MX383381B - Métodos y composiciones para detectar proteínas mal plegadas. - Google Patents

Métodos y composiciones para detectar proteínas mal plegadas.

Info

Publication number
MX383381B
MX383381B MX2016013255A MX2016013255A MX383381B MX 383381 B MX383381 B MX 383381B MX 2016013255 A MX2016013255 A MX 2016013255A MX 2016013255 A MX2016013255 A MX 2016013255A MX 383381 B MX383381 B MX 383381B
Authority
MX
Mexico
Prior art keywords
compositions
methods
misfolded proteins
detecting misfolded
pregnant woman
Prior art date
Application number
MX2016013255A
Other languages
English (en)
Other versions
MX2016013255A (es
Inventor
Catalin S Buhimschi
Hemant Tagare
Irina Buhimschi
Michael Choma
Stephan Michael Jonas
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Publication of MX2016013255A publication Critical patent/MX2016013255A/es
Publication of MX383381B publication Critical patent/MX383381B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827—Total protein determination, e.g. albumin in urine
    • G01N33/6839—Total protein determination, e.g. albumin in urine involving dyes, e.g. Coomassie blue, bromcresol green
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/106—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing an azo dye
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere a métodos y composiciones (por ejemplo, kits) para la identificación de sujetos con proteínas mal plegadas en su orina; por ejemplo, se proveen métodos y composiciones para determinar que una muestra de orina de una mujer embarazada contiene o no contiene proteínas mal plegadas; en algunas modalidades, la presencia de proteínas mal plegadas en una muestra de orina de una mujer embarazada, es una indicación de preeclampsia.
MX2016013255A 2014-04-10 2015-04-10 Métodos y composiciones para detectar proteínas mal plegadas. MX383381B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461978158P 2014-04-10 2014-04-10
PCT/US2015/025432 WO2015157704A2 (en) 2014-04-10 2015-04-10 Methods and compositions for detecting misfolded proteins

Publications (2)

Publication Number Publication Date
MX2016013255A MX2016013255A (es) 2017-05-03
MX383381B true MX383381B (es) 2025-03-13

Family

ID=54264908

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016013255A MX383381B (es) 2014-04-10 2015-04-10 Métodos y composiciones para detectar proteínas mal plegadas.
MX2021006791A MX2021006791A (es) 2014-04-10 2016-10-07 Metodos y composiciones para detectar proteinas mal plegadas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021006791A MX2021006791A (es) 2014-04-10 2016-10-07 Metodos y composiciones para detectar proteinas mal plegadas.

Country Status (11)

Country Link
US (3) US10324094B2 (es)
EP (2) EP3129779B1 (es)
JP (1) JP6697394B2 (es)
CN (2) CN116027043A (es)
AU (3) AU2015243171B2 (es)
CA (2) CA3157573C (es)
DK (1) DK3129779T3 (es)
ES (1) ES2817417T3 (es)
MX (2) MX383381B (es)
WO (1) WO2015157704A2 (es)
ZA (1) ZA201606987B (es)

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CA3157573C (en) 2014-04-10 2025-11-18 Yale University METHODS AND COMPOSITIONS FOR DETECTING MISFOLDED PROTEINS
EP3322985B1 (en) * 2015-07-15 2021-10-13 Gestvision, Inc. Device for detecting misfolded proteins and methods of use thereof
US11344121B2 (en) 2016-04-14 2022-05-31 The Texas A&M University System Methods of predicting preeclampsia using biomarkers
US10345244B2 (en) * 2016-06-03 2019-07-09 International Business Machines Corporation Diagnostic test device with patterned material spots
US10335045B2 (en) 2016-06-24 2019-07-02 Universita Degli Studi Di Trento Self-adaptive matrix completion for heart rate estimation from face videos under realistic conditions
US10269107B2 (en) * 2017-02-23 2019-04-23 Global Neighbor Inc Selective plant detection and treatment using green luminance photometric machine vision scan with real time chromaticity operations and image parameter floors for low processing load
WO2019071240A1 (en) 2017-10-06 2019-04-11 The Research Foundation For The State University For The State Of New York AQUEOUS AND NONAQUEOUS SELECTIVE OPTICAL DETECTION OF FREE SULPHITES
US20210156853A1 (en) * 2017-12-28 2021-05-27 Shuwen Biotech Co., Ltd. Devices, kits and methods for detecting misfolded proteins
US11255844B2 (en) * 2018-03-06 2022-02-22 Fresenius Medical Care Holdings, Inc. Peritoneal dialysis systems and related methods
CN109659011A (zh) * 2018-12-29 2019-04-19 杭州脉流科技有限公司 利用移动设备采集处理十二导联ecg图像的方法以及移动设备和计算机可读存储介质
US20230298758A1 (en) * 2020-11-06 2023-09-21 The Board Of Trustees Of The Leland Stanford Junior University Systems and Methods for Evaluating Gestational Progress and Applications Thereof
WO2022105923A1 (zh) * 2020-11-21 2022-05-27 浙江数问生物技术有限公司 用于检测生物样本中的错误折叠蛋白质的装置和方法
WO2022235564A1 (en) * 2021-05-03 2022-11-10 Memorial Sloan Kettering Cancer Center Detection of labels in biomedical images
WO2023222136A1 (zh) * 2022-05-20 2023-11-23 数问生物技术（宣城）有限公司 用于检测生物样本中的错误折叠蛋白质的装置和系统
WO2024249849A2 (en) * 2023-05-31 2024-12-05 Northwestern University Scalable platform for single cell proteomics via digitized detection of proteins and their proteoforms
CN117236201B (zh) * 2023-11-16 2024-02-23 南京信息工程大学 一种基于Diffusion和ViT的降尺度方法
CN120761295B (zh) * 2025-08-21 2026-02-13 赛克赛斯生物科技股份有限公司 三苯甲烷类化合物在检测阿尔茨海默症中的应用

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Also Published As

Publication number Publication date
CN106461644B (zh) 2022-05-13
CA3157573C (en) 2025-11-18
US20190353662A1 (en) 2019-11-21
EP3745127A1 (en) 2020-12-02
AU2022291625B2 (en) 2024-09-12
EP3129779A2 (en) 2017-02-15
JP6697394B2 (ja) 2020-05-20
AU2015243171B2 (en) 2020-10-15
US11079392B2 (en) 2021-08-03
CA3157573A1 (en) 2015-10-15
CA2945058A1 (en) 2015-10-15
ZA201606987B (en) 2020-01-29
CN106461644A (zh) 2017-02-22
EP3745127B1 (en) 2024-08-28
AU2022291625A1 (en) 2023-02-16
AU2015243171A1 (en) 2016-10-27
ES2817417T3 (es) 2021-04-07
US10324094B2 (en) 2019-06-18
EP3129779B1 (en) 2020-06-03
CN116027043A (zh) 2023-04-28
AU2020244572B2 (en) 2022-12-15
WO2015157704A2 (en) 2015-10-15
US20150293115A1 (en) 2015-10-15
CA2945058C (en) 2022-07-12
MX2016013255A (es) 2017-05-03
DK3129779T3 (da) 2020-09-07
WO2015157704A3 (en) 2016-04-28
MX2021006791A (es) 2021-07-15
JP2017518483A (ja) 2017-07-06
AU2020244572A1 (en) 2020-11-05
US20220043001A1 (en) 2022-02-10
US11953505B2 (en) 2024-04-09

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