AU1252099A - Improved selex procedure and an anti-cd4 aptamer - Google Patents

Improved selex procedure and an anti-cd4 aptamer

Info

Publication number
AU1252099A
AU1252099A AU12520/99A AU1252099A AU1252099A AU 1252099 A AU1252099 A AU 1252099A AU 12520/99 A AU12520/99 A AU 12520/99A AU 1252099 A AU1252099 A AU 1252099A AU 1252099 A AU1252099 A AU 1252099A
Authority
AU
Australia
Prior art keywords
aptamer
selex procedure
improved selex
improved
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU12520/99A
Inventor
Alan Neil Barclay
William Siward James
Elmar Kraus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9725024.5A external-priority patent/GB9725024D0/en
Application filed by Medical Research Council filed Critical Medical Research Council
Publication of AU1252099A publication Critical patent/AU1252099A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
AU12520/99A 1997-11-26 1998-11-26 Improved selex procedure and an anti-cd4 aptamer Abandoned AU1252099A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9725024.5A GB9725024D0 (en) 1997-11-26 1997-11-26 Procedure
GB9725024 1997-11-26
US7822198P 1998-03-16 1998-03-16
US60078221 1998-03-16
PCT/GB1998/003544 WO1999027133A1 (en) 1997-11-26 1998-11-26 Improved selex procedure and an anti-cd4 aptamer

Publications (1)

Publication Number Publication Date
AU1252099A true AU1252099A (en) 1999-06-15

Family

ID=26312662

Family Applications (1)

Application Number Title Priority Date Filing Date
AU12520/99A Abandoned AU1252099A (en) 1997-11-26 1998-11-26 Improved selex procedure and an anti-cd4 aptamer

Country Status (2)

Country Link
AU (1) AU1252099A (en)
WO (1) WO1999027133A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9809776D0 (en) 1998-05-07 1998-07-08 Nycomed Imaging As Method
GB9809780D0 (en) * 1998-05-07 1998-07-08 Nycomed Imaging As Method
US7312325B2 (en) * 2000-09-26 2007-12-25 Duke University RNA aptamers and methods for identifying the same
AU2002226571A1 (en) * 2001-01-29 2002-08-12 Isis Innovation Limited Biligands
WO2002061078A2 (en) * 2001-01-29 2002-08-08 Isis Innovation Limited Streptavidin aptamere
ATE514776T1 (en) 2004-10-05 2011-07-15 California Inst Of Techn APTAMER-REGULATED NUCLEIC ACIDS AND USES THEREOF
EP1940755A2 (en) 2005-10-28 2008-07-09 Praecis Pharmaceuticals Inc. Methods for identifying compounds of interest using encoded libraries
US7964356B2 (en) 2007-01-16 2011-06-21 Somalogic, Inc. Method for generating aptamers with improved off-rates
ES2604764T3 (en) 2007-07-17 2017-03-09 Somalogic, Inc. Analysis of test samples
WO2009012263A2 (en) 2007-07-18 2009-01-22 The Trustees Of Columbia University In The City Of New York Tissue-specific micrornas and compositions and uses thereof
US20120165387A1 (en) 2007-08-28 2012-06-28 Smolke Christina D General composition framework for ligand-controlled RNA regulatory systems
US8865667B2 (en) 2007-09-12 2014-10-21 California Institute Of Technology Higher-order cellular information processing devices
US9029524B2 (en) 2007-12-10 2015-05-12 California Institute Of Technology Signal activated RNA interference
US9599591B2 (en) 2009-03-06 2017-03-21 California Institute Of Technology Low cost, portable sensor for molecular assays
US9145555B2 (en) 2009-04-02 2015-09-29 California Institute Of Technology Integrated—ligand-responsive microRNAs
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
US20130195757A1 (en) * 2010-04-30 2013-08-01 Abraxis Bioscience, Llc Sparc binding aptamers and uses thereof
US9540439B2 (en) 2012-10-08 2017-01-10 St. Jude Children's Research Hospital Therapies based on control of regulatory T cell stability and function via a neuropilin-1:semaphorin axis
KR102649341B1 (en) 2014-06-16 2024-03-18 더 존스 홉킨스 유니버시티 Compositions and methods for the expression of crispr guide rnas using the h1 promoter
US20180156807A1 (en) 2015-04-29 2018-06-07 New York University Method for treating high-grade gliomas
EP3405577B8 (en) 2016-01-20 2023-02-15 396419 B.C. Ltd. Compositions and methods for inhibiting factor d
CN105777890A (en) * 2016-04-17 2016-07-20 孟繁好 Application of aptamer used for detecting protein GAT-1 in preparation of kit used for detecting anesthetic tolerance individuals
WO2018136827A1 (en) 2017-01-20 2018-07-26 Vitrisa Therapeutics, Inc. Stem-loop compositions and methods for inhibiting factor d
CN109468326A (en) * 2018-07-02 2019-03-15 广西医科大学 A kind of CD4+T aptamer and its application
WO2021142191A1 (en) 2020-01-08 2021-07-15 Regeneron Pharmaceuticals, Inc. Treatment of fibrodysplasia ossificans progressiva

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869641A (en) * 1990-06-11 1999-02-09 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands of CD4
US5861254A (en) * 1997-01-31 1999-01-19 Nexstar Pharmaceuticals, Inc. Flow cell SELEX
US5635615A (en) * 1990-06-11 1997-06-03 Nexstar Pharmaceuticals, Inc. High affinity HIV nucleocapsid nucleic acid ligands
WO1996040716A1 (en) * 1995-06-07 1996-12-19 Nexstar Pharmaceuticals, Inc. High affinity oligonucleotide ligands to chorionic gonadotropin hormone and related glycoprotein hormones

Also Published As

Publication number Publication date
WO1999027133A1 (en) 1999-06-03

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase