HK1132012A1 - 測試樣本的分析 - Google Patents

測試樣本的分析

Info

Publication number
HK1132012A1
HK1132012A1 HK09111557.3A HK09111557A HK1132012A1 HK 1132012 A1 HK1132012 A1 HK 1132012A1 HK 09111557 A HK09111557 A HK 09111557A HK 1132012 A1 HK1132012 A1 HK 1132012A1
Authority
HK
Hong Kong
Prior art keywords
analyses
test samples
samples
test
Prior art date
Application number
HK09111557.3A
Other languages
English (en)
Inventor
Daniel J Schneider
Dan Nieuwlandt
Bruce Eaton
Marty Stanton
Shashi Gupta
Stephan Kraemer
Dominic Zichi
Larry Gold
Original Assignee
Somalogic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40260081&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1132012(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Somalogic Inc filed Critical Somalogic Inc
Publication of HK1132012A1 publication Critical patent/HK1132012A1/zh

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811Selection methods for production or design of target specific oligonucleotides or binding molecules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1048SELEX
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/16Aptamers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/334Modified C
    • C12N2310/33415-Methylcytosine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/10Applications; Uses in screening processes
    • C12N2320/13Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10Modifications characterised by
    • C12Q2525/205Aptamer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2541/00Reactions characterised by directed evolution
    • C12Q2541/10Reactions characterised by directed evolution the purpose being the selection or design of target specific nucleic acid binding sequences
    • C12Q2541/101Selex

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK09111557.3A 2007-07-17 2009-12-10 測試樣本的分析 HK1132012A1 (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US95029307P 2007-07-17 2007-07-17
US95028307P 2007-07-17 2007-07-17
US95028107P 2007-07-17 2007-07-17
US3142008P 2008-02-26 2008-02-26
US5159408P 2008-05-08 2008-05-08
PCT/US2008/070386 WO2009012420A1 (en) 2007-07-17 2008-07-17 Multiplexed analyses of test samples

Publications (1)

Publication Number Publication Date
HK1132012A1 true HK1132012A1 (zh) 2010-02-12

Family

ID=40260081

Family Applications (6)

Application Number Title Priority Date Filing Date
HK09111389.7A HK1133046A1 (en) 2007-07-17 2009-12-04 Method for generating aptamers with improved off-rates
HK09111557.3A HK1132012A1 (zh) 2007-07-17 2009-12-10 測試樣本的分析
HK10108245.4A HK1141839A1 (zh) 2007-07-17 2010-08-31 用於產生具有改善的分離率的適體的方法
HK13101625.6A HK1174366A1 (zh) 2007-07-17 2013-02-05 具有 -萘基 替代的尿苷的適配子
HK16100803.9A HK1213020A1 (zh) 2007-07-17 2016-01-25 具有改良的解離速率的化學改性適配體
HK18105969.6A HK1246368A1 (zh) 2007-07-17 2018-05-08 用於產生具有改良的解離速率的適配體的方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK09111389.7A HK1133046A1 (en) 2007-07-17 2009-12-04 Method for generating aptamers with improved off-rates

Family Applications After (4)

Application Number Title Priority Date Filing Date
HK10108245.4A HK1141839A1 (zh) 2007-07-17 2010-08-31 用於產生具有改善的分離率的適體的方法
HK13101625.6A HK1174366A1 (zh) 2007-07-17 2013-02-05 具有 -萘基 替代的尿苷的適配子
HK16100803.9A HK1213020A1 (zh) 2007-07-17 2016-01-25 具有改良的解離速率的化學改性適配體
HK18105969.6A HK1246368A1 (zh) 2007-07-17 2018-05-08 用於產生具有改良的解離速率的適配體的方法

Country Status (18)

