MX2020009595A - Metodo para generar aptameros con constantes de disociacion mejoradas. - Google Patents

Metodo para generar aptameros con constantes de disociacion mejoradas.

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Publication number
MX2020009595A
MX2020009595A MX2020009595A MX2020009595A MX2020009595A MX 2020009595 A MX2020009595 A MX 2020009595A MX 2020009595 A MX2020009595 A MX 2020009595A MX 2020009595 A MX2020009595 A MX 2020009595A MX 2020009595 A MX2020009595 A MX 2020009595A
Authority
MX
Mexico
Prior art keywords
methods
aptamers
improved
producing
disclosure describes
Prior art date
Application number
MX2020009595A
Other languages
English (en)
Inventor
Chris Bock
Dominic Zichi
Sheri K Wilcox
Daniel J Schneider
Bruce Eaton
Larry Gold
Original Assignee
Somalogic Operating Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40260081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2020009595(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Somalogic Operating Co Inc filed Critical Somalogic Operating Co Inc
Publication of MX2020009595A publication Critical patent/MX2020009595A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/13—Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/205—Aptamer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2541/00—Reactions characterised by directed evolution
    • C12Q2541/10—Reactions characterised by directed evolution the purpose being the selection or design of target specific nucleic acid binding sequences
    • C12Q2541/101—Selex

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente descripción trata de métodos SELEX mejorados para producir aptámeros que son capaces de enlazarse a moléculas objetivo y métodos photoSELEX mejorados para producir aptámeros fotorreactivos que son capaces de tanto enlazarse como reticularse covalentemente a las moléculas objetivo. Específicamente, la presente descripción trata de métodos para producir aptámeros y fotoaptámeros que tienen constates de velocidad de disociación más lentas que se obtienen usando los métodos SELEX y photoSELEX anteriores. La descripción además describe aptámeros y fotoaptámeros que tienen constantes de velocidad de disociación más lentas que aquellas obtenidas usando Los métodos anteriores. Además, la descripción trata de constructor de aptámero que incluyen una variedad de funcionalidades, que incluyen un elemento escindible, un elemento de detección y un elemento de captura.
MX2020009595A 2007-07-17 2010-01-14 Metodo para generar aptameros con constantes de disociacion mejoradas. MX2020009595A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95028307P 2007-07-17 2007-07-17
US95029307P 2007-07-17 2007-07-17
US95028107P 2007-07-17 2007-07-17
US3142008P 2008-02-26 2008-02-26
US5159408P 2008-05-08 2008-05-08

Publications (1)

Publication Number Publication Date
MX2020009595A true MX2020009595A (es) 2020-10-07

Family

ID=40260081

Family Applications (6)

Application Number Title Priority Date Filing Date
MX2010000533A MX2010000533A (es) 2007-07-17 2008-07-17 Analisis multiplexados de muestras de pruebas.
MX2010000578A MX2010000578A (es) 2007-07-17 2008-07-17 Metodo para generar aptameros con constantes de disociacion mejoradas.
MX2014005658A MX344253B (es) 2007-07-17 2008-07-17 Metodo para generar aptameros con constantes de disociacion mejoradas.
MX2016010844A MX355017B (es) 2007-07-17 2010-01-13 Analisis multiplexados de muestras de pruebas.
MX2014013401A MX341491B (es) 2007-07-17 2010-01-13 Analisis multiplexados de muestras de pruebas.
MX2020009595A MX2020009595A (es) 2007-07-17 2010-01-14 Metodo para generar aptameros con constantes de disociacion mejoradas.

Family Applications Before (5)

Application Number Title Priority Date Filing Date
MX2010000533A MX2010000533A (es) 2007-07-17 2008-07-17 Analisis multiplexados de muestras de pruebas.
MX2010000578A MX2010000578A (es) 2007-07-17 2008-07-17 Metodo para generar aptameros con constantes de disociacion mejoradas.
MX2014005658A MX344253B (es) 2007-07-17 2008-07-17 Metodo para generar aptameros con constantes de disociacion mejoradas.
MX2016010844A MX355017B (es) 2007-07-17 2010-01-13 Analisis multiplexados de muestras de pruebas.
MX2014013401A MX341491B (es) 2007-07-17 2010-01-13 Analisis multiplexados de muestras de pruebas.

Country Status (18)

Country Link
US (1) US8409795B2 (es)
EP (10) EP2626436A3 (es)
JP (11) JP5684568B2 (es)
KR (3) KR101656240B1 (es)
CN (6) CN101809167B (es)
AU (3) AU2008275917B2 (es)
CA (4) CA2696431C (es)
DK (4) DK2489743T3 (es)
ES (5) ES2604764T3 (es)
FI (1) FI3284832T3 (es)
HK (6) HK1133046A1 (es)
HR (1) HRP20150382T1 (es)
MX (6) MX2010000533A (es)
NO (1) NO2933340T3 (es)
PL (1) PL2489743T3 (es)
PT (2) PT2489743E (es)
SI (1) SI2489743T1 (es)
WO (3) WO2009012410A1 (es)

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AU2008275917B2 (en) 2014-08-21
JP2020078311A (ja) 2020-05-28

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