JP2015520385A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015520385A5 JP2015520385A5 JP2015516253A JP2015516253A JP2015520385A5 JP 2015520385 A5 JP2015520385 A5 JP 2015520385A5 JP 2015516253 A JP2015516253 A JP 2015516253A JP 2015516253 A JP2015516253 A JP 2015516253A JP 2015520385 A5 JP2015520385 A5 JP 2015520385A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- solid support
- tag
- substrate
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 30
- 108091023037 Aptamer Proteins 0.000 claims 28
- 239000007787 solid Substances 0.000 claims 21
- 239000000758 substrate Substances 0.000 claims 12
- 239000011324 bead Substances 0.000 claims 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 230000003196 chaotropic effect Effects 0.000 claims 5
- 230000004048 modification Effects 0.000 claims 5
- 238000012986 modification Methods 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 238000012360 testing method Methods 0.000 claims 5
- 239000007853 buffer solution Substances 0.000 claims 4
- 150000004676 glycans Chemical class 0.000 claims 4
- 239000003960 organic solvent Substances 0.000 claims 4
- 229920001282 polysaccharide Polymers 0.000 claims 4
- 239000005017 polysaccharide Substances 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 108090001008 Avidin Proteins 0.000 claims 3
- 108091093037 Peptide nucleic acid Proteins 0.000 claims 3
- 108010090804 Streptavidin Proteins 0.000 claims 3
- 229960002685 biotin Drugs 0.000 claims 3
- 235000020958 biotin Nutrition 0.000 claims 3
- 239000011616 biotin Substances 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 150000002632 lipids Chemical class 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- 108010087904 neutravidin Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 229920001542 oligosaccharide Polymers 0.000 claims 3
- 150000002482 oligosaccharides Chemical class 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 108010081020 traptavidin Proteins 0.000 claims 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- -1 Extravidin Proteins 0.000 claims 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 239000011521 glass Substances 0.000 claims 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims 2
- 230000003278 mimic effect Effects 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000010703 silicon Substances 0.000 claims 2
- BAZAXWOYCMUHIX-UHFFFAOYSA-M sodium perchlorate Chemical compound [Na+].[O-]Cl(=O)(=O)=O BAZAXWOYCMUHIX-UHFFFAOYSA-M 0.000 claims 2
- 229910001488 sodium perchlorate Inorganic materials 0.000 claims 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical group OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 claims 1
- KISUPFXQEHWGAR-RRKCRQDMSA-N 4-amino-5-bromo-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical group C1=C(Br)C(N)=NC(=O)N1[C@@H]1O[C@H](CO)[C@@H](O)C1 KISUPFXQEHWGAR-RRKCRQDMSA-N 0.000 claims 1
- WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 claims 1
- LQLQRFGHAALLLE-UHFFFAOYSA-N 5-bromouracil Chemical class BrC1=CNC(=O)NC1=O LQLQRFGHAALLLE-UHFFFAOYSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- 102000006306 Antigen Receptors Human genes 0.000 claims 1
- 108010083359 Antigen Receptors Proteins 0.000 claims 1
- JBRZTFJDHDCESZ-UHFFFAOYSA-N AsGa Chemical compound [As]#[Ga] JBRZTFJDHDCESZ-UHFFFAOYSA-N 0.000 claims 1
- WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 claims 1
- 229920000089 Cyclic olefin copolymer Polymers 0.000 claims 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 239000004677 Nylon Substances 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 238000001190 Q-PCR Methods 0.000 claims 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 238000001574 biopsy Methods 0.000 claims 1
