MX352118B - Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes. - Google Patents
Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes.Info
- Publication number
- MX352118B MX352118B MX2014010318A MX2014010318A MX352118B MX 352118 B MX352118 B MX 352118B MX 2014010318 A MX2014010318 A MX 2014010318A MX 2014010318 A MX2014010318 A MX 2014010318A MX 352118 B MX352118 B MX 352118B
- Authority
- MX
- Mexico
- Prior art keywords
- determining
- immune
- immune complexes
- reported
- size
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
La presente invención se refiere a un método para terminar el tamaño de un anticuerpo anti-fármaco complejado con un fármaco polipéptido terapéutico exógeno (complejo ADA-D) que comprende una cromatografía por exclusión de tamaño, de una muestra obtenida de un mamífero al cual se le ha administrado el fármaco al menos una vez para determinar el peso/tamaño de los inmunocomplejos, opcionalmente una segunda cromatografía diferente a la SEC, y al menos un inmunoanálisis, por medio de esto el complejo inmune se caracteriza por la correlación del tamaño del complejo inmune y el resultado/lectura del inmunoanálisis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12158634 | 2012-03-08 | ||
| PCT/EP2013/054587 WO2013132000A1 (en) | 2012-03-08 | 2013-03-07 | Multiplexed chromatography-immunoassay method for the characterization of circulating immune complexes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014010318A MX2014010318A (es) | 2014-09-22 |
| MX352118B true MX352118B (es) | 2017-11-09 |
Family
ID=47833082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014010318A MX352118B (es) | 2012-03-08 | 2013-03-07 | Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9797900B2 (es) |
| EP (1) | EP2823310B1 (es) |
| JP (1) | JP6272788B2 (es) |
| KR (1) | KR102084805B1 (es) |
| CN (1) | CN104136923B (es) |
| CA (1) | CA2862824A1 (es) |
| HK (1) | HK1199103A1 (es) |
| MX (1) | MX352118B (es) |
| RU (1) | RU2638812C2 (es) |
| WO (1) | WO2013132000A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2015001202A (es) | 2012-08-08 | 2015-04-14 | Hoffmann La Roche | Determinacion de cinetica de enlace en solucion con base en inmunoanalisis. |
| ES2699581T3 (es) * | 2013-12-20 | 2019-02-11 | Phadia Ab | Análisis de anticuerpos |
| MX2016010413A (es) | 2014-02-11 | 2016-11-30 | Genzyme Corp | Ensayos para detectar la presencia o la cantidad de un anticuerpo antifarmaco. |
| WO2020234961A1 (ja) * | 2019-05-20 | 2020-11-26 | 三菱電機株式会社 | 状態推定装置および状態推定方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5084398A (en) * | 1987-11-20 | 1992-01-28 | Creative Biomolecules | Selective removal of immune complexes |
| US5068088A (en) | 1988-11-03 | 1991-11-26 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescent measurements |
| JP2992974B2 (ja) | 1988-11-03 | 1999-12-20 | イゲン，インコーポレーテッド | 電気化学ルミネセンス検定 |
| IL100866A (en) | 1991-02-06 | 1995-10-31 | Igen Inc | Luminescence test method and device based on magnetic tiny particles, containing many magnets |
| DE19522171C1 (de) | 1995-06-19 | 1996-08-22 | Brahms Diagnostica Gmbh | Verfahren zur Bestimmung von Anti-TSH-Rezeptor-Autoantikörpern |
| KR100950635B1 (ko) | 2004-12-23 | 2010-04-01 | 에프. 호프만-라 로슈 아게 | 실험동물의 치료용 항체의 검출 |
| CN101506659B (zh) * | 2006-09-12 | 2012-12-12 | 弗·哈夫曼-拉罗切有限公司 | 抗药物抗体测定法 |
| ES2428876T3 (es) * | 2006-09-12 | 2013-11-12 | F. Hoffmann-La Roche Ag | Ensayo de anticuerpo antifármaco |
| EP2277044B1 (en) * | 2008-05-13 | 2015-06-17 | Genentech, Inc. | Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry |
| RU2571489C2 (ru) * | 2009-10-26 | 2015-12-20 | Нестек С.А. | Способы выявления препаратов и аутоантител против tnf |
