MX2018003077A - Metodos para diagnosticar y evaluar esteatohepatitis no alcoholica. - Google Patents
Metodos para diagnosticar y evaluar esteatohepatitis no alcoholica.Info
- Publication number
- MX2018003077A MX2018003077A MX2018003077A MX2018003077A MX2018003077A MX 2018003077 A MX2018003077 A MX 2018003077A MX 2018003077 A MX2018003077 A MX 2018003077A MX 2018003077 A MX2018003077 A MX 2018003077A MX 2018003077 A MX2018003077 A MX 2018003077A
- Authority
- MX
- Mexico
- Prior art keywords
- nash
- alcoholic steatohepatitis
- diagnosing
- methods
- mir
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/723—Glycosylated haemoglobin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
- G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
La invención se refiere a un método para el diagnóstico de esteatohepatitis no alcohólica (NASH), para determinar la actividad, la etapa, o la severidad de NASH o para clasificar un sujeto como un posible receptor o no receptor de un tratamiento de NASH. También se refiere a un kit para implementar el método de la invención, y los compuestos para usar en un método para el tratamiento de NASH, en donde el sujeto a tratarse se identifica, evalúa o clasifica de acuerdo al método de la invención.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15306412 | 2015-09-14 | ||
PCT/EP2016/071727 WO2017046181A1 (en) | 2015-09-14 | 2016-09-14 | Methods for diagnosing and evaluating non-alcoholic steatohepatitis |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018003077A true MX2018003077A (es) | 2018-05-28 |
Family
ID=54199140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018003077A MX2018003077A (es) | 2015-09-14 | 2016-09-14 | Metodos para diagnosticar y evaluar esteatohepatitis no alcoholica. |
Country Status (18)
Country | Link |
---|---|
US (2) | US11371098B2 (es) |
EP (2) | EP3712279B1 (es) |
JP (2) | JP6947721B2 (es) |
KR (1) | KR20180049098A (es) |
CN (1) | CN108138232B (es) |
AU (1) | AU2016323380B2 (es) |
CA (1) | CA2997336A1 (es) |
DK (1) | DK3350341T3 (es) |
EA (1) | EA201890724A1 (es) |
ES (1) | ES2891347T3 (es) |
HK (1) | HK1255351A1 (es) |
HU (1) | HUE056299T2 (es) |
IL (1) | IL257680B2 (es) |
MX (1) | MX2018003077A (es) |
PH (1) | PH12018500513A1 (es) |
PT (1) | PT3350341T (es) |
WO (1) | WO2017046181A1 (es) |
ZA (1) | ZA201801630B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130252835A1 (en) | 2012-01-27 | 2013-09-26 | Lian Chye Winston Koh | Methods for profiling and quantitating cell-free rna |
AU2017242818B2 (en) * | 2016-03-30 | 2023-04-27 | Genfit | Non-invasive diagnostic of non-alcoholic steatohepatitis |
CA3070038A1 (en) | 2017-08-25 | 2019-02-28 | Genfit | Non-invasive diagnostic of non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis and/or liver fibrosis |
BR112020004136A2 (pt) | 2017-09-08 | 2020-09-08 | Bristol-Myers Squibb Company | fator de crescimento de fibroblastos modificado 21 (fgf-21) para uso nos métodos de tratamento de esteato-hepatite não alcoólica (nash) |
WO2019053235A1 (en) | 2017-09-15 | 2019-03-21 | Genfit | NON-INVASIVE DIAGNOSIS OF NON ALCOHOLIC LIVER DISEASES, NON ALCOHOLIC STHEATHEPATITIS AND / OR HEPATIC FIBROSIS |
KR20200051676A (ko) | 2017-09-18 | 2020-05-13 | 장피트 | 비알콜성 지방 간 질환, 비알콜성 지방간염 및/또는 간 섬유화의 비침습성 진단 |
EP3546597A1 (en) | 2018-03-28 | 2019-10-02 | Sanofi | Biomarker panel for nafld/nash |
WO2020168118A1 (en) | 2019-02-14 | 2020-08-20 | Mirvie, Inc. | Methods and systems for determining a pregnancy-related state of a subject |
MX2021010475A (es) | 2019-03-13 | 2021-10-01 | Genfit | Diagnostico de esteatohepatitis no alcoholica. |
CN110143890B (zh) * | 2019-06-12 | 2020-12-22 | 天津科技大学 | 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用 |
KR20210010100A (ko) | 2019-07-19 | 2021-01-27 | 고려대학교 산학협력단 | 체질량지수와 자기공명영상을 이용한 비알코올성 지방간 질환 진단방법 |
CN110484605B (zh) * | 2019-09-23 | 2020-07-28 | 中国人民解放军陆军军医大学第一附属医院 | 一种活细胞原位检测microRNA-34的基因及其制备方法和应用 |
CN110578003A (zh) * | 2019-10-22 | 2019-12-17 | 安徽医科大学第二附属医院 | miR-200a在制备肝癌诊断治疗试剂盒及在制备抗肿瘤药物中的应用 |
