KR101815123B1 - 5ht2b 수용체 길항제 - Google Patents

5ht2b 수용체 길항제 Download PDF

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Publication number
KR101815123B1
KR101815123B1 KR1020137005411A KR20137005411A KR101815123B1 KR 101815123 B1 KR101815123 B1 KR 101815123B1 KR 1020137005411 A KR1020137005411 A KR 1020137005411A KR 20137005411 A KR20137005411 A KR 20137005411A KR 101815123 B1 KR101815123 B1 KR 101815123B1
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KR
South Korea
Prior art keywords
compound
acid
mmol
pulmonary
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020137005411A
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English (en)
Korean (ko)
Other versions
KR20130101503A (ko
Inventor
요하네스 빌헬무스 존 에프. 투링
돈크 루크 아우구스트 라우렌티우스 베어
Original Assignee
얀센 파마슈티카 엔.브이.
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Publication of KR20130101503A publication Critical patent/KR20130101503A/ko
Application granted granted Critical
Publication of KR101815123B1 publication Critical patent/KR101815123B1/ko
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020137005411A 2010-09-01 2011-08-30 5ht2b 수용체 길항제 Expired - Fee Related KR101815123B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10174880 2010-09-01
EP10174880.4 2010-09-01
PCT/EP2011/064906 WO2012028614A1 (en) 2010-09-01 2011-08-30 5-ht2b receptor antagonists

Publications (2)

Publication Number Publication Date
KR20130101503A KR20130101503A (ko) 2013-09-13
KR101815123B1 true KR101815123B1 (ko) 2018-01-04

Family

ID=43127285

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137005411A Expired - Fee Related KR101815123B1 (ko) 2010-09-01 2011-08-30 5ht2b 수용체 길항제

Country Status (14)

Country Link
US (2) US8703958B2 (enExample)
EP (1) EP2619180B1 (enExample)
JP (1) JP5845263B2 (enExample)
KR (1) KR101815123B1 (enExample)
CN (1) CN103080089B (enExample)
AU (1) AU2011298361B2 (enExample)
BR (1) BR112013004503A2 (enExample)
CA (1) CA2806647C (enExample)
EA (1) EA020967B1 (enExample)
ES (1) ES2525515T3 (enExample)
MX (1) MX2013002409A (enExample)
SG (1) SG188233A1 (enExample)
WO (1) WO2012028614A1 (enExample)
ZA (1) ZA201301561B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA020967B1 (ru) 2010-09-01 2015-03-31 Янссен Фармацевтика Нв Антагонисты рецептора 5-ht
CN103467596A (zh) * 2012-06-06 2013-12-25 北京大学 一个治疗肺动脉高压的新靶点
WO2015134503A1 (en) * 2014-03-04 2015-09-11 The Children's Hospital Of Philadelphia Methods for managing care of patients predisposed to progressive mitral valve diseases
CN110950843B (zh) * 2019-11-28 2022-12-27 广东东阳光药业有限公司 取代的苯酰胺衍生物及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US4962115A (en) * 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
GB8519707D0 (en) * 1985-08-06 1985-09-11 Fordonal Sa Chemical compounds
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
WO2001093849A2 (en) * 2000-06-07 2001-12-13 Aryx Therapeutics Treatment of gastroesophageal reflux disease using piperidine derivatives
US6444477B1 (en) * 2000-11-28 2002-09-03 Pharmagene Laboratories Limited Assay method for detecting 5-HT2B antagonists
CN1918157B (zh) * 2004-01-07 2010-06-23 ARYx医疗有限公司 立体异构化合物及治疗胃肠道和中枢神经系统紊乱的方法
KR20080080211A (ko) 2005-12-23 2008-09-02 아스트라제네카 아베 항박테리아성 피롤로피리딘, 피롤로피리미딘 및피롤로아제핀
WO2008139152A1 (en) * 2007-05-11 2008-11-20 Sentinel Oncology Limited N-oxide-containing pharmaceutical compounds
EA020967B1 (ru) 2010-09-01 2015-03-31 Янссен Фармацевтика Нв Антагонисты рецептора 5-ht

Also Published As

Publication number Publication date
EA020967B1 (ru) 2015-03-31
US8703958B2 (en) 2014-04-22
ZA201301561B (en) 2014-08-27
SG188233A1 (en) 2013-04-30
US9139523B2 (en) 2015-09-22
US20130172386A1 (en) 2013-07-04
EA201390312A1 (ru) 2013-07-30
BR112013004503A2 (pt) 2016-06-07
WO2012028614A1 (en) 2012-03-08
EP2619180A1 (en) 2013-07-31
ES2525515T3 (es) 2014-12-23
MX2013002409A (es) 2013-04-03
JP5845263B2 (ja) 2016-01-20
HK1182097A1 (zh) 2013-11-22
KR20130101503A (ko) 2013-09-13
AU2011298361B2 (en) 2014-03-13
CN103080089A (zh) 2013-05-01
CA2806647C (en) 2018-09-18
AU2011298361A1 (en) 2013-02-14
CN103080089B (zh) 2015-09-23
EP2619180B1 (en) 2014-10-08
JP2013536823A (ja) 2013-09-26
CA2806647A1 (en) 2012-03-08
US20140187585A1 (en) 2014-07-03

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