DK3284832T3 - Aptamer med forbedret dissociationshastighed og ikke-kovalent aptamermålkompleks deraf - Google Patents
Aptamer med forbedret dissociationshastighed og ikke-kovalent aptamermålkompleks deraf Download PDFInfo
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- DK3284832T3 DK3284832T3 DK17181688.7T DK17181688T DK3284832T3 DK 3284832 T3 DK3284832 T3 DK 3284832T3 DK 17181688 T DK17181688 T DK 17181688T DK 3284832 T3 DK3284832 T3 DK 3284832T3
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- DK
- Denmark
- Prior art keywords
- aptamer
- dissociation rate
- covalent
- target complex
- enhanced dissociation
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1048—SELEX
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/13—Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/205—Aptamer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2541/00—Reactions characterised by directed evolution
- C12Q2541/10—Reactions characterised by directed evolution the purpose being the selection or design of target specific nucleic acid binding sequences
- C12Q2541/101—Selex
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95028307P | 2007-07-17 | 2007-07-17 | |
US95029307P | 2007-07-17 | 2007-07-17 | |
US95028107P | 2007-07-17 | 2007-07-17 | |
US3142008P | 2008-02-26 | 2008-02-26 | |
US5159408P | 2008-05-08 | 2008-05-08 | |
EP15152547.4A EP2933340B1 (en) | 2007-07-17 | 2008-07-17 | Aptamers with uridines and/or thymidines substituted at the 5-position with a benzyl group |
Publications (2)
Publication Number | Publication Date |
---|---|
DK3284832T3 true DK3284832T3 (da) | 2023-07-31 |
DK3284832T5 DK3284832T5 (da) | 2024-10-07 |
Family
ID=40260081
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12160299T DK2489743T3 (da) | 2007-07-17 | 2008-07-17 | Aptamerer med 5-(N-naphthyl)-substituerede uridiner |
DK09012809.1T DK2172566T4 (da) | 2007-07-17 | 2008-07-17 | Fremgangsmåde til generering af aptamerer med forbedrede off-rates |
DK17181688.7T DK3284832T5 (da) | 2007-07-17 | 2008-07-17 | Aptamer med forbedret dissociationshastighed og ikke-kovalent aptamermålkompleks deraf |
DK08782010.6T DK2069529T3 (da) | 2007-07-17 | 2008-07-17 | Fremgangsmåde til generering af aptamerer med forbedrede dissociationsrater |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12160299T DK2489743T3 (da) | 2007-07-17 | 2008-07-17 | Aptamerer med 5-(N-naphthyl)-substituerede uridiner |
DK09012809.1T DK2172566T4 (da) | 2007-07-17 | 2008-07-17 | Fremgangsmåde til generering af aptamerer med forbedrede off-rates |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK08782010.6T DK2069529T3 (da) | 2007-07-17 | 2008-07-17 | Fremgangsmåde til generering af aptamerer med forbedrede dissociationsrater |
Country Status (18)
Country | Link |
---|---|
US (1) | US8409795B2 (da) |
EP (10) | EP2626436A3 (da) |
JP (11) | JP5684568B2 (da) |
KR (3) | KR101656240B1 (da) |
CN (6) | CN101809167B (da) |
AU (3) | AU2008275917B2 (da) |
CA (4) | CA2696431C (da) |
DK (4) | DK2489743T3 (da) |
ES (5) | ES2604764T3 (da) |
FI (1) | FI3284832T3 (da) |
HK (6) | HK1133046A1 (da) |
HR (1) | HRP20150382T1 (da) |
MX (6) | MX2010000533A (da) |
NO (1) | NO2933340T3 (da) |
PL (1) | PL2489743T3 (da) |
PT (2) | PT2489743E (da) |
SI (1) | SI2489743T1 (da) |
WO (3) | WO2009012410A1 (da) |
Families Citing this family (124)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5993279A (ja) * | 1982-11-17 | 1984-05-29 | 富士通株式会社 | ロボツトによるカ−ド,レシ−ト分離取出し方法 |
US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
US7964356B2 (en) | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
US8975026B2 (en) | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
US8404830B2 (en) * | 2007-07-17 | 2013-03-26 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
CN101809167B (zh) * | 2007-07-17 | 2015-04-01 | 私募蛋白质体公司 | 产生具有改良的解离速率的适配体的方法 |
US8314052B2 (en) * | 2009-03-23 | 2012-11-20 | Base Pair Biotechnologies, Inc. | Methods for simultaneous generation of functional ligands |
US10196700B2 (en) | 2009-03-24 | 2019-02-05 | University Of Chicago | Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes |
US9447461B2 (en) | 2009-03-24 | 2016-09-20 | California Institute Of Technology | Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes |
US9464319B2 (en) | 2009-03-24 | 2016-10-11 | California Institute Of Technology | Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes |
JP5766178B2 (ja) | 2009-03-24 | 2015-08-19 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | SlipChip装置および方法 |
US8569252B2 (en) * | 2009-04-15 | 2013-10-29 | Postech Academy-Industry Foundation | Nucleolin specific aptamer and use thereof |
AU2013203588C1 (en) * | 2009-07-09 | 2016-06-30 | Somalogic Operating Co., Inc. | Method for generating aptamers with improved off-rates |
JP5967687B2 (ja) * | 2009-07-17 | 2016-08-10 | Necソリューションイノベータ株式会社 | スフィンゴシルホスホリルコリンに結合するアプタマー分子 |
US8236570B2 (en) | 2009-11-03 | 2012-08-07 | Infoscitex | Methods for identifying nucleic acid ligands |
US8841429B2 (en) * | 2009-11-03 | 2014-09-23 | Vivonics, Inc. | Nucleic acid ligands against infectious prions |
US9453845B2 (en) | 2010-02-01 | 2016-09-27 | Cell Signaling Technology, Inc. | Mass spectroscopy analysis of mutant polypeptides in biological samples |
RU2615143C2 (ru) * | 2010-03-24 | 2017-04-04 | Адвирна | Самодоставляющие PHKi соединения уменьшенного размера |
EP2558478B1 (en) * | 2010-04-12 | 2018-03-07 | Somalogic, Inc. | 5-position modified pyrimidines and their use |
AU2013202528B2 (en) * | 2010-04-12 | 2015-07-30 | Somalogic Operating Co., Inc. | 5-position modified pyrimidines and their use |
EP2591357A4 (en) * | 2010-07-09 | 2014-01-01 | Somalogic Inc | BIOMARKER FOR LUNG CANCER AND USE |
CA2809282C (en) | 2010-09-27 | 2017-09-12 | Somalogic, Inc. | Mesothelioma biomarkers and uses thereof |
EP2635681B8 (en) * | 2010-11-05 | 2017-10-04 | Miragen Therapeutics, Inc. | Base modified oligonucleotides |
KR101307616B1 (ko) * | 2011-02-08 | 2013-09-12 | 경희대학교 산학협력단 | Pna 앱타머를 이용하여 금속을 분리하는 방법 |
JP5805788B2 (ja) * | 2011-12-28 | 2015-11-10 | シスメックス株式会社 | 副腎皮質刺激ホルモンと結合する分子およびその利用 |
MX355567B (es) | 2011-12-30 | 2018-04-23 | Quest Diagnostics Invest Inc | Aptameros y metodos de diagnostico para detectar el receptor de egf. |
CN104379764B (zh) | 2012-03-28 | 2018-04-06 | 私募蛋白质体公司 | Pdgf和vegf的适体及它们在治疗pdgf和vegf介导的病状中的用途 |
US9617589B2 (en) * | 2012-05-25 | 2017-04-11 | The University Of North Carolina At Chapel Hill | Microfluidic devices, solid supports for reagents and related methods |
MY170164A (en) * | 2012-06-07 | 2019-07-09 | Somalogic Inc | Aptamer-based multiplexed assays |
CN102719430B (zh) * | 2012-06-13 | 2013-06-12 | 湖南大学 | 一种检测组氨酸标签重组蛋白的核酸适配体分子信标探针及其检测方法 |
KR101556339B1 (ko) * | 2012-07-02 | 2015-10-13 | 국립대학법인 울산과학기술대학교 산학협력단 | 페리오스틴에 대한 압타머 및 이를 포함하는 항암제 조성물 |
EP2690441A1 (en) * | 2012-07-26 | 2014-01-29 | Rheinische Friedrich-Wilhelms-Universität Bonn | Method of determining a protein in a sample |
CN102912020B (zh) * | 2012-10-20 | 2014-02-19 | 江南大学 | 一种测定赭曲霉毒素a的适配体传感器的构建方法 |
US10942184B2 (en) | 2012-10-23 | 2021-03-09 | Caris Science, Inc. | Aptamers and uses thereof |
EP4170031A1 (en) | 2012-10-23 | 2023-04-26 | Caris Science, Inc. | Aptamers and uses thereof |
WO2014074682A1 (en) | 2012-11-07 | 2014-05-15 | Somalogic, Inc. | Chronic obstructive pulmonary disease (copd) biomarkers and uses thereof |
AU2013361323B2 (en) | 2012-12-19 | 2018-09-06 | Caris Science, Inc. | Compositions and methods for aptamer screening |
