IN2014KN02647A - - Google Patents

Info

Publication number
IN2014KN02647A
IN2014KN02647A IN2647KON2014A IN2014KN02647A IN 2014KN02647 A IN2014KN02647 A IN 2014KN02647A IN 2647KON2014 A IN2647KON2014 A IN 2647KON2014A IN 2014KN02647 A IN2014KN02647 A IN 2014KN02647A
Authority
IN
India
Prior art keywords
aptamer
target
kits
nucleic acid
detection
Prior art date
Application number
Inventor
Glenn Sanders
Stephan Kraemer
Evaldas Katilius
Original Assignee
Somalogic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Somalogic Inc filed Critical Somalogic Inc
Publication of IN2014KN02647A publication Critical patent/IN2014KN02647A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/205—Aptamer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.
IN2647KON2014 2012-06-07 2013-06-07 IN2014KN02647A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261656956P 2012-06-07 2012-06-07
PCT/US2013/044792 WO2013185078A1 (en) 2012-06-07 2013-06-07 Aptamer-based multiplexed assays

Publications (1)

Publication Number Publication Date
IN2014KN02647A true IN2014KN02647A (en) 2015-05-08

Family

ID=49712701

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2647KON2014 IN2014KN02647A (en) 2012-06-07 2013-06-07

Country Status (21)

Country Link
US (5) US20150141259A1 (en)
EP (1) EP2859121B1 (en)
JP (1) JP6298456B2 (en)
KR (1) KR102088381B1 (en)
CN (2) CN104508150B (en)
AU (1) AU2013271401B2 (en)
BR (1) BR112014030298B1 (en)
CA (1) CA2873099C (en)
CY (1) CY1118748T1 (en)
ES (1) ES2617226T3 (en)
HR (1) HRP20170296T1 (en)
IL (1) IL235588B (en)
IN (1) IN2014KN02647A (en)
MX (1) MX356413B (en)
MY (1) MY170164A (en)
NZ (1) NZ701824A (en)
PH (1) PH12014502581B1 (en)
RU (1) RU2666989C2 (en)
SG (2) SG11201407505XA (en)
WO (1) WO2013185078A1 (en)
ZA (1) ZA201408409B (en)

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US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US8975026B2 (en) 2007-01-16 2015-03-10 Somalogic, Inc. Method for generating aptamers with improved off-rates
US20110136099A1 (en) 2007-01-16 2011-06-09 Somalogic, Inc. Multiplexed Analyses of Test Samples
CN106133211A (en) * 2014-01-14 2016-11-16 爱普济德生物技术有限公司 Nucleic acid reagent for carrying out hypersensitive Digital Detecting and quantitative purposes to target molecule
ES2764669T3 (en) 2014-02-18 2020-06-04 Somalogic Inc Compositions and methods for the detection of microorganisms
CN106574925B (en) * 2014-05-23 2019-07-26 萤火虫生物股份有限公司 Substrate-mediated reactors for bioassays
GB2528643A (en) * 2014-07-08 2016-02-03 Adc Biotechnology Ltd Method of synthesising ADCs
KR102003589B1 (en) * 2016-03-03 2019-07-24 성균관대학교산학협력단 Bid molecule detection sensor and method for detecting specific molecule using multi-wavelength fluorescence
CN105779609A (en) * 2016-04-15 2016-07-20 上海伊丽萨生物科技有限公司 Hypersensitivity immunodetection method
EP3526604A1 (en) * 2016-10-13 2019-08-21 Laboratory Corporation of America Holdings Devices and methods to reduce interfering compounds in biological samples
EP3775891A4 (en) * 2018-04-13 2022-04-13 Fluidigm Canada Inc. ACQUISITION OF STABILIZED CELLS FOR ELEMENTAL ANALYSIS
JP7526102B2 (en) * 2018-06-22 2024-07-31 ソマロジック・オペレイティング・カンパニー・インコーポレイテッド Improved Proteomic Multiplex Assays
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KR102177672B1 (en) * 2019-02-01 2020-11-12 주식회사 압타머사이언스 Multiplex PCR method using Aptamer
KR102113078B1 (en) * 2019-07-05 2020-05-20 광주과학기술원 A screening method of aptamer
CN110791551A (en) * 2019-09-17 2020-02-14 北京化工大学 Method for establishing carrier-free chloramphenicol aptamer signal amplification sensor
US20230093390A1 (en) * 2019-12-03 2023-03-23 Sung Chun Kim Method for obtaining profile of target molecule population of sample
CN113624724A (en) * 2020-05-07 2021-11-09 廖世奇 Multi-element detection and analysis method of aptamer molecular beacon for target molecule
CN111812313B (en) * 2020-06-22 2021-10-08 北京生物制品研究所有限责任公司 Dissociation method of antigen in aluminum adjuvant adsorption type novel coronavirus inactivated vaccine
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KR20220167781A (en) * 2021-06-14 2022-12-21 김성천 Method for Obtaining Profiles for Population of Target Protein Molecules of a Sample Using Aptamers
CA3241776A1 (en) * 2021-12-30 2023-07-06 Dom Zichi Next-generation sequencing for protein measurement
CN116103367B (en) * 2022-11-11 2025-12-23 杭州佰辰医学检验所有限公司 Method for detecting target object
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WO2025166038A1 (en) * 2024-02-02 2025-08-07 Illumina, Inc. Improved aptamer detection techniques
CN121272015A (en) * 2024-07-03 2026-01-06 常州福洛森医疗科技有限公司 Use of aptamers in addressability detection

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Also Published As

Publication number Publication date
US20180224444A1 (en) 2018-08-09
PH12014502581A1 (en) 2015-01-21
WO2013185078A1 (en) 2013-12-12
NZ701824A (en) 2017-01-27
ZA201408409B (en) 2017-08-30
MX2014014784A (en) 2015-03-19
AU2013271401A1 (en) 2014-11-27
JP2015520385A (en) 2015-07-16
IL235588B (en) 2018-07-31
CN108614102A (en) 2018-10-02
BR112014030298B1 (en) 2022-09-27
KR20150030655A (en) 2015-03-20
KR102088381B1 (en) 2020-03-13
SG11201407505XA (en) 2014-12-30
JP6298456B2 (en) 2018-03-20
BR112014030298A8 (en) 2022-03-08
EP2859121A4 (en) 2015-12-16
EP2859121B1 (en) 2016-11-30
US20170176422A1 (en) 2017-06-22
ES2617226T8 (en) 2019-08-27
HK1204341A1 (en) 2015-11-13
ES2617226T3 (en) 2017-06-15
CA2873099C (en) 2021-06-15
MY170164A (en) 2019-07-09
MX356413B (en) 2018-05-29
CY1118748T1 (en) 2017-07-12
AU2013271401B2 (en) 2018-04-05
EP2859121A1 (en) 2015-04-15
IL235588A0 (en) 2015-01-29
HRP20170296T1 (en) 2017-04-21
CA2873099A1 (en) 2013-12-12
CN104508150A (en) 2015-04-08
SG10201701361WA (en) 2017-04-27
CN104508150B (en) 2021-03-12
RU2014152698A (en) 2016-08-10
BR112014030298A2 (en) 2017-06-27
PH12014502581B1 (en) 2022-02-02
US20250147022A1 (en) 2025-05-08
US20150141259A1 (en) 2015-05-21
US20210239692A1 (en) 2021-08-05
RU2666989C2 (en) 2018-09-13

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