| EP2354792A1 (en) | 2010-02-08 | 2011-08-10 | Biomonitor A/S | Method for detecting anti-drug antibodies |
| EP2630495B1 (en) * | 2010-10-18 | 2017-02-08 | Nestec S.A. | Methods for determining anti-drug antibody isotypes |
-
2013
- 2013-03-07 KR KR1020147024884A patent/KR102084805B1/ko active IP Right Grant
- 2013-03-07 CN CN201380011056.0A patent/CN104136923B/zh active Active
- 2013-03-07 JP JP2014560373A patent/JP6272788B2/ja active Active
- 2013-03-07 CA CA2862824A patent/CA2862824A1/en not_active Abandoned
- 2013-03-07 RU RU2014140135A patent/RU2638812C2/ru not_active IP Right Cessation
- 2013-03-07 EP EP13707879.6A patent/EP2823310B1/en active Active
- 2013-03-07 MX MX2014010318A patent/MX352118B/es active IP Right Grant
- 2013-03-07 WO PCT/EP2013/054587 patent/WO2013132000A1/en active Application Filing
-
2014
- 2014-09-05 US US14/478,536 patent/US9797900B2/en active Active
- 2014-12-17 HK HK14112664.4A patent/HK1199103A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014010318A (es) | 2014-09-22 |
| KR102084805B1 (ko) | 2020-03-04 |
| RU2014140135A (ru) | 2016-04-27 |
| JP6272788B2 (ja) | 2018-01-31 |
| CN104136923A (zh) | 2014-11-05 |
| WO2013132000A1 (en) | 2013-09-12 |
| CA2862824A1 (en) | 2013-09-12 |
| US9797900B2 (en) | 2017-10-24 |
| EP2823310B1 (en) | 2018-06-20 |
| JP2015509598A (ja) | 2015-03-30 |
| EP2823310A1 (en) | 2015-01-14 |
| KR20140132360A (ko) | 2014-11-17 |
| HK1199103A1 (zh) | 2015-06-19 |
| CN104136923B (zh) | 2016-08-24 |
| RU2638812C2 (ru) | 2017-12-15 |
| US20150132781A1 (en) | 2015-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR125268A2 (es) | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos | |
| CO6351801A2 (es) | Anticuerpos neutralizantes de citomegalovirus humano y uso de los mismos | |
| CO6351751A2 (es) | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos | |
| WO2011069104A3 (en) | Multispecific antibodies, antibody analogs, compositions, and methods | |
| MX358517B (es) | Métodos para determinar eficacia de fármacos usando proteínas asociadas a cereblon. | |
| BR112014016299A2 (pt) | imunoglobulinas de domínio variável e usos das mesmas | |
| MX350200B (es) | Anticuerpos humanos y conjugados de anticuerpo-farmaco contra cd74. | |
| EA201590247A1 (ru) | Антитела к siglec-15 | |
| BR112014015851A2 (pt) | proteínas de ligação específicas duplas direcionadas contra il-13 e/ou il-17 | |
| BR112013000433A2 (pt) | diagnóstico e tratamento de câncer de mama | |
| MX352118B (es) | Metodo de inmunoanalisis cromatografico multiplexado para la caracterizacion de inmunocomplejos circulantes. | |
| EA201491977A1 (ru) | Молекула антитела к gcc и ее применение для тестирования на чувствительность к gcc-нацеленной терапии | |
| WO2011088385A3 (en) | Compositions and methods for detecting cancer | |
| EA201591423A1 (ru) | Введение антитела к активину-а пациентам | |
| CA2888908A1 (en) | Antibodies against kidney associated antigen 1 and antigen binding fragments thereof | |
| WO2012109466A3 (en) | Long non-coding rna spry4-it1 as a diagnostic and therapeutic agent | |
| WO2015013508A3 (en) | Methods for diagnosing and treating immune disease | |
| NZ701370A (en) | Il-6 binding molecules | |
| BR112015027249A2 (pt) | método de diagnóstico de câncer | |
| WO2014193800A3 (en) | Aptamers for the treatment of sickle cell disease | |
| WO2014169011A3 (en) | Methods for treating immune diseases | |
| WO2010118324A3 (en) | Antibodies against fatty acid synthase | |
| UA86387U (ru) | Способ оценки эффективности лечения больных с артериальной гипертензией, объединенной с метаболическим синдромом | |
| Lelonek | Psoriasis: 2 case reports | |
| Kim et al. | Structural Analysis of Fucosylated N-glycan in Gastric Cancer using LC-QTOF MS/MS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |