ME02149B - FORMULACIJE l METODE ZA LEČENJE AMILOIDOZE - Google Patents
FORMULACIJE l METODE ZA LEČENJE AMILOIDOZEInfo
- Publication number
- ME02149B ME02149B MEP-2015-85A MEP8515A ME02149B ME 02149 B ME02149 B ME 02149B ME P8515 A MEP8515 A ME P8515A ME 02149 B ME02149 B ME 02149B
- Authority
- ME
- Montenegro
- Prior art keywords
- pharmaceutical composition
- use according
- approximately
- administered
- pharmaceutically acceptable
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 4
- 238000009472 formulation Methods 0.000 title claims 3
- 206010002022 amyloidosis Diseases 0.000 title claims 2
- 238000000034 method Methods 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 6
- 229940109239 creatinine Drugs 0.000 claims 3
- 235000013305 food Nutrition 0.000 claims 3
- 235000012054 meals Nutrition 0.000 claims 3
- MGNVWUDMMXZUDI-UHFFFAOYSA-N propane-1,3-disulfonic acid Chemical compound OS(=O)(=O)CCCS(O)(=O)=O MGNVWUDMMXZUDI-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000023769 AA amyloidosis Diseases 0.000 claims 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (8)
1.Farmaceutska kompozicija koja sadrži l ,3-propandisulfonsku kiselinu ili njenu farmaceutski prihvatljivu so za upotrebu u metodi za lečenje ili prevenciju bolesti vezanih za am i lo ide kod subjekta, gde je l ,3-propandisu lfonska kiselina ili njena farmaceutski prihvatljiva so administr irana u dozi od približno 1200 mg dva puta u toku dana za stopu klirensa kreatinina od >80 mL/min , u dozi od približno 800 mg dva puta u toku dana za stopu klirensa kreatinina od između približno 30 i 80 mL/min, ili u dozi od približno 400 mg dva puta u toku dana za stopu klirensa kreatinina od i zmeđu približno 20 i 30 mL/min.
2.Farmaceutska kompozicija za upotrebu prema patentnom zahtevu l , gde je farmaceutski prihvatljiva so dinatrij umova so 1,3- propandisulfonske kiseline.
3.Farmaceutska kompozicija za upotrebu prema patentnom zahtevu 1 ili 2, gde kompozicija dalje sadrži farmaceutski prihvatljivi nosač.
4.Farmaceutska kompozicija za upotrebu prema bilo kojem od patentnih za hteva od 1 do 3, gde je bolest vezana za amiloide AA amiloidoza.
5.Farmaceutska kompozicija za upot rebu prema bilo kojem od patentnih za hteva od l do 4, gde farmaceutska formulacija treba da bude administrirana bez hrane.
6.Farmaceutska kompozicija za upotrebu prema patentnom zahtevu 5, gde administracija bez hrane za posledicu ima porast u bioraspoloživosti od približno 25% ili v i še u poređenju sa administracijom sa hranom.
7.Farmaceutska kompozicija za upotrebu prema patentnom za htevu 5, gde je formulacija administrirana najmanje 1 ili 2 sata pre ili posle bilo kog obroka.
8.Farmaceutska kompozicija za upotrebu prema patentnom zahtevu 6, gde je formulacija adm inistrirana najmanje 1 sat pre obroka ili najmanje 2 sata posle obroka. 74
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67186605P | 2005-04-15 | 2005-04-15 | |
| EP06795492.5A EP1885350B9 (en) | 2005-04-15 | 2006-04-17 | Formulations and methods for treating amyloidosis |
| PCT/IB2006/002540 WO2007004072A2 (en) | 2005-04-15 | 2006-04-17 | Formulations and methods for treating amyloidosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02149B true ME02149B (me) | 2015-10-20 |
Family
ID=37499595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2015-85A ME02149B (me) | 2005-04-15 | 2006-04-17 | FORMULACIJE l METODE ZA LEČENJE AMILOIDOZE |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US8178580B2 (me) |
| EP (2) | EP1885350B9 (me) |
| JP (2) | JP2008535906A (me) |
| KR (2) | KR20080003895A (me) |
| CN (2) | CN104873483A (me) |
| AU (1) | AU2006264498B2 (me) |
| BR (1) | BRPI0610592A2 (me) |
| CA (1) | CA2582556C (me) |
| DK (1) | DK1885350T3 (me) |
| EA (1) | EA018898B1 (me) |
| ES (1) | ES2534553T3 (me) |
| HK (1) | HK1214158A1 (me) |
| HR (1) | HRP20150320T1 (me) |
| HU (1) | HUE026044T2 (me) |
| IL (2) | IL186544A (me) |
| ME (1) | ME02149B (me) |
| MX (1) | MX2007012525A (me) |
| NO (1) | NO20075815L (me) |
| PL (1) | PL1885350T3 (me) |
| PT (1) | PT1885350E (me) |
| RS (1) | RS54050B1 (me) |
| SI (1) | SI1885350T1 (me) |
| TW (1) | TW200716088A (me) |
| WO (1) | WO2007004072A2 (me) |
| ZA (1) | ZA200709825B (me) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2375628A1 (en) * | 1999-07-09 | 2001-01-18 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
| US7244764B2 (en) | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US20070010573A1 (en) | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| JP5145537B2 (ja) | 2004-12-22 | 2013-02-20 | ビーエイチアイ リミテッド パートナーシップ | アミロイド関連疾患を治療するための方法および組成物 |
| TW200716088A (en) * | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
| US20070049638A1 (en) * | 2005-07-21 | 2007-03-01 | Neurochem (International) Limited | Polymorphic forms of 3-amino-1-propanesulfonic acid |
| ATE481094T1 (de) * | 2005-12-22 | 2010-10-15 | Kiacta Sarl | Behandlung von diabetischer nephropathie |
| ES2967330T3 (es) | 2006-10-12 | 2024-04-29 | Bellus Health Inc | Métodos, compuestos, composiciones y vehículos para suministrar ácido 3-amino-1-propanosulfónico |
| JP2010529947A (ja) * | 2006-12-22 | 2010-09-02 | ベラス ヘルス（インターナショナル）リミテッド | 代謝性疾患および糖尿病を治療するための方法、化合物、および組成物 |
| SG177645A1 (en) | 2009-08-10 | 2012-02-28 | Bellus Health Inc | Methods, compounds, and compositions for delivering 1,3-propan ed isulfonic acid |
| CN103180445B (zh) | 2010-10-22 | 2018-02-16 | 库尔纳公司 | 通过抑制α‑L‑艾杜糖醛酸酶(IDUA)的天然反义转录物而治疗IDUA相关疾病 |
| MX2016014261A (es) * | 2014-04-30 | 2017-05-04 | Icahn School Med Mount Sinai | Uso de acido 1,3-propandisulfonico o sales farmaceuticamente aceptables del mismo para el tratamiento de sarcoidosis. |
| WO2016023911A1 (en) * | 2014-08-11 | 2016-02-18 | Kiacta Sàrl | Use of 1,3-propanedisulfonic acid or salts thereof to prevent the onset of amyloidosis in select populations |
| CN116143672B (zh) * | 2023-02-28 | 2024-03-29 | 卫星化学股份有限公司 | 水溶性抗氧剂及其制备方法和应用 |
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