JP2010521990A5 - - Google Patents

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JP2010521990A5
JP2010521990A5 JP2010501136A JP2010501136A JP2010521990A5 JP 2010521990 A5 JP2010521990 A5 JP 2010521990A5 JP 2010501136 A JP2010501136 A JP 2010501136A JP 2010501136 A JP2010501136 A JP 2010501136A JP 2010521990 A5 JP2010521990 A5 JP 2010521990A5
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cell
primate
cells
potential
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JP5813321B2 (ja
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JP2010501136A 2007-03-23 2008-03-21 体細胞の再プログラム化 Active JP5813321B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US91968707P 2007-03-23 2007-03-23
US60/919,687 2007-03-23
US97498007P 2007-09-25 2007-09-25
US60/974,980 2007-09-25
US98905807P 2007-11-19 2007-11-19
US60/989,058 2007-11-19
PCT/US2008/057924 WO2008118820A2 (en) 2007-03-23 2008-03-21 Somatic cell reprogramming

Related Child Applications (1)

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JP2015094203A Division JP6788329B2 (ja) 2007-03-23 2015-05-01 体細胞の再プログラム化

Publications (3)

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JP2010521990A JP2010521990A (ja) 2010-07-01
JP2010521990A5 true JP2010521990A5 (OSRAM) 2011-04-14
JP5813321B2 JP5813321B2 (ja) 2015-11-17

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JP2010501136A Active JP5813321B2 (ja) 2007-03-23 2008-03-21 体細胞の再プログラム化
JP2015094203A Active JP6788329B2 (ja) 2007-03-23 2015-05-01 体細胞の再プログラム化
JP2018147684A Pending JP2018183183A (ja) 2007-03-23 2018-08-06 体細胞の再プログラム化
JP2018147683A Active JP6924732B2 (ja) 2007-03-23 2018-08-06 体細胞の再プログラム化
JP2021126772A Pending JP2021176331A (ja) 2007-03-23 2021-08-02 体細胞の再プログラム化
JP2024010931A Pending JP2024038501A (ja) 2007-03-23 2024-01-29 体細胞の再プログラム化

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JP2018147684A Pending JP2018183183A (ja) 2007-03-23 2018-08-06 体細胞の再プログラム化
JP2018147683A Active JP6924732B2 (ja) 2007-03-23 2018-08-06 体細胞の再プログラム化
JP2021126772A Pending JP2021176331A (ja) 2007-03-23 2021-08-02 体細胞の再プログラム化
JP2024010931A Pending JP2024038501A (ja) 2007-03-23 2024-01-29 体細胞の再プログラム化

Country Status (11)

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US (7) US8440461B2 (OSRAM)
EP (2) EP3399025B1 (OSRAM)
JP (6) JP5813321B2 (OSRAM)
KR (1) KR101516833B1 (OSRAM)
CN (1) CN101743306A (OSRAM)
AU (1) AU2008231020B2 (OSRAM)
CA (1) CA2684242C (OSRAM)
DK (1) DK3399025T3 (OSRAM)
IL (1) IL200982A (OSRAM)
SG (2) SG193652A1 (OSRAM)
WO (1) WO2008118820A2 (OSRAM)

Families Citing this family (248)

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Publication number Priority date Publication date Assignee Title
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US8034613B2 (en) 2005-06-01 2011-10-11 Wisconsin Alumni Research Foundation Multipotent lymphohematopoietic progenitor cells
GB2440494B (en) * 2005-06-01 2010-07-28 Wisconsin Alumni Res Found Method of forming dendritic from embryonic stem cells
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
EP4223769A3 (en) 2005-12-13 2023-11-01 Kyoto University Nuclear reprogramming factor
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
CA2641967C (en) 2006-02-09 2019-03-19 Wisconsin Alumni Research Foundation Erythroid cells producing adult-type .beta.-hemoglobin generated from human embryonic stem cells
CN101743306A (zh) 2007-03-23 2010-06-16 威斯康星校友研究基金会 体细胞重编程
EP3878949B1 (en) 2007-04-07 2025-06-04 Whitehead Institute for Biomedical Research Reprogramming of somatic cells
US9213999B2 (en) * 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US20110236971A2 (en) * 2007-09-25 2011-09-29 Maksym Vodyanyk Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions
AU2008297024B2 (en) * 2007-10-31 2014-08-28 Kyoto University Nuclear reprogramming method
AU2008286249B2 (en) * 2007-12-10 2013-10-10 Kyoto University Efficient method for nuclear reprogramming
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
US20100279404A1 (en) 2008-05-02 2010-11-04 Shinya Yamanaka Method of nuclear reprogramming
US20090280096A1 (en) * 2008-05-09 2009-11-12 Atsushi Kubo Pancreatic endocrine progenitor cells derived from pluripotent stem cells
KR101871192B1 (ko) * 2008-06-04 2018-06-27 후지필름 셀룰러 다이내믹스, 인코포레이티드 비-바이러스 접근법을 사용한 iPS 세포의 생산 방법
EP3231869A1 (en) 2008-06-13 2017-10-18 Whitehead Institute for Biomedical Research Programming and reprogramming of cells
JP5340265B2 (ja) 2008-06-27 2013-11-13 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
WO2010013845A1 (en) * 2008-07-30 2010-02-04 Kyoto University Method of efficiently establishing induced pluripotent stem cells
EP3330371A1 (en) 2008-08-12 2018-06-06 Cellular Dynamics International, Inc. Methods for the production of ips cells
WO2010033906A2 (en) * 2008-09-19 2010-03-25 President And Fellows Of Harvard College Efficient induction of pluripotent stem cells using small molecule compounds
WO2010042800A1 (en) * 2008-10-10 2010-04-15 Nevada Cancer Institute Methods of reprogramming somatic cells and methods of use for such cells
DK3450545T5 (da) * 2008-10-24 2024-09-09 Wisconsin Alumni Res Found Pluripotente stamceller opnået ved ikke-viral omprogrammering
EP2342333A4 (en) * 2008-10-30 2013-05-08 Univ Kyoto Method for producing induced pluripotent stem cells
WO2010056808A2 (en) * 2008-11-12 2010-05-20 The Regents Of The University Of California Compositions and methods for re-programming and re-differentiating cells
EP2376626A4 (en) * 2008-12-13 2012-10-17 Dna Microarray MICRO-ENVIRONMENTAL NICHE ASSAY FOR SCREENING OF INDUCED PLURIPOTENT STEM CELLS (CIPS)
US20110300627A1 (en) * 2009-01-20 2011-12-08 Sing George L Dedifferentiation and reprogramming of cells
US8557580B2 (en) 2009-02-20 2013-10-15 Cellular Dynamics International, Inc. Methods and compositions for the differentiation of stem cells
CA2753845C (en) * 2009-02-27 2019-10-29 Kyoto University Nuclear reprogramming substance comprising glis1
EP2408904B1 (en) 2009-03-20 2017-10-18 Mesoblast, Inc. Production of reprogrammed pluripotent cells
DK2421957T3 (da) 2009-04-22 2021-01-25 Viacyte Inc Cellesammensætninger afledt af dedifferentierede omprogrammerede celler
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
US9005975B2 (en) 2009-05-29 2015-04-14 Kyoto University Method for selecting clone of induced pluripotent stem cells
AU2010254811B2 (en) 2009-06-05 2015-02-19 FUJIFILM Cellular Dynamics, Inc. Reprogramming T cells and hematopoietic cells
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
JP5645197B2 (ja) * 2009-06-23 2014-12-24 学校法人日本大学 幹細胞の未分化状態を維持する新規方法
JP5751548B2 (ja) 2009-08-07 2015-07-22 国立大学法人京都大学 イヌiPS細胞及びその製造方法
SG10201608797WA (en) 2009-08-07 2016-12-29 Univ Kyoto Method of efficiently establishing induced pluripotent stem cells
JP5709015B2 (ja) 2009-08-19 2015-04-30 国立大学法人大阪大学 角膜移植用シート
JP5773393B2 (ja) 2009-09-24 2015-09-02 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
GB2474492B (en) * 2009-10-19 2014-05-21 Tristem Trading Cyprus Ltd Treatment using reprogrammed mature adult cells
JP5957382B2 (ja) * 2009-10-29 2016-07-27 ヤンセン バイオテツク,インコーポレーテツド 多能性幹細胞
CA2779039A1 (en) 2009-10-29 2011-05-05 Mcmaster University Generating induced pluripotent stem cells and progenitor cells from fibroblasts
JP5898086B2 (ja) 2009-11-04 2016-04-06 セルラー ダイナミクス インターナショナル, インコーポレイテッド 化学物質を用いるエピソームリプログラミング
WO2011071118A1 (ja) 2009-12-09 2011-06-16 国立大学法人京都大学 ニトロビンを含む多能性幹細胞の心筋細胞への分化促進剤
JP2011121949A (ja) 2009-12-14 2011-06-23 Kyoto Univ 筋萎縮性側索硬化症の予防および治療用医薬組成物
WO2011090221A1 (en) 2010-01-22 2011-07-28 Kyoto University Method for improving induced pluripotent stem cell generation efficiency
KR101857302B1 (ko) 2010-02-16 2018-05-11 고쿠리츠 다이가쿠 호진 교토 다이가쿠 유도된 다능성 줄기 세포의 효율적 확립 방법
CN102190731B (zh) * 2010-03-09 2016-01-27 中国科学院上海生命科学研究院 用人工转录因子诱导产生多能干细胞
US9080170B2 (en) 2010-03-17 2015-07-14 Association Institut De Myologie Modified U7 snRNAs for treatment of neuromuscular diseases
EP2551343B1 (en) * 2010-03-23 2018-05-02 Olympus Corporation Method for monitoring state of differentiation in a stem cell
CA2796616A1 (en) 2010-04-21 2011-10-27 Research Development Foundation Methods and compositions related to dopaminergic neuronal cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
WO2011143400A2 (en) * 2010-05-13 2011-11-17 The Regents Of The University Of California Method and composition for inducing human pluripotent stem cells
CN103003416B (zh) 2010-06-15 2016-11-16 细胞动力学国际有限公司 从小体积的外周血产生诱导性多潜能干细胞
US8932857B2 (en) 2010-06-15 2015-01-13 Kyoto University Method for selecting reduced differentiation resistance human induced pluripotent stem cells
US9938496B2 (en) 2010-08-13 2018-04-10 Kyoto University Method of inducing differentiation from pluripotent stem cells to germ cells
US9057734B2 (en) 2010-08-23 2015-06-16 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
WO2012026491A1 (ja) 2010-08-26 2012-03-01 国立大学法人京都大学 多能性幹細胞の心筋分化促進剤
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
JP5835729B2 (ja) 2010-09-02 2015-12-24 国立大学法人京都大学 筋萎縮性側索硬化症の予防および治療用医薬組成物
JP5794588B2 (ja) 2010-09-14 2015-10-14 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
CN103459611B (zh) 2010-09-17 2016-11-02 哈佛大学校长及研究员协会 对多能干细胞的效用和安全性进行表征的功能基因组学研究
EP2630232A4 (en) 2010-10-22 2014-04-02 Biotime Inc METHOD FOR MODIFYING TRANSCRIPTIONAL REGULATORY NETWORKS IN STEM CELLS
EP2647699B1 (en) 2010-12-03 2020-04-01 Kyoto University Efficient method for establishing induced pluripotent stem cells
JP2014506453A (ja) 2011-01-19 2014-03-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 生得的多能性体細胞
WO2012098260A1 (en) 2011-01-21 2012-07-26 Axiogenesis Ag A non-viral system for the generation of induced pluripotent stem (ips) cells
WO2012137970A1 (ja) 2011-04-08 2012-10-11 国立大学法人大阪大学 改変ラミニンおよびその利用
WO2012141181A1 (ja) * 2011-04-11 2012-10-18 国立大学法人京都大学 核初期化物質
US9133266B2 (en) 2011-05-06 2015-09-15 Wisconsin Alumni Research Foundation Vitronectin-derived cell culture substrate and uses thereof
KR101791926B1 (ko) 2011-07-25 2017-11-20 고쿠리츠 다이가쿠 호진 교토 다이가쿠 유도 만능 줄기 세포 스크리닝 방법
WO2013028702A1 (en) * 2011-08-22 2013-02-28 Mayo Foundation For Medical Education And Research Methods and materials for obtaining induced pluripotent stem cells
US20130058905A1 (en) 2011-08-23 2013-03-07 Igor Slukvin Angiohematopoietic Progenitor Cells
US20130274184A1 (en) * 2011-10-11 2013-10-17 The Trustees Of Columbia University In The City Of New York Er stress relievers in beta cell protection
WO2013058403A1 (ja) 2011-10-21 2013-04-25 国立大学法人京都大学 層流による多能性維持単一分散細胞培養法
GB2496375A (en) 2011-10-28 2013-05-15 Kymab Ltd A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
WO2013077423A1 (ja) 2011-11-25 2013-05-30 国立大学法人京都大学 多能性幹細胞の培養方法
US8450107B1 (en) 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
WO2013082268A1 (en) * 2011-11-30 2013-06-06 The Wistar Institute Of Anatomy And Biology Methods and compositions for regulation of cell aging, carcinogenesis, and reprogramming
GB201122047D0 (en) 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
BR112014013664A2 (pt) 2011-12-05 2020-11-03 Factor Bioscience Inc. métodos e produtos para transfectar células
US8772460B2 (en) 2011-12-16 2014-07-08 Wisconsin Alumni Research Foundation Thermostable FGF-2 mutant having enhanced stability
US9587220B2 (en) 2012-01-27 2017-03-07 Kyoto University Method for inducing cardiac differentiation of pluripotent stem cell
CA2874259C (en) 2012-05-23 2021-02-09 Kyoto University Highly efficient method for establishing induced pluripotent stem cell
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY
WO2014028493A2 (en) 2012-08-13 2014-02-20 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
US9175263B2 (en) 2012-08-22 2015-11-03 Biotime, Inc. Methods and compositions for targeting progenitor cell lines
JPWO2014057997A1 (ja) 2012-10-09 2016-09-05 仲信 林 初期化ペプチド及びその用途
JP6366582B2 (ja) 2012-10-23 2018-08-01 国立大学法人京都大学 効率的に人工多能性幹細胞を樹立する方法
BR122019025681B1 (pt) 2012-11-01 2023-04-18 Factor Bioscience Inc Método para inserir uma sequência de ácido nucleico em uma localização segura de um genoma de uma célula
DK3766962T3 (da) 2013-02-06 2025-11-17 Univ Rochester Inducerede, pluripotente, celleafledte oligodendrocyt-progenitorceller til behandling af myelinforstyrrelser
JP6495658B2 (ja) 2013-02-08 2019-04-03 国立大学法人京都大学 巨核球及び血小板の製造方法
WO2014136581A1 (ja) 2013-03-06 2014-09-12 国立大学法人京都大学 多能性幹細胞の培養システム及び多能性幹細胞の継代方法
JP6351567B2 (ja) 2013-03-08 2018-07-04 国立大学法人京都大学 Egf受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
CA3141731A1 (en) 2013-03-13 2014-10-09 Wisconsin Alumni Research Foundation Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
JP6473077B2 (ja) 2013-03-21 2019-02-20 国立大学法人京都大学 神経分化誘導用の多能性幹細胞
WO2014157257A1 (ja) 2013-03-25 2014-10-02 公益財団法人先端医療振興財団 細胞の選別方法
EP2985344B1 (en) 2013-04-12 2018-07-18 Kyoto University Method for inducing alveolar epithelium progenitor cells
EP2998391B1 (en) 2013-05-14 2020-02-19 Kyoto University Efficient myocardial cell induction method
KR101870174B1 (ko) 2013-05-31 2018-06-22 아이하트 재팬 가부시키가이샤 하이드로겔을 포함하는 적층화된 세포 시트
EP3888640B1 (en) 2013-06-05 2025-09-17 Reverse Bioengineering, Inc. Compositions and methods for induced tissue regeneration in mammalian species
WO2014200905A2 (en) 2013-06-10 2014-12-18 President And Fellows Of Harvard College Early developmental genomic assay for characterizing pluripotent stem cell utility and safety
BR112015030918A2 (pt) 2013-06-11 2017-12-05 Astellas Pharma Inc método para produção de células progenitoras renais, e fármacos contendo células progenitoras renais
