CA2591996A1 - Compositions including iron - Google Patents
Compositions including iron Download PDFInfo
- Publication number
- CA2591996A1 CA2591996A1 CA002591996A CA2591996A CA2591996A1 CA 2591996 A1 CA2591996 A1 CA 2591996A1 CA 002591996 A CA002591996 A CA 002591996A CA 2591996 A CA2591996 A CA 2591996A CA 2591996 A1 CA2591996 A1 CA 2591996A1
- Authority
- CA
- Canada
- Prior art keywords
- iron
- acid
- ferric
- composition
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 641
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 326
- 239000000203 mixture Substances 0.000 title claims abstract description 183
- 238000010521 absorption reaction Methods 0.000 claims abstract description 42
- 150000007524 organic acids Chemical class 0.000 claims abstract description 33
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 31
- 206010022971 Iron Deficiencies Diseases 0.000 claims abstract description 30
- 238000011282 treatment Methods 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 24
- 208000035475 disorder Diseases 0.000 claims abstract description 22
- 229940124532 absorption promoter Drugs 0.000 claims abstract description 18
- 230000002265 prevention Effects 0.000 claims abstract description 10
- 230000006641 stabilisation Effects 0.000 claims abstract description 10
- 238000011105 stabilization Methods 0.000 claims abstract description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 114
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 73
- 235000010323 ascorbic acid Nutrition 0.000 claims description 47
- 239000011668 ascorbic acid Substances 0.000 claims description 47
- 230000009469 supplementation Effects 0.000 claims description 47
- 229960005070 ascorbic acid Drugs 0.000 claims description 45
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 38
- 235000002639 sodium chloride Nutrition 0.000 claims description 36
- 241001465754 Metazoa Species 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 30
- 239000001384 succinic acid Substances 0.000 claims description 30
- -1 ferric albuminate Chemical compound 0.000 claims description 24
- 241000282414 Homo sapiens Species 0.000 claims description 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 20
- 235000019152 folic acid Nutrition 0.000 claims description 20
- 239000011724 folic acid Substances 0.000 claims description 20
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 19
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 18
- 229960000304 folic acid Drugs 0.000 claims description 18
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims description 17
- 230000000694 effects Effects 0.000 claims description 17
- DSLZVSRJTYRBFB-LLEIAEIESA-N D-glucaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O DSLZVSRJTYRBFB-LLEIAEIESA-N 0.000 claims description 16
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 16
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 claims description 15
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 claims description 15
- 150000002506 iron compounds Chemical class 0.000 claims description 14
- 159000000014 iron salts Chemical class 0.000 claims description 14
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 claims description 13
- 229930003779 Vitamin B12 Natural products 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 13
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 claims description 13
- 210000003743 erythrocyte Anatomy 0.000 claims description 13
- 235000019163 vitamin B12 Nutrition 0.000 claims description 13
- 239000011715 vitamin B12 Substances 0.000 claims description 13
- 238000013270 controlled release Methods 0.000 claims description 12
- 239000011773 ferrous fumarate Substances 0.000 claims description 12
- 235000002332 ferrous fumarate Nutrition 0.000 claims description 12
- 229960000225 ferrous fumarate Drugs 0.000 claims description 12
- 235000001014 amino acid Nutrition 0.000 claims description 11
- 229940024606 amino acid Drugs 0.000 claims description 11
- 150000001413 amino acids Chemical class 0.000 claims description 11
- 230000002441 reversible effect Effects 0.000 claims description 11
- 229960001781 ferrous sulfate Drugs 0.000 claims description 10