Country Link
US (1) US8409795B2 (zh)
EP (10) EP4056711A1 (zh)
JP (11) JP5404620B2 (zh)
KR (3) KR101656240B1 (zh)
CN (6) CN101802225B (zh)
AU (3) AU2008275917B2 (zh)
CA (4) CA2696431C (zh)
DK (4) DK3284832T5 (zh)
ES (5) ES2647587T3 (zh)
FI (1) FI3284832T3 (zh)
HK (6) HK1133046A1 (zh)
HR (1) HRP20150382T1 (zh)
MX (6) MX2010000578A (zh)
NO (1) NO2933340T3 (zh)
PL (1) PL2489743T3 (zh)
PT (2) PT2172566E (zh)
SI (1) SI2489743T1 (zh)
WO (3) WO2009012410A1 (zh)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5993279A (ja) * 1982-11-17 1984-05-29 富士通株式会社 ロボツトによるカ−ド,レシ−ト分離取出し方法
US20070166741A1 (en) 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US8975026B2 (en) 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7964356B2 (en) * 2007-01-16 2011-06-21 Somalogic, Inc. Method for generating aptamers with improved off-rates
US8404830B2 (en) * 2007-07-17 2013-03-26 Somalogic, Inc. Method for generating aptamers with improved off-rates
JP5404620B2 (ja) * 2007-07-17 2014-02-05 ソマロジック・インコーポレーテッド 試験試料の多重化分析
US8314052B2 (en) * 2009-03-23 2012-11-20 Base Pair Biotechnologies, Inc. Methods for simultaneous generation of functional ligands
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
WO2010111265A1 (en) 2009-03-24 2010-09-30 University Of Chicago Slip chip device and methods
US8569252B2 (en) * 2009-04-15 2013-10-29 Postech Academy-Industry Foundation Nucleolin specific aptamer and use thereof
AU2013203588C1 (en) * 2009-07-09 2016-06-30 Somalogic Operating Co., Inc. Method for generating aptamers with improved off-rates
JP5967687B2 (ja) * 2009-07-17 2016-08-10 Necソリューションイノベータ株式会社 スフィンゴシルホスホリルコリンに結合するアプタマー分子
US8841429B2 (en) * 2009-11-03 2014-09-23 Vivonics, Inc. Nucleic acid ligands against infectious prions
US8236570B2 (en) 2009-11-03 2012-08-07 Infoscitex Methods for identifying nucleic acid ligands
US9453845B2 (en) 2010-02-01 2016-09-27 Cell Signaling Technology, Inc. Mass spectroscopy analysis of mutant polypeptides in biological samples
RU2615143C2 (ru) * 2010-03-24 2017-04-04 Адвирна Самодоставляющие PHKi соединения уменьшенного размера
JP6012591B2 (ja) * 2010-04-12 2016-10-26 ソマロジック, インコーポレイテッドSomaLogic, Inc. β−NGFに対するアプタマー及びβ−NGF介在疾患及び障害の治療におけるその使用
AU2013202528B2 (en) * 2010-04-12 2015-07-30 Somalogic Operating Co., Inc. 5-position modified pyrimidines and their use
MX355020B (es) * 2010-07-09 2018-04-02 Somalogic Inc Biomarcadores de cancer de pulmon y usos de los mismos.
CN103429753A (zh) 2010-09-27 2013-12-04 私募蛋白质体公司 间皮瘤生物标记及其用途
US9416360B2 (en) 2010-11-05 2016-08-16 MiRagen Therapeutics, Inc. Base modified oligonucleotides
KR101307616B1 (ko) * 2011-02-08 2013-09-12 경희대학교 산학협력단 Pna 앱타머를 이용하여 금속을 분리하는 방법
EP2799549B1 (en) * 2011-12-28 2016-07-27 Sysmex Corporation Molecule capable of binding to adrenocorticotropic hormone, and use thereof
WO2013102101A1 (en) 2011-12-30 2013-07-04 Somalogic, Inc. Aptamers and diagnostic methods for detecting the egf receptor
US9410156B2 (en) 2012-03-28 2016-08-09 Somalogic, Inc. Aptamers to PDGF and VEGF and their use in treating PDGF and VEGF mediated conditions
US9617589B2 (en) * 2012-05-25 2017-04-11 The University Of North Carolina At Chapel Hill Microfluidic devices, solid supports for reagents and related methods
NZ701824A (en) * 2012-06-07 2017-01-27 Somalogic Inc Aptamer-based multiplexed assays
CN102719430B (zh) * 2012-06-13 2013-06-12 湖南大学 一种检测组氨酸标签重组蛋白的核酸适配体分子信标探针及其检测方法
