MX2015015023A - Metodo para la determinacion de cobre libre. - Google Patents

Metodo para la determinacion de cobre libre.

Info

Publication number
MX2015015023A
MX2015015023A MX2015015023A MX2015015023A MX2015015023A MX 2015015023 A MX2015015023 A MX 2015015023A MX 2015015023 A MX2015015023 A MX 2015015023A MX 2015015023 A MX2015015023 A MX 2015015023A MX 2015015023 A MX2015015023 A MX 2015015023A
Authority
MX
Mexico
Prior art keywords
free copper
copper
determining free
serum
determination
Prior art date
Application number
MX2015015023A
Other languages
English (en)
Inventor
Nicola Antonio Colabufo
Francesco Berardi
Marcello Leopoldo
Roberto Perrone
Rossana Squitti
Original Assignee
Canox4Drug S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Canox4Drug S P A filed Critical Canox4Drug S P A
Publication of MX2015015023A publication Critical patent/MX2015015023A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electrolytic Production Of Metals (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

La presente invención se refiere a un nuevo método para determinar la concentración de cobre "libre" en suero, es decir, la porción de cobre del suero no estructuralmente unido a ceruloplasmina. La presente invención se refiere también a un método con un alto grado de sensibilidad y precisión para la determinación de cobre libre en muestras de suero de pacientes con enfermedad de Alzheimer.
MX2015015023A 2013-04-29 2014-04-29 Metodo para la determinacion de cobre libre. MX2015015023A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000253A ITRM20130253A1 (it) 2013-04-29 2013-04-29 Metodo per la determinazione del rame libero
PCT/IB2014/061079 WO2014181215A2 (en) 2013-04-29 2014-04-29 Method for determining free copper

Publications (1)

Publication Number Publication Date
MX2015015023A true MX2015015023A (es) 2016-03-17

Family

ID=48628834

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015023A MX2015015023A (es) 2013-04-29 2014-04-29 Metodo para la determinacion de cobre libre.

Country Status (8)

Country Link
US (1) US20160146841A1 (es)
EP (1) EP2992326A2 (es)
JP (1) JP2016517021A (es)
CN (1) CN105556288A (es)
CA (1) CA2910773A1 (es)
IT (1) ITRM20130253A1 (es)
MX (1) MX2015015023A (es)
WO (1) WO2014181215A2 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105949160B (zh) * 2016-05-26 2018-12-11 徐州工程学院 一种铜离子荧光增强型分子探针及其制备方法和应用
CN107382981B (zh) * 2017-07-05 2020-04-07 河南理工大学 一种基于吡咯-香豆素双腙衍生物的荧光探针及其制备方法和应用
CN110804045B (zh) * 2019-11-08 2021-07-27 浙江工业大学 具潜在抗ad活性的香豆素杂合吡啶酮酰胺衍生物及其制备方法与应用
CN110964512A (zh) * 2019-12-13 2020-04-07 齐齐哈尔大学 一种氧化石墨烯荧光材料及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008762A1 (fr) * 1993-09-20 1995-03-30 Daikin Industries, Ltd. Procede de mesure de la concentration d'un inhibiteur de polymerisation contenu dans un monomere olefinique comprenant du fluor, et procede de polymerisation d'un monomere olefinique comprenant du fluor faisant appel audit procede de mesure
EP1626648A4 (en) * 2002-11-07 2010-04-28 Applied Neurosolutions METHODS FOR PREDICTING IF SUBJECTS WITH LIGHT COGNITIVE DISORDER (MCI) WILL DEVELOP ALZHEIMER'S DISEASE
US7256002B2 (en) * 2003-08-12 2007-08-14 The Institute For Ethnomedicine Screening for neurotoxic amino acid associated with neurological disorders
US6999173B2 (en) * 2003-09-25 2006-02-14 Ffa Sciences Llc Method and apparatus for ratio fluorometry
CN101718779A (zh) * 2009-10-29 2010-06-02 广西师范大学 检测人血清铜蓝蛋白的免疫纳米金同步散射光谱试剂盒及其使用方法
KR101129574B1 (ko) * 2009-12-15 2012-03-27 고려대학교 산학협력단 구리 이온 선택성을 갖는 쿠마린 유도체 및 이를 이용한 발광센서
US10663458B2 (en) * 2012-11-07 2020-05-26 Igea Research Corporation Method and kit for determination of free copper in serum

Also Published As

Publication number Publication date
CN105556288A (zh) 2016-05-04
ITRM20130253A1 (it) 2014-10-30
CA2910773A1 (en) 2014-11-13
JP2016517021A (ja) 2016-06-09
WO2014181215A2 (en) 2014-11-13
EP2992326A2 (en) 2016-03-09
WO2014181215A3 (en) 2015-12-30
US20160146841A1 (en) 2016-05-26

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