JP2010533872A5 - - Google Patents
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- JP2010533872A5 JP2010533872A5 JP2010517171A JP2010517171A JP2010533872A5 JP 2010533872 A5 JP2010533872 A5 JP 2010533872A5 JP 2010517171 A JP2010517171 A JP 2010517171A JP 2010517171 A JP2010517171 A JP 2010517171A JP 2010533872 A5 JP2010533872 A5 JP 2010533872A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- target molecule
- tag
- minutes
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091023037 Aptamer Proteins 0.000 claims 36
- 238000000034 method Methods 0.000 claims 33
- 239000007787 solid Substances 0.000 claims 17
- 239000000523 sample Substances 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 10
- 239000011324 bead Substances 0.000 claims 9
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 238000012360 testing method Methods 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 239000000975 dye Substances 0.000 claims 3
- 150000004676 glycans Chemical class 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- 238000000638 solvent extraction Methods 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 108090001008 Avidin Proteins 0.000 claims 2
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- 238000001190 Q-PCR Methods 0.000 claims 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- 108010090804 Streptavidin Proteins 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 238000007385 chemical modification Methods 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 239000007850 fluorescent dye Substances 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 108010087904 neutravidin Proteins 0.000 claims 2
- 229920001542 oligosaccharide Polymers 0.000 claims 2
- 150000002482 oligosaccharides Chemical class 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical group OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 claims 1
- 208000035657 Abasia Diseases 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- JBRZTFJDHDCESZ-UHFFFAOYSA-N AsGa Chemical compound [As]#[Ga] JBRZTFJDHDCESZ-UHFFFAOYSA-N 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- 239000004677 Nylon Substances 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 229960000633 dextran sulfate Drugs 0.000 claims 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
- 235000011180 diphosphates Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 235000013305 food Nutrition 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229910052732 germanium Inorganic materials 0.000 claims 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims 1
- 230000000762 glandular Effects 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229940094991 herring sperm dna Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 238000009830 intercalation Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 239000011325 microbead Substances 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 210000002445 nipple Anatomy 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 230000035764 nutrition Effects 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 150000004713 phosphodiesters Chemical class 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920000447 polyanionic polymer Polymers 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 239000002096 quantum dot Substances 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 210000001179 synovial fluid Anatomy 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95029307P | 2007-07-17 | 2007-07-17 | |
| US95028307P | 2007-07-17 | 2007-07-17 | |
| US95028107P | 2007-07-17 | 2007-07-17 | |
| US60/950,293 | 2007-07-17 | ||
| US60/950,283 | 2007-07-17 | ||
| US60/950,281 | 2007-07-17 | ||
| US3142008P | 2008-02-26 | 2008-02-26 | |
| US61/031,420 | 2008-02-26 | ||
| US5159408P | 2008-05-08 | 2008-05-08 | |
| US61/051,594 | 2008-05-08 | ||
