WO2010115118A3 - Methods for preparing and using multichaperone-antigen complexes - Google Patents
Methods for preparing and using multichaperone-antigen complexes Download PDFInfo
- Publication number
- WO2010115118A3 WO2010115118A3 PCT/US2010/029803 US2010029803W WO2010115118A3 WO 2010115118 A3 WO2010115118 A3 WO 2010115118A3 US 2010029803 W US2010029803 W US 2010029803W WO 2010115118 A3 WO2010115118 A3 WO 2010115118A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- multichaperone
- methods
- preparing
- antigen complexes
- complexes
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001176—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6043—Heat shock proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10712860.5A EP2413953B1 (en) | 2009-04-03 | 2010-04-02 | Methods for preparing and using multichaperone-antigen complexes |
CA2757524A CA2757524A1 (en) | 2009-04-03 | 2010-04-02 | Methods for preparing and using multichaperone-antigen complexes |
RU2011144575/10A RU2011144575A (en) | 2009-04-03 | 2010-04-02 | METHODS FOR PRODUCING AND USING MULTI-CHAPERON-ANTIGENIC COMPLEXES |
AU2010232490A AU2010232490B2 (en) | 2009-04-03 | 2010-04-02 | Methods for preparing and using multichaperone-antigen complexes |
US13/262,288 US20120100173A1 (en) | 2009-04-03 | 2010-04-02 | Methods for preparing and using multichaperone-antigen complexes |
US14/616,554 US20150307567A1 (en) | 2009-04-03 | 2015-02-06 | Methods for preparing and using multichaperone-antigen complexes |
US15/866,249 US20180371034A1 (en) | 2009-04-03 | 2018-01-09 | Methods for preparing and using multichaperone-antigen complexes |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21185009P | 2009-04-03 | 2009-04-03 | |
US61/211,850 | 2009-04-03 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/262,288 A-371-Of-International US20120100173A1 (en) | 2009-04-03 | 2010-04-02 | Methods for preparing and using multichaperone-antigen complexes |
US14/616,554 Continuation US20150307567A1 (en) | 2009-04-03 | 2015-02-06 | Methods for preparing and using multichaperone-antigen complexes |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010115118A2 WO2010115118A2 (en) | 2010-10-07 |
WO2010115118A3 true WO2010115118A3 (en) | 2011-08-25 |
Family
ID=42358392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/029803 WO2010115118A2 (en) | 2009-04-03 | 2010-04-02 | Methods for preparing and using multichaperone-antigen complexes |
Country Status (6)
Country | Link |
---|---|
US (3) | US20120100173A1 (en) |
EP (1) | EP2413953B1 (en) |
AU (1) | AU2010232490B2 (en) |
CA (1) | CA2757524A1 (en) |
RU (2) | RU2011144575A (en) |
WO (1) | WO2010115118A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009114085A2 (en) | 2008-03-03 | 2009-09-17 | The University Of Miami | Allogeneic cancer cell-based immunotherapy |
US9145449B2 (en) * | 2013-02-04 | 2015-09-29 | Chang Gung Memorial Hospital, Linkou Branch | STIP1 polypeptides and uses thereof |
AU2016215175B2 (en) * | 2015-02-06 | 2021-09-16 | Heat Biologics, Inc. | Vector co-expressing vaccine and costimulatory molecules |
CA2984643A1 (en) | 2015-05-13 | 2016-11-17 | Agenus Inc. | Vaccines for treatment and prevention of cancer |
JP7114477B2 (en) | 2015-12-16 | 2022-08-08 | グリットストーン バイオ インコーポレイテッド | Identification, production and use of neoantigens |
US11666649B2 (en) | 2016-10-11 | 2023-06-06 | University Of Miami | Vectors and vaccine cells for immunity against Zika virus |
WO2018187260A1 (en) | 2017-04-04 | 2018-10-11 | Heat Biologics, Inc. | Intratumoral vaccination |
AU2018348165A1 (en) | 2017-10-10 | 2020-05-21 | Gritstone Bio, Inc. | Neoantigen identification using hotspots |
AU2018373154A1 (en) | 2017-11-22 | 2020-07-02 | Gritstone Bio, Inc. | Reducing junction epitope presentation for neoantigens |
EP3784688A2 (en) | 2018-04-26 | 2021-03-03 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
