JP2008525445A5 - - Google Patents
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- JP2008525445A5 JP2008525445A5 JP2007548226A JP2007548226A JP2008525445A5 JP 2008525445 A5 JP2008525445 A5 JP 2008525445A5 JP 2007548226 A JP2007548226 A JP 2007548226A JP 2007548226 A JP2007548226 A JP 2007548226A JP 2008525445 A5 JP2008525445 A5 JP 2008525445A5
- Authority
- JP
- Japan
- Prior art keywords
- iron
- acid
- composition
- iron absorption
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 72
- 229910052742 iron Inorganic materials 0.000 claims 36
- 239000000203 mixture Substances 0.000 claims 22
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 16
- 238000010521 absorption reaction Methods 0.000 claims 15
- 229940124532 absorption promoter Drugs 0.000 claims 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 12
- 239000003623 enhancer Substances 0.000 claims 11
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 4
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 4
- 229930003268 Vitamin C Natural products 0.000 claims 4
- 235000011054 acetic acid Nutrition 0.000 claims 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 4
- 229960005070 ascorbic acid Drugs 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 150000002506 iron compounds Chemical class 0.000 claims 4
- 235000019154 vitamin C Nutrition 0.000 claims 4
- 239000011718 vitamin C Substances 0.000 claims 4
- 150000002505 iron Chemical class 0.000 claims 3
- 239000002994 raw material Substances 0.000 claims 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- QXKAIJAYHKCRRA-UHFFFAOYSA-N D-lyxonic acid Natural products OCC(O)C(O)C(O)C(O)=O QXKAIJAYHKCRRA-UHFFFAOYSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
- 239000002211 L-ascorbic acid Substances 0.000 claims 2
- 235000000069 L-ascorbic acid Nutrition 0.000 claims 2
- QXKAIJAYHKCRRA-PZGQECOJSA-N L-lyxonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)C(O)=O QXKAIJAYHKCRRA-PZGQECOJSA-N 0.000 claims 2
- JPIJQSOTBSSVTP-STHAYSLISA-N L-threonic acid Chemical compound OC[C@H](O)[C@@H](O)C(O)=O JPIJQSOTBSSVTP-STHAYSLISA-N 0.000 claims 2
- QXKAIJAYHKCRRA-NUNKFHFFSA-N L-xylonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(O)=O QXKAIJAYHKCRRA-NUNKFHFFSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 2
- 239000004260 Potassium ascorbate Substances 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical group O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 2
- 235000010376 calcium ascorbate Nutrition 0.000 claims 2
- 229940047036 calcium ascorbate Drugs 0.000 claims 2
- 239000011692 calcium ascorbate Substances 0.000 claims 2
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 claims 2
- 235000015165 citric acid Nutrition 0.000 claims 2
- 150000001860 citric acid derivatives Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229930195712 glutamate Natural products 0.000 claims 2
- 235000013922 glutamic acid Nutrition 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- 150000002306 glutamic acid derivatives Chemical class 0.000 claims 2
- 230000000968 intestinal effect Effects 0.000 claims 2
- 150000004698 iron complex Chemical class 0.000 claims 2
- 229940056902 l- threonic acid Drugs 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 229940074358 magnesium ascorbate Drugs 0.000 claims 2
- AIOKQVJVNPDJKA-ZZMNMWMASA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-olate Chemical compound [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] AIOKQVJVNPDJKA-ZZMNMWMASA-L 0.000 claims 2
- 229940049920 malate Drugs 0.000 claims 2
- 239000001630 malic acid Substances 0.000 claims 2
- 235000011090 malic acid Nutrition 0.000 claims 2
- 150000004701 malic acid derivatives Chemical class 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 235000019275 potassium ascorbate Nutrition 0.000 claims 2
- 229940017794 potassium ascorbate Drugs 0.000 claims 2
- CONVKSGEGAVTMB-RXSVEWSESA-M potassium-L-ascorbate Chemical compound [K+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] CONVKSGEGAVTMB-RXSVEWSESA-M 0.000 claims 2
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims 2
- 235000010378 sodium ascorbate Nutrition 0.000 claims 2
- 229960005055 sodium ascorbate Drugs 0.000 claims 2
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 2
- 239000001384 succinic acid Substances 0.000 claims 2
- 150000003443 succinic acid derivatives Chemical class 0.000 claims 2
- 230000009885 systemic effect Effects 0.000 claims 2
- 229940056904 zinc ascorbate Drugs 0.000 claims 2
- WWRJFSIRMWUMAE-ZZMNMWMASA-L zinc;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2h-furan-4-olate Chemical compound [Zn+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] WWRJFSIRMWUMAE-ZZMNMWMASA-L 0.000 claims 2
- OTTPVANZKZRSBY-UHFFFAOYSA-N 2-aminoacetic acid;iron Chemical compound [Fe].NCC(O)=O.NCC(O)=O OTTPVANZKZRSBY-UHFFFAOYSA-N 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
- -1 iron amino acid Chemical class 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/020,801 US20060134227A1 (en) | 2004-12-22 | 2004-12-22 | Compositions including iron |
| PCT/US2005/041139 WO2006068729A2 (en) | 2004-12-22 | 2005-11-09 | Methods and compositions for enhancing iron absorption |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008525445A JP2008525445A (ja) | 2008-07-17 |
| JP2008525445A5 true JP2008525445A5 (enExample) | 2008-12-25 |
Family
ID=36596132
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548207A Pending JP2008525442A (ja) | 2004-12-22 | 2005-10-27 | 鉄を含む組成物 |
| JP2007548226A Pending JP2008525445A (ja) | 2004-12-22 | 2005-11-09 | 鉄吸収増進のための方法および組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548207A Pending JP2008525442A (ja) | 2004-12-22 | 2005-10-27 | 鉄を含む組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US20060134227A1 (enExample) |
| EP (2) | EP1827418A4 (enExample) |
| JP (2) | JP2008525442A (enExample) |
| CN (1) | CN101102762A (enExample) |
| AR (1) | AR052837A1 (enExample) |
| AU (1) | AU2005319679A1 (enExample) |
| BR (1) | BRPI0519265A2 (enExample) |
| CA (1) | CA2591996A1 (enExample) |
| MX (1) | MX2007008021A (enExample) |
| PE (1) | PE20061122A1 (enExample) |
| WO (2) | WO2006068697A2 (enExample) |
Families Citing this family (80)
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| WO2007035760A1 (en) * | 2005-09-20 | 2007-03-29 | Board Of Regents, The University Of Texas System | Enhanced solubility of preformed calcium citrate by adding citric acid |
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| WO2023272693A1 (zh) * | 2021-07-01 | 2023-01-05 | 思瑰瑞保健食品有限公司 | 一种维生素c加硫酸亚铁缓控释片及其制备方法 |
| WO2023023029A1 (en) * | 2021-08-16 | 2023-02-23 | Thermolife International, Llc | Iron supplement compositions and methods of use thereof |
| CN114028423B (zh) * | 2021-12-13 | 2023-05-23 | 广东粤港澳大湾区国家纳米科技创新研究院 | 修饰的纳米氧化铁在制备预防和/或治疗炎性肠病的药物中的应用 |
| CN114288320A (zh) * | 2021-12-29 | 2022-04-08 | 珠海天翼医药技术开发有限公司 | 一种猪用口服补铁剂及其制备方法 |
| CN114767710B (zh) * | 2022-04-12 | 2023-07-07 | 中山大学 | 甘氨酸亚铁在治疗类风湿关节炎中的应用 |
| CN116636620B (zh) * | 2023-05-25 | 2025-02-14 | 南昌大学 | 一种乌鸡蛋清肽组合物及其应用 |
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2004
- 2004-12-22 US US11/020,801 patent/US20060134227A1/en not_active Abandoned
-
2005
- 2005-10-27 WO PCT/US2005/038859 patent/WO2006068697A2/en not_active Ceased
- 2005-10-27 CA CA002591996A patent/CA2591996A1/en not_active Abandoned
- 2005-10-27 AU AU2005319679A patent/AU2005319679A1/en not_active Abandoned
- 2005-10-27 JP JP2007548207A patent/JP2008525442A/ja active Pending
- 2005-10-27 EP EP05813755A patent/EP1827418A4/en not_active Withdrawn
- 2005-10-27 MX MX2007008021A patent/MX2007008021A/es unknown
- 2005-10-27 CN CNA2005800470364A patent/CN101102762A/zh active Pending
- 2005-10-27 BR BRPI0519265-0A patent/BRPI0519265A2/pt not_active IP Right Cessation
- 2005-11-09 US US11/793,517 patent/US20090028962A1/en not_active Abandoned
- 2005-11-09 WO PCT/US2005/041139 patent/WO2006068729A2/en not_active Ceased
- 2005-11-09 JP JP2007548226A patent/JP2008525445A/ja active Pending
- 2005-11-09 EP EP05820746A patent/EP1827419A4/en not_active Withdrawn
- 2005-12-01 PE PE2005001394A patent/PE20061122A1/es not_active Application Discontinuation
- 2005-12-21 AR ARP050105442A patent/AR052837A1/es unknown
-
2010
- 2010-09-27 US US12/891,376 patent/US20110015150A1/en not_active Abandoned
-
2012
- 2012-07-20 US US13/554,243 patent/US20130189374A1/en not_active Abandoned
-
2015
- 2015-02-27 US US14/634,312 patent/US20160022631A1/en not_active Abandoned
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