CN104411825B (zh) * 2012-07-02 2018-07-20 蔚山科学技术院 骨膜蛋白适配体及包含其的抗癌组合物
EP2690441A1 (en) 2012-07-26 2014-01-29 Rheinische Friedrich-Wilhelms-Universität Bonn Method of determining a protein in a sample
CN102912020B (zh) * 2012-10-20 2014-02-19 江南大学 一种测定赭曲霉毒素a的适配体传感器的构建方法
CA2928520C (en) * 2012-10-23 2023-03-14 Caris Life Sciences Switzerland Holdings, S.A.R.L. Aptamers and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
US9103837B2 (en) 2012-11-07 2015-08-11 Somalogic, Inc. Chronic obstructive pulmonary disease (COPD) biomarkers and uses thereof
EP2935628B1 (en) 2012-12-19 2018-03-21 Caris Life Sciences Switzerland Holdings GmbH Compositions and methods for aptamer screening
KR102242874B1 (ko) 2013-03-14 2021-04-21 소마로직, 인크. Il―6에 결합하는 압타머 및 il―6 매개된 질환을 치료하거나 진단하는 데에서 이의 용도
WO2014144744A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Aptamer methods and compositions
ES2662108T3 (es) 2013-03-15 2018-04-05 Somalogic, Inc. Biomarcadores de la enfermedad de hígado graso no alcohólico (EHGNA) y de la esteatohepatitis no alcohólica (EHNA) y usos de los mismos
JP6034261B2 (ja) * 2013-08-02 2016-11-30 日本電信電話株式会社 生体分子検出用チップの製造方法
CA2920508C (en) 2013-09-09 2024-01-16 Somalogic, Inc. Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders
EP3049523B1 (en) 2013-09-24 2019-08-07 Somalogic, Inc. Multiaptamer target detection
WO2015049356A1 (en) * 2013-10-02 2015-04-09 Tolle Fabian A method of identifying or producing an aptamer
CN105658658B (zh) 2013-11-21 2019-11-05 私募蛋白质体公司 胞苷-5-甲酰胺修饰的核苷酸组合物及其相关方法
WO2015126769A1 (en) 2014-02-18 2015-08-27 Somalogic, Inc. Compositions and methods for detecting microorganisms
WO2015164617A1 (en) 2014-04-24 2015-10-29 Somalogic, Inc. Tuberculosis biomarkers in urine and uses thereof
WO2015164616A1 (en) 2014-04-24 2015-10-29 Somalogic, Inc. Biomarkers for detection of tuberculosis
CN105378478B (zh) * 2014-07-01 2017-10-31 深圳迈瑞生物医疗电子股份有限公司 一种全血样本检测方法及血液检测仪
ES2792227T3 (es) 2014-09-26 2020-11-10 Somalogic Inc Predicción de evento de riesgo cardiovascular y usos de la misma
KR101849557B1 (ko) * 2014-09-29 2018-04-17 동국대학교 산학협력단 신규 세포 타겟 압타머 제조방법
ES2768723T3 (es) * 2014-10-02 2020-06-23 Univ Bonn Rheinische Friedrich Wilhelms Un método para identificar o producir un aptámero
KR101719285B1 (ko) 2014-11-04 2017-03-23 한국과학기술원 표적 물질에 의해 조절되는 핵산 중합효소 활성을 이용한 생체물질의 검출 및 정량 방법
EP3224361B1 (en) 2014-11-24 2019-06-19 Somalogic, Inc. Nucleic acid compounds for binding growth differentiation factor 11
CN104360077A (zh) * 2014-11-25 2015-02-18 重庆市科学技术研究院 一种用于检测多西环素残留的适配体核酸探针试剂盒、制备方法及其应用
WO2016123058A1 (en) 2015-01-27 2016-08-04 Somalogic, Inc. Biomarkers for detection of tuberculosis risk
TWI708845B (zh) 2015-02-09 2020-11-01 美商身體邏輯股份有限公司 用於結合生長分化因數8之核酸化合物
EP3524681A1 (en) 2015-03-12 2019-08-14 The Regents of The University of Michigan Inhibitors of dek protein and related methods
US20180356419A1 (en) 2015-05-08 2018-12-13 Somalogic, Inc. Biomarkers for detection of tuberculosis risk
KR102604025B1 (ko) 2015-09-09 2023-11-21 소마로직 오퍼레이팅 컴퍼니, 인코포레이티드 개인별 약물 치료 계획의 개발 방법 및 단백질체 프로파일을 기반으로 하는 표적 약물 개발 방법
JP7170535B2 (ja) * 2015-10-20 2022-11-14 ソレント・セラピューティクス・インコーポレイテッド 細胞内送達化合物
BR112018014842A8 (pt) 2016-02-08 2022-10-18 Somalogic Inc Métodos para determinar se um indivíduo tem doença hepática gordurosa não alcoólica (nafld) inflamação lobular, fibrose e hepatócitos balonizados referência cruzada aos pedidos relacionados
GB201603789D0 (en) * 2016-03-04 2016-04-20 Apta Biosciences Ltd Oligonucleotides and methods for preparing
EP3478843B1 (en) 2016-07-01 2021-08-04 Somalogic, Inc. Oligonucleotides comprising modified nucleosides
CN106248767B (zh) * 2016-07-15 2018-12-07 济南大学 一种用于检测癌细胞中h2s的三维纸分析器件的制备方法
CN107663220B (zh) * 2016-07-27 2020-10-02 上海伯豪医学检验所有限公司 修饰碱基、包含修饰碱基的核酸、适配体及其应用
JPWO2018038076A1 (ja) * 2016-08-22 2019-06-20 日産化学株式会社 E−カドヘリン結合型核酸アプタマーを用いる細胞足場材料
US11041849B2 (en) * 2016-12-01 2021-06-22 Aptitude Medical Systems, Inc. Methods and systems for identifying candidate nucleic acid agent
KR101993427B1 (ko) * 2017-04-26 2019-10-01 주식회사 압타머사이언스 백혈구에 선택적으로 결합하는 압타머 및 이의 용도
US11072816B2 (en) 2017-05-03 2021-07-27 The Broad Institute, Inc. Single-cell proteomic assay using aptamers
WO2019113506A1 (en) 2017-12-07 2019-06-13 The Broad Institute, Inc. Methods and compositions for multiplexing single cell and single nuclei sequencing
US10481155B2 (en) * 2018-03-09 2019-11-19 Somalogic, Inc. Proteomic assay using quantum sensors
US11841371B2 (en) 2018-03-13 2023-12-12 The Broad Institute, Inc. Proteomics and spatial patterning using antenna networks
US11231420B2 (en) 2018-04-09 2022-01-25 Aptalogic, Inc. Selection and optimization of aptamers to recognize ebola markers
WO2019202448A1 (en) 2018-04-16 2019-10-24 University Of Cape Town A three-protein proteomic biomarker for prospective determination of risk for development of active tuberculosis
US11957695B2 (en) 2018-04-26 2024-04-16 The Broad Institute, Inc. Methods and compositions targeting glucocorticoid signaling for modulating immune responses
AT521238B1 (de) 2018-05-09 2020-02-15 Lifetaq Analytics Gmbh In-situ zellanalyse im zellkultursystem
CA3104041A1 (en) * 2018-06-22 2019-12-26 Somalogic, Inc. Improved proteomic multiplex assays
WO2020037250A2 (en) * 2018-08-17 2020-02-20 The Trustees Of Columbia University In The City Of New York Stem-loop receptor-based field-effect transistor sensor devices target detection for small-molecule under physiological salt concentrations
WO2020068547A1 (en) 2018-09-25 2020-04-02 Siemens Healthcare Diagnostics Inc. Methods and compositions for removing biotin interference from assays using conjugated molecular traps
US20210338158A1 (en) 2018-10-02 2021-11-04 WearOptimo Pty Ltd Measurement system
WO2020077236A1 (en) 2018-10-12 2020-04-16 The Broad Institute, Inc. Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
US20210317456A1 (en) 2018-10-15 2021-10-14 Somalogic, Inc. Nucleic Acid Compounds for Binding Immunoglobulin G
JP7332694B2 (ja) 2018-12-04 2023-08-23 エフ. ホフマン-ラ ロシュ アーゲー 細胞標的の空間指向性量子バーコード化
US11739156B2 (en) 2019-01-06 2023-08-29 The Broad Institute, Inc. Massachusetts Institute of Technology Methods and compositions for overcoming immunosuppression
US20220142948A1 (en) 2019-03-18 2022-05-12 The Broad Institute, Inc. Compositions and methods for modulating metabolic regulators of t cell pathogenicity
EP3969900A1 (en) * 2019-05-17 2022-03-23 Somalogic, Inc. Controlling intersample analyte variability in complex biological matrices
WO2020243661A1 (en) 2019-05-31 2020-12-03 The Broad Institute, Inc. Methods for treating metabolic disorders by targeting adcy5
US11198908B2 (en) 2019-06-17 2021-12-14 Biorchestra Co., Ltd. Method for diagnosis of Alzheimer's disease using microRNA