WO2015006725A2 (en) 2013-07-12 2015-01-15 Cedars-Sinai Medical Center Generation of induced pluripotent stem cells from normal human mammary epithelial cells
EP3031905A4 (en) 2013-08-07 2017-04-26 Kyoto University Method for producing pancreatic hormone-producing cell
MY184219A (en) 2013-09-05 2021-03-26 Univ Kyoto New method for inducing dopamine-producing neural precursor cells
JP6611170B2 (ja) 2013-09-12 2019-11-27 株式会社カネカ 人工多能性幹細胞の分化誘導方法及び選別方法
JP6333830B2 (ja) 2013-09-13 2018-05-30 国立大学法人京都大学 多能性幹細胞の心筋分化を促進する化合物
WO2015064754A1 (ja) 2013-11-01 2015-05-07 国立大学法人京都大学 新規軟骨細胞誘導方法
WO2015069736A1 (en) 2013-11-08 2015-05-14 The Mclean Hospital Corporation METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS
US11377639B2 (en) 2013-11-15 2022-07-05 Wisconsin Alumni Research Foundation Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors
CN105814194A (zh) 2013-12-11 2016-07-27 辉瑞有限公司 产生视网膜色素上皮细胞的方法
US9770489B2 (en) 2014-01-31 2017-09-26 Factor Bioscience Inc. Methods and products for nucleic acid production and delivery
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US10233426B2 (en) 2014-05-30 2019-03-19 Kyoto University Method for inducing cardiac differentiation of pluripotent stem cell with low-molecular compounds
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
JP7012432B2 (ja) 2014-07-14 2022-01-28 中外製薬株式会社 タンパク質のエピトープを同定するための方法
SG11201701191WA (en) 2014-07-18 2017-03-30 Univ Kyoto Method for inducing t cells for cell-based immunotherapy from pluripotent stem cells
EP3194571A4 (en) 2014-09-18 2018-04-18 North Carolina State University Mammalian lung spheroids and lung spheroid cells and uses thereof
JP6878274B2 (ja) 2014-10-03 2021-05-26 シーダーズ−サイナイ・メディカル・センターCedars−Sinai Medical Center 筋ジストロフィーの処置における心筋球由来細胞およびこのような細胞によって分泌されたエキソソーム
WO2016057574A1 (en) 2014-10-06 2016-04-14 Memorial Sloan-Kettering Cancer Center Method to reduce oncogenic potential of induced pluripotent stem cells from aged donors
PL3233129T3 (pl) 2014-12-17 2020-11-02 Fundacion Para La Investigacion Medica Aplicada Konstrukty kwasu nukleinowego i wektory terapii genowej do zastosowania w leczeniu choroby Wilsona i innych schorzeń
US11147887B2 (en) 2014-12-17 2021-10-19 Fundación Para La Investigación Mèdica Aplicada Nucleic acid constructs and gene therapy vectors for use in the treatment of Wilson disease
US10711249B2 (en) 2014-12-26 2020-07-14 Kyoto University Method for inducing hepatocytes
KR102459458B1 (ko) 2015-01-16 2022-10-25 고쿠리츠켄큐카이하츠호진 상교기쥬츠 소고켄큐쇼 스텔스성을 가지는 rna를 사용한 유전자 발현계 및 당해 rna를 포함하는 유전자 도입ㆍ발현벡터
US11241505B2 (en) 2015-02-13 2022-02-08 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
JP2016202172A (ja) 2015-04-16 2016-12-08 国立大学法人京都大学 疑似膵島の製造方法
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
AU2016321170B2 (en) 2015-09-08 2022-09-01 Fujifilm Cellular Dynamics Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells
EP4001402A1 (en) 2015-09-08 2022-05-25 FUJIFILM Cellular Dynamics, Inc. Macs-based purification of stem cell-derived retinal pigment epithelium
ES2862676T3 (es) 2015-10-20 2021-10-07 Fujifilm Cellular Dynamics Inc Producción de células precursoras hematopoyéticas multilinaje mediante programación genética
SG11201804197RA (en) 2015-11-18 2018-06-28 Orbis Health Solutions Llc T7 alpha viral vector system
WO2017089307A1 (en) * 2015-11-24 2017-06-01 Glaxosmithkline Intellectual Property Development Limited Transient transfection method for retroviral production
CA3202332A1 (en) 2015-12-07 2017-06-15 Agex Therapeutics, Inc. Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
WO2017159862A1 (ja) 2016-03-18 2017-09-21 国立大学法人京都大学 多能性幹細胞由来心筋細胞の凝集体の凍結方法
HUE056387T2 (hu) 2016-04-15 2022-02-28 Univ Kyoto Eljárás antigénspecifikus CD8-pozitív T-sejtek indukálására
WO2017183736A1 (ja) 2016-04-22 2017-10-26 国立大学法人京都大学 ドーパミン産生神経前駆細胞の製造方法
EP3455346A1 (en) 2016-05-12 2019-03-20 Erasmus University Medical Center Rotterdam A method for culturing myogenic cells, cultures obtained therefrom, screening methods, and cell culture medium
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
CN105861447B (zh) * 2016-06-13 2017-12-19 广州市搏克生物技术有限公司 一种非病毒iPSCs诱导组合物及其试剂盒
US10221395B2 (en) 2016-06-16 2019-03-05 Cedars-Sinai Medical Center Efficient method for reprogramming blood to induced pluripotent stem cells
US11572545B2 (en) 2016-06-16 2023-02-07 Cedars-Sinai Medical Center Efficient method for reprogramming blood to induced pluripotent stem cells
