MX2016013255A - Metodos y composiciones para detectar proteinas mal plegadas. - Google Patents

Metodos y composiciones para detectar proteinas mal plegadas.

Info

Publication number
MX2016013255A
MX2016013255A MX2016013255A MX2016013255A MX2016013255A MX 2016013255 A MX2016013255 A MX 2016013255A MX 2016013255 A MX2016013255 A MX 2016013255A MX 2016013255 A MX2016013255 A MX 2016013255A MX 2016013255 A MX2016013255 A MX 2016013255A
Authority
MX
Mexico
Prior art keywords
compositions
misfolded proteins
methods
detecting misfolded
modalities
Prior art date
Application number
MX2016013255A
Other languages
English (en)
Other versions
MX383381B (es
Inventor
Buhimschi Irina
S Buhimschi Catalin
CHOMA Michael
TAGARE Hemant
Michael JONAS Stephan
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Publication of MX2016013255A publication Critical patent/MX2016013255A/es
Publication of MX383381B publication Critical patent/MX383381B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827—Total protein determination, e.g. albumin in urine
    • G01N33/6839—Total protein determination, e.g. albumin in urine involving dyes, e.g. Coomassie blue, bromcresol green
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/106—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an azo dye
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Varios aspectos y modalidades de la presente descripción están dirigidos hacia métodos y composiciones (por ejemplo, kits) para la identificación de sujetos con proteínas mal plegadas en su orina; por ejemplo, se proveen métodos y composiciones para determinar que una muestra de orina de una mujer embarazada contiene o no contiene proteínas mal plegadas; en algunas modalidades, la presencia de proteínas mal plegadas en una muestra de orina de una mujer embarazada, es una indicación de preeclampsia.
MX2016013255A 2014-04-10 2015-04-10 Métodos y composiciones para detectar proteínas mal plegadas. MX383381B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461978158P 2014-04-10 2014-04-10
PCT/US2015/025432 WO2015157704A2 (en) 2014-04-10 2015-04-10 Methods and compositions for detecting misfolded proteins

Publications (2)

Publication Number Publication Date
MX2016013255A true MX2016013255A (es) 2017-05-03
MX383381B MX383381B (es) 2025-03-13

Family

ID=54264908

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016013255A MX383381B (es) 2014-04-10 2015-04-10 Métodos y composiciones para detectar proteínas mal plegadas.
MX2021006791A MX2021006791A (es) 2014-04-10 2016-10-07 Metodos y composiciones para detectar proteinas mal plegadas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021006791A MX2021006791A (es) 2014-04-10 2016-10-07 Metodos y composiciones para detectar proteinas mal plegadas.

Country Status (11)

