BR112018006018A2 - detecção de beta-amiloide através de espectrometria de massa - Google Patents
detecção de beta-amiloide através de espectrometria de massaInfo
- Publication number
- BR112018006018A2 BR112018006018A2 BR112018006018A BR112018006018A BR112018006018A2 BR 112018006018 A2 BR112018006018 A2 BR 112018006018A2 BR 112018006018 A BR112018006018 A BR 112018006018A BR 112018006018 A BR112018006018 A BR 112018006018A BR 112018006018 A2 BR112018006018 A2 BR 112018006018A2
- Authority
- BR
- Brazil
- Prior art keywords
- beta
- amyloid
- mass spectrometry
- methods
- amyloid detection
- Prior art date
Links
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title abstract 3
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title abstract 3
- 238000004949 mass spectrometry Methods 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 108010064397 amyloid beta-protein (1-40) Proteins 0.000 abstract 1
- 108010064539 amyloid beta-protein (1-42) Proteins 0.000 abstract 1
- FEWOUVRMGWFWIH-ILZZQXMPSA-N amyloid-beta polypeptide 40 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 FEWOUVRMGWFWIH-ILZZQXMPSA-N 0.000 abstract 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6827—Total protein determination, e.g. albumin in urine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
a presente invenção refere-se a métodos para a detecção ou quantificação de beta-amiloide. em um aspecto específico, são providos no presente documento métodos para detectar beta-amiloide ou fragmentos da mesma através de espectrometria de massa. em um outro aspecto, são providos no presente documento métodos para determinar a razão de beta-amiloide 42 (aß42) para beta-amiloide 40 (aß40). em um outro aspecto, são providos no presente documento métodos para diagnóstico ou prognóstico do mal de alzheimer ou demência.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562234027P | 2015-09-28 | 2015-09-28 | |
| US201662277772P | 2016-01-12 | 2016-01-12 | |
| PCT/US2016/054148 WO2017058895A1 (en) | 2015-09-28 | 2016-09-28 | Amyloid beta detection by mass spectrometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018006018A2 true BR112018006018A2 (pt) | 2018-11-06 |
Family
ID=58407005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018006018A BR112018006018A2 (pt) | 2015-09-28 | 2016-09-28 | detecção de beta-amiloide através de espectrometria de massa |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11360098B2 (pt) |
| EP (2) | EP3356831B1 (pt) |
| JP (3) | JP6979401B2 (pt) |
| CN (2) | CN108291916B (pt) |
| BR (1) | BR112018006018A2 (pt) |
| CA (1) | CA3000178C (pt) |
| MX (2) | MX2018004017A (pt) |
| WO (1) | WO2017058895A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11360098B2 (en) * | 2015-09-28 | 2022-06-14 | Quest Diagnostics Investments Llc | Amyloid beta detection by mass spectrometry |
| BR112020002027A2 (pt) | 2017-07-31 | 2020-10-06 | Quest Diagnostics Investments Llc | detecção de isótipo de apolipoproteína e por espectrometria de massa |
| CN109045311B (zh) * | 2018-08-29 | 2021-07-20 | 王金环 | 普鲁士蓝纳米mri示踪剂及其制备方法和应用 |
| CN110045046A (zh) * | 2019-03-28 | 2019-07-23 | 东莞市中鼎检测技术有限公司 | 一种生鲜食材的预处理方法及氨基酸含量测定方法 |
| CN110441428B (zh) * | 2019-08-19 | 2021-08-24 | 江南大学 | 一种快速分析蛋白质及强极性长氨基酸序列糖肽的方法 |
| CN113527459B (zh) * | 2021-06-28 | 2023-07-11 | 广州睿徕医学诊断技术有限公司 | 一种萃取剂及其制备方法与应用 |
| WO2024133743A1 (en) * | 2022-12-21 | 2024-06-27 | EM Scientific Limited | Method for diagnosing and/or classifying the severity of a neurodegenerative disease |
| CN117471007B (zh) * | 2023-10-31 | 2024-08-09 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 一种血浆β-淀粉样蛋白检测方法 |
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| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| CA2163426C (en) | 1993-05-28 | 2005-11-01 | T. William Hutchens | Method and apparatus for desorption and ionization of analytes |
| US5772874A (en) | 1995-11-02 | 1998-06-30 | Cohesive Technologies, Inc. | High performance liquid chromatography method and apparatus |
| PL327920A1 (en) | 1996-01-19 | 1999-01-04 | Cohesive Technologies | Highly efficient liquid chromatography process and chromatographic apparatus therefor |
| GB9717926D0 (en) | 1997-08-22 | 1997-10-29 | Micromass Ltd | Methods and apparatus for tandem mass spectrometry |
| US6040575A (en) | 1998-01-23 | 2000-03-21 | Analytica Of Branford, Inc. | Mass spectrometry from surfaces |
| JP2002526508A (ja) * | 1998-09-21 | 2002-08-20 | イシス・イノベイシヨン・リミテツド | フィブリル |
| US20040226056A1 (en) * | 1998-12-22 | 2004-11-11 | Myriad Genetics, Incorporated | Compositions and methods for treating neurological disorders and diseases |
| SE0103084D0 (sv) | 2001-09-14 | 2001-09-14 | Amersham Pharm Biotech Ab | Generation of ion exchange media |
