MX343327B - Ensayos para detectar autoanticuerpos contra farmacos anti-tnfa. - Google Patents
Ensayos para detectar autoanticuerpos contra farmacos anti-tnfa.Info
- Publication number
- MX343327B MX343327B MX2013009570A MX2013009570A MX343327B MX 343327 B MX343327 B MX 343327B MX 2013009570 A MX2013009570 A MX 2013009570A MX 2013009570 A MX2013009570 A MX 2013009570A MX 343327 B MX343327 B MX 343327B
- Authority
- MX
- Mexico
- Prior art keywords
- tnfa
- assays
- present
- autoantibodies
- detecting autoantibodies
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
La presente invención se refiere a ensayos para detectar y medir la presencia o nivel de autoanticuerpos contra terapéuticos de fármaco anti-TNFa en una muestra. La presente invención es útil para optimizar terapia y monitorear pacientes que reciban terapéuticos de fármaco anti-TNFa para detectar la presencia o nivel de autoanticuerpos contra el fármaco. La presente invención también proporciona métodos para seleccionar terapia, optimizar terapia y/o reducir toxicidad en sujetos que reciban fármacos anti-TNFa para el tratamiento de enfermedades o trastornos mediados por TNFa.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161444097P | 2011-02-17 | 2011-02-17 | |
US201161484594P | 2011-05-10 | 2011-05-10 | |
US201161496501P | 2011-06-13 | 2011-06-13 | |
PCT/US2012/025437 WO2012154253A1 (en) | 2011-02-17 | 2012-02-16 | ASSAYS FOR DETECTING AUTOANTIBODIES TO ANTI-TNFα DRUGS |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013009570A MX2013009570A (es) | 2013-09-06 |
MX343327B true MX343327B (es) | 2016-11-01 |
Family
ID=45809635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013009570A MX343327B (es) | 2011-02-17 | 2012-02-16 | Ensayos para detectar autoanticuerpos contra farmacos anti-tnfa. |
Country Status (17)
Country | Link |
---|---|
US (1) | US20140045276A1 (es) |
EP (1) | EP2676137B1 (es) |
JP (1) | JP6063398B2 (es) |
KR (1) | KR20140008397A (es) |
CN (1) | CN103502815B (es) |
AU (1) | AU2012254150B2 (es) |
BR (1) | BR112013020981A2 (es) |
CA (1) | CA2827609A1 (es) |
DK (1) | DK2676137T3 (es) |
ES (1) | ES2530175T3 (es) |
HK (1) | HK1191688A1 (es) |
IL (1) | IL227853A (es) |
MX (1) | MX343327B (es) |
RU (1) | RU2013142278A (es) |
SG (1) | SG192770A1 (es) |
WO (1) | WO2012154253A1 (es) |
ZA (1) | ZA201306950B (es) |
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RU2571489C2 (ru) | 2009-10-26 | 2015-12-20 | Нестек С.А. | Способы выявления препаратов и аутоантител против tnf |
BR112013009376A2 (pt) | 2010-10-18 | 2016-07-26 | Nestec Sa | métodos para determinar isótipos de anticorpos antifármacos |
MX343324B (es) | 2011-07-06 | 2016-11-01 | Nestec Sa | Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha. |
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CN104034896A (zh) * | 2014-06-19 | 2014-09-10 | 华北制药集团新药研究开发有限责任公司 | 一种双抗体夹心elisa检测方法 |
EP3175242A4 (en) | 2014-07-29 | 2017-12-27 | Mayo Foundation for Medical Education and Research | Quantifying monoclonal antibody therapeutics by lc-ms/ms |
WO2016063204A1 (en) * | 2014-10-20 | 2016-04-28 | Nestec S.A. | Methods for prediction of anti-tnf alpha drug levels and autoantibody formation |
JP6739428B2 (ja) * | 2014-11-05 | 2020-08-12 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | エフェクター機能抑制型ヒトまたはヒト化薬物抗体に対する抗薬物抗体の決定方法 |
BR112017011545A2 (pt) | 2014-12-05 | 2018-03-13 | Nestec Sa | ensaio de desvio de mobilidade homogênea indireto para a detecção de produtos biológicos nas amostras do paciente |
CN107110853A (zh) | 2015-01-09 | 2017-08-29 | 阿通诺米斯公司 | 确定TNFα抑制药及其相应抗药抗体的量的通用测定法 |
WO2016135707A1 (en) | 2015-02-27 | 2016-09-01 | Nestec S.A. | Diagnosis of major depressive disorder, mild cognitive impairment, and alzheimer's disease and other neurologic and psychiatric disorders |
