JP5845263B2 - ５−ｈｔ２ｂ受容体アンタゴニスト - Google Patents
５−ｈｔ２ｂ受容体アンタゴニスト Download PDFInfo
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- JP5845263B2 JP5845263B2 JP2013526445A JP2013526445A JP5845263B2 JP 5845263 B2 JP5845263 B2 JP 5845263B2 JP 2013526445 A JP2013526445 A JP 2013526445A JP 2013526445 A JP2013526445 A JP 2013526445A JP 5845263 B2 JP5845263 B2 JP 5845263B2
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- JZNWQLLPLOQGOI-UHFFFAOYSA-N tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(=O)C(F)C1 JZNWQLLPLOQGOI-UHFFFAOYSA-N 0.000 description 1
- LOLMNJCLVIROCK-UHFFFAOYSA-N tert-butyl 4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-fluoropiperidine-1-carboxylate Chemical compound COC1=CC(N)=C(Cl)C=C1C(=O)NC1C(F)CN(C(=O)OC(C)(C)C)CC1 LOLMNJCLVIROCK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10174880 | 2010-09-01 | ||
| EP10174880.4 | 2010-09-01 | ||
| PCT/EP2011/064906 WO2012028614A1 (en) | 2010-09-01 | 2011-08-30 | 5-ht2b receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013536823A JP2013536823A (ja) | 2013-09-26 |
| JP2013536823A5 JP2013536823A5 (enExample) | 2014-10-16 |
| JP5845263B2 true JP5845263B2 (ja) | 2016-01-20 |
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| JP2013526445A Expired - Fee Related JP5845263B2 (ja) | 2010-09-01 | 2011-08-30 | ５−ｈｔ２ｂ受容体アンタゴニスト |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8703958B2 (enExample) |
| EP (1) | EP2619180B1 (enExample) |
| JP (1) | JP5845263B2 (enExample) |
| KR (1) | KR101815123B1 (enExample) |
| CN (1) | CN103080089B (enExample) |
| AU (1) | AU2011298361B2 (enExample) |
| BR (1) | BR112013004503A2 (enExample) |
| CA (1) | CA2806647C (enExample) |
| EA (1) | EA020967B1 (enExample) |
| ES (1) | ES2525515T3 (enExample) |
| MX (1) | MX2013002409A (enExample) |
| SG (1) | SG188233A1 (enExample) |
| WO (1) | WO2012028614A1 (enExample) |
| ZA (1) | ZA201301561B (enExample) |
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| ES2525515T3 (es) | 2010-09-01 | 2014-12-23 | Janssen Pharmaceutica, N.V. | Antagonistas del receptor 5-HT2B |
| CN103467596A (zh) * | 2012-06-06 | 2013-12-25 | 北京大学 | 一个治疗肺动脉高压的新靶点 |
| US20170058349A1 (en) * | 2014-03-04 | 2017-03-02 | The Children's Hospital Of Philadelphia | Methods for managing care of patients predisposed to progressive mitral valve diseases |
| CN110950843B (zh) * | 2019-11-28 | 2022-12-27 | 广东东阳光药业有限公司 | 取代的苯酰胺衍生物及其用途 |
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| US4962115A (en) * | 1981-10-01 | 1990-10-09 | Janssen Pharmaceutica N.V. | Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| CA1183847A (en) * | 1981-10-01 | 1985-03-12 | Georges Van Daele | N-(3-hydroxy-4-piperidinyl)benzamide derivatives |
| GB8519707D0 (en) * | 1985-08-06 | 1985-09-11 | Fordonal Sa | Chemical compounds |
| CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
| US6552046B2 (en) * | 2000-06-07 | 2003-04-22 | Aryx Therapeutics | Materials and methods for the treatment of gastroesophageal reflux disease |