- 229950004398 broxuridine Drugs 0.000 claims 1
- 239000008366 buffered solution Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 238000007385 chemical modification Methods 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 150000001925 cycloalkenes Chemical class 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 238000000151 deposition Methods 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229910052732 germanium Inorganic materials 0.000 claims 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims 1
- 230000000762 glandular Effects 0.000 claims 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 1
- 239000010931 gold Substances 0.000 claims 1
- 229910052737 gold Inorganic materials 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 239000011325 microbead Substances 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 238000007481 next generation sequencing Methods 0.000 claims 1
- 210000002445 nipple Anatomy 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 239000002096 quantum dot Substances 0.000 claims 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 229910052709 silver Inorganic materials 0.000 claims 1
- 239000004332 silver Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 230000000153 supplemental effect Effects 0.000 claims 1
- 210000001179 synovial fluid Anatomy 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261656956P | 2012-06-07 | 2012-06-07 | |
| US61/656,956 | 2012-06-07 | ||
| PCT/US2013/044792 WO2013185078A1 (en) | 2012-06-07 | 2013-06-07 | Aptamer-based multiplexed assays |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520385A JP2015520385A (ja) | 2015-07-16 |
| JP2015520385A5 true JP2015520385A5 (enExample) | 2016-07-07 |
| JP6298456B2 JP6298456B2 (ja) | 2018-03-20 |
Family
ID=49712701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516253A Active JP6298456B2 (ja) | 2012-06-07 | 2013-06-07 | アプタマーに基づく多重化アッセイ |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20150141259A1 (enExample) |
| EP (1) | EP2859121B1 (enExample) |
| JP (1) | JP6298456B2 (enExample) |
| KR (1) | KR102088381B1 (enExample) |
| CN (2) | CN104508150B (enExample) |
| AU (1) | AU2013271401B2 (enExample) |
| BR (1) | BR112014030298B1 (enExample) |
| CA (1) | CA2873099C (enExample) |
| CY (1) | CY1118748T1 (enExample) |
| ES (1) | ES2617226T3 (enExample) |
| HR (1) | HRP20170296T1 (enExample) |
| IL (1) | IL235588B (enExample) |
| IN (1) | IN2014KN02647A (enExample) |
| MX (1) | MX356413B (enExample) |
| MY (1) | MY170164A (enExample) |
| NZ (1) | NZ701824A (enExample) |
| PH (1) | PH12014502581B1 (enExample) |
| RU (1) | RU2666989C2 (enExample) |
| SG (2) | SG11201407505XA (enExample) |
| WO (1) | WO2013185078A1 (enExample) |
| ZA (1) | ZA201408409B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US8975026B2 (en) | 2007-01-16 | 2015-03-10 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US20110136099A1 (en) | 2007-01-16 | 2011-06-09 | Somalogic, Inc. | Multiplexed Analyses of Test Samples |
| CN106133211A (zh) * | 2014-01-14 | 2016-11-16 | 爱普济德生物技术有限公司 | 核酸试剂用于对靶分子进行超灵敏数字检测和定量的用途 |
| ES2764669T3 (es) | 2014-02-18 | 2020-06-04 | Somalogic Inc | Composiciones y métodos para la detección de microorganismos |
| CN106574925B (zh) * | 2014-05-23 | 2019-07-26 | 萤火虫生物股份有限公司 | 用于生物测定的底物介导的反应器 |
| GB2528643A (en) * | 2014-07-08 | 2016-02-03 | Adc Biotechnology Ltd | Method of synthesising ADCs |
| KR102003589B1 (ko) * | 2016-03-03 | 2019-07-24 | 성균관대학교산학협력단 | 생화학 분자 검출센서 및 다파장 형광을 이용한 생화학 분자 검출방법 |
| CN105779609A (zh) * | 2016-04-15 | 2016-07-20 | 上海伊丽萨生物科技有限公司 | 一种超敏免疫检测方法 |
| EP3526604A1 (en) * | 2016-10-13 | 2019-08-21 | Laboratory Corporation of America Holdings | Devices and methods to reduce interfering compounds in biological samples |