KR102341336B1 (ko) * | 2019-11-20 | 2021-12-21 | 숙명여자대학교산학협력단 | 만성간질환의 예후 예측용 바이오마커 조성물 |
JP2023548156A (ja) * | 2020-10-30 | 2023-11-15 | ザ ジェネラル ホスピタル コーポレイション | 肝疾患の評価のためのキット、試薬、及び方法 |
CN116507918A (zh) | 2020-10-30 | 2023-07-28 | 基恩菲特公司 | 肝纤维化的诊断方法 |
WO2024038901A1 (ja) * | 2022-08-17 | 2024-02-22 | 公益財団法人東京都医学総合研究所 | 肝疾患非侵襲性バイオマーカー及びこれを用いた肝疾患の検出 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010058295A2 (en) * | 2008-11-18 | 2010-05-27 | Universite D'angers | Non-invasive in vitro method for quantifying liver lesions |
PL2641596T3 (pl) * | 2009-11-26 | 2018-10-31 | Genfit | Zastosowanie pochodnych 1,3-difenyloprop-2-en-1-onu do leczenia zaburzeń wątroby |
DK2776590T3 (en) * | 2011-11-07 | 2016-12-05 | Roche Innovation Ct Copenhagen As | Prognostic method of assessing the efficacy of MICRO-RNA-122 inhibitors for HCV + patients |
WO2013068348A1 (en) | 2011-11-07 | 2013-05-16 | Santaris Pharma A/S | Lna oligomers for improvement in hepatic function |
WO2013125691A1 (ja) | 2012-02-23 | 2013-08-29 | 住友ベークライト株式会社 | テスト体液サンプルの分類方法 |
EP2684513A1 (en) * | 2012-07-13 | 2014-01-15 | Universite D'angers | Method for providing reliable non-invasive diagnostic tests |
WO2014049131A1 (en) * | 2012-09-28 | 2014-04-03 | Université d'Angers | Accurate blood test for the non-invasive diagnosis of non-alcoholic steatohepatitis |
KR20140147920A (ko) * | 2013-06-19 | 2014-12-31 | 가톨릭대학교 산학협력단 | 비알코올성 지방간염 감별용 바이오마커 miR-34a |
CN104293908A (zh) * | 2014-06-18 | 2015-01-21 | 镇江市第三人民医院 | 用于检测非酒精性脂肪肝的血清miRNA标志物组合及应用 |
-
2016
- 2016-09-14 ES ES16769923T patent/ES2891347T3/es active Active
- 2016-09-14 JP JP2018513289A patent/JP6947721B2/ja active Active
- 2016-09-14 EA EA201890724A patent/EA201890724A1/ru unknown
- 2016-09-14 EP EP20169118.5A patent/EP3712279B1/en active Active
- 2016-09-14 MX MX2018003077A patent/MX2018003077A/es unknown
- 2016-09-14 CN CN201680053197.2A patent/CN108138232B/zh active Active
- 2016-09-14 US US15/759,484 patent/US11371098B2/en active Active
- 2016-09-14 IL IL257680A patent/IL257680B2/en unknown
- 2016-09-14 HU HUE16769923A patent/HUE056299T2/hu unknown
- 2016-09-14 AU AU2016323380A patent/AU2016323380B2/en active Active
- 2016-09-14 EP EP16769923.0A patent/EP3350341B1/en active Active
- 2016-09-14 CA CA2997336A patent/CA2997336A1/en active Pending
- 2016-09-14 WO PCT/EP2016/071727 patent/WO2017046181A1/en active Application Filing
- 2016-09-14 DK DK16769923.0T patent/DK3350341T3/da active
- 2016-09-14 PT PT167699230T patent/PT3350341T/pt unknown
- 2016-09-14 KR KR1020187010656A patent/KR20180049098A/ko not_active Application Discontinuation
-
2018
- 2018-03-08 PH PH12018500513A patent/PH12018500513A1/en unknown
- 2018-03-09 ZA ZA2018/01630A patent/ZA201801630B/en unknown
- 2018-11-13 HK HK18114490.6A patent/HK1255351A1/zh unknown
-
2021
- 2021-06-01 JP JP2021092441A patent/JP7274523B2/ja active Active
-
2022
- 2022-06-24 US US17/849,161 patent/US20220411874A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
HK1255351A1 (zh) | 2019-08-16 |
AU2016323380B2 (en) | 2023-01-05 |
US20220411874A1 (en) | 2022-12-29 |
PT3350341T (pt) | 2021-09-28 |
EP3350341A1 (en) | 2018-07-25 |
IL257680B (en) | 2022-11-01 |
AU2016323380A1 (en) | 2018-03-29 |
PH12018500513A1 (en) | 2018-09-24 |
IL257680B2 (en) | 2023-03-01 |
CN108138232B (zh) | 2023-07-18 |
CA2997336A1 (en) | 2017-03-23 |
EP3712279B1 (en) | 2024-03-20 |
ZA201801630B (en) | 2019-01-30 |
JP2021144048A (ja) | 2021-09-24 |
DK3350341T3 (da) | 2021-09-27 |
ES2891347T3 (es) | 2022-01-27 |
WO2017046181A1 (en) | 2017-03-23 |
JP2018534542A (ja) | 2018-11-22 |
EP3712279A1 (en) | 2020-09-23 |
JP6947721B2 (ja) | 2021-10-13 |
US20180265924A1 (en) | 2018-09-20 |
KR20180049098A (ko) | 2018-05-10 |
IL257680A (en) | 2018-04-30 |
EA201890724A1 (ru) | 2018-10-31 |
HUE056299T2 (hu) | 2022-02-28 |
JP7274523B2 (ja) | 2023-05-16 |
US11371098B2 (en) | 2022-06-28 |
CN108138232A (zh) | 2018-06-08 |
EP3350341B1 (en) | 2021-08-11 |
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