KR102113078B1 (ko) * 2019-07-05 2020-05-20 광주과학기술원 압타머의 선별 방법
US20220282333A1 (en) 2019-08-13 2022-09-08 The General Hospital Corporation Methods for predicting outcomes of checkpoint inhibition and treatment thereof
CN110396536A (zh) * 2019-08-14 2019-11-01 东南大学 一种基于分支滚环扩增的外泌体荧光检测传感器
KR20220057534A (ko) 2019-09-03 2022-05-09 소마로직 오퍼레이팅 컴퍼니, 인코포레이티드 심혈관 위험 사건 예측 및 이의 용도
CN110618265B (zh) * 2019-09-12 2023-04-18 广东省药品检验所(广东省药品质量研究所、广东省口岸药品检验所) 一种沙丁胺醇的可视化检测方法
US11981922B2 (en) 2019-10-03 2024-05-14 Dana-Farber Cancer Institute, Inc. Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
US11793787B2 (en) 2019-10-07 2023-10-24 The Broad Institute, Inc. Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
EP4045656A1 (en) 2019-10-16 2022-08-24 SomaLogic Operating Co., Inc. Nucleic acid compounds that bind to retinoic acid-inducible gene i protein
JP2023504683A (ja) * 2019-12-03 2023-02-06 キム・ソンチョン 試料の標的分子集団に対するプロファイルを得る方法
CN115023615A (zh) 2020-01-10 2022-09-06 私募蛋白质体操作有限公司 确定葡萄糖耐量减低的方法
EP4103948A1 (en) 2020-02-10 2022-12-21 SomaLogic Operating Co., Inc. Nonalcoholic steatohepatitis (nash) biomarkers and uses thereof
CN111304202B (zh) * 2020-02-26 2023-03-28 西安交通大学 一种用于识别且增强hmgb1生物学活性的核酸适配子及其应用
CN113624724A (zh) * 2020-05-07 2021-11-09 廖世奇 一种适配体分子信标对靶分子的多元检测分析方法
WO2021233303A1 (en) * 2020-05-18 2021-11-25 Shanghai Polaris Biology Co., Ltd. Microbeads and uses thereof
CN111735869A (zh) * 2020-05-29 2020-10-02 中山大学 一种蛋白质的检测试剂及检测方法
AU2021364805A1 (en) 2020-10-20 2023-05-18 Somalogic Operating Co., Inc. Cardiovascular event risk prediction
EP4323374A1 (en) 2021-04-13 2024-02-21 SomaLogic Operating Co., Inc. Modified nucleosides
CA3214181A1 (en) 2021-04-14 2022-10-20 Amy D. GELINAS Nucleic acid compounds that bind coronavirus proteins
CA3217456A1 (en) * 2021-05-06 2022-11-10 Spyro Mousses Multitargeting rna compositions
EP4356140A2 (en) 2021-06-15 2024-04-24 SomaLogic Operating Co., Inc. Renal insufficiency prediction and uses thereof
CA3233138A1 (en) 2021-10-07 2023-04-13 Leigh Alexander Lung cancer prediction and uses thereof
CN114058613B (zh) * 2021-11-18 2023-10-27 广州血液中心(中国医学科学院输血研究所广州分所、广州器官移植配型中心) 一种大体积、高灵敏度核酸提取方法
CN114295594B (zh) * 2021-12-06 2023-09-19 贵州理工学院 一种基于分子信标筛选三螺旋DNA嵌入剂的“turn on”型荧光传感器
MX2024008874A (es) 2022-01-21 2024-07-29 Somalogic Operating Co Inc Metodos de evaluacion de calidad de muestras.
WO2023183873A1 (en) 2022-03-24 2023-09-28 Mensura Health Inc. Aptamers and uses thereof
AU2023260315A1 (en) 2022-04-24 2024-09-12 Somalogic Operating Co., Inc. Methods for sample quality assessment
CN118765373A (zh) 2022-04-24 2024-10-11 私募蛋白质体操作有限公司 用于样品质量评估的方法
CN118805086A (zh) 2022-04-24 2024-10-18 私募蛋白质体操作有限公司 用于样品质量评估的方法
WO2023211771A1 (en) 2022-04-24 2023-11-02 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2024015486A1 (en) 2022-07-14 2024-01-18 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2024015485A1 (en) 2022-07-14 2024-01-18 Somalogic Operating Co., Inc. Methods of assessing dementia risk
WO2024064322A2 (en) 2022-09-23 2024-03-28 Somalogic Operating Co., Inc. Methods of assessing tobacco use status
WO2024192141A1 (en) 2023-03-13 2024-09-19 Dana-Farber Cancer Institute, Inc. Treatment of cancers having a drug-resistant mesenchymal cell state
EP4442282A1 (en) 2023-04-07 2024-10-09 POSTECH Research and Business Development Foundation Preparation of site-specific polypeptide conjugates