| US20040096907A1 (en) | 2002-11-06 | 2004-05-20 | Bernd Bohrmann | Quantification of beta amyloid |
| AU2005297854A1 (en) * | 2004-10-28 | 2006-05-04 | Sanko Junyaku Co., Ltd. | Method of examining Alzheimer's disease and diagnostic reagent |
| CA2604057C (en) * | 2005-04-06 | 2014-02-11 | Randall John Bateman | Methods for measuring the metabolism of neurally derived biomolecules in vivo |
| WO2006138325A2 (en) * | 2005-06-16 | 2006-12-28 | Vermillion, Inc. | Fragment of neurosecretory protein vgf as a biomarker for alzheimer's disease |
| US20070134802A1 (en) * | 2005-06-30 | 2007-06-14 | Heinz Doebeli | Ionization modifier for mass spectrometry |
| WO2007011639A2 (en) * | 2005-07-13 | 2007-01-25 | Coimmune Inc. | Catalytic immunoglobulins |
| CN101196526A (zh) * | 2006-12-06 | 2008-06-11 | 许洋 | 一种结核快速诊断的质谱分析试剂盒和方法 |
| WO2009036760A2 (en) * | 2007-09-18 | 2009-03-26 | Dako Denmark A/S | A rapid and sensitive method for detection of biological targets |
| JP5080945B2 (ja) * | 2007-11-09 | 2012-11-21 | 株式会社日立ハイテクノロジーズ | 質量分析装置および質量分析方法 |
| US20090142766A1 (en) * | 2007-11-09 | 2009-06-04 | Washington University In St. Louis | Methods for measuring the metabolism of cns derived biomolecules in vivo |
| US20090134325A1 (en) * | 2007-11-27 | 2009-05-28 | Goldman Mildred M | Methods for detecting estradiol by mass spectrometry |
| US8916385B2 (en) | 2007-12-13 | 2014-12-23 | Quest Diagnostics Investments, Inc. | Methods for detecting estrone by mass spectrometry |
| AU2014265047A1 (en) * | 2008-11-12 | 2014-12-11 | The Washington University | Simultaneous measurement of the in vivo metabolism of isoforms of a biomolecule |
| EP2891882B1 (en) | 2008-12-05 | 2018-08-15 | C2N Diagnostics | Methods for measuring concentrations of biomolecules |
| KR20120122869A (ko) * | 2009-06-02 | 2012-11-07 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 신경변성 질환을 갖는 대상에서 항체에 의해 인식되는 소분자의 확인법 |
| CN102596230B (zh) * | 2009-11-05 | 2015-08-05 | 奎斯特诊断投资公司 | 用高分辨率质谱法量化胰岛素样生长因子-i和胰岛素样生长因子-ii |
| JP5400903B2 (ja) * | 2010-01-28 | 2014-01-29 | パナソニック株式会社 | アミロイドβ測定方法 |
| DE102010026094B4 (de) * | 2010-07-05 | 2012-01-12 | Sigeng Han | Ein neues Verfahren zum Charakterisieren und multidimensionalen Darstellen des Faltungsvorgangs der Proteine |
| WO2012058632A1 (en) | 2010-10-29 | 2012-05-03 | Thermo Fisher Scientific Oy | Automated system for sample preparation and analysis |
| CA2859808A1 (en) | 2011-12-19 | 2013-06-27 | The Washington University | Methods for diagnosing alzheimer's disease |
| JP5902357B2 (ja) * | 2012-09-20 | 2016-04-13 | クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド | 質量分析によるサイログロブリン定量 |
| US11360098B2 (en) * | 2015-09-28 | 2022-06-14 | Quest Diagnostics Investments Llc | Amyloid beta detection by mass spectrometry |
-
2016
- 2016-09-27 US US15/277,879 patent/US11360098B2/en active Active
- 2016-09-28 MX MX2018004017A patent/MX2018004017A/es unknown
- 2016-09-28 CN CN201680068333.5A patent/CN108291916B/zh active Active
- 2016-09-28 JP JP2018515954A patent/JP6979401B2/ja active Active
- 2016-09-28 CN CN202311809070.7A patent/CN117761323A/zh active Pending
- 2016-09-28 EP EP16852474.2A patent/EP3356831B1/en active Active
- 2016-09-28 CA CA3000178A patent/CA3000178C/en active Active
- 2016-09-28 BR BR112018006018A patent/BR112018006018A2/pt active Search and Examination
- 2016-09-28 EP EP23187203.7A patent/EP4275777A3/en active Pending
- 2016-09-28 WO PCT/US2016/054148 patent/WO2017058895A1/en active Application Filing
-
2018
- 2018-03-28 MX MX2023005452A patent/MX2023005452A/es unknown
-
2021
- 2021-08-06 JP JP2021129885A patent/JP7407776B2/ja active Active
-
2022
- 2022-06-13 US US17/839,262 patent/US20220349897A1/en active Pending
-
2023
- 2023-12-19 JP JP2023214277A patent/JP2024050535A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20170089917A1 (en) | 2017-03-30 |
| CN108291916A (zh) | 2018-07-17 |
| CA3000178C (en) | 2022-07-12 |
| JP2024050535A (ja) | 2024-04-10 |
| CN108291916B (zh) | 2024-01-02 |
| CA3000178A1 (en) | 2017-04-06 |
| EP3356831B1 (en) | 2023-09-27 |
| JP2021192038A (ja) | 2021-12-16 |
| JP6979401B2 (ja) | 2021-12-15 |
| EP4275777A2 (en) | 2023-11-15 |
| WO2017058895A1 (en) | 2017-04-06 |
| JP2018535398A (ja) | 2018-11-29 |
| US11360098B2 (en) | 2022-06-14 |
| US20220349897A1 (en) | 2022-11-03 |
| EP3356831A4 (en) | 2019-08-21 |
| MX2018004017A (es) | 2018-06-27 |
| MX2023005452A (es) | 2023-05-26 |
| EP4275777A3 (en) | 2024-01-10 |
| CN117761323A (zh) | 2024-03-26 |
| JP7407776B2 (ja) | 2024-01-04 |
| EP3356831A1 (en) | 2018-08-08 |
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| Date | Code | Title | Description |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] |