SG11201507335QA (en) | 2013-03-14 | 2015-10-29 | Somalogic Inc | Aptamers that bind to il-6 and their use in treating or diagnosing il-6 mediated conditions |
WO2014144744A1 (en) | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Aptamer methods and compositions |
MX360140B (es) | 2013-03-15 | 2018-10-24 | Somalogic Inc | Biomarcadores de la enfermedad del higado graso no alcoholico (nafld) y la esteatohepatitis no alcoholica (nash) y usos de estos. |
JP6034261B2 (ja) * | 2013-08-02 | 2016-11-30 | 日本電信電話株式会社 | 生体分子検出用チップの製造方法 |
EP3044334B1 (en) | 2013-09-09 | 2020-08-12 | Somalogic, Inc. | Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders |
JP6506768B2 (ja) | 2013-09-24 | 2019-04-24 | ソマロジック・インコーポレーテッド | 多重アプタマー標的の検出 |
ES2714324T3 (es) * | 2013-10-02 | 2019-05-28 | Fabian Tolle | Un método para identificar o producir un aptámero |
US9938314B2 (en) | 2013-11-21 | 2018-04-10 | Somalogic, Inc. | Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto |
ES2764669T3 (es) | 2014-02-18 | 2020-06-04 | Somalogic Inc | Composiciones y métodos para la detección de microorganismos |
WO2015164616A1 (en) | 2014-04-24 | 2015-10-29 | Somalogic, Inc. | Biomarkers for detection of tuberculosis |
WO2015164617A1 (en) | 2014-04-24 | 2015-10-29 | Somalogic, Inc. | Tuberculosis biomarkers in urine and uses thereof |
WO2016000216A1 (zh) * | 2014-07-01 | 2016-01-07 | 深圳迈瑞生物医疗电子股份有限公司 | 一种全血样本检测方法及血液检测仪 |
US10670611B2 (en) | 2014-09-26 | 2020-06-02 | Somalogic, Inc. | Cardiovascular risk event prediction and uses thereof |
KR101849557B1 (ko) * | 2014-09-29 | 2018-04-17 | 동국대학교 산학협력단 | 신규 세포 타겟 압타머 제조방법 |
EP3201353B1 (en) * | 2014-10-02 | 2019-12-25 | Rheinische Friedrich-Wilhelms-Universität Bonn | A method of identifying or producing an aptamer |
KR101719285B1 (ko) | 2014-11-04 | 2017-03-23 | 한국과학기술원 | 표적 물질에 의해 조절되는 핵산 중합효소 활성을 이용한 생체물질의 검출 및 정량 방법 |
TWI695068B (zh) | 2014-11-24 | 2020-06-01 | 美商身體邏輯股份有限公司 | 用於結合生長分化因子11的核酸化合物 |
CN104360077A (zh) * | 2014-11-25 | 2015-02-18 | 重庆市科学技术研究院 | 一种用于检测多西环素残留的适配体核酸探针试剂盒、制备方法及其应用 |
WO2016123058A1 (en) | 2015-01-27 | 2016-08-04 | Somalogic, Inc. | Biomarkers for detection of tuberculosis risk |
US10370669B2 (en) | 2015-02-09 | 2019-08-06 | Somalogic, Inc. | Nucleic acid compounds for binding growth differentiation factor 8 |
US10138486B2 (en) | 2015-03-12 | 2018-11-27 | The Regents Of The University Of Michigan | Inhibitors of DEK protein and related methods |
EP3295176A1 (en) | 2015-05-08 | 2018-03-21 | Somalogic, Inc. | Biomarkers for detection of tuberculosis risk |
US20180259533A1 (en) | 2015-09-09 | 2018-09-13 | Somalogic, Inc. | Methods for developing personalized drug treatment plans and targeted drug development based on proteomic profiles |
CA3002073A1 (en) * | 2015-10-20 | 2017-04-27 | Sorrento Therapeutics, Inc. | Intracellular delivery compounds |
US20210215711A1 (en) | 2016-02-08 | 2021-07-15 | Somalogic, Inc. | Nonalcoholic Fatty Liver Disease (NAFLD) and Nonalcoholic Steatohepatitis (NASH) Biomarkers and Uses Thereof |
GB201603789D0 (en) * | 2016-03-04 | 2016-04-20 | Apta Biosciences Ltd | Oligonucleotides and methods for preparing |
EP3913058A1 (en) | 2016-07-01 | 2021-11-24 | Somalogic, Inc. | Oligonucleotides comprising modified nucleosides |
CN106248767B (zh) * | 2016-07-15 | 2018-12-07 | 济南大学 | 一种用于检测癌细胞中h2s的三维纸分析器件的制备方法 |
CN107663220B (zh) * | 2016-07-27 | 2020-10-02 | 上海伯豪医学检验所有限公司 | 修饰碱基、包含修饰碱基的核酸、适配体及其应用 |
TW201821609A (zh) * | 2016-08-22 | 2018-06-16 | Nissan Chemical Ind Ltd | 使用e-鈣黏蛋白結合型核酸適體之細胞貼附材料 |
US11041849B2 (en) * | 2016-12-01 | 2021-06-22 | Aptitude Medical Systems, Inc. | Methods and systems for identifying candidate nucleic acid agent |
KR101993427B1 (ko) * | 2017-04-26 | 2019-10-01 | 주식회사 압타머사이언스 | 백혈구에 선택적으로 결합하는 압타머 및 이의 용도 |
