulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4737—C-reactive protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/38—Pediatrics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/54—Determining the risk of relapse

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to an in vitro diagnostic method for diagnosis of the risk of relapses in arthritis, preferably in juvenile idiopathic arthritis in a patient by combined testing of the patient sample for S100A12 and high sensitivity C-Reactive Protein (hsCRP). The present invention relates to an in vitro diagnostic method for excluding the risk of developing arthritis relapses in a patient by combined testing of the patient sample for S100A12 and hsCRP.
PCT/EP2013/059707 2012-05-11 2013-05-10 Method for determining arthritis relapse risk WO2013167727A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12167742 2012-05-11
EP12167742.1 2012-05-11

Publications (2)

Publication Number Publication Date
WO2013167727A2 WO2013167727A2 (en) 2013-11-14
WO2013167727A3 true WO2013167727A3 (en) 2014-01-09

Family

ID=48579012

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2013/059707 WO2013167727A2 (en) 2012-05-11 2013-05-10 Method for determining arthritis relapse risk

Country Status (1)

Country Link
WO (1) WO2013167727A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102858991A (en) 2009-10-15 2013-01-02 克雷桑多生物科技公司 Biomarkers and methods for measuring and monitoring inflammatory disease activity
CA2943821A1 (en) 2014-04-02 2015-10-08 Crescendo Bioscience Biomarkers and methods for measuring and monitoring juvenile idiopathic arthritis activity
CA2950771A1 (en) 2014-06-10 2015-12-17 Crescendo Bioscience Biomarkers and methods for measuring and monitoring axial spondyloarthritis disease activity
JP6830105B2 (en) 2015-09-29 2021-02-17 クレッシェンド バイオサイエンス インコーポレイテッド Biomarkers and methods for assessing disease activity in psoriatic arthritis
WO2017058999A2 (en) 2015-09-29 2017-04-06 Crescendo Bioscience Biomarkers and methods for assessing response to inflammatory disease therapy withdrawal
US11448648B2 (en) 2016-11-11 2022-09-20 Ascendant Diagnostics, LLC Compositions and methods for diagnosing and differentiating systemic juvenile idiopathic arthritis and Kawasaki disease

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003069341A2 (en) * 2002-02-15 2003-08-21 Clemens Sorg Method of diagnosis of inflammatory diseases using calgranulin c
WO2009050277A2 (en) * 2007-10-19 2009-04-23 Erac As Edta resistant s100a12 complexes (erac)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976A (en) 1848-12-19 Sash bearer and fastener
US832A (en) 1838-07-12 Improvement in m any-cham bered-cyli nder fire-arms

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003069341A2 (en) * 2002-02-15 2003-08-21 Clemens Sorg Method of diagnosis of inflammatory diseases using calgranulin c
WO2009050277A2 (en) * 2007-10-19 2009-04-23 Erac As Edta resistant s100a12 complexes (erac)

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"Abstracts", ZEITSCHRIFT FÜR RHEUMATOLOGIE, STEINKOPFF-VERLAG, DA, vol. 69, no. 1, 12 September 2010 (2010-09-12), pages 3 - 92, XP019846721, ISSN: 1435-1250 *
BON SAN ET AL: "OP11. REACTIVATION OF LATENT TUBERCULOSIS INFECTION AND NEW INFECTION OF TUBERCULOSIS IN PATIENTS WITH ANTI-TUMOR NECROSIS FACTOR THERAPY FOR TUBERCULOSIS-ENDEMIC AREA LARGE VESSEL DISEASE IN GIANT CELL ARTERITIS: A POPULATION-BASED COHORT STUDY OF INCIDENCE TRENDS", 1 February 2012 (2012-02-01), XP055087963, Retrieved from the Internet <URL:http://rheumatology.oxfordjournals.org/content/51/suppl_1/i18.full.pdf> [retrieved on 20131113] *
D. FOELL ET AL: "Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis", RHEUMATOLOGY, vol. 42, no. 11, 1 November 2003 (2003-11-01), pages 1383 - 1389, XP055071431, ISSN: 1462-0324, DOI: 10.1093/rheumatology/keg385 *
DIRK FOELL ET AL: "Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrations", ARTHRITIS & RHEUMATISM, vol. 50, no. 4, 1 April 2004 (2004-04-01), pages 1286 - 1295, XP055071733, ISSN: 0004-3591, DOI: 10.1002/art.20125 *
DIRK FOELL ET AL: "Phagocyte-specific calcium-binding S100 proteins as clinical laboratory markers of inflammation", CLINICA CHIMICA ACTA, vol. 344, no. 1-2, 1 June 2004 (2004-06-01), pages 37 - 51, XP055087841, ISSN: 0009-8981, DOI: 10.1016/j.cccn.2004.02.023 *
DIRK HOLZINGER ET AL: "The Toll-like receptor 4 agonist MRP8/14 protein complex is a sensitive indicator for disease activity and predicts relapses in systemic-onset juvenile idiopathic arthritis", ANNALS OF THE RHEUMATIC DISEASES, BRITISH MEDICAL ASSOCIATION, LONDON, GB, vol. 71, 1 January 2012 (2012-01-01), pages 974 - 980, XP009171191, ISSN: 0003-4967, [retrieved on 20120120], DOI: 10.1136/ANNRHEUMDIS-2011-200598 *
KISS LS ET AL: "High-sensitivity C-reactive Protein for Identification of Disease Phenotype, Active Disease, and Clinical Relapses in Crohn's Disease: A Marker for Patient Classification?", INFLAMMATORY BOWEL DISEASES, JOHN WILEY & SONS, INC, UNITED STATES, vol. 18, no. 9, 13 November 2011 (2011-11-13), pages 1647 - 1654, XP009171290, ISSN: 1536-4844, [retrieved on 20110101], DOI: 10.1002/IBD.21933 *
SITA NAIK: "Laboratory tests and the paediatric rheumatologist: What does he need to know?", INDIAN JOURNAL OF RHEUMATOLOGY, vol. 7, no. 1, 1 May 2012 (2012-05-01), pages 106 - 111, XP055071734, ISSN: 0973-3698, DOI: 10.1016/S0973-3698(12)60036-3 *

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Publication number Publication date
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