MX2023005452A - Deteccion de beta amiloide por espectrometria de masas. - Google Patents

Deteccion de beta amiloide por espectrometria de masas.

Info

Publication number
MX2023005452A
MX2023005452A MX2023005452A MX2023005452A MX2023005452A MX 2023005452 A MX2023005452 A MX 2023005452A MX 2023005452 A MX2023005452 A MX 2023005452A MX 2023005452 A MX2023005452 A MX 2023005452A MX 2023005452 A MX2023005452 A MX 2023005452A
Authority
MX
Mexico
Prior art keywords
amyloid beta
mass spectrometry
methods
beta detection
detection
Prior art date
Application number
MX2023005452A
Other languages
English (en)
Inventor
Diana Tran
Darren Weber
Nigel Clarke
Original Assignee
Quest Diagnostics Invest Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quest Diagnostics Invest Llc filed Critical Quest Diagnostics Invest Llc
Publication of MX2023005452A publication Critical patent/MX2023005452A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827—Total protein determination, e.g. albumin in urine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Se proporcionan métodos para la detección o cuantificación de beta amiloide. En un aspecto particular, se proporcionan métodos para la detección de beta amiloide o sus fragmentos mediante espectrometría de masas. En otro aspecto, se proporcionan métodos para determinar la relación de beta amiloide 42 (Aß42) a beta amiloide 40 (Aß40). En otro aspecto, se proporcionan métodos para el diagnóstico o pronóstico de la enfermedad de Alzheimer o demencia.
MX2023005452A 2015-09-28 2018-03-28 Deteccion de beta amiloide por espectrometria de masas. MX2023005452A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562234027P 2015-09-28 2015-09-28
US201662277772P 2016-01-12 2016-01-12

Publications (1)

Publication Number Publication Date
MX2023005452A true MX2023005452A (es) 2023-05-26

Family

ID=58407005

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018004017A MX2018004017A (es) 2015-09-28 2016-09-28 Deteccion de beta amiloide por espectrometria de masas.
MX2023005452A MX2023005452A (es) 2015-09-28 2018-03-28 Deteccion de beta amiloide por espectrometria de masas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018004017A MX2018004017A (es) 2015-09-28 2016-09-28 Deteccion de beta amiloide por espectrometria de masas.

Country Status (8)