CN105936889B (zh) * 2016-06-24 2019-10-18 肇庆大华农生物药品有限公司 一种ad293球形细胞团的培养方法
AU2017290805B2 (en) 2016-07-01 2023-11-16 Research Development Foundation Elimination of proliferating cells from stem cell-derived grafts
US10576167B2 (en) 2016-08-17 2020-03-03 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
JP7248571B2 (ja) 2016-10-05 2023-03-29 フジフィルム セルラー ダイナミクス,インコーポレイテッド MeCP2が破壊された誘導多能性幹細胞からの成熟系列の生成
CN110114470A (zh) 2016-12-27 2019-08-09 住友化学株式会社 诱导的多能性干细胞的评价方法及选择方法、以及诱导的多能性干细胞的制备方法
EP3572502B1 (en) 2017-01-20 2023-01-11 Kyoto University Method for producing cd8alpha +beta + cytotoxic t cells
WO2018139548A1 (ja) 2017-01-26 2018-08-02 国立大学法人大阪大学 幹細胞の中胚葉系細胞への分化誘導用培地および中胚葉系細胞の製造方法
US20190390169A1 (en) 2017-03-03 2019-12-26 Kyoto University Pancreatic progenitor cell production method
EP3597734A4 (en) 2017-03-14 2021-03-03 Kyoto University METHOD FOR PRODUCING HELPER T-CELLS FROM PLURIPOTENT STEM CELLS
AU2018254442B2 (en) 2017-04-18 2024-03-28 FUJIFILM Cellular Dynamics, Inc. Antigen-specific immune effector cells
WO2018195210A1 (en) 2017-04-19 2018-10-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
JP7457505B2 (ja) 2017-05-10 2024-03-28 ユニバーシティー オブ ロチェスター 神経精神障害を処置する方法
KR102594102B1 (ko) 2017-05-25 2023-10-25 고쿠리츠 다이가쿠 호진 교토 다이가쿠 중간 중배엽 세포로부터 신장 전구 세포로의 분화 유도 방법 및 다능성 줄기세포로부터 신장 전구 세포로의 분화 유도 방법
EP3640318A4 (en) 2017-06-14 2021-03-17 Takeda Pharmaceutical Company Limited CELL SEALING DEVICE
JP6758631B2 (ja) 2017-06-19 2020-09-23 国立大学法人大阪大学 角膜内皮細胞マーカー及びその利用
CN111164209A (zh) 2017-06-19 2020-05-15 公益财团法人神户医疗产业都市推进机构 多能干细胞的分化能力的预测方法和用于该预测方法的试剂
US10760057B2 (en) 2017-07-06 2020-09-01 Wisconsin Alumni Research Foundation Human pluripotent stem cell-based screening for smooth muscle cell differentiation and disease
US11718829B2 (en) * 2017-07-28 2023-08-08 Breakthrough Tech Llc Methods and compositions for manufacturing extracellular matrix
NL2019517B1 (en) 2017-09-08 2019-03-19 Univ Erasmus Med Ct Rotterdam New therapy for Pompe disease
US20210363496A1 (en) 2017-10-17 2021-11-25 Kyoto University Method for obtaining artificial neuromuscular junction from pluripotent stem cells
BR112020010883A2 (pt) 2017-12-01 2020-11-10 Encoded Therapeutics, Inc. proteínas de ligação a dna engenheiradas
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center MANIPULATED EXTRACELLULAR VESICLES FOR ENHANCED RELEASE INTO TISSUE
US12146137B2 (en) 2018-02-05 2024-11-19 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and Y-RNAS
TW201945536A (zh) 2018-03-19 2019-12-01 國立大學法人京都大學 水凝膠膠囊
BR112020021802A2 (pt) 2018-04-23 2021-02-23 Kyoto University métodos para produzir uma população de células produtoras de insulina ou uma população de células beta pancreáticas e para diminuir o número ou inibir a proliferação de células positivas para ki67, e, população de células progenitoras pancreáticas ou células em um estágio posterior de diferenciação
KR102847197B1 (ko) 2018-06-18 2025-08-20 유니버시티 오브 로체스터 정신분열증 및 다른 신경정신장애를 치료하는 방법
US12303549B2 (en) 2018-06-21 2025-05-20 University Of Rochester Methods of treating or inhibiting onset of Huntington's disease
SG11202100260QA (en) 2018-07-13 2021-02-25 Univ Kyoto METHOD FOR PRODUCING γδ T CELLS
US20210299331A1 (en) 2018-07-19 2021-09-30 Kyoto University Pluripotent stem cell-derived plate-shaped cartilage and method for producing the same
WO2020022261A1 (ja) 2018-07-23 2020-01-30 国立大学法人京都大学 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法
TW202016293A (zh) 2018-08-10 2020-05-01 國立大學法人京都大學 Cd3陽性細胞的製造方法
CA3109546A1 (en) 2018-09-07 2020-03-12 Wisconsin Alumni Research Foundation Generation of hematopoietic progenitor cells from human pluripotent stem cells
US20210292791A1 (en) 2018-10-12 2021-09-23 Vivet Therapeutics Codon-optimized transgene for the treatment of progressive familiar intrahepatic cholestasis type 3 (pfic3)
JP2022512930A (ja) 2018-11-07 2022-02-07 ヴィヴェ テラピューティクス 進行性家族性肝内胆汁鬱滞タイプ2(pfic2)の治療のためのコドン最適化abcb11導入遺伝子
WO2020102715A1 (en) * 2018-11-16 2020-05-22 Rapa Therapeutics, Llc Method for t cell de-differentiation and resulting cells
EP3880306A4 (en) 2018-11-16 2023-01-25 Rapa Therapeutics, LLC ALS TREATMENT USING INDUCED REGULATORY T (IT REG) CELLS
JP7532360B2 (ja) 2018-11-16 2024-08-13 エンコーデッド セラピューティクス, インコーポレイテッド ウィルソン病を処置するための組成物および方法
MX2021006208A (es) 2018-11-28 2021-10-01 Univ Texas Edición por multiplexación del genoma de células inmunitarias para mejorar la funcionalidad y resistencia al entorno supresor.
