MX374652B - Ensayos para detectar la presencia o la cantidad de un anticuerpo antifármaco. - Google Patents

Ensayos para detectar la presencia o la cantidad de un anticuerpo antifármaco.

Info

Publication number
MX374652B
MX374652B MX2016010413A MX2016010413A MX374652B MX 374652 B MX374652 B MX 374652B MX 2016010413 A MX2016010413 A MX 2016010413A MX 2016010413 A MX2016010413 A MX 2016010413A MX 374652 B MX374652 B MX 374652B
Authority
MX
Mexico
Prior art keywords
tests
detect
antidrug antibody
antidrug
antibody
Prior art date
Application number
MX2016010413A
Other languages
English (en)
Other versions
MX2016010413A (es
Inventor
Jad Zoghbi
Ryan Grabert
Susan Richards
Valerie Theobald
Yuanxin Xu
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MX2016010413A publication Critical patent/MX2016010413A/es
Publication of MX374652B publication Critical patent/MX374652B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2430/00—Assays, e.g. immunoassays or enzyme assays, involving synthetic organic compounds as analytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención se refiere a métodos y kits para detectar anticuerpos (por ejemplo, anticuerpos antifármaco). Estos métodos y kits permiten la detección, por ejemplo, de anticuerpos antifármaco en fluidos corporales humanos, tales como sangre, plasma y suero.
MX2016010413A 2014-02-11 2015-02-11 Ensayos para detectar la presencia o la cantidad de un anticuerpo antifármaco. MX374652B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461938556P 2014-02-11 2014-02-11
PCT/US2015/015442 WO2015123315A1 (en) 2014-02-11 2015-02-11 Assays for detecting the presence or amount of an anti-drug antibody

Publications (2)

Publication Number Publication Date
MX2016010413A MX2016010413A (es) 2016-11-30
MX374652B true MX374652B (es) 2025-03-06

Family

ID=52684652

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016010413A MX374652B (es) 2014-02-11 2015-02-11 Ensayos para detectar la presencia o la cantidad de un anticuerpo antifármaco.
MX2020009021A MX2020009021A (es) 2014-02-11 2016-08-10 Ensayos para detectar la presencia o la cantidad de un anticuerpo antifarmaco.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020009021A MX2020009021A (es) 2014-02-11 2016-08-10 Ensayos para detectar la presencia o la cantidad de un anticuerpo antifarmaco.

Country Status (19)