| EP3775891A4 (en) * | 2018-04-13 | 2022-04-13 | Fluidigm Canada Inc. | STABILIZED CELL DETECTION FOR ELEMENTARY ANALYSIS |
| JP7526102B2 (ja) * | 2018-06-22 | 2024-07-31 | ソマロジック・オペレイティング・カンパニー・インコーポレイテッド | 改良されたプロテオミクスマルチプレックスアッセイ |
| US11181501B2 (en) | 2018-09-11 | 2021-11-23 | City University Of Hong Kong | Method and an apparatus for determining a presence or an amount of a polyamine or its derivative in a sample |
| LU101073B1 (en) | 2018-12-21 | 2020-06-24 | Luxembourg Inst Science & Tech List | Dna aptamers specific of adenovirus types |
| KR102177672B1 (ko) * | 2019-02-01 | 2020-11-12 | 주식회사 압타머사이언스 | 압타머를 이용한 다중(multiplex) PCR 방법 |
| KR102113078B1 (ko) * | 2019-07-05 | 2020-05-20 | 광주과학기술원 | 압타머의 선별 방법 |
| CN110791551A (zh) * | 2019-09-17 | 2020-02-14 | 北京化工大学 | 一种无载体氯霉素适配体信号放大传感器的建立方法 |
| US20230093390A1 (en) * | 2019-12-03 | 2023-03-23 | Sung Chun Kim | Method for obtaining profile of target molecule population of sample |
| CN113624724A (zh) * | 2020-05-07 | 2021-11-09 | 廖世奇 | 一种适配体分子信标对靶分子的多元检测分析方法 |
| CN111812313B (zh) * | 2020-06-22 | 2021-10-08 | 北京生物制品研究所有限责任公司 | 铝佐剂吸附型新型冠状病毒灭活疫苗中抗原的解离方法 |
| EP4294920A4 (en) | 2021-04-27 | 2025-01-22 | Singular Genomics Systems, Inc. | HIGH-DENSITY SEQUENCING AND MULTIPLEX PRIMING |
| KR20220167781A (ko) * | 2021-06-14 | 2022-12-21 | 김성천 | 압타머를 이용하여 시료의 표적 단백질 분자 집단에 대한 프로파일을 얻는 방법 |
| CA3241776A1 (en) * | 2021-12-30 | 2023-07-06 | Dom Zichi | Next-generation sequencing for protein measurement |
| CN116103367B (zh) * | 2022-11-11 | 2025-12-23 | 杭州佰辰医学检验所有限公司 | 一种检测靶标物的方法 |
| US20250092447A1 (en) * | 2023-09-19 | 2025-03-20 | Somalogic Operating Co., Inc. | Methods of Solid-Phase Nucleic Acid Hybridization |
| WO2025166038A1 (en) * | 2024-02-02 | 2025-08-07 | Illumina, Inc. | Improved aptamer detection techniques |
| CN121272015A (zh) * | 2024-07-03 | 2026-01-06 | 常州福洛森医疗科技有限公司 | 适配体在可寻址性检测中应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2084987C (en) | 1990-06-11 | 2007-02-13 | Gilead Sciences, Inc. | Nucleic acid ligands |
| US6242246B1 (en) | 1997-12-15 | 2001-06-05 | Somalogic, Inc. | Nucleic acid ligand diagnostic Biochip |
| JP2003514383A (ja) * | 1999-11-17 | 2003-04-15 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 磁性ガラス粒子、それらの製造方法、及びそれらの使用 |
| US7601497B2 (en) * | 2000-06-15 | 2009-10-13 | Qiagen Gaithersburg, Inc. | Detection of nucleic acids by target-specific hybrid capture method |
| DE60326864D1 (de) * | 2002-07-24 | 2009-05-07 | Bio Rad Laboratories | Proteininteraktionsdifferenzabbildung |
| JP4806411B2 (ja) * | 2004-05-19 | 2011-11-02 | ブィピー ホールディング、エルエルシー | 可視光レーザ励起ビーム及びラマン分光検出器と共に使用する光センサ、及び分析物の化学基を検出する方法 |
| US7699979B2 (en) * | 2005-01-07 | 2010-04-20 | Board Of Trustees Of The University Of Arkansas | Separation system and efficient capture of contaminants using magnetic nanoparticles |
| US7285835B2 (en) * | 2005-02-24 | 2007-10-23 | Freescale Semiconductor, Inc. | Low power magnetoelectronic device structures utilizing enhanced permeability materials |
| EP1918372A4 (en) * | 2005-07-05 | 2009-08-12 | Ribomic Inc | FOR BINDING TO IMMOBILIZABLE LOBULIN G-NUCLEIC ACID AND USE THEREOF |
| EP2952894B1 (en) * | 2006-01-17 | 2017-08-30 | Somalogic, Inc. | Kits comprising aptamers |
| US7947447B2 (en) * | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US7964356B2 (en) | 2007-01-16 | 2011-06-21 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US7855054B2 (en) * | 2007-01-16 | 2010-12-21 | Somalogic, Inc. | Multiplexed analyses of test samples |
| MX344253B (es) * | 2007-07-17 | 2016-12-09 | Somalogic Inc | Metodo para generar aptameros con constantes de disociacion mejoradas. |
| US8291501B2 (en) * | 2008-02-08 | 2012-10-16 | Cheng Holdings, Llc | Validation of protected intra-system interconnects for digital rights management in electrical computers and digital data processing systems |
| EP2291168A2 (fr) * | 2008-05-30 | 2011-03-09 | L'Oréal | Procedes et kits de traitement des cheveux |
| CN102099471B (zh) * | 2008-07-14 | 2014-05-07 | 国立大学法人东京大学 | 针对il-17的适配体及其用途 |
| ES2564190T3 (es) * | 2009-04-13 | 2016-03-18 | Agriculture And Food Development Authority (Teagasc) | Método para producir microperlas |
| GB0916700D0 (en) * | 2009-09-23 | 2009-11-04 | Nanoco Technologies Ltd | Semiconductor nanoparticle-based materials |
-
2013
- 2013-06-07 HR HRP20170296TT patent/HRP20170296T1/hr unknown
- 2013-06-07 WO PCT/US2013/044792 patent/WO2013185078A1/en not_active Ceased
- 2013-06-07 CN CN201380040107.2A patent/CN104508150B/zh active Active
- 2013-06-07 ES ES13801106.9T patent/ES2617226T3/es active Active
- 2013-06-07 CA CA2873099A patent/CA2873099C/en active Active
- 2013-06-07 EP EP13801106.9A patent/EP2859121B1/en active Active
- 2013-06-07 US US14/401,791 patent/US20150141259A1/en not_active Abandoned
- 2013-06-07 RU RU2014152698A patent/RU2666989C2/ru not_active Application Discontinuation
- 2013-06-07 SG SG11201407505XA patent/SG11201407505XA/en unknown
- 2013-06-07 JP JP2015516253A patent/JP6298456B2/ja active Active
- 2013-06-07 NZ NZ701824A patent/NZ701824A/en not_active IP Right Cessation
- 2013-06-07 KR KR1020147034387A patent/KR102088381B1/ko active Active
- 2013-06-07 CN CN201810446555.7A patent/CN108614102A/zh active Pending
- 2013-06-07 SG SG10201701361WA patent/SG10201701361WA/en unknown
- 2013-06-07 BR BR112014030298-7A patent/BR112014030298B1/pt active IP Right Grant
- 2013-06-07 IN IN2647KON2014 patent/IN2014KN02647A/en unknown
- 2013-06-07 AU AU2013271401A patent/AU2013271401B2/en active Active
- 2013-06-07 MY MYPI2014703374A patent/MY170164A/en unknown
- 2013-06-07 MX MX2014014784A patent/MX356413B/es active IP Right Grant
-
2014
- 2014-11-09 IL IL235588A patent/IL235588B/en active IP Right Grant
- 2014-11-17 ZA ZA2014/08409A patent/ZA201408409B/en unknown
- 2014-11-19 PH PH12014502581A patent/PH12014502581B1/en unknown
-
2017
- 2017-02-22 CY CY20171100249T patent/CY1118748T1/el unknown
- 2017-03-09 US US15/454,080 patent/US20170176422A1/en not_active Abandoned
- 2017-11-30 US US15/827,441 patent/US20180224444A1/en not_active Abandoned
-
2021
- 2021-03-30 US US17/217,006 patent/US20210239692A1/en not_active Abandoned
-
2025
- 2025-01-10 US US19/015,991 patent/US20250147022A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015520385A5 (enExample) | ||
| US20250147022A1 (en) | Multiplexed Analyses of Test Samples | |
| JP2010533872A5 (enExample) | ||
| JP6525872B2 (ja) | 細胞中の複数のエピトープを同定するためのダイナミックレンジを高めること | |
| US20140249043A1 (en) | Multiplexed Analyses of Test Samples | |
| CN101384733A (zh) | 通过元素分析实施的基因表达检测 | |
| US20110262922A1 (en) | Aptamer sandwich assays | |
| JP2022501005A (ja) | アッセイを改善する為の化合物、組成物、及び方法 | |
| JP2009000070A (ja) | 大規模並列核酸分析方法 | |
| Nguyen et al. | Microfluidic aptameric affinity sensing of vasopressin for clinical diagnostic and therapeutic applications | |
| JP2002505846A (ja) | シグナル増幅およびプロセッシングのための多重逐次的ポリヌクレオチド置換反応 | |
| CN113913944B (zh) | 蛋白共修饰dna芯片及其制备方法 | |
| CN101148667B (zh) | 一种亲和人白蛋白核酸适配子的制备与用途 | |
| KR102177672B1 (ko) | 압타머를 이용한 다중(multiplex) PCR 방법 | |
| KR101580360B1 (ko) | 연자성미세구조물을 이용한 리간드의 스크리닝 시스템 및 그 용도 | |
| KR102403628B1 (ko) | 시료의 표적분자 집단에 대한 프로파일을 얻는 방법 | |
| US12480158B1 (en) | Methods and systems for processing polynucleotides | |
| CN201473549U (zh) | 适配子型生物芯片 | |
| WO2022146745A1 (en) | Rehydration buffer solutions and methods | |
| KR20220077546A (ko) | 시료의 표적분자 집단에 대한 프로파일을 얻는 방법 | |
| JP2011072210A (ja) | センサーチップ及びその使用方法 | |
| CN113740535A (zh) | 检测肝肿瘤组织豪猪音配体的方法 | |
| JP2020000157A5 (enExample) |