WO2020112493A1 (en) 2018-11-29 2020-06-04 Board Of Regents, The University Of Texas System Methods for ex vivo expansion of natural killer cells and use thereof
US12168781B2 (en) 2018-12-06 2024-12-17 Kirin Holdings Kabushiki Kaisha Production method for T cells or NK cells, medium for culturing T cells or NK cells, method for culturing T cells or NK cells, method for maintaining undifferentiated state of undifferentiated T cells, and growth-accelerating agent for T cells or NK cells
JP7518547B2 (ja) 2018-12-11 2024-07-18 ユニバーシティー オブ ロチェスター 統合失調症及び他の神経精神障害の治療方法
WO2020130147A1 (ja) 2018-12-21 2020-06-25 国立大学法人京都大学 ルブリシン局在軟骨様組織、その製造方法及びそれを含む関節軟骨損傷治療用組成物
WO2020138371A1 (ja) 2018-12-26 2020-07-02 キリンホールディングス株式会社 改変tcr及びその製造方法
WO2020167822A2 (en) 2019-02-13 2020-08-20 University Of Rochester Gene networks that mediate remyelination of the human brain
EP3933033A4 (en) 2019-02-26 2022-11-23 Tohoku University METHOD FOR PRODUCING AN AGGREGATE OF OSTEOBLASTS USING HUMAN IPS CELLS
CN113811316A (zh) 2019-05-15 2021-12-17 味之素株式会社 神经嵴细胞或角膜上皮细胞的纯化方法
CA3141455A1 (en) 2019-05-20 2020-11-26 Ajinomoto Co., Inc. Expansion culture method for cartilage or bone precursor cells
SG11202113048SA (en) 2019-05-29 2021-12-30 Encoded Therapeutics Inc Compositions and methods for selective gene regulation
KR20220039719A (ko) 2019-07-03 2022-03-29 팩터 바이오사이언스 인크. 양이온성 지질 및 이의 용도
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
US20230030814A1 (en) 2019-12-12 2023-02-02 National University Corporation Chiba University Freeze-Dried Preparations Comprising Megakaryocytes and Platelets
TWI886220B (zh) 2020-02-28 2025-06-11 美商千禧製藥公司 用於自富潛能幹細胞生產自然殺手細胞之方法
WO2021200901A1 (ja) 2020-03-31 2021-10-07 国立大学法人京都大学 T前駆細胞の製造方法
CA3185067A1 (en) 2020-05-26 2021-12-02 Kouichi Tamura Hypoimmunogenic cells
EP3922431A1 (en) 2020-06-08 2021-12-15 Erasmus University Medical Center Rotterdam Method of manufacturing microdevices for lab-on-chip applications
EP4170020A4 (en) 2020-06-17 2025-01-22 Kyoto University IMMUNOCOMPETENT CELLS WITH CHIMERIC ANTIGEN RECEPTOR EXPRESSION
EP4180516A4 (en) 2020-07-13 2024-01-17 Kyoto University SKELETON MUSCLE PRECURSOR CELLS AND METHOD FOR PURIFICATION THEREOF, COMPOSITION FOR THE TREATMENT OF MYOGENIC DISEASES AND METHOD FOR PRODUCING SKELETON MUSCLE PRECURSOR CELLS CONTAINING CELL GROUPS
JPWO2022019152A1 (OSRAM) 2020-07-20 2022-01-27
US20230265456A1 (en) 2020-08-10 2023-08-24 Fundacion Para La Investigacion Medica Aplicada Gene therapy vector expressing cyp27a1 for the treatment of cerebrotendinous xanthomatosis
CN116323917A (zh) 2020-08-18 2023-06-23 国立大学法人京都大学 人原始生殖细胞/人原始生殖细胞样细胞的维持扩增方法
CN116018402A (zh) 2020-09-04 2023-04-25 心脏康复株式会社 iPS细胞的品质改善剂、iPS细胞的制备方法、iPS细胞、及iPS细胞制备用组合物
US20230272433A1 (en) 2020-09-29 2023-08-31 Genethon Enhancing Utrophin Expression in Cell by Inducing Mutations Within Utrophin Regulatory Elements and Therapeutic Use Thereof
AU2021377699A1 (en) 2020-11-13 2023-06-15 Catamaran Bio, Inc. Genetically modified natural killer cells and methods of use thereof
EP4263818A1 (en) 2020-12-16 2023-10-25 Universitat Pompeu Fabra Therapeutic lama2 payload for treatment of congenital muscular dystrophy
EP4267197A1 (en) 2020-12-23 2023-11-01 Vivet Therapeutics Minimal bile acid inducible promoters for gene therapy
EP4310176A4 (en) 2021-03-17 2025-03-26 Astellas Pharma Inc. Pericyte with basic fibroblast growth factor (BFGF) gene inserted into it
JP2024513906A (ja) 2021-04-07 2024-03-27 センチュリー セラピューティクス,インコーポレイテッド 人工多能性幹細胞からアルファ-ベータt細胞を生成するための組成物および方法
BR112023018844A2 (pt) 2021-04-07 2023-10-10 Century Therapeutics Inc Composições e métodos para geração de células t gama-delta de células-tronco pluripotentes induzidas
JPWO2022230977A1 (OSRAM) 2021-04-30 2022-11-03
US20240254441A1 (en) 2021-06-04 2024-08-01 Kirin Holdings Kabushiki Kaisha Cell composition, method for producing cell composition, and pharmaceutical composition containing cell composition
WO2022259721A1 (ja) 2021-06-10 2022-12-15 味の素株式会社 間葉系幹細胞の製造方法
KR20240021878A (ko) 2021-06-15 2024-02-19 다케다 야쿠힌 고교 가부시키가이샤 다능성 줄기 세포로부터 자연 살해 세포를 생산하기 위한 방법
US20240316115A1 (en) 2021-07-15 2024-09-26 Astellas Pharma Inc. Method for producing vascular endothelial growth factor (vegf)- highly expressing pericyte-like cell
JPWO2023286834A1 (OSRAM) 2021-07-15 2023-01-19
WO2023003025A1 (ja) 2021-07-21 2023-01-26 国立大学法人京都大学 網膜組織の製造方法
WO2023017848A1 (ja) 2021-08-11 2023-02-16 国立大学法人京都大学 腎間質前駆細胞の製造方法並びにエリスロポエチン産生細胞、およびレニン産生細胞の製造方法
KR20240056604A (ko) 2021-09-13 2024-04-30 후지필름 셀룰러 다이내믹스, 인코포레이티드 수임 심장 전구세포의 제조 방법
WO2023049826A1 (en) 2021-09-23 2023-03-30 President And Fellows Of Harvard College Genetically encoded voltage indicators and uses thereof