Country Link
US (4) US9759732B2 (es)
EP (5) EP3105592B1 (es)
CN (1) CN106164670B (es)
AU (2) AU2015217261B2 (es)
CA (1) CA2939080A1 (es)
CY (1) CY1121341T1 (es)
DK (1) DK3105592T3 (es)
ES (1) ES2705403T3 (es)
HR (1) HRP20190026T1 (es)
HU (1) HUE041669T2 (es)
LT (1) LT3105592T (es)
MX (2) MX374652B (es)
PL (1) PL3105592T3 (es)
PT (1) PT3105592T (es)
RS (1) RS58212B1 (es)
SG (2) SG10201906750XA (es)
SI (1) SI3105592T1 (es)
TR (1) TR201900160T4 (es)
WO (1) WO2015123315A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3105592B1 (en) 2014-02-11 2018-10-17 Genzyme Corporation Assays for detecting the presence or amount of an anti-drug antibody
EP2982987A1 (en) 2014-08-08 2016-02-10 Proteomika, S.L. Lateral flow immunoassays for the detection of antibodies against biological drugs
US9927443B2 (en) * 2015-04-10 2018-03-27 Conquerab Inc. Risk assessment for therapeutic drugs
MX384636B (es) * 2015-10-15 2025-03-14 Biocon Ltd Método para detectar anticuerpos neutralizantes contra la insulina humana recombinante en suero humano.
JP6889160B2 (ja) 2015-12-16 2021-06-18 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ３段階酸解離酵素結合免疫吸着（ｔａｄｅｌｉｓ）アッセイ法
US9903866B2 (en) 2016-04-05 2018-02-27 Conquerab Inc. Portable devices for detection of antibodies against therapeutic drugs
EP3239711B1 (en) 2016-04-27 2019-12-25 JIMRO Co., Ltd. Method for measuring anti-drug antibody
KR102423086B1 (ko) 2016-10-20 2022-07-20 아이-맵 바이오파마 유에스 리미티드 새로운 cd47 단일클론 항체 및 그 용도
EP3665203B1 (en) * 2017-08-08 2022-06-29 F. Hoffmann-La Roche AG Method for determining anti-drug antibodies in a minipig sample
CA3081801C (en) * 2017-11-29 2022-12-20 F. Hoffman-La Roche Ag Target interference suppressed anti-drug antibody assay
CN109358192B (zh) * 2018-02-08 2020-05-12 中国科学院上海药物研究所 一种去除抗药抗体检测样品中游离药物的装置和方法、该装置的制备方法及应用
IL277890B2 (en) * 2018-04-11 2024-03-01 Regeneron Pharma Methods for quantifying il-33
MA53130A (fr) * 2018-07-10 2021-05-19 Regeneron Pharma Procédés d'atténuation d'interférence de cible médicamenteuse dans un dosage immunologique d'anticorps anti-médicament (ada)
WO2020028764A1 (en) * 2018-08-03 2020-02-06 Bristol-Myers Squibb Company Methods for detecting anti-drug antibodies
CN114556099A (zh) * 2019-04-16 2022-05-27 美国控股实验室公司 通过表面等离子体共振来检测抗体的方法和系统
KR102695013B1 (ko) 2019-04-24 2024-08-13 삼성전자주식회사 펠리클 조립체의 제조 방법 및 포토마스크 조립체의 제조 방법
KR20220007586A (ko) * 2019-05-13 2022-01-18 리제너론 파마슈티칼스 인코포레이티드 개선된 경쟁적 리간드 결합 검정
CN111982615A (zh) * 2019-05-23 2020-11-24 百奥泰生物制药股份有限公司 一种用于解离药物/ada复合物的解离液及其应用
CN112285351A (zh) * 2019-07-22 2021-01-29 上海益诺思生物技术股份有限公司 一种抗IgE单抗的ELISA检测方法
CA3148161A1 (en) * 2019-09-05 2021-03-11 Adverum Biotechnologies Anti-drug antibody assay
CN111171141A (zh) * 2020-01-20 2020-05-19 苏州药明康德新药开发有限公司 聚乙二醇在临床前安全性评价中的应用
CN111024958B (zh) * 2020-03-11 2020-06-23 同昕生物技术（北京）有限公司 用于检测单抗药物和抗单抗药物抗体的试剂及其应用
US20210341487A1 (en) * 2020-05-01 2021-11-04 Regeneron Pharmaceuticals, Inc. Neutralizing antibody assay for therapeutic proteins
JP7478040B2 (ja) * 2020-06-25 2024-05-02 シスメックス株式会社 Ａβペプチドの測定方法及びその方法に用いられる試薬組成物
CN116261662B (zh) * 2020-10-14 2024-05-31 天境生物科技(上海)有限公司 用于减轻输血前测定中治疗性抗cd47抗体的干扰的方法
WO2022190007A1 (en) 2021-03-09 2022-09-15 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries
JP7062803B1 (ja) 2021-03-31 2022-05-06 積水メディカル株式会社 抗薬物抗体測定方法
KR20240116828A (ko) 2021-12-14 2024-07-30 씨디알-라이프 아게 이중 mhc-표적화 t 세포 관여자
CN114047343B (zh) * 2022-01-13 2022-05-31 美迪西普亚医药科技(上海)有限公司 双耐受型抗IgE单抗药物的免疫原性分析试剂盒及其使用方法和应用
US20250326851A1 (en) 2022-09-09 2025-10-23 Bayer Aktiengesellschaft Medical use of ccr8 antibodies and dosing schedule
EP4587046A1 (en) 2022-09-14 2025-07-23 CDR-Life AG Mage-a4 peptide dual t cell engagers
CN120239821A (zh) * 2022-09-23 2025-07-01 默沙东有限责任公司 中和抗体测定方法
CN115561355B (zh) * 2022-09-26 2024-04-30 重庆迪纳利医药科技有限责任公司 羧肽酶g2的中和抗体检测方法以及基于lc-ms/ms的检测系统
CN116699147A (zh) * 2023-08-04 2023-09-05 军科正源（北京）药物研究有限责任公司 检测总IgE含量的方法以及相关试剂盒
CN117849327A (zh) * 2024-03-06 2024-04-09 军科正源（北京）药物研究有限责任公司 用于检测苏金单抗抗药性抗体的方法
US20250388688A1 (en) 2024-04-04 2025-12-25 Ethyreal Bio, Inc. Anti-tshr antibodies and uses thereof
WO2025210181A1 (en) 2024-04-04 2025-10-09 Cdr-Life Ag Antigen binding proteins targeting an hla-restricted kk-lc-1 peptide
US20250333514A1 (en) 2024-04-11 2025-10-30 Cdr-Life Ag Antigen binding proteins targeting an hla-restricted prame peptide
CN120761634B (zh) * 2025-09-02 2025-12-05 宁波熙宁检测技术有限公司 一种针对多特异性单克隆抗体药物的ada检测方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448632A1 (en) * 1988-12-09 1991-10-02 Centocor, Inc. Anti-idiotopic immunometric assay
US5187065A (en) * 1989-12-22 1993-02-16 Schutzer Steven E Method and materials for detecting lyme disease
US20090061466A1 (en) * 2006-03-09 2009-03-05 Wolfgang Hoesel Anti-drug antibody assay
RU2009141159A (ru) * 2007-05-07 2011-06-20 Вайет (Us) Устранение интерференции при иммунном анализе, обусловленной антителами к углеводам
JP2011510291A (ja) * 2008-01-15 2011-03-31 スティヒティンク サンクイン ブロイドフォーツィーニンク 治療用抗体に対する抗体を検出する方法およびキット
JP2010078374A (ja) 2008-09-24 2010-04-08 Olympus Corp 抗赤血球抗体の検出方法
US7799532B2 (en) * 2008-11-12 2010-09-21 Hemopet Detection and measurement of thyroid hormone autoantibodies
CA2827609A1 (en) 2011-02-17 2012-11-15 Nestec S.A. Assays for detecting autoantibodies to anti-tnf.alpha. drugs
MX352118B (es) * 2012-03-08 2017-11-09 Hoffmann La Roche Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes.
KR102248581B1 (ko) * 2013-07-04 2021-05-06 에프. 호프만-라 로슈 아게 혈청 샘플 중 항-약물 항체를 검출하기 위한 간섭-억제된 면역분석
EP3105592B1 (en) 2014-02-11 2018-10-17 Genzyme Corporation Assays for detecting the presence or amount of an anti-drug antibody