CN110508029B (en) * | 2019-09-04 | 2022-01-28 | 武玉香 | Immunoaffinity column for simultaneously extracting florfenicol, chloramphenicol and thiamphenicol |
CN112327883B (en) * | 2020-11-27 | 2023-01-03 | 哈尔滨工程大学 | Under-actuated surface vessel path tracking control method based on extended state observer |
WO2023122327A2 (en) * | 2021-12-24 | 2023-06-29 | Avitide LLC | Chi domain affinity ligands and agents |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001023421A2 (en) * | 1999-09-30 | 2001-04-05 | Corixa Corporation | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
WO2002028407A1 (en) * | 2000-09-29 | 2002-04-11 | University Of Connecticut Health Center | Methods of recovering heat shock proteins and complexes thereof |
WO2004035602A2 (en) * | 2002-05-02 | 2004-04-29 | University Of Connecticut Health Center | Using heat shock proteins and alpha-2-macroglobulins to increase immune response to vaccines |
CN1640887A (en) * | 2004-01-08 | 2005-07-20 | 北京中天康泰生物科技有限公司 | 'Heat shock protein special extraction kit' for biological therapy |
CN101297966A (en) * | 2008-06-16 | 2008-11-05 | 黄常新 | Tumor vaccine for intestinal cancer containing rich chaperone-antigenic peptide complexes and preparation thereof |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5137819A (en) | 1988-07-08 | 1992-08-11 | University Of British Columbia | Cellulose binding fusion proteins for immobilization and purification of polypeptides |
US5306307A (en) | 1991-07-22 | 1994-04-26 | Calcitek, Inc. | Spinal disk implant |
GB9223816D0 (en) | 1992-11-13 | 1993-01-06 | Medical Res Council | Heat shock proteins and the treatment of tumours |
US5496934A (en) | 1993-04-14 | 1996-03-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Nucleic acids encoding a cellulose binding domain |
ES2171454T3 (en) | 1993-06-04 | 2002-09-16 | Whitehead Biomedical Inst | STRESS PROTEINS AND ITS USES. |
US5750119A (en) | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
US5961979A (en) | 1994-03-16 | 1999-10-05 | Mount Sinai School Of Medicine Of The City University Of New York | Stress protein-peptide complexes as prophylactic and therapeutic vaccines against intracellular pathogens |
US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
DE69535905D1 (en) | 1994-07-15 | 2009-02-26 | Coley Pharm Group Inc | Immunomodulatory oligonucleotides |
US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
CA2231998A1 (en) | 1995-09-13 | 1997-03-20 | Fordham University | Therapeutic and prophylactic methods using heat shock proteins |
US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
US5985270A (en) | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
US5837251A (en) | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
WO1998040100A1 (en) | 1997-03-10 | 1998-09-17 | Ottawa Civic Loeb Research Institute | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE AS AN ADJUVANT |
ES2439014T3 (en) | 1998-02-20 | 2014-01-21 | The University Of Miami | Complex of antigenic peptide-modified heat shock protein |
DE69935507T2 (en) | 1998-04-03 | 2007-12-06 | University Of Iowa Research Foundation | METHOD AND PRODUCTS FOR STIMULATING THE IMMUNE SYSTEM BY IMMUNOTHERAPEUTIC OLIGONUCLEOTIDES AND CYTOKINES |
SI1077722T1 (en) | 1998-05-22 | 2007-02-28 | Ottawa Health Research Inst | Methods and products for inducing mucosal immunity |
UA77152C2 (en) | 1999-09-25 | 2006-11-15 | Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma | |
JP2003527352A (en) | 2000-01-13 | 2003-09-16 | アンティジェニクス インコーポレーテッド | Innate immune stimulating compounds of CPG and saponin and methods thereof |
CA2427858A1 (en) * | 2000-11-03 | 2002-05-10 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
-
2010
- 2010-04-02 CA CA2757524A patent/CA2757524A1/en not_active Abandoned
- 2010-04-02 RU RU2011144575/10A patent/RU2011144575A/en not_active Application Discontinuation
- 2010-04-02 RU RU2015117604/10A patent/RU2015117604A/en not_active Application Discontinuation
- 2010-04-02 WO PCT/US2010/029803 patent/WO2010115118A2/en active Application Filing
- 2010-04-02 US US13/262,288 patent/US20120100173A1/en not_active Abandoned
- 2010-04-02 AU AU2010232490A patent/AU2010232490B2/en not_active Ceased
- 2010-04-02 EP EP10712860.5A patent/EP2413953B1/en not_active Not-in-force
-
2015
- 2015-02-06 US US14/616,554 patent/US20150307567A1/en not_active Abandoned
-
2018
- 2018-01-09 US US15/866,249 patent/US20180371034A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001023421A2 (en) * | 1999-09-30 | 2001-04-05 | Corixa Corporation | Stress protein compositions and methods for prevention and treatment of cancer and infectious disease |
WO2002028407A1 (en) * | 2000-09-29 | 2002-04-11 | University Of Connecticut Health Center | Methods of recovering heat shock proteins and complexes thereof |
WO2004035602A2 (en) * | 2002-05-02 | 2004-04-29 | University Of Connecticut Health Center | Using heat shock proteins and alpha-2-macroglobulins to increase immune response to vaccines |
CN1640887A (en) * | 2004-01-08 | 2005-07-20 | 北京中天康泰生物科技有限公司 | 'Heat shock protein special extraction kit' for biological therapy |
CN101297966A (en) * | 2008-06-16 | 2008-11-05 | 黄常新 | Tumor vaccine for intestinal cancer containing rich chaperone-antigenic peptide complexes and preparation thereof |
Non-Patent Citations (8)
Title |
---|
ARNOLD-SCHILD DANIELE ET AL: "One-step single-chain Fv recombinant antibody-based purification of gp96 for vaccine development", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER REREARCH, US, vol. 60, no. 15, 1 August 2000 (2000-08-01), pages 4175 - 4178, XP002175252, ISSN: 0008-5472 * |
CARRIGAN PATRICIA E ET AL: "Domain : domain interactions within Hop, the Hsp70/Hsp90 organizing protein, are required for protein stability and structure", PROTEIN SCIENCE, vol. 15, no. 3, March 2006 (2006-03-01), pages 522 - 532, XP002639945, ISSN: 0961-8368 * |
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; May 2009 (2009-05-01), ZHAO JIAN-GANG ET AL: "[Preparation of anticolon carcinoma vaccine with rich chaperone peptides and study on its anticancer efficacy].", XP002639948, Database accession no. NLM19434541 * |
GONG JIANLIN ET AL: "A Heat Shock Protein 70-Based Vaccine with Enhanced Immunogenicity for Clinical Use", JOURNAL OF IMMUNOLOGY, vol. 184, no. 1, January 2010 (2010-01-01), pages 488 - 496, XP002639947, ISSN: 0022-1767 * |
GRANER M ET AL: "Immunoprotective activities of multiple chaperone proteins isolated from murine B-cell leukemia/lymphoma.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH MAR 2000 LNKD- PUBMED:10741715, vol. 6, no. 3, March 2000 (2000-03-01), pages 909 - 915, XP002639946, ISSN: 1078-0432 * |
KING FRANK W ET AL: "Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 20, no. 22, 15 November 2001 (2001-11-15), pages 6297 - 6305, XP002639944, ISSN: 0261-4189 * |
YI ZENG ET AL: "Chaperone-rich cell lysates, immune activation and tumor vaccination", CANCER IMMUNOLOGY, IMMUNOTHERAPY, SPRINGER, BERLIN, DE, vol. 55, no. 3, 1 March 2006 (2006-03-01), pages 329 - 338, XP019333212, ISSN: 1432-0851, DOI: DOI:10.1007/S00262-005-0694-1 * |
ZHONGHUA WEI CHANG WAI KE ZA ZHI = CHINESE JOURNAL OF GASTROINTESTINAL SURGERY MAY 2009 LNKD- PUBMED:19434541, vol. 12, no. 3, May 2009 (2009-05-01), pages 290 - 293, ISSN: 1671-0274 * |
Also Published As
Publication number | Publication date |
---|---|
RU2015117604A3 (en) | 2018-12-20 |
CA2757524A1 (en) | 2010-10-07 |
WO2010115118A2 (en) | 2010-10-07 |
EP2413953B1 (en) | 2017-11-08 |
US20150307567A1 (en) | 2015-10-29 |
US20120100173A1 (en) | 2012-04-26 |
AU2010232490B2 (en) | 2016-08-11 |
US20180371034A1 (en) | 2018-12-27 |
RU2015117604A (en) | 2015-10-27 |
RU2011144575A (en) | 2013-05-10 |
EP2413953A2 (en) | 2012-02-08 |
AU2010232490A1 (en) | 2011-12-01 |
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