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE3590766T (zh) 1985-03-30 1987-04-23
US4753983A (en) 1986-05-07 1988-06-28 Bioprobe International, Inc. Polymeric matrix for affinity chromatography and immobilization of ligands
WO1989006694A1 (en) 1988-01-15 1989-07-27 Trustees Of The University Of Pennsylvania Process for selection of proteinaceous substances which mimic growth-inducing molecules
US5035996A (en) 1989-06-01 1991-07-30 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US6001577A (en) 1998-06-08 1999-12-14 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US6168778B1 (en) 1990-06-11 2001-01-02 Nexstar Pharmaceuticals, Inc. Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5763173A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand inhibitors to DNA polymerases
US6346611B1 (en) * 1990-06-11 2002-02-12 Gilead Sciences, Inc. High affinity TGfβ nucleic acid ligands and inhibitors
US5861254A (en) * 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US5874218A (en) 1990-06-11 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for detecting a target compound in a substance using a nucleic acid ligand
US5853984A (en) 1990-06-11 1998-12-29 Nexstar Pharmaceuticals, Inc. Use of nucleic acid ligands in flow cytometry
US6716580B2 (en) * 1990-06-11 2004-04-06 Somalogic, Inc. Method for the automated generation of nucleic acid ligands
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US6232071B1 (en) * 1990-06-11 2001-05-15 Gilead Sciences, Inc. Tenascin-C nucleic acid ligands
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US6083696A (en) * 1990-06-11 2000-07-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands exponential enrichment: blended selex
US5693502A (en) 1990-06-11 1997-12-02 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand inhibitors to DNA polymerases
US5459015A (en) 1990-06-11 1995-10-17 Nexstar Pharmaceuticals, Inc. High-affinity RNA ligands of basic fibroblast growth factor
US5789163A (en) 1990-06-11 1998-08-04 Nexstar Pharmaceuticals, Inc. Enzyme linked oligonucleotide assays (ELONAS)
WO1995008003A1 (en) * 1993-09-17 1995-03-23 University Research Corporation Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
EP1493825A3 (en) 1990-06-11 2005-02-09 Gilead Sciences, Inc. Method for producing nucleic acid ligands
US5707796A (en) 1990-06-11 1998-01-13 Nexstar Pharmaceuticals, Inc. Method for selecting nucleic acids on the basis of structure
US5962219A (en) 1990-06-11 1999-10-05 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-selex
US5874557A (en) 1990-06-11 1999-02-23 Nexstar Pharmaceuticals, Inc. Nucleic acid ligand inhibitors to DNA polymerases
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5580737A (en) 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
US6030776A (en) * 1990-06-11 2000-02-29 Nexstar Pharmaceuticals, Inc. Parallel SELEX
US5472841A (en) 1990-06-11 1995-12-05 Nexstar Pharmaceuticals, Inc. Methods for identifying nucleic acid ligands of human neutrophil elastase
US20040132067A1 (en) 1990-06-11 2004-07-08 Somalogic, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
SE501013C2 (sv) 1990-10-01 1994-10-17 Pharmacia Biosensor Ab Förfarande för förbättring av analys med bindning till fast fas
CA2104698A1 (en) 1991-02-21 1992-08-22 John J. Toole Aptamers specific for biomolecules and methods of making