| PCT/US2008/070386 WO2009012420A1 (en) | 2007-07-17 | 2008-07-17 | Multiplexed analyses of test samples |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013220095A Division JP5956404B2 (ja) | 2007-07-17 | 2013-10-23 | 試験試料の多重化分析 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010533872A JP2010533872A (ja) | 2010-10-28 |
| JP2010533872A5 true JP2010533872A5 (enExample) | 2011-07-28 |
| JP5404620B2 JP5404620B2 (ja) | 2014-02-05 |
Family
ID=40260081
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517171A Active JP5404620B2 (ja) | 2007-07-17 | 2008-07-17 | 試験試料の多重化分析 |
| JP2010517170A Active JP5684568B2 (ja) | 2007-07-17 | 2008-07-17 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2013220095A Active JP5956404B2 (ja) | 2007-07-17 | 2013-10-23 | 試験試料の多重化分析 |
| JP2014203867A Active JP5938080B2 (ja) | 2007-07-17 | 2014-10-02 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2016028563A Active JP6491610B2 (ja) | 2007-07-17 | 2016-02-18 | 試験試料の多重化分析 |
| JP2016095782A Active JP6407195B2 (ja) | 2007-07-17 | 2016-05-12 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018165689A Pending JP2019004901A (ja) | 2007-07-17 | 2018-09-05 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018206262A Pending JP2019039929A (ja) | 2007-07-17 | 2018-11-01 | 試験試料の多重化分析 |
| JP2020009000A Withdrawn JP2020078311A (ja) | 2007-07-17 | 2020-01-23 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2021081339A Active JP7303244B2 (ja) | 2007-07-17 | 2021-05-13 | 改善されたオフ速度（ｏｆｆ－ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2023102137A Active JP7755619B2 (ja) | 2007-07-17 | 2023-06-22 | 改善されたオフ速度（ｏｆｆ－ｒａｔｅ）を持つアプタマーを生成するための方法 |
Family Applications After (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517170A Active JP5684568B2 (ja) | 2007-07-17 | 2008-07-17 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2013220095A Active JP5956404B2 (ja) | 2007-07-17 | 2013-10-23 | 試験試料の多重化分析 |
| JP2014203867A Active JP5938080B2 (ja) | 2007-07-17 | 2014-10-02 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2016028563A Active JP6491610B2 (ja) | 2007-07-17 | 2016-02-18 | 試験試料の多重化分析 |
| JP2016095782A Active JP6407195B2 (ja) | 2007-07-17 | 2016-05-12 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018165689A Pending JP2019004901A (ja) | 2007-07-17 | 2018-09-05 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2018206262A Pending JP2019039929A (ja) | 2007-07-17 | 2018-11-01 | 試験試料の多重化分析 |
| JP2020009000A Withdrawn JP2020078311A (ja) | 2007-07-17 | 2020-01-23 | 改善されたオフ速度（ｏｆｆ−ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2021081339A Active JP7303244B2 (ja) | 2007-07-17 | 2021-05-13 | 改善されたオフ速度（ｏｆｆ－ｒａｔｅ）を持つアプタマーを生成するための方法 |
| JP2023102137A Active JP7755619B2 (ja) | 2007-07-17 | 2023-06-22 | 改善されたオフ速度（ｏｆｆ－ｒａｔｅ）を持つアプタマーを生成するための方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8409795B2 (enExample) |
| EP (10) | EP2933340B1 (enExample) |
| JP (11) | JP5404620B2 (enExample) |
| KR (3) | KR101747665B1 (enExample) |
| CN (6) | CN101802225B (enExample) |
| AU (3) | AU2008276001A1 (enExample) |
| CA (4) | CA2693448A1 (enExample) |
| DK (4) | DK2069529T3 (enExample) |
| ES (6) | ES2533711T3 (enExample) |
| FI (1) | FI3284832T3 (enExample) |
| HR (1) | HRP20150382T1 (enExample) |
| MX (7) | MX2010000533A (enExample) |
| NO (1) | NO2933340T3 (enExample) |
| PL (1) | PL2489743T3 (enExample) |
| PT (2) | PT2172566E (enExample) |
| SI (1) | SI2489743T1 (enExample) |
| WO (3) | WO2009012410A1 (enExample) |
Families Citing this family (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5993279A (ja) * | 1982-11-17 | 1984-05-29 | 富士通株式会社 | ロボツトによるカ−ド，レシ−ト分離取出し方法 |
| US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| US7964356B2 (en) * | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8975026B2 (en) | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8404830B2 (en) * | 2007-07-17 | 2013-03-26 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| DK2069529T3 (da) | 2007-07-17 | 2013-04-15 | Somalogic Inc | Fremgangsmåde til generering af aptamerer med forbedrede dissociationsrater |