Country Link
US (3) US10324094B2 (es)
EP (2) EP3745127B1 (es)
JP (1) JP6697394B2 (es)
CN (2) CN106461644B (es)
AU (3) AU2015243171B2 (es)
CA (2) CA2945058C (es)
DK (1) DK3129779T3 (es)
ES (1) ES2817417T3 (es)
MX (2) MX383381B (es)
WO (1) WO2015157704A2 (es)
ZA (1) ZA201606987B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105021821B (zh) 2008-10-31 2018-05-11 耶鲁大学 先兆子痫检测和治疗的方法和组合物
ES2817417T3 (es) 2014-04-10 2021-04-07 Univ Yale Métodos y composiciones para la detección de proteínas mal plegadas
TWI800009B (zh) * 2015-07-15 2023-04-21 美商蓋斯特維炫股份有限公司 用於檢測折疊錯誤蛋白質之裝置及其使用方法
WO2017180984A1 (en) * 2016-04-14 2017-10-19 The Texas A&M University System First trimester epigenetic and microrna biomarkers for preeclampsia
US10345244B2 (en) * 2016-06-03 2019-07-09 International Business Machines Corporation Diagnostic test device with patterned material spots
US10335045B2 (en) 2016-06-24 2019-07-02 Universita Degli Studi Di Trento Self-adaptive matrix completion for heart rate estimation from face videos under realistic conditions
US10269107B2 (en) * 2017-02-23 2019-04-23 Global Neighbor Inc Selective plant detection and treatment using green luminance photometric machine vision scan with real time chromaticity operations and image parameter floors for low processing load
WO2019071240A1 (en) 2017-10-06 2019-04-11 The Research Foundation For The State University For The State Of New York AQUEOUS AND NONAQUEOUS SELECTIVE OPTICAL DETECTION OF FREE SULPHITES
WO2019128506A1 (zh) * 2017-12-28 2019-07-04 浙江数问生物技术有限公司 一种检测错误折叠蛋白质的装置、试剂盒和方法
US11255844B2 (en) * 2018-03-06 2022-02-22 Fresenius Medical Care Holdings, Inc. Peritoneal dialysis systems and related methods
CN109659011A (zh) * 2018-12-29 2019-04-19 杭州脉流科技有限公司 利用移动设备采集处理十二导联ecg图像的方法以及移动设备和计算机可读存储介质
EP4241285A4 (en) * 2020-11-06 2024-09-04 The Board of Trustees of the Leland Stanford Junior University SYSTEMS AND METHODS FOR ASSESSING GESTATIONAL PROGRESS AND APPLICATIONS THEREOF
CA3199642A1 (en) * 2020-11-21 2022-05-27 Shuwen Biotech Co. Ltd. Apparatus and method for detecting misfolded protein in biological sample
WO2022235564A1 (en) * 2021-05-03 2022-11-10 Memorial Sloan Kettering Cancer Center Detection of labels in biomedical images
TW202409564A (zh) * 2022-05-20 2024-03-01 大陸商數問生物技術（宣城）有限公司 用於檢測生物樣本中的錯誤折疊蛋白質的裝置和方法
WO2024249849A2 (en) * 2023-05-31 2024-12-05 Northwestern University Scalable platform for single cell proteomics via digitized detection of proteins and their proteoforms
CN117236201B (zh) * 2023-11-16 2024-02-23 南京信息工程大学 一种基于Diffusion和ViT的降尺度方法
CN120761295B (zh) * 2025-08-21 2026-02-13 赛克赛斯生物科技股份有限公司 三苯甲烷类化合物在检测阿尔茨海默症中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US234610A (en) * 1880-11-16 Robert o
US4444879A (en) 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
WO1992017769A1 (en) * 1991-03-28 1992-10-15 Micro Research Inc. Controlled-release solid phase assay device including encapsulated reagents for detecting chemical substances
US5998216A (en) 1996-10-01 1999-12-07 Beth Israel Deaconess Medical Center Stabilizing formulation for preserving the integrity of proteins present in a body fluid sampled ex-vivo for evaluation as a specimen
AU5331298A (en) 1996-12-23 1998-07-17 Cambridge University Technical Services Limited Diagnosis and treatment of pathological pregnancies
US6444435B1 (en) * 2000-11-30 2002-09-03 Serim Research Corporation Test strip for determining dialysate composition
US7355044B2 (en) 2001-10-25 2008-04-08 Agfa-Gevaert N.V. Self-assembling dyes
BRPI0312818B8 (pt) 2002-07-19 2021-05-25 Beth Israel Deaconess Medical Ct Inc uso de uma medida do nível do polipeptídeo sflt-1 em uma amostra de uma paciente e uso de uma medida dos níveis de pelo menos dois dos peptídeos sflt1, vegf livre ou polipeptídio pigf livre em uma amostra de um paciente usando um métrico
ATE506072T1 (de) 2002-09-12 2011-05-15 Univ California Immunogene und entsprechende antikörper, die spezifisch sind für häufige hochmolekulare aggregations-zwischenprodukte von amyloiden aus proteinen unterschiedlicher sequenz
BRPI0519096A2 (pt) 2004-12-15 2008-12-23 Beth Israel Hospital Ácidos nuclÉicos e polipeptÍdeos éteis para o diagnàstico e tratamento de complicaÇÕes na gravidez
ATE519109T1 (de) 2004-12-21 2011-08-15 Univ Yale Präeklampsie-diagnose
EP1733762A1 (en) 2005-05-25 2006-12-20 3M Espe AG Dental composition for detection of carious tissue, detection method
WO2007051069A2 (en) 2005-10-27 2007-05-03 Yale University Urinary proteomic biomarker patterns in preeclampsia
KR20100098606A (ko) * 2007-10-18 2010-09-08 몸텍 라이프 리미티드 임신중에 양막 파열을 확인하는 진단기
US20110065139A1 (en) * 2007-11-27 2011-03-17 Jacob Mullerad diagnostic device for identifying rupture of membrane during pregnancy
CN105021821B (zh) 2008-10-31 2018-05-11 耶鲁大学 先兆子痫检测和治疗的方法和组合物
CN103012599B (zh) 2012-11-28 2015-04-29 龙岩九健生物芯片技术研究所 一种调节硝酸纤维素硝化取代度的方法
ES2817417T3 (es) 2014-04-10 2021-04-07 Univ Yale Métodos y composiciones para la detección de proteínas mal plegadas