AU2580892A (en) 1991-09-05 1993-04-05 Isis Pharmaceuticals, Inc. Determination of oligonucleotides for therapeutics, diagnostics and research reagents
JP3739785B2 (ja) 1991-11-26 2006-01-25 アイシス ファーマシューティカルズ,インコーポレイティド 修飾されたピリミジンを含有するオリゴマーを使用する増強された三重らせんおよび二重らせんの成形
US5312730A (en) * 1992-05-27 1994-05-17 Ciba Corning Diagnostics Corp. Immune complex transfer with lypophilic bridge
US5756291A (en) * 1992-08-21 1998-05-26 Gilead Sciences, Inc. Aptamers specific for biomolecules and methods of making
US5985548A (en) 1993-02-04 1999-11-16 E. I. Du Pont De Nemours And Company Amplification of assay reporters by nucleic acid replication
US5428149A (en) * 1993-06-14 1995-06-27 Washington State University Research Foundation Method for palladium catalyzed carbon-carbon coulping and products
US5580972A (en) 1993-06-14 1996-12-03 Nexstar Pharmaceuticals, Inc. Purine nucleoside modifications by palladium catalyzed methods
US5719273A (en) 1993-06-14 1998-02-17 Nexstar Pharmaceuticals, Inc. Palladium catalyzed nucleoside modifications methods using nucleophiles and carbon monoxide
US5998142A (en) 1993-09-08 1999-12-07 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
AU692469B2 (en) 1993-09-08 1998-06-11 Gilead Sciences, Inc. Nucleic acid ligands and improved methods for producing the same
US6458539B1 (en) 1993-09-17 2002-10-01 Somalogic, Inc. Photoselection of nucleic acid ligands
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5610287A (en) 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
JP4899014B2 (ja) * 1995-06-02 2012-03-21 イーシー・テクノロジー・エルエルシー 求核試薬および一酸化炭素を用いるパラジウム触媒ヌクレオシド修飾方法
US6183967B1 (en) 1995-06-07 2001-02-06 Nexstar Pharmaceuticals Nucleic acid ligand inhibitors to DNA polymerases
ATE494394T1 (de) 1995-06-07 2011-01-15 Gilead Sciences Inc Nukleinsäureliganden, die an dna-polymerasen binden und diese inhibieren
US5737498A (en) 1995-07-11 1998-04-07 Beckman Instruments, Inc. Process automation method and apparatus
KR19990067080A (ko) * 1995-10-27 1999-08-16 엘리엇 알. 램버그 특정 뉴클레오티드 서열의 검출방법 및 조성물
US5727498A (en) * 1996-02-13 1998-03-17 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Retractable visual indicator assembly
US5945527A (en) * 1996-05-30 1999-08-31 Nexstar Pharmaceuticals, Inc. Palladium catalyzed nucleoside modification methods using nucleophiles and carbon monoxide
US5866336A (en) 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6426335B1 (en) 1997-10-17 2002-07-30 Gilead Sciences, Inc. Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US6051698A (en) 1997-06-06 2000-04-18 Janjic; Nebojsa Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
AU1252099A (en) 1997-11-26 1999-06-15 Medical Research Council Improved selex procedure and an anti-cd4 aptamer
WO1999031276A1 (en) 1997-12-15 1999-06-24 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US5989823A (en) 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US6242246B1 (en) 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
US20070166741A1 (en) * 1998-12-14 2007-07-19 Somalogic, Incorporated Multiplexed analyses of test samples
WO2003070984A1 (en) * 2002-02-15 2003-08-28 Somalogic, Inc. Methods and reagents for detecting target binding by nucleic acid ligands
US6175001B1 (en) * 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
US20030054360A1 (en) * 1999-01-19 2003-03-20 Larry Gold Method and apparatus for the automated generation of nucleic acid ligands
