JP2013535505A5 - - Google Patents

Info

Publication number

JP2013535505A5

JP2013535505A5 JP2013524232A JP2013524232A JP2013535505A5 JP 2013535505 A5 JP2013535505 A5 JP 2013535505A5 JP 2013524232 A JP2013524232 A JP 2013524232A JP 2013524232 A JP2013524232 A JP 2013524232A JP 2013535505 A5 JP2013535505 A5 JP 2013535505A5

Authority

JP

Japan

Prior art keywords

composition

histidine

item

meglumine

cation

Prior art date

2011-08-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims description 73
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 24
• 238000000034 method Methods 0.000 claims description 23
• 208000018522 Gastrointestinal disease Diseases 0.000 claims description 19
• MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims description 18
• 229960003194 meglumine Drugs 0.000 claims description 18
• 208000010643 digestive system disease Diseases 0.000 claims description 17
• 208000018685 gastrointestinal system disease Diseases 0.000 claims description 17
• 206010010774 Constipation Diseases 0.000 claims description 16
• 150000001768 cations Chemical class 0.000 claims description 16
• KXGCNMMJRFDFNR-WDRJZQOASA-N linaclotide Chemical compound C([C@H](NC(=O)[C@@H]1CSSC[C@H]2C(=O)N[C@H]3CSSC[C@H](N)C(=O)N[C@H](C(N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N2)=O)CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC3=O)C(=O)N[C@H](C(NCC(=O)N1)=O)[C@H](O)C)C(O)=O)C1=CC=C(O)C=C1 KXGCNMMJRFDFNR-WDRJZQOASA-N 0.000 claims description 12
• 229960000812 linaclotide Drugs 0.000 claims description 12
• 108010024409 linaclotide Proteins 0.000 claims description 12
• 150000003839 salts Chemical class 0.000 claims description 12
• HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 8
• 239000004372 Polyvinyl alcohol Substances 0.000 claims description 8
• 150000001413 amino acids Chemical class 0.000 claims description 8
• 230000001684 chronic effect Effects 0.000 claims description 8
• 208000002551 irritable bowel syndrome Diseases 0.000 claims description 8
• 229920000642 polymer Polymers 0.000 claims description 8
• 229920002451 polyvinyl alcohol Polymers 0.000 claims description 8
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
• 239000008194 pharmaceutical composition Substances 0.000 claims description 7
• 150000001412 amines Chemical class 0.000 claims description 6
• 238000004519 manufacturing process Methods 0.000 claims description 6
• 108010016626 Dipeptides Proteins 0.000 claims description 5
• AYORUWNJMKYNAD-JEDNCBNOSA-N 2-aminoacetic acid;(2s)-2-amino-4-methylpentanoic acid Chemical compound NCC(O)=O.CC(C)C[C@H](N)C(O)=O AYORUWNJMKYNAD-JEDNCBNOSA-N 0.000 claims description 4
• 239000004471 Glycine Substances 0.000 claims description 4
• 208000030053 Opioid-Induced Constipation Diseases 0.000 claims description 4
• 201000006549 dyspepsia Diseases 0.000 claims description 4