Also Published As

Publication number Publication date
JP2017518483A (ja) 2017-07-06
US11953505B2 (en) 2024-04-09
US10324094B2 (en) 2019-06-18
EP3745127A1 (en) 2020-12-02
EP3129779A2 (en) 2017-02-15
ES2817417T3 (es) 2021-04-07
WO2015157704A3 (en) 2016-04-28
CA2945058A1 (en) 2015-10-15
AU2020244572B2 (en) 2022-12-15
US20220043001A1 (en) 2022-02-10
CN106461644B (zh) 2022-05-13
CN116027043A (zh) 2023-04-28
EP3129779B1 (en) 2020-06-03
AU2020244572A1 (en) 2020-11-05
AU2015243171B2 (en) 2020-10-15
CN106461644A (zh) 2017-02-22
CA3157573C (en) 2025-11-18
AU2022291625B2 (en) 2024-09-12
EP3745127B1 (en) 2024-08-28
WO2015157704A2 (en) 2015-10-15
MX383381B (es) 2025-03-13
CA2945058C (en) 2022-07-12
DK3129779T3 (da) 2020-09-07
MX2021006791A (es) 2021-07-15
ZA201606987B (en) 2020-01-29
CA3157573A1 (en) 2015-10-15
AU2015243171A1 (en) 2016-10-27
US20190353662A1 (en) 2019-11-21
JP6697394B2 (ja) 2020-05-20
AU2022291625A1 (en) 2023-02-16
US11079392B2 (en) 2021-08-03
US20150293115A1 (en) 2015-10-15

Similar Documents

Publication Publication Date Title
MX383381B (es) Métodos y composiciones para detectar proteínas mal plegadas.
BR112016019836A2 (pt) método para analisar uma amostra de um sujeito, dispositivo de diagnóstico para utilização no diagnóstico da endometriose, kit, uso de um biomarcador, e, método para aumentar uma resposta de anticorpos em um sujeito
MX374652B (es) Ensayos para detectar la presencia o la cantidad de un anticuerpo antifármaco.
BR112016029634A2 (pt) kit, dispositivo e método para a detecção de câncer de fígado
BR112016029521A2 (pt) ?kit, dispositivo e método para a detecção de câncer de estômago?
BR112016029583A2 (pt) ?kit ou dispositivo para a detecção de câncer esofágico e método de detecção?
MX2014004860A (es) Biomarcadores de cancer de pulmon y usos de los mismos.
MX2017005750A (es) Ensayos para detectar subgrupos inmunes de células t y sus métodos de uso.
BR112015026246A2 (pt) dispositivo de transferência de coleta de sangue e separação de sangue e sistema de teste
MX2016001719A (es) Metodos y equipos para predecir el riesgo de tener una enfermedad o evento cardiovascular.
MX2015013436A (es) Metodo de determinacion del sexo de un embrion en un huevo.
MX368995B (es) Dispositivo de separación de fluidos biológicos y sistema de separación y análisis de fluidos biológicos.
MX2022010954A (es) Dispositivo para la deteccion de proteinas mal plegadas y metodos de uso del mismo.
MX383423B (es) Método in vitro para el diagnóstico del síndrqme del intestino irritable y la enfermedad inflamatoria intestinal.
GB2545850A (en) System and method using a combined modality optical probe
BR112016024730A2 (pt) dispositivo, método e conjunto de análise imunocromatográfica
CL2018002522A1 (es) Método de cuantificación de pureza de muestras de partículas subvisibles
BR112017011026A2 (pt) métodos analíticos e arranjos para uso nos mesmos
MX384485B (es) Deteccion temprana de preeclampsia.
NZ720608A (en) Β-glucan assay methods
MX2015015015A (es) Metodo para diagnosticar cancer.
BR112016002709A2 (pt) queratinas como biomarcadores para câncer cervical e sobrevivência
MX2015015023A (es) Metodo para la determinacion de cobre libre.
MX2020005562A (es) Anticuerpos anti-pd-l1 y métodos para utilizarlos para la detección de pd-l1.
BR112017009605A2 (pt) método para o diagnóstico da doença de niemann-pick usando um biomarcador