US6329145B1 (en) 1999-02-09 2001-12-11 Gilead Science, Inc. Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand
US6376190B1 (en) 2000-09-22 2002-04-23 Somalogic, Inc. Modified SELEX processes without purified protein
AU2440102A (en) * 2000-10-16 2002-04-29 Gilead Sciences Inc Nucleic acid ligands to the prostate specific membrane antigen
WO2002044726A1 (fr) * 2000-12-01 2002-06-06 International Reagents Corporation Procede de mesure ultrarapide et ultrasensible
WO2003014369A1 (en) 2001-08-09 2003-02-20 Somalogic, Inc. Nucleic acid ligands with intramolecular duplexes
US20030219801A1 (en) * 2002-03-06 2003-11-27 Affymetrix, Inc. Aptamer base technique for ligand identification
WO2003078623A1 (fr) * 2002-03-19 2003-09-25 Fujitsu Limited Molecule fonctionnelle et son procede de production
US20030228603A1 (en) * 2002-04-05 2003-12-11 Cload Sharon T. Compositions selective for caffeine or aspartame and methods of using same
US7767803B2 (en) 2002-06-18 2010-08-03 Archemix Corp. Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
DE10241938A1 (de) * 2002-09-10 2004-03-25 Noxxon Pharma Ag Verfahren zur Selektion von Nukleinsäureliganden
CA2407825A1 (en) * 2002-10-11 2004-04-11 Andrew J. Simmonds Trap-tagging: a novel method for the identification and purification of rna-protein complexes
JP2004307464A (ja) * 2002-10-23 2004-11-04 Sankyo Co Ltd 糖部s型配座の新規人工核酸
GB0226374D0 (en) * 2002-11-12 2002-12-18 Isis Innovation Ligands
AU2004204456A1 (en) * 2003-01-09 2004-07-29 Invitrogen Corporation Cellular delivery and activation polypeptide-nucleic acid complexes
US20040235053A1 (en) * 2003-03-28 2004-11-25 The Regents Of The University Of California Preparation and application of encoded bead aggregates in combinatorial chemistry
US7672786B2 (en) 2003-07-02 2010-03-02 Sergey Krylov Non-equilibrium capillary electrophoresis of equilibrium mixtures (NECEEM)—based methods for drug and diagnostic development
CA2535510C (en) * 2003-08-11 2013-10-15 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
KR100540509B1 (ko) * 2004-01-07 2006-01-11 학교법인 포항공과대학교 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체
US20050227225A1 (en) * 2004-04-07 2005-10-13 Roche Molecular Systems, Inc. Stabilization of biomolecules in samples
JP4839051B2 (ja) * 2004-10-08 2011-12-14 シスメックス株式会社 核酸プローブを用いる被検物質の検出方法
US20090105172A1 (en) * 2005-03-07 2009-04-23 Diener John L Stabilized Aptamers to PSMA and Their Use as Prostate Cancer Therapeutics
DE602006014149D1 (de) * 2005-06-24 2010-06-17 Mag Aerospace Ind Inc Grauwasserschnittstellenventilsysteme und verfahren
EP1910837B1 (en) * 2005-07-01 2012-03-14 Arbor Vita Corporation Methods and compositions for diagnosis and treatment of influenza
DE602006018477D1 (de) * 2005-08-19 2011-01-05 Nanosphere Inc Dna und antikörpern sowie verwendungen davon
HUE025489T2 (en) * 2006-01-17 2016-04-28 Somalogic Inc Multiplexed analysis of test samples
CA2673029C (en) * 2006-12-22 2017-03-28 Archemix Corp. Materials and methods for the generation of transcripts comprising modified nucleotides
EP2106595A4 (en) * 2007-01-23 2011-07-13 Jostens Inc METHOD AND SYSTEM FOR CREATING USER-SPECIFIC EXPENDITURE
JP5404620B2 (ja) * 2007-07-17 2014-02-05 ソマロジック・インコーポレーテッド 試験試料の多重化分析
JP2013220095A (ja) * 2012-04-12 2013-10-28 Toyohiro Fujita 苗床
JP2018078250A (ja) 2016-11-11 2018-05-17 株式会社ニューフレアテクノロジー マルチ荷電粒子ビーム描画装置

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