US11072816B2 (en) | 2017-05-03 | 2021-07-27 | The Broad Institute, Inc. | Single-cell proteomic assay using aptamers |
WO2019113506A1 (en) | 2017-12-07 | 2019-06-13 | The Broad Institute, Inc. | Methods and compositions for multiplexing single cell and single nuclei sequencing |
US10481155B2 (en) * | 2018-03-09 | 2019-11-19 | Somalogic, Inc. | Proteomic assay using quantum sensors |
US11841371B2 (en) | 2018-03-13 | 2023-12-12 | The Broad Institute, Inc. | Proteomics and spatial patterning using antenna networks |
US11231420B2 (en) | 2018-04-09 | 2022-01-25 | Aptalogic, Inc. | Selection and optimization of aptamers to recognize ebola markers |
US20210140977A1 (en) | 2018-04-16 | 2021-05-13 | University Of Cape Town | A three-protein proteomic biomarker for prospective determination of risk for development of active tuberculosis |
US11957695B2 (en) | 2018-04-26 | 2024-04-16 | The Broad Institute, Inc. | Methods and compositions targeting glucocorticoid signaling for modulating immune responses |
AT521238B1 (de) | 2018-05-09 | 2020-02-15 | Lifetaq Analytics Gmbh | In-situ zellanalyse im zellkultursystem |
BR112020026129B1 (pt) * | 2018-06-22 | 2023-10-10 | Somalogic Operating Co., Inc | Métodos para melhorar o desempenho de ensaios proteômicos multiplex |
WO2020037250A2 (en) * | 2018-08-17 | 2020-02-20 | The Trustees Of Columbia University In The City Of New York | Stem-loop receptor-based field-effect transistor sensor devices target detection for small-molecule under physiological salt concentrations |
US11313855B2 (en) | 2018-09-25 | 2022-04-26 | Siemens Healthcare Diagnostics Inc. | Methods and compositions for removing biotin interference from assays using conjugated molecular traps |
AU2019352901A1 (en) | 2018-10-02 | 2021-05-27 | WearOptimo Pty Ltd | Measurement system |
US20220411783A1 (en) | 2018-10-12 | 2022-12-29 | The Broad Institute, Inc. | Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues |
US20210317456A1 (en) | 2018-10-15 | 2021-10-14 | Somalogic, Inc. | Nucleic Acid Compounds for Binding Immunoglobulin G |
CN113227395A (zh) | 2018-12-04 | 2021-08-06 | 豪夫迈·罗氏有限公司 | 细胞靶标的空间上定向的量子条形编码 |
US11739156B2 (en) | 2019-01-06 | 2023-08-29 | The Broad Institute, Inc. Massachusetts Institute of Technology | Methods and compositions for overcoming immunosuppression |
US20220142948A1 (en) | 2019-03-18 | 2022-05-12 | The Broad Institute, Inc. | Compositions and methods for modulating metabolic regulators of t cell pathogenicity |
EP3969900A1 (en) * | 2019-05-17 | 2022-03-23 | Somalogic, Inc. | Controlling intersample analyte variability in complex biological matrices |
US20220243178A1 (en) | 2019-05-31 | 2022-08-04 | The Broad Institute, Inc. | Methods for treating metabolic disorders by targeting adcy5 |
US11198908B2 (en) | 2019-06-17 | 2021-12-14 | Biorchestra Co., Ltd. | Method for diagnosis of Alzheimer's disease using microRNA |
KR102113078B1 (ko) * | 2019-07-05 | 2020-05-20 | 광주과학기술원 | 압타머의 선별 방법 |
US20220282333A1 (en) | 2019-08-13 | 2022-09-08 | The General Hospital Corporation | Methods for predicting outcomes of checkpoint inhibition and treatment thereof |
CN110396536A (zh) * | 2019-08-14 | 2019-11-01 | 东南大学 | 一种基于分支滚环扩增的外泌体荧光检测传感器 |
US20220349904A1 (en) | 2019-09-03 | 2022-11-03 | Somalogic Operating Co., Inc. | Cardiovascular Risk Event Prediction and Uses Thereof |
CN110618265B (zh) * | 2019-09-12 | 2023-04-18 | 广东省药品检验所(广东省药品质量研究所、广东省口岸药品检验所) | 一种沙丁胺醇的可视化检测方法 |
US11981922B2 (en) | 2019-10-03 | 2024-05-14 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment |
US11793787B2 (en) | 2019-10-07 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis |
WO2021076713A1 (en) | 2019-10-16 | 2021-04-22 | Somalogic, Inc. | Nucleic acid compounds that bind to retinoic acid-inducible gene i protein |
US20230093390A1 (en) * | 2019-12-03 | 2023-03-23 | Sung Chun Kim | Method for obtaining profile of target molecule population of sample |
JP2023509677A (ja) | 2020-01-10 | 2023-03-09 | ソマロジック オペレーティング カンパニー インコーポレイテッド | 耐糖能異常障害を決定する方法 |
AU2021220787A1 (en) | 2020-02-10 | 2022-09-01 | Somalogic Operating Co., Inc. | Nonalcoholic steatohepatitis (NASH) biomarkers and uses thereof |
CN111304202B (zh) * | 2020-02-26 | 2023-03-28 | 西安交通大学 | 一种用于识别且增强hmgb1生物学活性的核酸适配子及其应用 |
CN113624724A (zh) * | 2020-05-07 | 2021-11-09 | 廖世奇 | 一种适配体分子信标对靶分子的多元检测分析方法 |
CA3177923A1 (en) * | 2020-05-18 | 2021-11-25 | Shanghai Polaris Biology Co., Ltd. | Microbeads and uses thereof |
CN111735869A (zh) * | 2020-05-29 | 2020-10-02 | 中山大学 | 一种蛋白质的检测试剂及检测方法 |
EP4232825A2 (en) | 2020-10-20 | 2023-08-30 | SomaLogic Operating Co., Inc. | Cardiovascular event risk prediction |
MX2023012081A (es) | 2021-04-13 | 2023-10-25 | Somalogic Operating Co Inc | Nucleosidos modificados. |
US20240218374A1 (en) | 2021-04-14 | 2024-07-04 | Somalogic Operating Co., Inc. | Nucleic Acid Compounds That Bind Coronavirus Proteins |
WO2022235957A2 (en) * | 2021-05-06 | 2022-11-10 | Systems Oncology, Llc | Multitargeting rna immunotherapy compositions |
US20240255524A1 (en) | 2021-06-15 | 2024-08-01 | Somalogic Operating Co., Inc. | Renal Insufficiency Prediction and Uses Thereof |
WO2023059854A1 (en) | 2021-10-07 | 2023-04-13 | Somalogic Operating Co., Inc. | Lung cancer prediction and uses thereof |
CN114058613B (zh) * | 2021-11-18 | 2023-10-27 | 广州血液中心(中国医学科学院输血研究所广州分所、广州器官移植配型中心) | 一种大体积、高灵敏度核酸提取方法 |
CN114295594B (zh) * | 2021-12-06 | 2023-09-19 | 贵州理工学院 | 一种基于分子信标筛选三螺旋DNA嵌入剂的“turn on”型荧光传感器 |
CA3242172A1 (en) | 2022-01-21 | 2023-07-27 | David ASTLING | Methods for sample quality assessment |
WO2023183873A1 (en) | 2022-03-24 | 2023-09-28 | Mensura Health Inc. | Aptamers and uses thereof |
WO2023211773A1 (en) | 2022-04-24 | 2023-11-02 | Somalogic Operating Co., Inc. | Methods for sample quality assessment |
AU2023260452A1 (en) | 2022-04-24 | 2024-09-12 | Somalogic Operating Co., Inc. | Methods for sample quality assessment |
WO2023211769A1 (en) | 2022-04-24 | 2023-11-02 | Somalogic Operating Co., Inc. | Methods for sample quality assessment |
WO2023211771A1 (en) | 2022-04-24 | 2023-11-02 | Somalogic Operating Co., Inc. | Methods for sample quality assessment |
WO2024015485A1 (en) | 2022-07-14 | 2024-01-18 | Somalogic Operating Co., Inc. | Methods of assessing dementia risk |
WO2024015486A1 (en) | 2022-07-14 | 2024-01-18 | Somalogic Operating Co., Inc. | Methods for sample quality assessment |
WO2024064322A2 (en) | 2022-09-23 | 2024-03-28 | Somalogic Operating Co., Inc. | Methods of assessing tobacco use status |
WO2024192141A1 (en) | 2023-03-13 | 2024-09-19 | Dana-Farber Cancer Institute, Inc. | Treatment of cancers having a drug-resistant mesenchymal cell state |
EP4442282A1 (en) | 2023-04-07 | 2024-10-09 | POSTECH Research and Business Development Foundation | Preparation of site-specific polypeptide conjugates |
Family Cites Families (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
CH0229046H1 (de) * | 1985-03-30 | 1998-07-15 | Stuart Alan Kauffman | Method for obtaining dna, rna, peptides, polypeptinique. des or proteins by means of a dna recombinant tech |
US4753983A (en) * | 1986-05-07 | 1988-06-28 | Bioprobe International, Inc. | Polymeric matrix for affinity chromatography and immobilization of ligands |
WO1989006694A1 (en) | 1988-01-15 | 1989-07-27 | Trustees Of The University Of Pennsylvania | Process for selection of proteinaceous substances which mimic growth-inducing molecules |
US5035996A (en) * | 1989-06-01 | 1991-07-30 | Life Technologies, Inc. | Process for controlling contamination of nucleic acid amplification reactions |
US5874557A (en) | 1990-06-11 | 1999-02-23 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand inhibitors to DNA polymerases |
US5962219A (en) | 1990-06-11 | 1999-10-05 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-selex |
US6083696A (en) * | 1990-06-11 | 2000-07-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands exponential enrichment: blended selex |
US5874218A (en) | 1990-06-11 | 1999-02-23 | Nexstar Pharmaceuticals, Inc. | Method for detecting a target compound in a substance using a nucleic acid ligand |
US6168778B1 (en) | 1990-06-11 | 2001-01-02 | Nexstar Pharmaceuticals, Inc. | Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes |
US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
US6001577A (en) * | 1998-06-08 | 1999-12-14 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex |
US5763177A (en) | 1990-06-11 | 1998-06-09 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex |
US5861254A (en) * | 1997-01-31 | 1999-01-19 | Nexstar Pharmaceuticals, Inc. | Flow cell SELEX |
US5580737A (en) | 1990-06-11 | 1996-12-03 | Nexstar Pharmaceuticals, Inc. | High-affinity nucleic acid ligands that discriminate between theophylline and caffeine |
US6716580B2 (en) * | 1990-06-11 | 2004-04-06 | Somalogic, Inc. | Method for the automated generation of nucleic acid ligands |
US5472841A (en) * | 1990-06-11 | 1995-12-05 | Nexstar Pharmaceuticals, Inc. | Methods for identifying nucleic acid ligands of human neutrophil elastase |
US6346611B1 (en) * | 1990-06-11 | 2002-02-12 | Gilead Sciences, Inc. | High affinity TGfβ nucleic acid ligands and inhibitors |
US5763173A (en) | 1990-06-11 | 1998-06-09 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand inhibitors to DNA polymerases |
US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
US20040132067A1 (en) * | 1990-06-11 | 2004-07-08 | Somalogic, Inc. | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex |
US5707796A (en) | 1990-06-11 | 1998-01-13 | Nexstar Pharmaceuticals, Inc. | Method for selecting nucleic acids on the basis of structure |
US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
US5459015A (en) * | 1990-06-11 | 1995-10-17 | Nexstar Pharmaceuticals, Inc. | High-affinity RNA ligands of basic fibroblast growth factor |
ATE318832T1 (de) | 1990-06-11 | 2006-03-15 | Gilead Sciences Inc | Verfahren zur vervendung von nukleinsäureliganden |
US5705337A (en) | 1990-06-11 | 1998-01-06 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-SELEX |
US5693502A (en) | 1990-06-11 | 1997-12-02 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand inhibitors to DNA polymerases |
US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
US6030776A (en) * | 1990-06-11 | 2000-02-29 | Nexstar Pharmaceuticals, Inc. | Parallel SELEX |
US5789163A (en) | 1990-06-11 | 1998-08-04 | Nexstar Pharmaceuticals, Inc. | Enzyme linked oligonucleotide assays (ELONAS) |
US5853984A (en) | 1990-06-11 | 1998-12-29 | Nexstar Pharmaceuticals, Inc. | Use of nucleic acid ligands in flow cytometry |
US6232071B1 (en) * | 1990-06-11 | 2001-05-15 | Gilead Sciences, Inc. | Tenascin-C nucleic acid ligands |
US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
SE501013C2 (sv) | 1990-10-01 | 1994-10-17 | Pharmacia Biosensor Ab | Förfarande för förbättring av analys med bindning till fast fas |
EP0572529A4 (en) * | 1991-02-21 | 1994-11-02 | Gilead Sciences Inc | SPECIFIC APTAMER OF BIOMOLECULES AND PROCESS FOR PRODUCING THE SAME. |
AU2580892A (en) | 1991-09-05 | 1993-04-05 | Isis Pharmaceuticals, Inc. | Determination of oligonucleotides for therapeutics, diagnostics and research reagents |
EP0637965B1 (en) * | 1991-11-26 | 2002-10-16 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
US5312730A (en) * | 1992-05-27 | 1994-05-17 | Ciba Corning Diagnostics Corp. | Immune complex transfer with lypophilic bridge |
US5756291A (en) * | 1992-08-21 | 1998-05-26 | Gilead Sciences, Inc. | Aptamers specific for biomolecules and methods of making |
US5985548A (en) * | 1993-02-04 | 1999-11-16 | E. I. Du Pont De Nemours And Company | Amplification of assay reporters by nucleic acid replication |
US5428149A (en) | 1993-06-14 | 1995-06-27 | Washington State University Research Foundation | Method for palladium catalyzed carbon-carbon coulping and products |
US5580972A (en) | 1993-06-14 | 1996-12-03 | Nexstar Pharmaceuticals, Inc. | Purine nucleoside modifications by palladium catalyzed methods |
US5719273A (en) | 1993-06-14 | 1998-02-17 | Nexstar Pharmaceuticals, Inc. | Palladium catalyzed nucleoside modifications methods using nucleophiles and carbon monoxide |
US5998142A (en) * | 1993-09-08 | 1999-12-07 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-SELEX |
EP1793006A3 (en) * | 1993-09-08 | 2007-08-22 | Gilead Sciences, Inc. | Nucleic acid ligands and improved methods for producing the same |
US6458539B1 (en) | 1993-09-17 | 2002-10-01 | Somalogic, Inc. | Photoselection of nucleic acid ligands |
DE69435048T2 (de) | 1993-09-17 | 2008-10-02 | Somalogic, Inc., Boulder | Systematische evolution von liganden durch exponentielle anreicherung: fotoselektion von nukleinsäureliganden |
US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
US5610287A (en) * | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
JP4899014B2 (ja) * | 1995-06-02 | 2012-03-21 | イーシー・テクノロジー・エルエルシー | 求核試薬および一酸化炭素を用いるパラジウム触媒ヌクレオシド修飾方法 |
US6183967B1 (en) * | 1995-06-07 | 2001-02-06 | Nexstar Pharmaceuticals | Nucleic acid ligand inhibitors to DNA polymerases |
DE69637805D1 (de) | 1995-06-07 | 2009-02-26 | Gilead Sciences Inc | Nukleinsäure liganden die dna-polymerase binden und inhibieren |
US5737498A (en) | 1995-07-11 | 1998-04-07 | Beckman Instruments, Inc. | Process automation method and apparatus |
JPH11513887A (ja) * | 1995-10-27 | 1999-11-30 | ランバーグ,エリオット,アール. | 特定のヌクレオチド配列の検出方法および組成物 |
US5727498A (en) * | 1996-02-13 | 1998-03-17 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Retractable visual indicator assembly |
US5945527A (en) * | 1996-05-30 | 1999-08-31 | Nexstar Pharmaceuticals, Inc. | Palladium catalyzed nucleoside modification methods using nucleophiles and carbon monoxide |
US5866336A (en) * | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
US6426335B1 (en) | 1997-10-17 | 2002-07-30 | Gilead Sciences, Inc. | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
US6051698A (en) | 1997-06-06 | 2000-04-18 | Janjic; Nebojsa | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
US6235471B1 (en) * | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
AU1252099A (en) | 1997-11-26 | 1999-06-15 | Medical Research Council | Improved selex procedure and an anti-cd4 aptamer |
US5989823A (en) | 1998-09-18 | 1999-11-23 | Nexstar Pharmaceuticals, Inc. | Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction |
US6242246B1 (en) | 1997-12-15 | 2001-06-05 | Somalogic, Inc. | Nucleic acid ligand diagnostic Biochip |
US20070166741A1 (en) * | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
EP1049803A4 (en) | 1997-12-15 | 2002-08-21 | Nexstar Pharmaceuticals Inc | HOMOGENEOUS DETECTION OF TARGET MOLECULES BY LIGAND NUCLEIC ACID AND LIGAND BEACON INTERACTION |
US6175001B1 (en) * | 1998-10-16 | 2001-01-16 | The Scripps Research Institute | Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same |
US20030054360A1 (en) | 1999-01-19 | 2003-03-20 | Larry Gold | Method and apparatus for the automated generation of nucleic acid ligands |
US6329145B1 (en) * | 1999-02-09 | 2001-12-11 | Gilead Science, Inc. | Determining non-nucleic acid molecule binding to target by competition with nucleic acid ligand |
US6376190B1 (en) | 2000-09-22 | 2002-04-23 | Somalogic, Inc. | Modified SELEX processes without purified protein |
WO2002033116A2 (en) * | 2000-10-16 | 2002-04-25 | Gilead Sciences, Inc. | Nucleic acid ligands to the prostate specific membrane antigen |
EP1347301A1 (en) * | 2000-12-01 | 2003-09-24 | International Reagents Corporation | Method for ultra-rapid and ultra-sensitive measurement |
WO2003014369A1 (en) | 2001-08-09 | 2003-02-20 | Somalogic, Inc. | Nucleic acid ligands with intramolecular duplexes |
AU2003217379A1 (en) | 2002-02-15 | 2003-09-09 | Somalogic, Inc. | Methods and reagents for detecting target binding by nucleic acid ligands |
US20030219801A1 (en) * | 2002-03-06 | 2003-11-27 | Affymetrix, Inc. | Aptamer base technique for ligand identification |
JP3978187B2 (ja) * | 2002-03-19 | 2007-09-19 | 富士通株式会社 | 機能性分子及びその製造方法 |
US20030228603A1 (en) * | 2002-04-05 | 2003-12-11 | Cload Sharon T. | Compositions selective for caffeine or aspartame and methods of using same |
US7767803B2 (en) | 2002-06-18 | 2010-08-03 | Archemix Corp. | Stabilized aptamers to PSMA and their use as prostate cancer therapeutics |
DE10241938A1 (de) * | 2002-09-10 | 2004-03-25 | Noxxon Pharma Ag | Verfahren zur Selektion von Nukleinsäureliganden |
CA2407825A1 (en) | 2002-10-11 | 2004-04-11 | Andrew J. Simmonds | Trap-tagging: a novel method for the identification and purification of rna-protein complexes |
JP2004307464A (ja) * | 2002-10-23 | 2004-11-04 | Sankyo Co Ltd | 糖部s型配座の新規人工核酸 |
GB0226374D0 (en) * | 2002-11-12 | 2002-12-18 | Isis Innovation | Ligands |
EP1587908A4 (en) * | 2003-01-09 | 2008-02-20 | Invitrogen Corp | RELEASE AND ACTIVATION OF COMPLEX CELLS OF POLYPEPTIDES AND NUCLEIC ACIDS |
US20040235053A1 (en) * | 2003-03-28 | 2004-11-25 | The Regents Of The University Of California | Preparation and application of encoded bead aggregates in combinatorial chemistry |
US7672786B2 (en) | 2003-07-02 | 2010-03-02 | Sergey Krylov | Non-equilibrium capillary electrophoresis of equilibrium mixtures (NECEEM)—based methods for drug and diagnostic development |
JP2007502417A (ja) * | 2003-08-11 | 2007-02-08 | モノグラム バイオサイエンシズ,インコーポレーテッド | 分子複合体の検出および特徴づけ |
KR100540509B1 (ko) * | 2004-01-07 | 2006-01-11 | 학교법인 포항공과대학교 | 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체 |
US20050227225A1 (en) * | 2004-04-07 | 2005-10-13 | Roche Molecular Systems, Inc. | Stabilization of biomolecules in samples |
JP4839051B2 (ja) * | 2004-10-08 | 2011-12-14 | シスメックス株式会社 | 核酸プローブを用いる被検物質の検出方法 |
EP1863828A4 (en) * | 2005-03-07 | 2010-10-13 | Archemix Corp | STABILIZED APTAMERS FOR PSMA AND THEIR USE AS PROSTATE ACID THERAPEUTICS |
WO2007002119A1 (en) * | 2005-06-24 | 2007-01-04 | Mag Aerospace Industries, Inc. | Gray water interface valve systems and methods |
EP1910837B1 (en) * | 2005-07-01 | 2012-03-14 | Arbor Vita Corporation | Methods and compositions for diagnosis and treatment of influenza |
JP2009505106A (ja) * | 2005-08-19 | 2009-02-05 | ナノスフェアー インコーポレイテッド | Dna及び抗体を含むハイブリッド基板を調製するための方法及びその使用 |
AU2007205974A1 (en) * | 2006-01-17 | 2007-07-26 | Somalogic, Incorporated | Multiplexed analyses of test samples |
EP2207891B1 (en) * | 2006-12-22 | 2012-07-25 | Archemix LLC | Materials and methods for the generation of transcripts comprising modified nucleotides |
AU2008209447B2 (en) * | 2007-01-23 | 2013-01-17 | Jostens, Inc. | Method and system for creating customized output |
CN101809167B (zh) * | 2007-07-17 | 2015-04-01 | 私募蛋白质体公司 | 产生具有改良的解离速率的适配体的方法 |
JP2013220095A (ja) * | 2012-04-12 | 2013-10-28 | Toyohiro Fujita | 苗床 |
JP2018078250A (ja) | 2016-11-11 | 2018-05-17 | 株式会社ニューフレアテクノロジー | マルチ荷電粒子ビーム描画装置 |
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