JP2013536823A5 - - Google Patents
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- Publication number
- JP2013536823A5 JP2013536823A5 JP2013526445A JP2013526445A JP2013536823A5 JP 2013536823 A5 JP2013536823 A5 JP 2013536823A5 JP 2013526445 A JP2013526445 A JP 2013526445A JP 2013526445 A JP2013526445 A JP 2013526445A JP 2013536823 A5 JP2013536823 A5 JP 2013536823A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compound according
- solvate
- fluoro
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 2
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10174880.4 | 2010-09-01 | ||
| EP10174880 | 2010-09-01 | ||
| PCT/EP2011/064906 WO2012028614A1 (en) | 2010-09-01 | 2011-08-30 | 5-ht2b receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536823A JP2013536823A (ja) | 2013-09-26 |
| JP2013536823A5 true JP2013536823A5 (enExample) | 2014-10-16 |
| JP5845263B2 JP5845263B2 (ja) | 2016-01-20 |
Family
ID=43127285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526445A Expired - Fee Related JP5845263B2 (ja) | 2010-09-01 | 2011-08-30 | ５−ｈｔ２ｂ受容体アンタゴニスト |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8703958B2 (enExample) |
| EP (1) | EP2619180B1 (enExample) |
| JP (1) | JP5845263B2 (enExample) |
| KR (1) | KR101815123B1 (enExample) |
| CN (1) | CN103080089B (enExample) |
| AU (1) | AU2011298361B2 (enExample) |
| BR (1) | BR112013004503A2 (enExample) |
| CA (1) | CA2806647C (enExample) |
| EA (1) | EA020967B1 (enExample) |
| ES (1) | ES2525515T3 (enExample) |
| MX (1) | MX2013002409A (enExample) |
| SG (1) | SG188233A1 (enExample) |
| WO (1) | WO2012028614A1 (enExample) |
| ZA (1) | ZA201301561B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG188233A1 (en) | 2010-09-01 | 2013-04-30 | Janssen Pharmaceutica Nv | 5-ht2b receptor antagonists |
| CN103467596A (zh) * | 2012-06-06 | 2013-12-25 | 北京大学 | 一个治疗肺动脉高压的新靶点 |
| CA2941686A1 (en) * | 2014-03-04 | 2015-09-11 | The Children's Hospital Of Philadelphia | Methods for managing care of patients predisposed to progressive mitral valve diseases |
| CN110950843B (zh) * | 2019-11-28 | 2022-12-27 | 广东东阳光药业有限公司 | 取代的苯酰胺衍生物及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| CA1183847A (en) * | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| GB8519707D0 (en) * | 1985-08-06 | 1985-09-11 | Fordonal Sa | Chemical compounds |
| CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
| AU2001275326C1 (en) * | 2000-06-07 | 2006-09-21 | Aryx Therapeutics | Treatment of gastroesophageal reflux disease using piperidine derivatives |
| US6444477B1 (en) * | 2000-11-28 | 2002-09-03 | Pharmagene Laboratories Limited | Assay method for detecting 5-HT2B antagonists |
| CN1918157B (zh) * | 2004-01-07 | 2010-06-23 | ARYx医疗有限公司 | 立体异构化合物及治疗胃肠道和中枢神经系统紊乱的方法 |
| JP2009520785A (ja) | 2005-12-23 | 2009-05-28 | アストラゼネカ アクチボラグ | 抗菌性のピロロピリジン、ピロロピリミジン、及びピロロアゼピン |
| WO2008139152A1 (en) * | 2007-05-11 | 2008-11-20 | Sentinel Oncology Limited | N-oxide-containing pharmaceutical compounds |
| SG188233A1 (en) | 2010-09-01 | 2013-04-30 | Janssen Pharmaceutica Nv | 5-ht2b receptor antagonists |
-
2011
- 2011-08-30 SG SG2013011929A patent/SG188233A1/en unknown
- 2011-08-30 MX MX2013002409A patent/MX2013002409A/es active IP Right Grant
- 2011-08-30 WO PCT/EP2011/064906 patent/WO2012028614A1/en not_active Ceased
- 2011-08-30 EP EP11748693.6A patent/EP2619180B1/en active Active
- 2011-08-30 KR KR1020137005411A patent/KR101815123B1/ko not_active Expired - Fee Related
- 2011-08-30 JP JP2013526445A patent/JP5845263B2/ja not_active Expired - Fee Related
- 2011-08-30 BR BR112013004503A patent/BR112013004503A2/pt active Search and Examination
- 2011-08-30 CN CN201180041597.9A patent/CN103080089B/zh not_active Expired - Fee Related
- 2011-08-30 EA EA201390312A patent/EA020967B1/ru not_active IP Right Cessation
- 2011-08-30 CA CA2806647A patent/CA2806647C/en active Active
- 2011-08-30 AU AU2011298361A patent/AU2011298361B2/en not_active Ceased
- 2011-08-30 ES ES11748693.6T patent/ES2525515T3/es active Active
-
2013
- 2013-02-28 US US13/779,962 patent/US8703958B2/en active Active
- 2013-02-28 ZA ZA2013/01561A patent/ZA201301561B/en unknown
-
2014
- 2014-03-04 US US14/196,502 patent/US9139523B2/en not_active Expired - Fee Related