US11209439B2 (en) | 2015-09-24 | 2021-12-28 | Mayo Foundation For Medical Education And Research | Identification of immunoglobulin free light chains by mass spectrometry |
EP3165922B1 (en) * | 2015-11-06 | 2020-06-17 | Promise Proteomics | A method for quantifying therapeutic antibodies |
EP3430172A4 (en) | 2016-03-17 | 2019-08-21 | Cedars-Sinai Medical Center | METHOD FOR DIAGNOSIS OF INFLAMMATORY ENDURANCE THROUGH RNASET2 |
JP2019522199A (ja) | 2016-07-08 | 2019-08-08 | アトノミックス アクティーゼルスカブ | 試料中の治療用モノクローナル抗体及びそれらの対応する抗薬物抗体の量を確定するためのユニバーサルアッセイ |
CN109564223A (zh) * | 2016-09-06 | 2019-04-02 | 富士瑞必欧株式会社 | 肿瘤标记物的测定方法及测定试剂 |
CN109863395B (zh) | 2016-09-07 | 2023-05-23 | 梅约医学教育与研究基金会 | 分子量法鉴定和监测裂解免疫球蛋白 |
EP3681528A4 (en) | 2017-09-13 | 2021-07-21 | Mayo Foundation for Medical Education and Research | IDENTIFICATION AND MONITORING OF THE APOPTOSIS INHIBITOR OF MACROPHAGES |
EP3830579A1 (en) * | 2018-08-03 | 2021-06-09 | Bristol-Myers Squibb Company | Methods for detecting anti-drug antibodies |
JP2020115139A (ja) * | 2020-03-11 | 2020-07-30 | 国立大学法人千葉大学 | 血管炎の検査方法 |
CN112362649A (zh) * | 2020-11-09 | 2021-02-12 | 长春金赛药业有限责任公司 | 一种rhGH中和抗体的检测方法 |
KR102562006B1 (ko) | 2020-11-09 | 2023-08-02 | 바디텍메드(주) | 항tnf-알파 약물 모니터링을 위한 신속 검출 키트 |
KR102568430B1 (ko) * | 2020-11-16 | 2023-08-24 | 바디텍메드(주) | 항 약물 항체의 신속 검출 방법 |
CN114236139A (zh) * | 2021-12-30 | 2022-03-25 | 苏州和锐生物科技有限公司 | 一种TNF-α生物制剂的抗体检测试剂盒、制备方法 |
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-
2012
- 2012-02-16 BR BR112013020981A patent/BR112013020981A2/pt not_active Application Discontinuation
- 2012-02-16 KR KR1020137024583A patent/KR20140008397A/ko not_active Application Discontinuation
- 2012-02-16 AU AU2012254150A patent/AU2012254150B2/en not_active Ceased
- 2012-02-16 WO PCT/US2012/025437 patent/WO2012154253A1/en active Application Filing
- 2012-02-16 JP JP2013554602A patent/JP6063398B2/ja not_active Expired - Fee Related
- 2012-02-16 ES ES12707193.4T patent/ES2530175T3/es active Active
- 2012-02-16 CA CA2827609A patent/CA2827609A1/en not_active Abandoned
- 2012-02-16 MX MX2013009570A patent/MX343327B/es active IP Right Grant
- 2012-02-16 EP EP12707193.4A patent/EP2676137B1/en active Active
- 2012-02-16 DK DK12707193.4T patent/DK2676137T3/en active
- 2012-02-16 CN CN201280018741.1A patent/CN103502815B/zh not_active Expired - Fee Related
- 2012-02-16 SG SG2013061692A patent/SG192770A1/en unknown
- 2012-02-16 RU RU2013142278/15A patent/RU2013142278A/ru not_active Application Discontinuation
-
2013
- 2013-08-07 US US13/961,841 patent/US20140045276A1/en not_active Abandoned
- 2013-09-03 IL IL227853A patent/IL227853A/en active IP Right Grant
- 2013-09-16 ZA ZA2013/06950A patent/ZA201306950B/en unknown
-
2014
- 2014-05-12 HK HK14104474.1A patent/HK1191688A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ614170A (en) | 2015-04-24 |
EP2676137B1 (en) | 2014-12-31 |
IL227853A0 (en) | 2013-09-30 |
ZA201306950B (en) | 2015-04-29 |
CN103502815A (zh) | 2014-01-08 |
AU2012254150A1 (en) | 2013-05-02 |
RU2013142278A (ru) | 2015-03-27 |
BR112013020981A2 (pt) | 2016-10-11 |
IL227853A (en) | 2017-07-31 |
KR20140008397A (ko) | 2014-01-21 |
US20140045276A1 (en) | 2014-02-13 |
JP6063398B2 (ja) | 2017-01-18 |
DK2676137T3 (en) | 2015-01-19 |
JP2014508930A (ja) | 2014-04-10 |
MX2013009570A (es) | 2013-09-06 |
HK1191688A1 (en) | 2014-08-01 |
ES2530175T3 (es) | 2015-02-26 |
CN103502815B (zh) | 2015-09-23 |
AU2012254150B2 (en) | 2015-08-13 |
SG192770A1 (en) | 2013-09-30 |
EP2676137A1 (en) | 2013-12-25 |
CA2827609A1 (en) | 2012-11-15 |
WO2012154253A1 (en) | 2012-11-15 |
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