CN104474004A - 改善贫血的赖氨酸螯合铁生血素 - Google Patents
改善贫血的赖氨酸螯合铁生血素 Download PDFInfo
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- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 239000004472 Lysine Substances 0.000 title abstract 7
- 239000013522 chelant Substances 0.000 title abstract 7
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- 235000019152 folic acid Nutrition 0.000 claims abstract description 16
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- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
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- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
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- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
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- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
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- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
本发明提供了一种改善贫血的赖氨酸螯合铁生血素,其特征在于:主要由重量份数的以下组份组成:L-赖氨酸螯合铁80-120份,L赖氨酸盐酸盐500-600份,叶酸2-4份,1%的维生素B125-10份,当归提取物80-120份,党参提取物80-120份,黄氏多糖80-120份,果味香精1-3份,甜蜜素5-15份。本发明采用L赖氨酸螯合铁铁元素能直接吸收、运输,生物学效价高,生血补血作用强,对肠胃无刺激,能改善缺铁性贫血,能预防贫血,增强免疫力。
Description
技术领域
本发明涉及一种改善贫血的赖氨酸螯合铁生血素。
背景技术
缺铁性贫血(iron deficiency anemia,IDA)是由于体内缺少铁质而影响血红蛋白合成所引起的一种常见贫血。在红细胞的产生受到限制之前,体内的铁贮存已耗尽,此时称为缺铁。这种贫血特点是骨髓、肝、脾及其他组织中缺乏可染色铁,血清铁浓度和血清转铁蛋白饱和度均降低。典型病例贫血是属于小细胞低色素型。本病是贫血中常见类型,普遍存在于世界各地。女性缺铁性贫血更为严重。
缺铁性贫血的原因:一是铁的需要量增加而摄入不足,二是铁的吸收不良,三是失血过多等,均会影响血红蛋白和红细胞生存而发生贫血。目前市场上抗贫血的补血剂的主要缺陷是吸收差,对肠胃有一定的刺激。
发明内容
本发明的目的是针对现有技术的不足,提供一种改善铁的吸收、对肠胃无刺激的改善贫血的赖氨酸螯合铁生血素。
本发明的目的是这样实现的:一种改善贫血的赖氨酸螯合铁生血素,其特征在于:主要由重量份数的以下组份组成:
L-赖氨酸螯合铁80-120份,L赖氨酸盐酸盐500-600份,叶酸2-4份,1%的维生素B125-10份,当归提取物80-120份,党参提取物80-120份,黄氏多糖80-120份,果味香精1-3份,甜蜜素5-15份。
采用上述方案采用L赖氨酸螯合铁比采用硫酸亚铁或葡聚糖铁更有利于吸收,铁元素可以直接吸收、运输,生物学效价是其它补铁剂的三倍以上,能有效改善缺铁性贫血、预防贫血。
叶酸对人体的重要营养作用早在1948年即已得到证实,人类如缺乏叶酸可引起巨红细胞性贫血以及白细胞减少症,还会导致身体无力、易怒、没胃口以及精神病症状。叶酸也可预防贫血。
当归提取物含挥发油类成分和有机酸,主要为丁二酸、菸酸、尿嘧啶、腺嘌呤、藁本内酯、维生素B12、维生素E、谷固醇、亚叶酸、丁烯基酞内酯、阿魏酸等。用于补血活血,调经止痛,润肠通便,血虚萎黄,眩晕心悸,月经不调,经闭痛经,虚寒腹痛,肠燥便秘,风湿痹痛,跌扑损伤,痈疽疮疡的植物提取物。
党参提取物补中益气,健脾益肺。用于脾肺虚弱,气短心悸,食少便溏,喘虚咳嗽,内热消渴。
维生素B12用于预防和治疗维生素B1缺乏症,如脚气病﹑神经炎﹑消化不良等。
在上述方案中:主要由重量份数的以下组份组成:
L-赖氨酸螯合铁90-110份,L赖氨酸盐酸盐550-680份,叶酸2.5-3.5份,1%的维生素B126-9份,当归提取物90-110份,党参提取物90-110份,黄氏多糖90-110份,果味香精1.5-2.5份,甜蜜素8-12份。
在上述方案中:主要由重量份数的以下组份组成:
L-赖氨酸螯合铁95-105份,L赖氨酸盐酸盐560-600份,叶酸2.8-3份,1%的维生素B128-9份,当归提取物95-100份,党参提取物95-100份,黄氏多糖95-100份,果味香精2.0-2.5份,甜蜜素8-10份。
在上述方案中:所述当归提取物为当归20:1提取物。
在上述方案中:所述党参提取物为党参20:1提取物。
在上述方案中:将本方制成1g/片的片剂。早晚各服用1片。能起到改善缺铁性贫血的、增强免疫力,预防缺铁性贫血的效果。
本发明的有益效果是:本发明采用L赖氨酸螯合铁铁元素能直接吸收、运输,生物学效价高,生血补血作用强,对肠胃无刺激,能改善缺铁性贫血,能预防贫血,增强免疫力。
具体实施方式
下面结合实施例对本发明做进一步的描述。
实施例1
一种改善贫血的赖氨酸螯合铁生血素,由重量份数的以下组份组成:
L-赖氨酸螯合铁80份,L赖氨酸盐酸盐500份,叶酸2份,1%的维生素B125份,当归(20:1)提取物80份,党参(20:1)提取物80份,黄氏多糖80份,果味香精1份,甜蜜素5份。将以上组份搅拌混合均匀制成1g/片的片剂,早晚各服用一片,对于缺铁性贫血有改善作用,可以预防贫血。
实施例2
一种改善贫血的赖氨酸螯合铁生血素,由重量份数的以下组份组成:
L-赖氨酸螯合铁120份,L赖氨酸盐酸盐600份,叶酸4份,1%的维生素B1210份,当归(20:1)提取物120份,党参(20:1)提取物120份,黄氏多糖120份,果味香精3份,甜蜜素15份。将以上组份搅拌混合均匀制成1g/片的片剂,早晚各服用一片,对于缺铁性贫血有改善作用,可以预防贫血。
实施例3
一种改善贫血的赖氨酸螯合铁生血素,由重量份数的以下组份组成:
L-赖氨酸螯合铁90份,L赖氨酸盐酸盐550份,叶酸2.5份,1%的维生素B126份,当归(20:1)提取物90份,党参(20:1)提取物90份,黄氏多糖110份,果味香精1.5份,甜蜜素8份。将以上组份搅拌混合均匀制成1g/片的片剂,早晚各服用一片,对于缺铁性贫血有改善作用,可以预防贫血。
实施例4
一种改善贫血的赖氨酸螯合铁生血素,由重量份数的以下组份组成:
L-赖氨酸螯合铁110份,L赖氨酸盐酸盐680份,叶酸3.5份,1%的维生素B129份,当归(20:1)提取物110份,党参(20:1)提取物110份,黄氏多糖90份,果味香精2.5份,甜蜜素12份。将以上组份搅拌混合均匀制成1g/片的片剂,早晚各服用一片,对于缺铁性贫血有改善作用,可以预防贫血。
实施例5
一种改善贫血的赖氨酸螯合铁生血素,由重量份数的以下组份组成:
L-赖氨酸螯合铁95份,L赖氨酸盐酸盐560份,叶酸3份,1%的维生素B128份,当归(20:1)提取物100份,党参(20:1)提取物100份,黄氏多糖95份,果味香精2.0份,甜蜜素10份。将以上组份搅拌混合均匀制成1g/片的片剂,早晚各服用一片,对于缺铁性贫血有改善作用,可以预防贫血。
实施例5
一种改善贫血的赖氨酸螯合铁生血素,由重量份数的以下组份组成:
L-赖氨酸螯合铁105份,L赖氨酸盐酸盐600份,叶酸2.8份,1%的维生素B128份,当归(20:1)提取物100份,党参(20:1)提取物100份,黄氏多糖95份,果味香精2.5份,甜蜜素8份。将以上组份搅拌混合均匀制成1g/片的片剂,早晚各服用一片,对于缺铁性贫血有改善作用,可以预防贫血。
Claims (6)
1.一种改善贫血的赖氨酸螯合铁生血素,其特征在于:主要由重量份数的以下组份组成:
L-赖氨酸螯合铁80-120份,L赖氨酸盐酸盐500-600份,叶酸2-4份,1%的维生素B125-10份,当归提取物80-120份,党参提取物80-120份,黄氏多糖80-120份,果味香精1-3份,甜蜜素5-15份。
2.根据权利要求1所述改善贫血的赖氨酸螯合铁生血素,其特征在于:主要由重量份数的以下组份组成:
L-赖氨酸螯合铁90-110份,L赖氨酸盐酸盐550-680份,叶酸2.5-3.5份,1%的维生素B126-9份,当归提取物90-110份,党参提取物90-110份,黄氏多糖90-110份,果味香精1.5-2.5份,甜蜜素8-12份。
3.根据权利要求1所述改善贫血的赖氨酸螯合铁生血素,其特征在于:主要由重量份数的以下组份组成:
L-赖氨酸螯合铁95-105份,L赖氨酸盐酸盐560-600份,叶酸2.8-3份,1%的维生素B128-9份,当归提取物95-100份,党参提取物95-100份,黄氏多糖95-100份,果味香精2.0-2.5份,甜蜜素8-10份。
4.根据权利要求1-3任一项所述改善贫血的赖氨酸螯合铁生血素,其特征在于:所述当归提取物为当归20:1提取物。
5.根据权利要求4所述改善贫血的赖氨酸螯合铁生血素,其特征在于:所述党参提取物为党参20:1提取物。
6.根据权利要求1-3任一项所述改善贫血的赖氨酸螯合铁生血素,其特征在于:将本方制成1g/片的片剂。
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1759877A (zh) * | 2004-07-28 | 2006-04-19 | 成都地奥九泓制药厂 | 一种治疗贫血的药物组合物及用途 |
CN101102762A (zh) * | 2004-12-22 | 2008-01-09 | 药物技术公司 | 含铁组合物 |
CN103223128A (zh) * | 2012-01-30 | 2013-07-31 | 王凡 | 一种改善营养性贫血的中药组合物及其制备方法 |
-
2014
- 2014-12-09 CN CN201410748199.6A patent/CN104474004A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1759877A (zh) * | 2004-07-28 | 2006-04-19 | 成都地奥九泓制药厂 | 一种治疗贫血的药物组合物及用途 |
CN101102762A (zh) * | 2004-12-22 | 2008-01-09 | 药物技术公司 | 含铁组合物 |
CN103223128A (zh) * | 2012-01-30 | 2013-07-31 | 王凡 | 一种改善营养性贫血的中药组合物及其制备方法 |
Non-Patent Citations (6)
Title |
---|
单安山: "《饲料配置大全》", 31 July 2005 * |
张骠等: "《贫血患者吃什么》", 30 April 2005 * |
田颖等: ""赖氨酸生理功能的研究进展"", 《美食研究》 * |
陈仲铭: "《赛鸽全书》", 31 October 2010 * |
顾景范等: "《现代临床营养学》", 31 May 2003, 科学出版社 * |
马薇等: ""不同人群缺铁性贫血危险因素探讨"", 《中国临床医生》 * |
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