WO2023053220A1 (ja) 2021-09-28 2023-04-06 公益財団法人京都大学iPS細胞研究財団 多能性幹細胞の製造方法
US20230123017A1 (en) * 2021-10-18 2023-04-20 Wisconsin Alumni Research Foundation Systems and methods for label-free tracking of human somatic cell reprogramming
US20230226116A1 (en) 2021-10-20 2023-07-20 University Of Rochester Method for rejuvenating glial progenitor cells and rejuvenated glial progenitor cells per se
CN118660710A (zh) 2021-10-20 2024-09-17 罗切斯特大学 用于年龄相关白质损失的竞争性治疗的分离神经胶质祖细胞
WO2023069843A1 (en) 2021-10-20 2023-04-27 University Of Rochester Humanized chimeras for the prospective assessment of cell addition and replacement therapies
WO2023081633A1 (en) 2021-11-02 2023-05-11 University Of Rochester Tcf7l2 mediated remyelination in the brain
EP4431605A4 (en) 2021-11-11 2025-12-10 Healios Kk Genetically modified pluripotent stem cell, derived immunocompetent cell, method for producing these cells and associated uses
EP4472648A1 (en) 2022-02-01 2024-12-11 University of Rochester Methods of generating a population of neurons from human glial progenitor cells and genetic constructs for carrying out such methods
WO2023153464A1 (ja) 2022-02-09 2023-08-17 住友ファーマ株式会社 多能性幹細胞から中脳底板領域の神経系細胞への分化における、培養液中の細胞の分化能を判定する方法
JPWO2023210713A1 (OSRAM) 2022-04-27 2023-11-02
EP4518876A1 (en) 2022-05-05 2025-03-12 University of Rochester Dual macroglial-microglial approach towards therapeutic cell replacement in neurodegenerative and neuropsychiatric disease
JP2025522360A (ja) 2022-06-08 2025-07-15 センチュリー セラピューティクス,インコーポレイテッド Cd16変異体およびnkg2dを発現する遺伝子操作した細胞ならびにその使用
EP4538384A1 (en) 2022-06-10 2025-04-16 Kyoto University Detection method and detection reagent for undifferentiated pluripotent stem cells
EP4563703A4 (en) 2022-07-26 2025-09-24 Univ Kyoto ARTIFICIAL RECEIVER HAVING A LOAD-SHEDDING STRUCTURE
EP4594471A1 (en) 2022-09-30 2025-08-06 Fujifilm Cellular Dynamics, Inc. Methods for the production of cardiac fibroblasts
WO2024157929A1 (ja) 2023-01-23 2024-08-02 住友ファーマ株式会社 網膜組織の製造方法
EP4658294A2 (en) 2023-02-02 2025-12-10 University of Rochester Competitive replacement of glial cells
WO2024248017A1 (ja) 2023-05-29 2024-12-05 国立研究開発法人理化学研究所 心筋細胞を成熟させる方法及び成熟した心筋細胞の製造方法

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4228457A1 (de) 1992-08-27 1994-04-28 Beiersdorf Ag Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen
DE4228458A1 (de) 1992-08-27 1994-06-01 Beiersdorf Ag Multicistronische Expressionseinheiten und deren Verwendung
FR2722208B1 (fr) 1994-07-05 1996-10-04 Inst Nat Sante Rech Med Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
DE19910044A1 (de) * 1999-03-08 2000-09-14 Bodo Plachter Virale Partikel, die nach Infektion durch humanes Cytomegalovirus freigesetzt werden und ihre Verwendung als Impfstoff
US20040199935A1 (en) * 1999-06-30 2004-10-07 Chapman Karen B. Cytoplasmic transfer to de-differentiate recipient cells
WO2001096532A2 (en) * 2000-06-15 2001-12-20 Tanja Dominko Method of generating pluripotent mammalian cells by fusion of a cytoplast fragment with a karyoplast
US20040235173A1 (en) 2000-07-03 2004-11-25 Gala Design, Inc. Production of host cells containing multiple integrating vectors by serial transduction
US20020136709A1 (en) * 2000-12-12 2002-09-26 Nucleus Remodeling, Inc. In vitro-derived adult pluripotent stem cells and uses therefor
AU2002247733B2 (en) * 2001-02-21 2007-12-13 The Wistar Institute Of Anatomy And Biology Recombinant vector containing infectious human cytomegalovirus genome with preserved wild-type characteristics of clinical isolates
WO2003018780A1 (en) * 2001-08-27 2003-03-06 Advanced Cell Technology, Inc. De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
JP2004248505A (ja) * 2001-09-21 2004-09-09 Norio Nakatsuji 移植抗原の一部または全てを欠除したes細胞由来の未分化な体細胞融合細胞およびその製造
ITMI20012110A1 (it) 2001-10-12 2003-04-12 Keryos Spa Vettori multi-cistronici utilizzabili in protocolli di trsferimento genico
EP1468094A4 (en) 2001-12-24 2005-01-26 Es Cell Int Pte Ltd METHOD OF TRANSDUCTING ES CELLS
GB0202149D0 (en) 2002-01-30 2002-03-20 Univ Edinburgh Pluripotency determining factors and uses thereof
GB0206357D0 (en) 2002-03-18 2002-05-01 Univ Bath Cells
JP5570677B2 (ja) * 2002-04-25 2014-08-13 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド α−ガラクトシダーゼA欠損症の治療
SI1572984T1 (sl) * 2002-12-16 2016-07-29 Technion Research & Development Foundation Ltd. Kulturni sistem brez hranilnih celic, brez kseno-komponent, za humane embrionalne matične celice
CA2515108A1 (en) 2003-02-07 2004-08-26 Wisconsin Alumni Research Foundation Directed genetic modifications of human stem cells
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
US7638331B2 (en) * 2004-01-02 2009-12-29 The Administration of the Tulane Rducation Fund Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery
WO2005080598A1 (ja) * 2004-02-19 2005-09-01 Dainippon Sumitomo Pharma Co., Ltd. 体細胞核初期化物質のスクリーニング方法
CN1950498A (zh) * 2004-03-10 2007-04-18 加利福尼亚大学董事会 培养胚胎干细胞的组合物和方法
KR100484653B1 (ko) 2004-05-06 2005-04-20 주식회사 대웅 원핵세포에서 활성형의 가용성 단백질을 제조하는 방법 및 이를 위한 폴리시스트론 벡터
US7465580B2 (en) 2004-05-19 2008-12-16 Wisconsin Alumni Research Foundation Non-cytotoxic oriP replicon
EP1756094A1 (en) 2004-06-18 2007-02-28 Glaxo Group Limited 3-cycloalkylbenzazepines as histamine h3 antagonists
US7566548B2 (en) * 2004-08-13 2009-07-28 University Of Massachusetts Methods for identifying therapeutic agents and for treating disease
ES2836764T3 (es) * 2005-08-03 2021-06-28 Astellas Inst For Regenerative Medicine Métodos mejorados de reprogramación de células somáticas animales
EP1943334A1 (en) 2005-09-02 2008-07-16 Agency for Science, Technology and Research Method of deriving progenitor cell line
WO2008020815A1 (en) 2006-08-15 2008-02-21 Agency For Science, Technology And Research Mesenchymal stem cell conditioned medium
US20070087437A1 (en) 2005-10-14 2007-04-19 Jifan Hu Methods for rejuvenating cells in vitro and in vivo
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
EP4223769A3 (en) * 2005-12-13 2023-11-01 Kyoto University Nuclear reprogramming factor
JP4803584B2 (ja) 2006-02-08 2011-10-26 独立行政法人産業技術総合研究所 脂質生産性の高い形質転換微生物
TW200817512A (en) 2006-07-07 2008-04-16 Kirin Pharma Kk Human artificial chromosome (hac) vector, and human cell pharmaceutical comprising human artificial chromosome (hac) vector
CN101553245A (zh) 2006-07-19 2009-10-07 佛罗里达大学研究基金会有限公司 用于细胞重编程的组合物及其用途
JP2008067693A (ja) 2006-08-15 2008-03-27 Ishihara Sangyo Kaisha Ltd 微生物変異体の新規利用方法
WO2008020595A1 (en) 2006-08-15 2008-02-21 Ishihara Sangyo Kaisha, Ltd. Novel method for utilization of microbial mutant
US20100069251A1 (en) 2006-09-15 2010-03-18 Children's Medical Center Corporation Methods for producing embryonic stem cells from parthenogenetic embryos
CN101743306A (zh) * 2007-03-23 2010-06-16 威斯康星校友研究基金会 体细胞重编程
PL2164993T3 (pl) 2007-05-29 2017-08-31 Christopher B. Reid Sposoby wytwarzania i zastosowań populacji komórek multipotencjalnych, populacji komórek pluripotencjalnych, populacji komórek zróżnicowanych i populacji komórek odpornych na HIV
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US20120282229A1 (en) 2007-08-01 2012-11-08 Christian Kannemeier Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
EP3078738B1 (en) 2007-08-31 2020-05-20 Whitehead Institute for Biomedical Research Wnt pathway stimulation in reprogramming somatic cells
US20110236971A2 (en) 2007-09-25 2011-09-29 Maksym Vodyanyk Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions
US7615374B2 (en) 2007-09-25 2009-11-10 Wisconsin Alumni Research Foundation Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions
WO2009058712A1 (en) * 2007-10-29 2009-05-07 Trustees Of Dartmouth College Toxoplasma gondii mutant with enhanced homologous recombination and uses thereof
AU2008297024B2 (en) 2007-10-31 2014-08-28 Kyoto University Nuclear reprogramming method
WO2009061442A1 (en) * 2007-11-06 2009-05-14 Children's Medical Center Corporation Method to produce induced pluripotent stem (ips) cells form non-embryonic human cells
US9005966B2 (en) 2007-11-19 2015-04-14 The Regents Of The University Of California Generation of pluripotent cells from fibroblasts
EP2072618A1 (en) 2007-12-14 2009-06-24 Johannes Gutenberg-Universität Mainz Use of RNA for reprogramming somatic cells
WO2009091543A1 (en) 2008-01-14 2009-07-23 Lindner Scott E An efficient orip/ebna-1 plasmid vector
WO2009092042A1 (en) 2008-01-18 2009-07-23 Nevada Cancer Institute Reprogramming of differentiated progenitor or somatic cells using homologous recombination
WO2009102983A2 (en) * 2008-02-15 2009-08-20 President And Fellows Of Harvard College Efficient induction of pluripotent stem cells using small molecule compounds
US20100279404A1 (en) 2008-05-02 2010-11-04 Shinya Yamanaka Method of nuclear reprogramming
KR101871192B1 (ko) 2008-06-04 2018-06-27 후지필름 셀룰러 다이내믹스, 인코포레이티드 비-바이러스 접근법을 사용한 iPS 세포의 생산 방법
WO2010012077A1 (en) 2008-07-28 2010-02-04 Mount Sinai Hospital Compositions, methods and kits for reprogramming somatic cells
EP3330371A1 (en) 2008-08-12 2018-06-06 Cellular Dynamics International, Inc. Methods for the production of ips cells
WO2010028019A2 (en) 2008-09-03 2010-03-11 The General Hospital Corporation Direct reprogramming of somatic cells using non-integrating vectors
DK3450545T5 (da) 2008-10-24 2024-09-09 Wisconsin Alumni Res Found Pluripotente stamceller opnået ved ikke-viral omprogrammering

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