Also Published As

Publication number Publication date
AU2015217261A1 (en) 2016-09-08
AU2015217261B2 (en) 2020-08-27
EP4582812A2 (en) 2025-07-09
US20180088140A1 (en) 2018-03-29
ES2705403T3 (es) 2019-03-25
US9759732B2 (en) 2017-09-12
US20220187327A1 (en) 2022-06-16
SI3105592T1 (sl) 2019-02-28
EP4137816A1 (en) 2023-02-22
CN106164670B (zh) 2019-06-14
CY1121341T1 (el) 2020-05-29
HRP20190026T1 (hr) 2019-02-22
MX2016010413A (es) 2016-11-30
US11215623B2 (en) 2022-01-04
US11927596B2 (en) 2024-03-12
MX2020009021A (es) 2020-10-12
CN106164670A (zh) 2016-11-23
EP4582812A3 (en) 2025-10-22
HUE041669T2 (hu) 2019-05-28
US20240288454A1 (en) 2024-08-29
EP3422001A1 (en) 2019-01-02
RS58212B1 (sr) 2019-03-29
LT3105592T (lt) 2019-01-25
TR201900160T4 (tr) 2019-02-21
WO2015123315A1 (en) 2015-08-20
EP3667321A1 (en) 2020-06-17
CA2939080A1 (en) 2015-08-20
US20150226758A1 (en) 2015-08-13
EP3422001B1 (en) 2020-03-25
PL3105592T3 (pl) 2019-04-30
EP3667321B1 (en) 2022-07-27
EP4137816B1 (en) 2025-03-19
AU2020264316A1 (en) 2020-11-26
EP3105592B1 (en) 2018-10-17
SG10201906750XA (en) 2019-09-27
SG11201606291VA (en) 2016-08-30
EP3105592A1 (en) 2016-12-21
PT3105592T (pt) 2019-01-23
DK3105592T3 (en) 2019-02-04

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