| US6444477B1 (en) * | 2000-11-28 | 2002-09-03 | Pharmagene Laboratories Limited | Assay method for detecting 5-HT2B antagonists |
| CN1918157B (zh) * | 2004-01-07 | 2010-06-23 | ARYx医疗有限公司 | 立体异构化合物及治疗胃肠道和中枢神经系统紊乱的方法 |
| BRPI0620196A2 (pt) | 2005-12-23 | 2013-01-15 | Astrazeneca Ab | composto, processo para a preparaÇço do mesmo, composiÇço farmacÊutica, uso de um composto, e, mÉtodos para a produÇço de um efeito antibacteriano em um animal de sangue quente, para a inibiÇço de dna girase e/ou topoisomerase iv bacteriana em um animal de sangue quente e para o tratamento de uma infecÇço bacteriana em um animal de sangue quente |
| WO2008139152A1 (en) * | 2007-05-11 | 2008-11-20 | Sentinel Oncology Limited | N-oxide-containing pharmaceutical compounds |
| ES2525515T3 (es) | 2010-09-01 | 2014-12-23 | Janssen Pharmaceutica, N.V. | Antagonistas del receptor 5-HT2B |
-
2011
- 2011-08-30 ES ES11748693.6T patent/ES2525515T3/es active Active
- 2011-08-30 CN CN201180041597.9A patent/CN103080089B/zh not_active Expired - Fee Related
- 2011-08-30 JP JP2013526445A patent/JP5845263B2/ja not_active Expired - Fee Related
- 2011-08-30 BR BR112013004503A patent/BR112013004503A2/pt active Search and Examination
- 2011-08-30 EP EP11748693.6A patent/EP2619180B1/en active Active
- 2011-08-30 AU AU2011298361A patent/AU2011298361B2/en not_active Ceased
- 2011-08-30 EA EA201390312A patent/EA020967B1/ru not_active IP Right Cessation
- 2011-08-30 MX MX2013002409A patent/MX2013002409A/es active IP Right Grant
- 2011-08-30 SG SG2013011929A patent/SG188233A1/en unknown
- 2011-08-30 KR KR1020137005411A patent/KR101815123B1/ko not_active Expired - Fee Related
- 2011-08-30 WO PCT/EP2011/064906 patent/WO2012028614A1/en not_active Ceased
- 2011-08-30 CA CA2806647A patent/CA2806647C/en active Active
-
2013
- 2013-02-28 ZA ZA2013/01561A patent/ZA201301561B/en unknown
- 2013-02-28 US US13/779,962 patent/US8703958B2/en not_active Expired - Fee Related
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2014
- 2014-03-04 US US14/196,502 patent/US9139523B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN103080089A (zh) | 2013-05-01 |
| KR20130101503A (ko) | 2013-09-13 |
| EP2619180A1 (en) | 2013-07-31 |
| ZA201301561B (en) | 2014-08-27 |
| KR101815123B1 (ko) | 2018-01-04 |
| MX2013002409A (es) | 2013-04-03 |
| EA020967B1 (ru) | 2015-03-31 |
| SG188233A1 (en) | 2013-04-30 |
| US20130172386A1 (en) | 2013-07-04 |
| US20140187585A1 (en) | 2014-07-03 |
| US8703958B2 (en) | 2014-04-22 |
| CA2806647C (en) | 2018-09-18 |
| JP2013536823A (ja) | 2013-09-26 |
| WO2012028614A1 (en) | 2012-03-08 |
| AU2011298361B2 (en) | 2014-03-13 |
| US9139523B2 (en) | 2015-09-22 |
| EP2619180B1 (en) | 2014-10-08 |
| CN103080089B (zh) | 2015-09-23 |
| BR112013004503A2 (pt) | 2016-06-07 |
| HK1182097A1 (zh) | 2013-11-22 |
| EA201390312A1 (ru) | 2013-07-30 |
| ES2525515T3 (es) | 2014-12-23 |
| CA2806647A1 (en) | 2012-03-08 |
| AU2011298361A1 (en) | 2013-02-14 |
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