MX352118B - Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes. - Google Patents

Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes.

Info

Publication number
MX352118B
MX352118B MX2014010318A MX2014010318A MX352118B MX 352118 B MX352118 B MX 352118B MX 2014010318 A MX2014010318 A MX 2014010318A MX 2014010318 A MX2014010318 A MX 2014010318A MX 352118 B MX352118 B MX 352118B
Authority
MX
Mexico
Prior art keywords
determining
immune
immune complexes
reported
size
Prior art date
Application number
MX2014010318A
Other languages
English (en)
Other versions
MX2014010318A (es
Inventor
Dahl Uwe
Jordan Gregor
Staack Roland
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2014010318A publication Critical patent/MX2014010318A/es
Publication of MX352118B publication Critical patent/MX352118B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere a un método para terminar el tamaño de un anticuerpo anti-fármaco complejado con un fármaco polipéptido terapéutico exógeno (complejo ADA-D) que comprende una cromatografía por exclusión de tamaño, de una muestra obtenida de un mamífero al cual se le ha administrado el fármaco al menos una vez para determinar el peso/tamaño de los inmunocomplejos, opcionalmente una segunda cromatografía diferente a la SEC, y al menos un inmunoanálisis, por medio de esto el complejo inmune se caracteriza por la correlación del tamaño del complejo inmune y el resultado/lectura del inmunoanálisis.
MX2014010318A 2012-03-08 2013-03-07 Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes. MX352118B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12158634 2012-03-08
PCT/EP2013/054587 WO2013132000A1 (en) 2012-03-08 2013-03-07 Multiplexed chromatography-immunoassay method for the characterization of circulating immune complexes

Publications (2)

Publication Number Publication Date
MX2014010318A MX2014010318A (es) 2014-09-22
MX352118B true MX352118B (es) 2017-11-09

Family

ID=47833082

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014010318A MX352118B (es) 2012-03-08 2013-03-07 Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes.

Country Status (10)

Country Link
US (1) US9797900B2 (es)
EP (1) EP2823310B1 (es)
JP (1) JP6272788B2 (es)
KR (1) KR102084805B1 (es)
CN (1) CN104136923B (es)
CA (1) CA2862824A1 (es)
HK (1) HK1199103A1 (es)
MX (1) MX352118B (es)
RU (1) RU2638812C2 (es)
WO (1) WO2013132000A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2883051B1 (en) 2012-08-08 2017-09-20 F. Hoffmann-La Roche AG Immunoassay-based determination of in-solution binding kinetics
ES2699581T3 (es) * 2013-12-20 2019-02-11 Phadia Ab Análisis de anticuerpos
US9759732B2 (en) 2014-02-11 2017-09-12 Genzyme Corporation Assays for detecting the presence or amount of an anti-drug antibody
CN113826128B (zh) * 2019-05-20 2023-08-08 三菱电机株式会社 状态推定装置及状态推定方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238808A (en) 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection
US5084398A (en) * 1987-11-20 1992-01-28 Creative Biomolecules Selective removal of immune complexes
WO1990005301A1 (en) 1988-11-03 1990-05-17 Igen, Inc. Electrochemiluminescent assays
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
IL100866A (en) 1991-02-06 1995-10-31 Igen Inc Luminescence test method and device based on magnetic tiny particles, containing many magnets
DE19522171C1 (de) * 1995-06-19 1996-08-22 Brahms Diagnostica Gmbh Verfahren zur Bestimmung von Anti-TSH-Rezeptor-Autoantikörpern
ES2360369T5 (es) 2004-12-23 2021-12-13 Hoffmann La Roche Detección de un anticuerpo terapéutico en un animal de experimentación
CN101506659B (zh) * 2006-09-12 2012-12-12 弗·哈夫曼-拉罗切有限公司 抗药物抗体测定法
EP2067044B1 (en) * 2006-09-12 2013-07-03 F. Hoffmann-La Roche AG Anti-drug antibody assay
ES2544971T3 (es) * 2008-05-13 2015-09-07 Genentech, Inc. Análisis de conjugados de fármacos y anticuerpos mediante espectrometría de masas con captura por afinidad basada en esferas
EP2494352B1 (en) * 2009-10-26 2020-04-08 Prometheus Biosciences, Inc. Assays for the detection of anti-tnf drugs and autoantibodies
EP2354792A1 (en) * 2010-02-08 2011-08-10 Biomonitor A/S Method for detecting anti-drug antibodies
SG189391A1 (en) * 2010-10-18 2013-05-31 Nestec Sa Methods for determining anti-drug antibody isotypes

Also Published As

Publication number Publication date
RU2014140135A (ru) 2016-04-27
CN104136923B (zh) 2016-08-24
EP2823310B1 (en) 2018-06-20
CN104136923A (zh) 2014-11-05
HK1199103A1 (zh) 2015-06-19
RU2638812C2 (ru) 2017-12-15
US9797900B2 (en) 2017-10-24
WO2013132000A1 (en) 2013-09-12
JP2015509598A (ja) 2015-03-30
JP6272788B2 (ja) 2018-01-31
KR20140132360A (ko) 2014-11-17
EP2823310A1 (en) 2015-01-14
KR102084805B1 (ko) 2020-03-04
US20150132781A1 (en) 2015-05-14
CA2862824A1 (en) 2013-09-12
MX2014010318A (es) 2014-09-22

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