| US8314052B2 (en) * | 2009-03-23 | 2012-11-20 | Base Pair Biotechnologies, Inc. | Methods for simultaneous generation of functional ligands |
| US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
| JP5766178B2 (ja) | 2009-03-24 | 2015-08-19 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | ＳｌｉｐＣｈｉｐ装置および方法 |
| US9464319B2 (en) | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
| US10196700B2 (en) | 2009-03-24 | 2019-02-05 | University Of Chicago | Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes |
| US8569252B2 (en) * | 2009-04-15 | 2013-10-29 | Postech Academy-Industry Foundation | Nucleolin specific aptamer and use thereof |
| AU2013203588C1 (en) * | 2009-07-09 | 2016-06-30 | Somalogic Operating Co., Inc. | Method for generating aptamers with improved off-rates |
| JP5967687B2 (ja) * | 2009-07-17 | 2016-08-10 | Ｎｅｃソリューションイノベータ株式会社 | スフィンゴシルホスホリルコリンに結合するアプタマー分子 |
| US8236570B2 (en) | 2009-11-03 | 2012-08-07 | Infoscitex | Methods for identifying nucleic acid ligands |
| US8841429B2 (en) * | 2009-11-03 | 2014-09-23 | Vivonics, Inc. | Nucleic acid ligands against infectious prions |
| US9453845B2 (en) | 2010-02-01 | 2016-09-27 | Cell Signaling Technology, Inc. | Mass spectroscopy analysis of mutant polypeptides in biological samples |
| WO2011119852A1 (en) * | 2010-03-24 | 2011-09-29 | Rxi Pharmaceuticals Corporation | Reduced size self-delivering rnai compounds |
| MX2012011779A (es) | 2010-04-12 | 2012-12-17 | Somalogic Inc | Pirimidinas modificadas en la posicion 5 y su uso. |
| AU2013202528B2 (en) * | 2010-04-12 | 2015-07-30 | Somalogic Operating Co., Inc. | 5-position modified pyrimidines and their use |
| BR112012032537B8 (pt) * | 2010-07-09 | 2022-10-18 | Somalogic Inc | Métodos para diagnosticar se um indivíduo tem ou não câncer de pulmão de não pequenas células, ou para fornecer informações sobre câncer de pulmão de não pequenas células em um indivíduo |
| CN103429753A (zh) | 2010-09-27 | 2013-12-04 | 私募蛋白质体公司 | 间皮瘤生物标记及其用途 |
| EP2635681B8 (en) * | 2010-11-05 | 2017-10-04 | Miragen Therapeutics, Inc. | Base modified oligonucleotides |
| KR101307616B1 (ko) * | 2011-02-08 | 2013-09-12 | 경희대학교 산학협력단 | Ｐｎａ 앱타머를 이용하여 금속을 분리하는 방법 |
| WO2013099762A1 (ja) * | 2011-12-28 | 2013-07-04 | シスメックス株式会社 | 副腎皮質刺激ホルモンと結合する分子およびその利用 |
| EP2797603B1 (en) | 2011-12-30 | 2019-02-20 | Somalogic, Inc. | Aptamers and diagnostic methods for detecting the egf receptor |
| JP6587934B2 (ja) | 2012-03-28 | 2019-10-09 | ソマロジック・インコーポレーテッド | Ｐｄｇｆおよびｖｅｇｆ結合アプタマー、および、ｐｄｇｆおよびｖｅｇｆが介在する病気の治療へのそれらの使用 |
| JP6200948B2 (ja) * | 2012-05-25 | 2017-09-20 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | マイクロ流体デバイス |
| SG11201407505XA (en) * | 2012-06-07 | 2014-12-30 | Somalogic Inc | Aptamer-based multiplexed assays |
| CN102719430B (zh) * | 2012-06-13 | 2013-06-12 | 湖南大学 | 一种检测组氨酸标签重组蛋白的核酸适配体分子信标探针及其检测方法 |
| US9650638B2 (en) | 2012-07-02 | 2017-05-16 | Unist (Ulsan National Institute Of Science And Technology) | Aptamer for periostin and anti-cancer composition including same |
| EP2690441A1 (en) * | 2012-07-26 | 2014-01-29 | Rheinische Friedrich-Wilhelms-Universität Bonn | Method of determining a protein in a sample |
| CN102912020B (zh) * | 2012-10-20 | 2014-02-19 | 江南大学 | 一种测定赭曲霉毒素a的适配体传感器的构建方法 |
| US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
| CN105452466A (zh) | 2012-10-23 | 2016-03-30 | 卡里斯生命科学瑞士控股有限责任公司 | 适体及其用途 |
| WO2014074682A1 (en) | 2012-11-07 | 2014-05-15 | Somalogic, Inc. | Chronic obstructive pulmonary disease (copd) biomarkers and uses thereof |
| CA2895847C (en) | 2012-12-19 | 2019-01-08 | Caris Science, Inc. | Compositions and methods for aptamer screening |
| WO2014159669A2 (en) | 2013-03-14 | 2014-10-02 | Somalogic, Inc. | Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions |
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