- 239000011790 ferrous sulphate Substances 0.000 claims description 10
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 10
- 150000002505 iron Chemical class 0.000 claims description 10
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 10
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 10
- 238000002560 therapeutic procedure Methods 0.000 claims description 10
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 9
- 229930003268 Vitamin C Natural products 0.000 claims description 9
- 201000010099 disease Diseases 0.000 claims description 9
- 235000019154 vitamin C Nutrition 0.000 claims description 9
- 239000011718 vitamin C Substances 0.000 claims description 9
- 150000000996 L-ascorbic acids Chemical class 0.000 claims description 8
- 238000000576 coating method Methods 0.000 claims description 8
- 150000004698 iron complex Chemical class 0.000 claims description 8
- 229910021506 iron(II) hydroxide Inorganic materials 0.000 claims description 8
- NCNCGGDMXMBVIA-UHFFFAOYSA-L iron(ii) hydroxide Chemical compound [OH-].[OH-].[Fe+2] NCNCGGDMXMBVIA-UHFFFAOYSA-L 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 229940088594 vitamin Drugs 0.000 claims description 8
- 239000011782 vitamin Substances 0.000 claims description 8
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 7
- 239000004277 Ferrous carbonate Substances 0.000 claims description 7
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 7
- 235000011054 acetic acid Nutrition 0.000 claims description 7
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 7
- RAQDACVRFCEPDA-UHFFFAOYSA-L ferrous carbonate Chemical compound [Fe+2].[O-]C([O-])=O RAQDACVRFCEPDA-UHFFFAOYSA-L 0.000 claims description 7
- 235000019268 ferrous carbonate Nutrition 0.000 claims description 7
- 229960004652 ferrous carbonate Drugs 0.000 claims description 7
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 claims description 7
- 229910000015 iron(II) carbonate Inorganic materials 0.000 claims description 7
- 239000004310 lactic acid Substances 0.000 claims description 7
- 235000014655 lactic acid Nutrition 0.000 claims description 7
- 239000001630 malic acid Substances 0.000 claims description 7
- 235000011090 malic acid Nutrition 0.000 claims description 7
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 6
- 235000015165 citric acid Nutrition 0.000 claims description 6
- 229960004887 ferric hydroxide Drugs 0.000 claims description 6
- 239000004222 ferrous gluconate Substances 0.000 claims description 6
- 235000013924 ferrous gluconate Nutrition 0.000 claims description 6
- 229960001645 ferrous gluconate Drugs 0.000 claims description 6
- NPFOYSMITVOQOS-UHFFFAOYSA-K iron(III) citrate Chemical compound [Fe+3].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NPFOYSMITVOQOS-UHFFFAOYSA-K 0.000 claims description 6
- 229910052748 manganese Inorganic materials 0.000 claims description 6
- 239000011572 manganese Substances 0.000 claims description 6
- 229930003231 vitamin Natural products 0.000 claims description 6
- 235000013343 vitamin Nutrition 0.000 claims description 6
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 235000013922 glutamic acid Nutrition 0.000 claims description 5
- 239000004220 glutamic acid Substances 0.000 claims description 5
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 claims description 5
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims description 4
- 239000004471 Glycine Substances 0.000 claims description 4
- 229910021578 Iron(III) chloride Inorganic materials 0.000 claims description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 4
- 229940009098 aspartate Drugs 0.000 claims description 4
- MDXRFOWKIZPNTA-UHFFFAOYSA-L butanedioate;iron(2+) Chemical compound [Fe+2].[O-]C(=O)CCC([O-])=O MDXRFOWKIZPNTA-UHFFFAOYSA-L 0.000 claims description 4
- CHYQSXLXQCXPAA-UHFFFAOYSA-H butanedioate;iron(3+) Chemical compound [Fe+3].[Fe+3].[O-]C(=O)CCC([O-])=O.[O-]C(=O)CCC([O-])=O.[O-]C(=O)CCC([O-])=O CHYQSXLXQCXPAA-UHFFFAOYSA-H 0.000 claims description 4
- 208000020832 chronic kidney disease Diseases 0.000 claims description 4
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 4
- 239000011706 ferric diphosphate Substances 0.000 claims description 4
- 235000007144 ferric diphosphate Nutrition 0.000 claims description 4
- CADNYOZXMIKYPR-UHFFFAOYSA-B ferric pyrophosphate Chemical compound [Fe+3].[Fe+3].[Fe+3].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])([O-])=O CADNYOZXMIKYPR-UHFFFAOYSA-B 0.000 claims description 4
- 229940036404 ferric pyrophosphate Drugs 0.000 claims description 4
- 239000011645 ferric sodium diphosphate Substances 0.000 claims description 4
- 235000019851 ferric sodium diphosphate Nutrition 0.000 claims description 4
- 239000011640 ferrous citrate Substances 0.000 claims description 4
- 235000019850 ferrous citrate Nutrition 0.000 claims description 4
- 229960001604 ferrous succinate Drugs 0.000 claims description 4
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 claims description 4
- SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 claims description 4
- VCJMYUPGQJHHFU-UHFFFAOYSA-N iron(3+);trinitrate Chemical compound [Fe+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VCJMYUPGQJHHFU-UHFFFAOYSA-N 0.000 claims description 4
- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 claims description 4
- 229940078042 polysaccharide iron complex Drugs 0.000 claims description 4
- XWQGIDJIEPIQBD-UHFFFAOYSA-J sodium;iron(3+);phosphonato phosphate Chemical compound [Na+].[Fe+3].[O-]P([O-])(=O)OP([O-])([O-])=O XWQGIDJIEPIQBD-UHFFFAOYSA-J 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- QXKAIJAYHKCRRA-UHFFFAOYSA-N D-lyxonic acid Natural products OCC(O)C(O)C(O)C(O)=O QXKAIJAYHKCRRA-UHFFFAOYSA-N 0.000 claims description 3
- SBJKKFFYIZUCET-JLAZNSOCSA-N Dehydro-L-ascorbic acid Chemical class OC[C@H](O)[C@H]1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-JLAZNSOCSA-N 0.000 claims description 3
- SBJKKFFYIZUCET-UHFFFAOYSA-N Dehydroascorbic acid Chemical class OCC(O)C1OC(=O)C(=O)C1=O SBJKKFFYIZUCET-UHFFFAOYSA-N 0.000 claims description 3
- 239000005955 Ferric phosphate Substances 0.000 claims description 3
- QXKAIJAYHKCRRA-PZGQECOJSA-N L-lyxonic acid Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)C(O)=O QXKAIJAYHKCRRA-PZGQECOJSA-N 0.000 claims description 3
- JPIJQSOTBSSVTP-STHAYSLISA-N L-threonic acid Chemical compound OC[C@H](O)[C@@H](O)C(O)=O JPIJQSOTBSSVTP-STHAYSLISA-N 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 3
- 229940072107 ascorbate Drugs 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 235000020960 dehydroascorbic acid Nutrition 0.000 claims description 3
- 239000011615 dehydroascorbic acid Chemical class 0.000 claims description 3
- 238000000502 dialysis Methods 0.000 claims description 3
- FWZTTZUKDVJDCM-CEJAUHOTSA-M disodium;(2r,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;iron(3+);oxygen(2-);hydroxide;trihydrate Chemical compound O.O.O.[OH-].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Na+].[Na+].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 FWZTTZUKDVJDCM-CEJAUHOTSA-M 0.000 claims description 3
- 239000012990 dithiocarbamate Substances 0.000 claims description 3
- 229960001484 edetic acid Drugs 0.000 claims description 3
- 229940032958 ferric phosphate Drugs 0.000 claims description 3
- IMBKASBLAKCLEM-UHFFFAOYSA-L ferrous ammonium sulfate (anhydrous) Chemical compound [NH4+].[NH4+].[Fe+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O IMBKASBLAKCLEM-UHFFFAOYSA-L 0.000 claims description 3
- WBJZTOZJJYAKHQ-UHFFFAOYSA-K iron(3+) phosphate Chemical compound [Fe+3].[O-]P([O-])([O-])=O WBJZTOZJJYAKHQ-UHFFFAOYSA-K 0.000 claims description 3
- 229910000399 iron(III) phosphate Inorganic materials 0.000 claims description 3
- 229940056902 l- threonic acid Drugs 0.000 claims description 3
- 229940074358 magnesium ascorbate Drugs 0.000 claims description 3
- AIOKQVJVNPDJKA-ZZMNMWMASA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-olate Chemical class [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] AIOKQVJVNPDJKA-ZZMNMWMASA-L 0.000 claims description 3
- 239000003539 oral contraceptive agent Substances 0.000 claims description 3
- 229960003330 pentetic acid Drugs 0.000 claims description 3
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Chemical class [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 claims description 3
- 235000010378 sodium ascorbate Nutrition 0.000 claims description 3
- 229960005055 sodium ascorbate Drugs 0.000 claims description 3
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical class [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 claims description 3
- 230000000087 stabilizing effect Effects 0.000 claims description 3
- 229940056904 zinc ascorbate Drugs 0.000 claims description 3
- WWRJFSIRMWUMAE-ZZMNMWMASA-L zinc;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2h-furan-4-olate Chemical class [Zn+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] WWRJFSIRMWUMAE-ZZMNMWMASA-L 0.000 claims description 3
- OHZCFWMJMWFNFP-ZVGUSBNCSA-L (2r,3r)-2,3-dihydroxybutanedioate;iron(2+) Chemical compound [Fe+2].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O OHZCFWMJMWFNFP-ZVGUSBNCSA-L 0.000 claims description 2
- XXDVUVPHJGZWQC-QHTZZOMLSA-L (2s)-2-amino-5-hydroxy-5-oxopentanoate;iron(2+) Chemical compound [Fe+2].[O-]C(=O)[C@@H](N)CCC(O)=O.[O-]C(=O)[C@@H](N)CCC(O)=O XXDVUVPHJGZWQC-QHTZZOMLSA-L 0.000 claims description 2
- YSFIPRFOHJQXJF-VMJVVOMYSA-N (r)-[(2s,4s,5r)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21.C([C@H]([C@H](C1)C=C)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 YSFIPRFOHJQXJF-VMJVVOMYSA-N 0.000 claims description 2
- MDAXKAUIABOHTD-UHFFFAOYSA-N 1,4,8,11-tetraazacyclotetradecane Chemical compound C1CNCCNCCCNCCNC1 MDAXKAUIABOHTD-UHFFFAOYSA-N 0.000 claims description 2
- CBEYZWBXIPZYNH-UHFFFAOYSA-J 1,5-dihydroxypentan-3-yl phosphate;2,3-dihydroxypropyl phosphate;iron(2+) Chemical compound [Fe+2].[Fe+2].OCC(O)COP([O-])([O-])=O.OCCC(CCO)OP([O-])([O-])=O CBEYZWBXIPZYNH-UHFFFAOYSA-J 0.000 claims description 2
- NLGYGIHWYOPKIX-UHFFFAOYSA-N 2-[carboxymethyl(methyl)amino]acetic acid;iron Chemical compound [Fe].OC(=O)CN(C)CC(O)=O NLGYGIHWYOPKIX-UHFFFAOYSA-N 0.000 claims description 2
- GIPOFCXYHMWROH-UHFFFAOYSA-L 2-aminoacetate;iron(2+) Chemical compound [Fe+2].NCC([O-])=O.NCC([O-])=O GIPOFCXYHMWROH-UHFFFAOYSA-L 0.000 claims description 2
- ZITFTYGHYGPDAV-UHFFFAOYSA-L 2-aminoacetic acid;iron(2+);sulfate Chemical compound [H+].[Fe+2].NCC([O-])=O.[O-]S([O-])(=O)=O ZITFTYGHYGPDAV-UHFFFAOYSA-L 0.000 claims description 2
- ZEYKLMDPUOVUCR-UHFFFAOYSA-N 2-chloro-5-(trifluoromethyl)benzenesulfonyl chloride Chemical compound FC(F)(F)C1=CC=C(Cl)C(S(Cl)(=O)=O)=C1 ZEYKLMDPUOVUCR-UHFFFAOYSA-N 0.000 claims description 2
- KRUJOKMDEHYPOP-UHFFFAOYSA-L 2-hydroxybutanedioate;iron(2+) Chemical compound [Fe+2].[O-]C(=O)C(O)CC([O-])=O KRUJOKMDEHYPOP-UHFFFAOYSA-L 0.000 claims description 2
- RPERJPYDELTDMR-UHFFFAOYSA-K 2-hydroxyethyl(trimethyl)azanium;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound C[N+](C)(C)CCO.C[N+](C)(C)CCO.C[N+](C)(C)CCO.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O RPERJPYDELTDMR-UHFFFAOYSA-K 0.000 claims description 2
- OAVRWNUUOUXDFH-UHFFFAOYSA-H 2-hydroxypropane-1,2,3-tricarboxylate;manganese(2+) Chemical compound [Mn+2].[Mn+2].[Mn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O OAVRWNUUOUXDFH-UHFFFAOYSA-H 0.000 claims description 2
- LIPRKYKMVQPYPG-UHFFFAOYSA-N 3-Hydroxy-2H-pyran-2-one Chemical class OC1=CC=COC1=O LIPRKYKMVQPYPG-UHFFFAOYSA-N 0.000 claims description 2
- MBOSIQQMKNDSDJ-UHFFFAOYSA-N 4,5-dichloro-2-(2,4-dichlorophenyl)pyridazin-3-one Chemical compound ClC1=CC(Cl)=CC=C1N1C(=O)C(Cl)=C(Cl)C=N1 MBOSIQQMKNDSDJ-UHFFFAOYSA-N 0.000 claims description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
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| US11/020,801 | 2004-12-22 | ||
| US11/020,801 US20060134227A1 (en) | 2004-12-22 | 2004-12-22 | Compositions including iron |
| PCT/US2005/038859 WO2006068697A2 (en) | 2004-12-22 | 2005-10-27 | Compositions including iron |
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| CA2591996A1 true CA2591996A1 (en) | 2006-06-29 |
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| US (5) | US20060134227A1 (enExample) |
| EP (2) | EP1827418A4 (enExample) |
| JP (2) | JP2008525442A (enExample) |
| CN (1) | CN101102762A (enExample) |
| AR (1) | AR052837A1 (enExample) |
| AU (1) | AU2005319679A1 (enExample) |
| BR (1) | BRPI0519265A2 (enExample) |
| CA (1) | CA2591996A1 (enExample) |
| MX (1) | MX2007008021A (enExample) |
| PE (1) | PE20061122A1 (enExample) |
| WO (2) | WO2006068697A2 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10249552A1 (de) | 2002-10-23 | 2004-05-13 | Vifor (International) Ag | Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel |
| WO2007035760A1 (en) * | 2005-09-20 | 2007-03-29 | Board Of Regents, The University Of Texas System | Enhanced solubility of preformed calcium citrate by adding citric acid |
| ES2380952T3 (es) * | 2005-10-11 | 2012-05-21 | Bayer Consumer Care Ag | Mezcla de sales de hierro y cobre que enmascaran el sabor metálico. |
| EP1790356A1 (de) * | 2005-11-24 | 2007-05-30 | Vifor (International) Ag | Präparat, umfassend Eisen(III)-Komplexverbindungen und redoxaktive Substanz(en) |
| CA2953964A1 (en) | 2006-01-06 | 2007-07-19 | Luitpold Pharmaceuticals, Inc. | Methods and compositions for administration of iron |
| ES2395862T3 (es) * | 2006-09-28 | 2013-02-15 | Bayer Consumer Care Ag | Mezcla de sales de hierro y de cobre para enmascarar el sabor metálico |
| US8142803B2 (en) | 2007-03-22 | 2012-03-27 | Magceutics, Inc. | Magnesium compositions and uses thereof for neurological disorders |
| ES2769583T3 (es) * | 2007-03-22 | 2020-06-26 | Neurocentria Inc | Composiciones de magnesio y usos de las mismas |
| US7816404B2 (en) | 2007-07-20 | 2010-10-19 | Rockwell Medical Technologies, Inc. | Methods for the preparation and use of ferric pyrophosphate citrate chelate compositions |
| US20090047362A1 (en) * | 2007-08-13 | 2009-02-19 | Keith Edward Forrester | Method for in-vitro stabilization of heavy metals |
| US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
| US9125844B1 (en) | 2007-09-25 | 2015-09-08 | Argent Development Group, Llc | Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women |
| US7964189B1 (en) | 2007-09-25 | 2011-06-21 | Argent Development Group, Llc | Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women |
| ITMI20071979A1 (it) * | 2007-10-12 | 2009-04-13 | Massimo Baldacci | Formulazioni farmaceutiche contenenti ferro bisglicinato chelato |
| US20090124572A1 (en) * | 2007-11-09 | 2009-05-14 | Deanna Jean Nelson | Iron-containing nutritional supplement |
| US8535659B1 (en) | 2008-05-27 | 2013-09-17 | Argent Development Group, Llc | Nutritional supplements for pregnant women |
| US8535660B1 (en) | 2008-05-27 | 2013-09-17 | Argent Development Group, Llc | Nutritional supplements for pregnant women |
| US9913806B2 (en) * | 2008-06-25 | 2018-03-13 | Fe3 Medical, Inc. | Patches and methods for the transdermal delivery of a therapeutically effective amount of iron |
| WO2010036977A2 (en) * | 2008-09-25 | 2010-04-01 | New England Medical Center Hospitals, Inc. | Combination therapies with topiramate for seizures, restless legs syndrome, and other neurological conditions |
| JP5702307B2 (ja) * | 2009-01-30 | 2015-04-15 | エコラボ インコーポレイティド | アルミニウムヒドロキシカルボキシレートビルダーの開発 |
| US8202830B2 (en) | 2009-01-30 | 2012-06-19 | Ecolab Usa Inc. | Development of an aluminum hydroxydicarboxylate builder |
| US8821945B2 (en) | 2009-04-25 | 2014-09-02 | Fe3 Medical, Inc. | Method for transdermal iontophoretic delivery of chelated agents |
| WO2010136839A1 (en) * | 2009-05-29 | 2010-12-02 | Carlo Ghisalberti | Use of deferoxamine and related compounds in targeted delivery forms to treat an inflammatory bowel disease |
| US8178709B2 (en) * | 2009-07-21 | 2012-05-15 | Biolink Life Sciences, Inc. | Iron preparation suitable for pharmaceutical formulation and process for the preparation thereof |
| CN102573807A (zh) | 2009-07-21 | 2012-07-11 | 凯克斯生物制药公司 | 柠檬酸铁剂型 |
| US8536106B2 (en) | 2010-04-14 | 2013-09-17 | Ecolab Usa Inc. | Ferric hydroxycarboxylate as a builder |
| JP5357102B2 (ja) * | 2010-04-27 | 2013-12-04 | 日本炉機工業株式会社 | 石化遺骨灰の製造方法 |
| EP2420243A1 (en) | 2010-08-18 | 2012-02-22 | Inovativo Biomedicinas Tehnologiju Instituts, SIA | Compositions obtainable from bred beetroot juice to promote iron absorption and blood forming |
| IT1402142B1 (it) * | 2010-09-24 | 2013-08-28 | Just Pharma S R L | Formulazione integrativa finalizzata al controllo delle alterazioni multifattoriali ricorrenti nell'anemia da carenza di ferro e per colmare eventuali carenze o aumentati fabbisogni nutrizionali in alcune condizioni fisiopatologiche. |
| EP2497380A1 (en) * | 2011-03-10 | 2012-09-12 | DSM IP Assets B.V. | Process for iron supplementation of beverages |
| WO2012163938A1 (de) | 2011-05-31 | 2012-12-06 | Vifor (International) Ag | Fe(iii)-2,4-dioxo-1-carbonyl-komplexverbindungen zur behandlung und prophylaxe von eisenmangelerscheinungen und eisenmangelanämien |
| CA2849732C (en) * | 2011-09-22 | 2019-10-01 | Jonathan Bortz | Buffered upper gi absorption promoter |
| EA201590062A1 (ru) * | 2012-06-21 | 2016-02-29 | Керикс Байофармасьютикалз, Инк. | Применение лимонно-кислого железа при лечении пациентов с хронической почечной недостаточностью |
| US20150250839A1 (en) * | 2012-09-11 | 2015-09-10 | Dakota Star Capital Llc | Nutritional supplement containing iron |
| CN102961338B (zh) * | 2012-12-07 | 2015-03-18 | 青岛黄海制药有限责任公司 | 一种多糖铁缓释微丸制剂及其制备方法 |
| CA2913413C (en) * | 2013-06-06 | 2021-11-23 | Amip, Llc | Iron supplement |
| ES2683212T3 (es) * | 2013-08-28 | 2018-09-25 | Dsm Ip Assets B.V. | Complementación de hierro de un concentrado de caldo |
| PL3048903T3 (pl) * | 2013-08-28 | 2017-09-29 | Dsm Ip Assets B.V. | Suplementacja żelaza koncentratu bulionu |
| TWI483721B (zh) | 2013-09-05 | 2015-05-11 | Profeat Biotechnology Co Ltd | The use of a composition containing a ferrous amino acid chelate for the manufacture of anti-cancer medicaments |
| AU2013400082B2 (en) * | 2013-09-05 | 2016-01-28 | Profeat Biotechnology Co., Ltd. | Use of composition containing ferrous amino acid chelate in preparation of anti-cancer medicament |
| US9492421B1 (en) | 2013-11-14 | 2016-11-15 | Argent Development Group, Llc | Nutritional supplements for treatment of iron deficiency anemia |
| US9629846B1 (en) | 2013-11-14 | 2017-04-25 | Argent Development Group, Llc | Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women |
| CN104644557B (zh) * | 2013-11-22 | 2017-10-31 | 上海宣泰医药科技有限公司 | 卟啉铁固体分散体及其制备方法 |
| JP2014051535A (ja) * | 2013-12-19 | 2014-03-20 | Fujifilm Corp | 鉄、カルシウム、又はマグネシウムの吸収を促進する方法 |
| CN104887696B (zh) * | 2014-03-04 | 2018-06-29 | 天津怀仁制药有限公司 | 右旋糖酐铁和维生素c的复方制剂 |
| EP3179249A4 (en) * | 2014-08-05 | 2017-07-26 | Fujifilm Corporation | Nucleated erythrocyte sorting method |
| US9961886B2 (en) | 2014-08-13 | 2018-05-08 | Akeso Biomedical, Inc. | Antimicrobial compounds and compositions, and uses thereof |
| GB201416293D0 (en) * | 2014-09-15 | 2014-10-29 | Solvotrin Therapeutics Ltd | Methods and preparations |
| JP5757493B1 (ja) * | 2014-09-24 | 2015-07-29 | 富田製薬株式会社 | 経口型鉄分補給用固形組成物及びその製造方法 |
| EP3216782B1 (en) * | 2014-11-07 | 2021-06-02 | NPA - Núcleo De Pesquisas Aplicadas LTDA. | Iron amino acid compounds, method for preparing iron amino acid compounds, compositions containing iron amino acid compounds, and uses thereof |
| AU2014413288B2 (en) | 2014-12-01 | 2018-06-28 | Profeat Biotechnology Co., Ltd. | Use of composition containing iron (II) amino acid chelate in preparing drug for regulating and controlling fat metabolism |
| CN104474004A (zh) * | 2014-12-09 | 2015-04-01 | 重庆综艺营养科技有限责任公司 | 改善贫血的赖氨酸螯合铁生血素 |
| US20170360075A1 (en) * | 2014-12-11 | 2017-12-21 | The Penn State Research Foundation | Medical food for the treatment of malaria and/or iron deficiency |
| ES2880321T3 (es) | 2015-08-11 | 2021-11-24 | Akeso Biomedical Inc | Composiciones de inhibición de biopelícula que potencian el aumento de peso en el ganado |
| US10653658B2 (en) | 2015-08-11 | 2020-05-19 | Akeso Biomedical, Inc. | Biofilm inhibiting compositions enhancing weight gain in livestock |
| CN105476953B (zh) * | 2015-09-01 | 2018-10-30 | 张伟 | 一种用于补铁的液体制剂及其制备方法 |
| US11517555B2 (en) * | 2015-09-04 | 2022-12-06 | Rockwell Medical, Inc. | Solid soluble ferric pyrophosphate formulations, kits, and methods using the same |
| JP6919117B2 (ja) * | 2015-12-15 | 2021-08-18 | 三菱ケミカル株式会社 | 鉄化合物含有組成物の粒子、鉄化合物の変色抑制方法、並びに鉄化合物及びビタミンｃ含有組成物 |
| EP3199167A1 (de) | 2016-01-28 | 2017-08-02 | G.L. Pharma GmbH | Arzneimittel zur behandlung von eisenmangelzuständen mit folsäuredefizit |
| MY196575A (en) * | 2016-03-15 | 2023-04-19 | Solvotrin Therapeutics Ltd | Compositions and Methods for Increasing Iron Intake in a Mammal |
| ES2891773T3 (es) * | 2016-05-20 | 2022-01-31 | Obshestvo S Ogranichennoj Otvetstvennostju Vikzdorove Zhivotnyh | Composición inyectable que comprende un complejo de dextrano de hierro y vitaminas para prevenir y tratar la anemia |
| CN109069533A (zh) * | 2016-05-26 | 2018-12-21 | 普惠德生技股份有限公司 | 含有亚铁氨基酸螯合物的组合物用于制造降低乳酸的药物的用途 |
| CN106265731B (zh) * | 2016-09-30 | 2019-07-19 | 广西科技大学 | 硫酸亚铁骨架型缓释滴丸的制备方法 |
| US20190365697A1 (en) * | 2017-02-17 | 2019-12-05 | Profeat Biotechnology Co., Ltd. | Method for Treating Liver Dysfunction |
| MA50229A (fr) * | 2017-09-11 | 2020-07-22 | Pharmacosmos Holding As | Composés complexes de fer à usage thérapeutique |
| CN108635370A (zh) * | 2018-07-13 | 2018-10-12 | 山东达因海洋生物制药股份有限公司 | 一种含有右旋糖酐铁的组合物制剂及其制备方法 |
| CN110464011A (zh) * | 2018-08-07 | 2019-11-19 | 美安康质量检测技术（上海）有限公司 | 一种补血营养粉及其制备方法 |
| EP3860621A4 (en) * | 2018-10-05 | 2022-07-06 | Ampersand Biopharmaceuticals, Inc. | IRON FORMULATIONS FOR TOPICAL ADMINISTRATION AND METHODS OF TREATMENT OF IRON DEFICIENCY |
| EP3873493A4 (en) * | 2018-10-31 | 2023-04-19 | My-Or Diagnostics Ltd. | PERSONALIZED FOODS TO ENSURE ADEQUATE IRON ABSORPTION |
| EP3900719A4 (en) | 2018-12-20 | 2022-08-03 | Profeat Biotechnology Co. Ltd. | COMPOSITION CONTAINING AN AMINO ACID FERROUS PARTICLE AND ITS USE IN THE PREPARATION OF A PHARMACEUTICAL PRODUCT FOR THE TREATMENT OR IMPROVEMENT OF A PANCREAS-RELATED DISEASE |
| TWI717139B (zh) * | 2018-12-20 | 2021-01-21 | 普惠德生技股份有限公司 | 含有亞鐵胺基酸螯合物粒子的組合物用於製備治療或減緩自體免疫相關疾病的醫藥品的用途 |
| CN112168843A (zh) * | 2019-07-05 | 2021-01-05 | 普惠德生技股份有限公司 | 经烧结的纳米粒子及其抗病毒的用途 |
| IL315206A (en) | 2021-02-11 | 2024-10-01 | Thermolife Int Llc | A method of administering nitric oxide gas |
| US12059399B2 (en) * | 2021-06-30 | 2024-08-13 | Getwing Biotechnology Medical Co., Ltd | Methods for alleviating kidney disease and fibrosis of organ |
| WO2023272693A1 (zh) * | 2021-07-01 | 2023-01-05 | 思瑰瑞保健食品有限公司 | 一种维生素c加硫酸亚铁缓控释片及其制备方法 |
| WO2023023029A1 (en) * | 2021-08-16 | 2023-02-23 | Thermolife International, Llc | Iron supplement compositions and methods of use thereof |
| CN114028423B (zh) * | 2021-12-13 | 2023-05-23 | 广东粤港澳大湾区国家纳米科技创新研究院 | 修饰的纳米氧化铁在制备预防和/或治疗炎性肠病的药物中的应用 |
| CN114288320A (zh) * | 2021-12-29 | 2022-04-08 | 珠海天翼医药技术开发有限公司 | 一种猪用口服补铁剂及其制备方法 |
| CN114767710B (zh) * | 2022-04-12 | 2023-07-07 | 中山大学 | 甘氨酸亚铁在治疗类风湿关节炎中的应用 |
| CN116636620B (zh) * | 2023-05-25 | 2025-02-14 | 南昌大学 | 一种乌鸡蛋清肽组合物及其应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB933108A (en) * | 1960-02-03 | 1963-08-08 | Haessle Ab | Improvements in or relating to pharmaceutical iron preparations |
| GB1266356A (enExample) * | 1968-08-08 | 1972-03-08 | ||
| GB1292820A (en) * | 1969-08-28 | 1972-10-11 | Aspro Nicholas Ltd | Haematinic preparations |
| GB1338071A (en) * | 1970-11-25 | 1973-11-21 | Laso Martinez V | Pharmaceutical iron preparations |
| US3773929A (en) * | 1972-11-02 | 1973-11-20 | Diagnostic Data Inc | Pharmaceutical compositions comprising orgotein and their use |
| US4362710A (en) * | 1980-07-04 | 1982-12-07 | Nissan Gosei Kogyo Co., Ltd. | Feeds for baby pigs, process for preparing the same and method of breeding baby pigs |
| US4599152A (en) * | 1985-05-24 | 1986-07-08 | Albion Laboratories | Pure amino acid chelates |
| US4863898A (en) * | 1986-02-06 | 1989-09-05 | Albion International, Inc. | Amino acid chelated compositions for delivery to specific biological tissue sites |
| US4752479A (en) * | 1986-05-27 | 1988-06-21 | Ciba-Geigy Corporaton | Multi vitamin and mineral dietary supplement with controlled release bioavailable iron |
| US4830716B1 (en) * | 1986-07-03 | 1999-12-07 | Albion Int | Preparation of pharmaceutical grade amino acid chelates |
| US5070085A (en) * | 1987-04-10 | 1991-12-03 | Oxycal Laboratories, Inc. | Compositions and methods for administering therapeutically active compounds |
| US4822816A (en) * | 1987-04-10 | 1989-04-18 | Oxycal Laboratories, Inc. | Compositions and methods for administering vitamin C |
| FR2642420B1 (fr) * | 1989-01-27 | 1991-09-06 | Valpan Sa Labo Pharma | Nouvelle forme galenique a liberation programmee contenant une association de sels ferreux, d'acide succinique et d'acide ascorbique |
| JPH0674206B2 (ja) * | 1989-12-28 | 1994-09-21 | 田辺製薬株式会社 | 放出制御型製剤およびその製法 |
| US6451341B1 (en) * | 1990-02-05 | 2002-09-17 | Thomas J. Slaga | Time release formulation of vitamins, minerals and other beneficial supplements |
| HU207799B (en) * | 1991-07-24 | 1993-06-28 | Beres Export Import Rt | Process for producing pharmaceutical composition for influencing the reticuloendothelial system, for treating chronic pain symptomes of degenerative locomotor disorders or tumors, and for treating mucoviscidosis |
| US5662922A (en) * | 1992-01-20 | 1997-09-02 | Christensen; Borge Holm | Iron-containing composition for the prevention of anaemia and a method for producing the composition |
| US5516925A (en) * | 1994-08-23 | 1996-05-14 | Albion International, Inc. | Amino acid chelates having improved palatability |
| JP2590449B2 (ja) * | 1995-04-21 | 1997-03-12 | 農林水産省畜産試験場長 | 新生子牛の造血機能の改善及び貧血の予防方法 |
| PL184140B1 (pl) * | 1995-10-27 | 2002-09-30 | Procter & Gamble | Napój w proszku |
| US5770226A (en) * | 1996-07-10 | 1998-06-23 | Wake Forest University | Combined pharmaceutical estrogen-androgen-progestin oral contraceptive |
| CA2230801A1 (en) * | 1998-02-27 | 1999-08-27 | Stanley H. Zlotkin | Composition comprising micro-encapsulated iron |
| US6495177B1 (en) * | 1999-08-13 | 2002-12-17 | Warner Chilcott Laboratories Ireland Limited | Orally dissolvable nutritional supplement |
| US6521247B1 (en) * | 1999-08-13 | 2003-02-18 | Warner Chilcott Laboratories Ireland Limited | Dual iron containing nutritional supplement |
| CN1396908A (zh) * | 2000-01-28 | 2003-02-12 | 宝洁公司 | 美味的精氨酸化合物及其用于心血管健康的应用 |
| US20020013331A1 (en) * | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
| US6924273B2 (en) * | 2000-10-03 | 2005-08-02 | Scott W. Pierce | Chondroprotective/restorative compositions and methods of use thereof |
| US6716814B2 (en) * | 2001-08-16 | 2004-04-06 | Albion International, Inc. | Enhancing solubility of iron amino acid chelates and iron proteinates |
| US6906038B2 (en) * | 2001-08-29 | 2005-06-14 | Abbott Laboratories | Methods for alleviating mucositis |
| US20030190355A1 (en) * | 2002-04-05 | 2003-10-09 | Hermelin Marc S. | Modified release minerals |
| US7994217B2 (en) * | 2002-05-02 | 2011-08-09 | Xanodyne Pharmaceuticals, Inc. | Prenatal multivitamin/multimineral supplement |
| US20060148690A1 (en) * | 2002-07-08 | 2006-07-06 | Lydie Bougueleret | Secreted peptides |
| US20030045473A1 (en) * | 2002-07-19 | 2003-03-06 | Sarama Robert Joseph | Compositions, kits, and methods for cardiovascular health |
| US8007846B2 (en) * | 2006-01-18 | 2011-08-30 | Albion International, Inc. | Mixed amino acid/mineral compounds having improved solubility |
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- 2005-10-27 CA CA002591996A patent/CA2591996A1/en not_active Abandoned
- 2005-10-27 AU AU2005319679A patent/AU2005319679A1/en not_active Abandoned
- 2005-10-27 JP JP2007548207A patent/JP2008525442A/ja active Pending
- 2005-10-27 EP EP05813755A patent/EP1827418A4/en not_active Withdrawn
- 2005-10-27 MX MX2007008021A patent/MX2007008021A/es unknown
- 2005-10-27 CN CNA2005800470364A patent/CN101102762A/zh active Pending
- 2005-10-27 BR BRPI0519265-0A patent/BRPI0519265A2/pt not_active IP Right Cessation
- 2005-11-09 US US11/793,517 patent/US20090028962A1/en not_active Abandoned
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- 2005-11-09 EP EP05820746A patent/EP1827419A4/en not_active Withdrawn
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| JP2008525445A (ja) | 2008-07-17 |
| JP2008525442A (ja) | 2008-07-17 |
| BRPI0519265A2 (pt) | 2009-01-06 |
| EP1827419A4 (en) | 2011-08-17 |
| AU2005319679A1 (en) | 2006-06-29 |
| US20090028962A1 (en) | 2009-01-29 |
| CN101102762A (zh) | 2008-01-09 |
| WO2006068697A3 (en) | 2006-12-21 |
| PE20061122A1 (es) | 2006-10-16 |
| AR052837A1 (es) | 2007-04-04 |
| US20160022631A1 (en) | 2016-01-28 |
| WO2006068729A3 (en) | 2007-01-18 |
| EP1827418A4 (en) | 2011-08-24 |
| WO2006068729A2 (en) | 2006-06-29 |
| MX2007008021A (es) | 2008-04-11 |
| EP1827418A2 (en) | 2007-09-05 |
| US20110015150A1 (en) | 2011-01-20 |
| US20060134227A1 (en) | 2006-06-22 |
| WO2006068697A2 (en) | 2006-06-29 |
| EP1827419A2 (en) | 2007-09-05 |
| US20130189374A1 (en) | 2013-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |