DK3284832T3 - Aptamer med forbedret dissociationshastighed og ikke-kovalent aptamermålkompleks deraf - Google Patents

Aptamer med forbedret dissociationshastighed og ikke-kovalent aptamermålkompleks deraf Download PDF

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Publication number
DK3284832T3
DK3284832T3 DK17181688.7T DK17181688T DK3284832T3 DK 3284832 T3 DK3284832 T3 DK 3284832T3 DK 17181688 T DK17181688 T DK 17181688T DK 3284832 T3 DK3284832 T3 DK 3284832T3
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aptamer
dissociation rate
covalent
target complex
enhanced dissociation
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DK17181688.7T
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DK3284832T5 (da
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Dominic Zichi
Sheri K Wilcox
Daniel J Schneider
Bruce Eaton
Larry Gold
Chris Bock
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Somalogic Operating Co Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1048—SELEX
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/13—Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/205—Aptamer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2541/00—Reactions characterised by directed evolution
    • C12Q2541/10—Reactions characterised by directed evolution the purpose being the selection or design of target specific nucleic acid binding sequences
    • C12Q2541/101—Selex

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  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
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  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK17181688.7T 2007-07-17 2008-07-17 Aptamer med forbedret dissociationshastighed og ikke-kovalent aptamermålkompleks deraf DK3284832T5 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US95028307P 2007-07-17 2007-07-17
US95029307P 2007-07-17 2007-07-17
US95028107P 2007-07-17 2007-07-17
US3142008P 2008-02-26 2008-02-26
US5159408P 2008-05-08 2008-05-08
EP15152547.4A EP2933340B1 (en) 2007-07-17 2008-07-17 Aptamers with uridines and/or thymidines substituted at the 5-position with a benzyl group

Publications (2)

Publication Number Publication Date
DK3284832T3 true DK3284832T3 (da) 2023-07-31
DK3284832T5 DK3284832T5 (da) 2024-10-07

Family

ID=40260081

Family Applications (4)

Application Number Title Priority Date Filing Date
DK12160299T DK2489743T3 (da) 2007-07-17 2008-07-17 Aptamerer med 5-(N-naphthyl)-substituerede uridiner
DK09012809.1T DK2172566T4 (da) 2007-07-17 2008-07-17 Fremgangsmåde til generering af aptamerer med forbedrede off-rates
DK17181688.7T DK3284832T5 (da) 2007-07-17 2008-07-17 Aptamer med forbedret dissociationshastighed og ikke-kovalent aptamermålkompleks deraf
DK08782010.6T DK2069529T3 (da) 2007-07-17 2008-07-17 Fremgangsmåde til generering af aptamerer med forbedrede dissociationsrater

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK12160299T DK2489743T3 (da) 2007-07-17 2008-07-17 Aptamerer med 5-(N-naphthyl)-substituerede uridiner
DK09012809.1T DK2172566T4 (da) 2007-07-17 2008-07-17 Fremgangsmåde til generering af aptamerer med forbedrede off-rates

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK08782010.6T DK2069529T3 (da) 2007-07-17 2008-07-17 Fremgangsmåde til generering af aptamerer med forbedrede dissociationsrater

Country Status (18)

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US (1) US8409795B2 (da)
EP (10) EP2626436A3 (da)
JP (11) JP5684568B2 (da)
KR (3) KR101656240B1 (da)
CN (6) CN101809167B (da)
AU (3) AU2008275917B2 (da)
CA (4) CA2696431C (da)
DK (4) DK2489743T3 (da)
ES (5) ES2604764T3 (da)
FI (1) FI3284832T3 (da)
HK (6) HK1133046A1 (da)
HR (1) HRP20150382T1 (da)
MX (6) MX2010000533A (da)
NO (1) NO2933340T3 (da)
PL (1) PL2489743T3 (da)
PT (2) PT2489743E (da)
SI (1) SI2489743T1 (da)
WO (3) WO2009012410A1 (da)

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