Country Link
US (2) US11360098B2 (es)
EP (2) EP3356831B1 (es)
JP (3) JP6979401B2 (es)
CN (2) CN108291916B (es)
BR (1) BR112018006018A2 (es)
CA (1) CA3000178C (es)
MX (2) MX2018004017A (es)
WO (1) WO2017058895A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11360098B2 (en) * 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry
CA3071626A1 (en) 2017-07-31 2019-02-07 Quest Diagnostics Investments Llc Apolipoprotein e isotype detection by mass spectrometry
CN109045311B (zh) * 2018-08-29 2021-07-20 王金环 普鲁士蓝纳米mri示踪剂及其制备方法和应用
CN110045046A (zh) * 2019-03-28 2019-07-23 东莞市中鼎检测技术有限公司 一种生鲜食材的预处理方法及氨基酸含量测定方法
CN110441428B (zh) * 2019-08-19 2021-08-24 江南大学 一种快速分析蛋白质及强极性长氨基酸序列糖肽的方法
CN113527459B (zh) * 2021-06-28 2023-07-11 广州睿徕医学诊断技术有限公司 一种萃取剂及其制备方法与应用
WO2024133743A1 (en) * 2022-12-21 2024-06-27 EM Scientific Limited Method for diagnosing and/or classifying the severity of a neurodegenerative disease
CN117471007A (zh) * 2023-10-31 2024-01-30 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一种血浆β-淀粉样蛋白检测方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4774175A (en) * 1985-03-01 1988-09-27 Centocor, Inc. Immunochemical methods for the detection of antibody against HTLV-III
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
ES2201077T3 (es) 1993-05-28 2004-03-16 Baylor College Of Medicine Metodo y espectrometro de masas para la desorcion e ionizacion de analitos.
US5772874A (en) 1995-11-02 1998-06-30 Cohesive Technologies, Inc. High performance liquid chromatography method and apparatus
PL327920A1 (en) 1996-01-19 1999-01-04 Cohesive Technologies Highly efficient liquid chromatography process and chromatographic apparatus therefor
GB9717926D0 (en) 1997-08-22 1997-10-29 Micromass Ltd Methods and apparatus for tandem mass spectrometry
US6040575A (en) 1998-01-23 2000-03-21 Analytica Of Branford, Inc. Mass spectrometry from surfaces
WO2000017328A2 (en) * 1998-09-21 2000-03-30 Isis Innovation Limited Fibrils
US20040226056A1 (en) * 1998-12-22 2004-11-11 Myriad Genetics, Incorporated Compositions and methods for treating neurological disorders and diseases
SE0103084D0 (sv) 2001-09-14 2001-09-14 Amersham Pharm Biotech Ab Generation of ion exchange media
US20040096907A1 (en) 2002-11-06 2004-05-20 Bernd Bohrmann Quantification of beta amyloid
CA2585148A1 (en) * 2004-10-28 2006-05-04 Sanko Junyaku Co., Ltd. Method of examining alzheimer's disease and diagnostic reagent
CN101374555B (zh) * 2005-04-06 2013-04-17 圣路易斯华盛顿州立大学 神经衍生的生物分子体内代谢的检测方法
WO2006138325A2 (en) * 2005-06-16 2006-12-28 Vermillion, Inc. Fragment of neurosecretory protein vgf as a biomarker for alzheimer's disease
US20070134802A1 (en) * 2005-06-30 2007-06-14 Heinz Doebeli Ionization modifier for mass spectrometry
JP5102205B2 (ja) * 2005-07-13 2012-12-19 コイミュン インコーポレイテッド 触媒免疫グロブリン
CN101196526A (zh) * 2006-12-06 2008-06-11 许洋 一种结核快速诊断的质谱分析试剂盒和方法
JP5639889B2 (ja) * 2007-09-18 2014-12-10 ダコ デンマーク アクティーゼルスカブ 生物学的標的の高速で高感度な検出方法
WO2009062152A1 (en) * 2007-11-09 2009-05-14 Washington University In St. Louis Methods for measuring the metabolism of cns derived biomolecules in vivo
JP5080945B2 (ja) * 2007-11-09 2012-11-21 株式会社日立ハイテクノロジーズ 質量分析装置および質量分析方法
US20090134325A1 (en) * 2007-11-27 2009-05-28 Goldman Mildred M Methods for detecting estradiol by mass spectrometry
US8916385B2 (en) * 2007-12-13 2014-12-23 Quest Diagnostics Investments, Inc. Methods for detecting estrone by mass spectrometry
AU2014265047A1 (en) * 2008-11-12 2014-12-11 The Washington University Simultaneous measurement of the in vivo metabolism of isoforms of a biomolecule
JP6166016B2 (ja) 2008-12-05 2017-07-19 シー２エヌ ダイアグノスティクス 生体分子の濃度を測定するための方法
CA2764153C (en) * 2009-06-02 2021-07-27 The Board Of Regents Of The University Of Texas System Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
CN105067698B (zh) * 2009-11-05 2018-11-20 奎斯特诊断投资公司 用高分辨率质谱法量化胰岛素样生长因子-i和胰岛素样生长因子-ii
US20130137120A1 (en) * 2010-01-28 2013-05-30 Panasonic Corporation Amyloid b measurement method
DE102010026094B4 (de) * 2010-07-05 2012-01-12 Sigeng Han Ein neues Verfahren zum Charakterisieren und multidimensionalen Darstellen des Faltungsvorgangs der Proteine
HUE055674T2 (hu) 2010-10-29 2021-12-28 Thermo Fisher Scientific Oy Rendszerelrendezés automatizált mintaelõkészítõ és -elemzõ rendszerhez
BR112014014960A2 (pt) 2011-12-19 2017-06-13 Univ Washington métodos para o diagnóstico da doença de alzheimer
BR112015005887B1 (pt) * 2012-09-20 2022-04-19 Quest Diagnostics Investments Incorporated Método para a determinação da quantidade de tiroglobulina em uma amostra de teste
US11360098B2 (en) * 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry

Also Published As

Publication number Publication date
CA3000178C (en) 2022-07-12
JP2021192038A (ja) 2021-12-16
JP7407776B2 (ja) 2024-01-04
US11360098B2 (en) 2022-06-14
WO2017058895A1 (en) 2017-04-06
JP2024050535A (ja) 2024-04-10
CN108291916A (zh) 2018-07-17
US20220349897A1 (en) 2022-11-03
EP4275777A2 (en) 2023-11-15
BR112018006018A2 (pt) 2018-11-06
EP4275777A3 (en) 2024-01-10
CA3000178A1 (en) 2017-04-06
JP2018535398A (ja) 2018-11-29
JP6979401B2 (ja) 2021-12-15
EP3356831B1 (en) 2023-09-27
MX2018004017A (es) 2018-06-27
EP3356831A1 (en) 2018-08-08
CN117761323A (zh) 2024-03-26
CN108291916B (zh) 2024-01-02
EP3356831A4 (en) 2019-08-21
US20170089917A1 (en) 2017-03-30

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