MX352118B - Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes. - Google Patents
Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes.Info
- Publication number
- MX352118B MX352118B MX2014010318A MX2014010318A MX352118B MX 352118 B MX352118 B MX 352118B MX 2014010318 A MX2014010318 A MX 2014010318A MX 2014010318 A MX2014010318 A MX 2014010318A MX 352118 B MX352118 B MX 352118B
- Authority
- MX
- Mexico
- Prior art keywords
- determining
- immune
- immune complexes
- reported
- size
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invención se refiere a un método para terminar el tamaño de un anticuerpo anti-fármaco complejado con un fármaco polipéptido terapéutico exógeno (complejo ADA-D) que comprende una cromatografía por exclusión de tamaño, de una muestra obtenida de un mamífero al cual se le ha administrado el fármaco al menos una vez para determinar el peso/tamaño de los inmunocomplejos, opcionalmente una segunda cromatografía diferente a la SEC, y al menos un inmunoanálisis, por medio de esto el complejo inmune se caracteriza por la correlación del tamaño del complejo inmune y el resultado/lectura del inmunoanálisis.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12158634 | 2012-03-08 | ||
PCT/EP2013/054587 WO2013132000A1 (en) | 2012-03-08 | 2013-03-07 | Multiplexed chromatography-immunoassay method for the characterization of circulating immune complexes |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014010318A MX2014010318A (es) | 2014-09-22 |
MX352118B true MX352118B (es) | 2017-11-09 |
Family
ID=47833082
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014010318A MX352118B (es) | 2012-03-08 | 2013-03-07 | Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes. |
Country Status (10)
Country | Link |
---|---|
US (1) | US9797900B2 (es) |
EP (1) | EP2823310B1 (es) |
JP (1) | JP6272788B2 (es) |
KR (1) | KR102084805B1 (es) |
CN (1) | CN104136923B (es) |
CA (1) | CA2862824A1 (es) |
HK (1) | HK1199103A1 (es) |
MX (1) | MX352118B (es) |
RU (1) | RU2638812C2 (es) |
WO (1) | WO2013132000A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2883051B1 (en) | 2012-08-08 | 2017-09-20 | F. Hoffmann-La Roche AG | Immunoassay-based determination of in-solution binding kinetics |
ES2699581T3 (es) * | 2013-12-20 | 2019-02-11 | Phadia Ab | Análisis de anticuerpos |
US9759732B2 (en) | 2014-02-11 | 2017-09-12 | Genzyme Corporation | Assays for detecting the presence or amount of an anti-drug antibody |
CN113826128B (zh) * | 2019-05-20 | 2023-08-08 | 三菱电机株式会社 | 状态推定装置及状态推定方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
US5084398A (en) * | 1987-11-20 | 1992-01-28 | Creative Biomolecules | Selective removal of immune complexes |
WO1990005301A1 (en) | 1988-11-03 | 1990-05-17 | Igen, Inc. | Electrochemiluminescent assays |
US5068088A (en) | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
IL100866A (en) | 1991-02-06 | 1995-10-31 | Igen Inc | Luminescence test method and device based on magnetic tiny particles, containing many magnets |
DE19522171C1 (de) * | 1995-06-19 | 1996-08-22 | Brahms Diagnostica Gmbh | Verfahren zur Bestimmung von Anti-TSH-Rezeptor-Autoantikörpern |
ES2360369T5 (es) | 2004-12-23 | 2021-12-13 | Hoffmann La Roche | Detección de un anticuerpo terapéutico en un animal de experimentación |
CN101506659B (zh) * | 2006-09-12 | 2012-12-12 | 弗·哈夫曼-拉罗切有限公司 | 抗药物抗体测定法 |
EP2067044B1 (en) * | 2006-09-12 | 2013-07-03 | F. Hoffmann-La Roche AG | Anti-drug antibody assay |
ES2544971T3 (es) * | 2008-05-13 | 2015-09-07 | Genentech, Inc. | Análisis de conjugados de fármacos y anticuerpos mediante espectrometría de masas con captura por afinidad basada en esferas |
EP2494352B1 (en) * | 2009-10-26 | 2020-04-08 | Prometheus Biosciences, Inc. | Assays for the detection of anti-tnf drugs and autoantibodies |
EP2354792A1 (en) * | 2010-02-08 | 2011-08-10 | Biomonitor A/S | Method for detecting anti-drug antibodies |
SG189391A1 (en) * | 2010-10-18 | 2013-05-31 | Nestec Sa | Methods for determining anti-drug antibody isotypes |
-
2013
- 2013-03-07 EP EP13707879.6A patent/EP2823310B1/en active Active
- 2013-03-07 WO PCT/EP2013/054587 patent/WO2013132000A1/en active Application Filing
- 2013-03-07 CN CN201380011056.0A patent/CN104136923B/zh active Active
- 2013-03-07 RU RU2014140135A patent/RU2638812C2/ru not_active IP Right Cessation
- 2013-03-07 JP JP2014560373A patent/JP6272788B2/ja active Active
- 2013-03-07 MX MX2014010318A patent/MX352118B/es active IP Right Grant
- 2013-03-07 CA CA2862824A patent/CA2862824A1/en not_active Abandoned
- 2013-03-07 KR KR1020147024884A patent/KR102084805B1/ko active IP Right Grant
-
2014
- 2014-09-05 US US14/478,536 patent/US9797900B2/en active Active
- 2014-12-17 HK HK14112664.4A patent/HK1199103A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
RU2014140135A (ru) | 2016-04-27 |
CN104136923B (zh) | 2016-08-24 |
EP2823310B1 (en) | 2018-06-20 |
CN104136923A (zh) | 2014-11-05 |
HK1199103A1 (zh) | 2015-06-19 |
RU2638812C2 (ru) | 2017-12-15 |
US9797900B2 (en) | 2017-10-24 |
WO2013132000A1 (en) | 2013-09-12 |
JP2015509598A (ja) | 2015-03-30 |
JP6272788B2 (ja) | 2018-01-31 |
KR20140132360A (ko) | 2014-11-17 |
EP2823310A1 (en) | 2015-01-14 |
KR102084805B1 (ko) | 2020-03-04 |
US20150132781A1 (en) | 2015-05-14 |
CA2862824A1 (en) | 2013-09-12 |
MX2014010318A (es) | 2014-09-22 |
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