JP2009511468A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009511468A5 JP2009511468A5 JP2008534469A JP2008534469A JP2009511468A5 JP 2009511468 A5 JP2009511468 A5 JP 2009511468A5 JP 2008534469 A JP2008534469 A JP 2008534469A JP 2008534469 A JP2008534469 A JP 2008534469A JP 2009511468 A5 JP2009511468 A5 JP 2009511468A5
- Authority
- JP
- Japan
- Prior art keywords
- extract
- composition
- weight
- parts
- obesity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 168
- 239000000284 extract Substances 0.000 claims description 163
- 244000062730 Melissa officinalis Species 0.000 claims description 82
- 230000003579 anti-obesity Effects 0.000 claims description 60
- 240000000249 Morus alba Species 0.000 claims description 47
- 240000006891 Artemisia vulgaris Species 0.000 claims description 42
- 235000008708 Morus alba Nutrition 0.000 claims description 42
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims description 41
- 238000000034 method Methods 0.000 claims description 39
- 239000004480 active ingredient Substances 0.000 claims description 31
- 208000008589 Obesity Diseases 0.000 claims description 26
- 235000020824 obesity Nutrition 0.000 claims description 26
- 239000000843 powder Substances 0.000 claims description 23
- 241000196324 Embryophyta Species 0.000 claims description 15
- 244000269722 Thea sinensis Species 0.000 claims description 15
- 239000000835 fiber Substances 0.000 claims description 15
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 14
- 235000009569 green tea Nutrition 0.000 claims description 14
- 229940094952 green tea extract Drugs 0.000 claims description 13
- 235000020688 green tea extract Nutrition 0.000 claims description 13
- 235000020710 ginseng extract Nutrition 0.000 claims description 12
- 241000208340 Araliaceae Species 0.000 claims description 8
- 244000000626 Daucus carota Species 0.000 claims description 8
- 235000002767 Daucus carota Nutrition 0.000 claims description 8
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 8
- 239000001913 cellulose Substances 0.000 claims description 8
- 229920002678 cellulose Polymers 0.000 claims description 8
- 235000008434 ginseng Nutrition 0.000 claims description 8
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- 229920002774 Maltodextrin Polymers 0.000 claims description 7
- 229940030961 sorghum extract Drugs 0.000 claims description 7
- 239000005913 Maltodextrin Substances 0.000 claims description 6
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims description 6
- 229940025902 konjac mannan Drugs 0.000 claims description 6
- 229940035034 maltodextrin Drugs 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 claims description 4
- 244000215068 Acacia senegal Species 0.000 claims description 4
- 229920000189 Arabinogalactan Polymers 0.000 claims description 4
- 239000001904 Arabinogalactan Substances 0.000 claims description 4
- 229920002907 Guar gum Polymers 0.000 claims description 4
- 229920000084 Gum arabic Polymers 0.000 claims description 4
- 229920002488 Hemicellulose Polymers 0.000 claims description 4
- 229920001202 Inulin Polymers 0.000 claims description 4
- 244000134552 Plantago ovata Species 0.000 claims description 4
- 235000003421 Plantago ovata Nutrition 0.000 claims description 4
- 239000009223 Psyllium Substances 0.000 claims description 4
- 239000000205 acacia gum Substances 0.000 claims description 4
- 235000010489 acacia gum Nutrition 0.000 claims description 4
- 239000000783 alginic acid Substances 0.000 claims description 4
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 229960001126 alginic acid Drugs 0.000 claims description 4
- 150000004781 alginic acids Chemical class 0.000 claims description 4
- 235000019312 arabinogalactan Nutrition 0.000 claims description 4
- 239000000665 guar gum Substances 0.000 claims description 4
- 235000010417 guar gum Nutrition 0.000 claims description 4
- 229960002154 guar gum Drugs 0.000 claims description 4
- 239000010903 husk Substances 0.000 claims description 4
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 4
- 229940029339 inulin Drugs 0.000 claims description 4
- AIHDCSAXVMAMJH-GFBKWZILSA-N levan Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(CO[C@@H]2[C@H]([C@H](O)[C@@](O)(CO)O2)O)O1 AIHDCSAXVMAMJH-GFBKWZILSA-N 0.000 claims description 4
- 229920005610 lignin Polymers 0.000 claims description 4
- 235000010987 pectin Nutrition 0.000 claims description 4
- 239000001814 pectin Substances 0.000 claims description 4
- 229920001277 pectin Polymers 0.000 claims description 4
- 229940070687 psyllium Drugs 0.000 claims description 4
- 229920001100 Polydextrose Polymers 0.000 claims description 3
- 239000008121 dextrose Substances 0.000 claims description 3
- 239000001259 polydextrose Substances 0.000 claims description 3
- 235000013856 polydextrose Nutrition 0.000 claims description 3
- 229940035035 polydextrose Drugs 0.000 claims description 3
- 241001125046 Sardina pilchardus Species 0.000 claims 1
- 235000019512 sardine Nutrition 0.000 claims 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 36
- 230000000694 effects Effects 0.000 description 34
- 210000004369 blood Anatomy 0.000 description 24
- 239000008280 blood Substances 0.000 description 24
- 230000037396 body weight Effects 0.000 description 24
- 210000000577 adipose tissue Anatomy 0.000 description 22
- 238000002360 preparation method Methods 0.000 description 22
- 238000011282 treatment Methods 0.000 description 16
- 210000004003 subcutaneous fat Anatomy 0.000 description 14
- 238000009472 formulation Methods 0.000 description 13
- 241000699670 Mus sp. Species 0.000 description 11
- 239000002775 capsule Substances 0.000 description 11
- 239000008103 glucose Substances 0.000 description 11
- 235000012000 cholesterol Nutrition 0.000 description 10
- 210000002149 gonad Anatomy 0.000 description 10
- 238000013116 obese mouse model Methods 0.000 description 10
- 235000015701 Artemisia arbuscula Nutrition 0.000 description 9
- 235000002657 Artemisia tridentata Nutrition 0.000 description 9
- 230000003247 decreasing effect Effects 0.000 description 9
- 239000002504 physiological saline solution Substances 0.000 description 9
- 210000001789 adipocyte Anatomy 0.000 description 8
- 230000008859 change Effects 0.000 description 8
- 238000000605 extraction Methods 0.000 description 8
- 235000013305 food Nutrition 0.000 description 8
- 230000001965 increasing effect Effects 0.000 description 8
- 150000002632 lipids Chemical class 0.000 description 8
- 210000004185 liver Anatomy 0.000 description 8
- 230000004584 weight gain Effects 0.000 description 8
- 235000019786 weight gain Nutrition 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 6
- -1 antibacterials Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 238000013224 high-fat diet-induced obese mouse Methods 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 210000001596 intra-abdominal fat Anatomy 0.000 description 6
- 210000003205 muscle Anatomy 0.000 description 6
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 description 6
- DHHVAGZRUROJKS-UHFFFAOYSA-N phentermine Chemical compound CC(C)(N)CC1=CC=CC=C1 DHHVAGZRUROJKS-UHFFFAOYSA-N 0.000 description 6
- 238000002591 computed tomography Methods 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- UNAANXDKBXWMLN-UHFFFAOYSA-N sibutramine Chemical compound C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 UNAANXDKBXWMLN-UHFFFAOYSA-N 0.000 description 5
- 210000003934 vacuole Anatomy 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 238000008214 LDL Cholesterol Methods 0.000 description 4
- 235000014679 Morus rubra var. rubra Nutrition 0.000 description 4
- 235000014677 Morus rubra var. tomentosa Nutrition 0.000 description 4
- 206010033307 Overweight Diseases 0.000 description 4
- 230000036772 blood pressure Effects 0.000 description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
- 230000002354 daily effect Effects 0.000 description 4
- 235000008216 herbs Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 4
- 229960004425 sibutramine Drugs 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 101710095342 Apolipoprotein B Proteins 0.000 description 3
- 102100040202 Apolipoprotein B-100 Human genes 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 235000010654 Melissa officinalis Nutrition 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 239000007963 capsule composition Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 3
- 238000005265 energy consumption Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 235000012631 food intake Nutrition 0.000 description 3
- 230000037406 food intake Effects 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 239000012676 herbal extract Substances 0.000 description 3
- 235000009200 high fat diet Nutrition 0.000 description 3
- 230000006372 lipid accumulation Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 229960001243 orlistat Drugs 0.000 description 3
- 229910000489 osmium tetroxide Inorganic materials 0.000 description 3
- 239000012285 osmium tetroxide Substances 0.000 description 3
- 108010071584 oxidized low density lipoprotein Proteins 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 229960003562 phentermine Drugs 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- 229940002552 xenical Drugs 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- 238000011746 C57BL/6J (JAX™ mouse strain) Methods 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 description 2
- 240000006394 Sorghum bicolor Species 0.000 description 2
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000035508 accumulation Effects 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- RAZOKRUZEQERLH-UHFFFAOYSA-N capillin Chemical compound CC#CC#CC(=O)C1=CC=CC=C1 RAZOKRUZEQERLH-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 229940109239 creatinine Drugs 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 230000003292 diminished effect Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 235000013376 functional food Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000001969 hypertrophic effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 description 2
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 description 2
- 229940076279 serotonin Drugs 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- QKPLRMLTKYXDST-NSEZLWDYSA-N (3r,4r,5s,6r)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol;hydrochloride Chemical compound Cl.N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O QKPLRMLTKYXDST-NSEZLWDYSA-N 0.000 description 1
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- KFNNPQDSPLWLCX-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)cyclobutyl]-n,n,3-trimethylbutan-1-amine;hydron;chloride;hydrate Chemical compound O.Cl.C=1C=C(Cl)C=CC=1C1(C(N(C)C)CC(C)C)CCC1 KFNNPQDSPLWLCX-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- NKDFYOWSKOHCCO-YPVLXUMRSA-N 20-hydroxyecdysone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@@](C)(O)[C@H](O)CCC(C)(O)C)CC[C@]33O)C)C3=CC(=O)[C@@H]21 NKDFYOWSKOHCCO-YPVLXUMRSA-N 0.000 description 1
- HXWZQRICWSADMH-SEHXZECUSA-N 20-hydroxyecdysone Natural products CC(C)(C)CC[C@@H](O)[C@@](C)(O)[C@H]1CC[C@@]2(O)C3=CC(=O)[C@@H]4C[C@@H](O)[C@@H](O)C[C@]4(C)[C@H]3CC[C@]12C HXWZQRICWSADMH-SEHXZECUSA-N 0.000 description 1
- 208000004611 Abdominal Obesity Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 102100022451 Actin-related protein T1 Human genes 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 108010071619 Apolipoproteins Proteins 0.000 description 1
- 102000007592 Apolipoproteins Human genes 0.000 description 1
- 235000003826 Artemisia Nutrition 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010049993 Cardiac death Diseases 0.000 description 1
- 206010065941 Central obesity Diseases 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010011906 Death Diseases 0.000 description 1
- 208000035859 Drug effect increased Diseases 0.000 description 1
- DCEFCUHVANGEOE-UHFFFAOYSA-N Ecdysterone Natural products CC(CC(C)(C)O)C(O)C(C)(O)C1CCC2(O)C3=CC(=O)C4CC(O)C(O)CC4(C)C3CCC12C DCEFCUHVANGEOE-UHFFFAOYSA-N 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000208688 Eucommia Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- OVSQVDMCBVZWGM-IDRAQACASA-N Hirsutrin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1)C1=C(c2cc(O)c(O)cc2)Oc2c(c(O)cc(O)c2)C1=O OVSQVDMCBVZWGM-IDRAQACASA-N 0.000 description 1
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033425 Pain in extremity Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000024799 Thyroid disease Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 210000000579 abdominal fat Anatomy 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000009102 absorption Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 108010029777 actin interacting protein 1 Proteins 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 239000000883 anti-obesity agent Substances 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 239000013059 antihormonal agent Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000002830 appetite depressant Substances 0.000 description 1
- 235000009052 artemisia Nutrition 0.000 description 1
- 230000000923 atherogenic effect Effects 0.000 description 1
- 238000013542 behavioral therapy Methods 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- NKDFYOWSKOHCCO-UHFFFAOYSA-N beta-ecdysone Natural products C1C(O)C(O)CC2(C)C(CCC3(C(C(C)(O)C(O)CCC(C)(O)C)CCC33O)C)C3=CC(=O)C21 NKDFYOWSKOHCCO-UHFFFAOYSA-N 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 238000010876 biochemical test Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- GHNBEBDYYSVNEK-UHFFFAOYSA-N capillon Natural products CC=CC=CC(=O)C1=CC=CC=C1 GHNBEBDYYSVNEK-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229940008396 carrot extract Drugs 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 235000019219 chocolate Nutrition 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000018823 dietary intake Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 229960003638 dopamine Drugs 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 238000013110 gastrectomy Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- OVSQVDMCBVZWGM-QCKGUQPXSA-N isoquercetin Natural products OC[C@@H]1O[C@@H](OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O OVSQVDMCBVZWGM-QCKGUQPXSA-N 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 230000004130 lipolysis Effects 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000006984 memory degeneration Effects 0.000 description 1
- 208000023060 memory loss Diseases 0.000 description 1
- 229940045623 meridia Drugs 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000029052 metamorphosis Effects 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000012454 non-polar solvent Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 235000006286 nutrient intake Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 238000001050 pharmacotherapy Methods 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Chemical class 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 231100000272 reduced body weight Toxicity 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- GUAFOGOEJLSQBT-UHFFFAOYSA-N scoparone Chemical compound C1=CC(=O)OC2=C1C=C(OC)C(OC)=C2 GUAFOGOEJLSQBT-UHFFFAOYSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 208000021510 thyroid gland disease Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical class OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050093577A KR100645385B1 (ko) | 2005-10-05 | 2005-10-05 | 비만 억제용 조성물 |
| KR10-2005-0093577 | 2005-10-05 | ||
| PCT/KR2006/004049 WO2007040377A1 (en) | 2005-10-05 | 2006-10-09 | Antiobesity composition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009511468A JP2009511468A (ja) | 2009-03-19 |
| JP2009511468A5 true JP2009511468A5 (enExample) | 2012-07-19 |
| JP5284097B2 JP5284097B2 (ja) | 2013-09-11 |
Family
ID=37712520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008534469A Active JP5284097B2 (ja) | 2005-10-05 | 2006-10-09 | 抗肥満組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9155773B2 (enExample) |
| EP (1) | EP1951275B8 (enExample) |
| JP (1) | JP5284097B2 (enExample) |
| KR (1) | KR100645385B1 (enExample) |
| CN (1) | CN101277710B (enExample) |
| AU (2) | AU2006297973A1 (enExample) |
| BR (1) | BRPI0617988A2 (enExample) |
| CA (1) | CA2624929C (enExample) |
| ES (1) | ES2581336T3 (enExample) |
| WO (1) | WO2007040377A1 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008050301A (ja) * | 2006-08-24 | 2008-03-06 | Prima Meat Packers Ltd | 膵リパーゼ阻害剤 |
| KR20080090169A (ko) * | 2007-04-04 | 2008-10-08 | (주) 아디포젠 | 쑥 또는 율피 추출물 또는 이로부터 분리된 스코파론을함유하는 체중조절용 조성물 |
| KR100868261B1 (ko) | 2007-04-30 | 2008-11-11 | 한국식품연구원 | 근력 향상 활성을 갖는 조성물 |
| KR100903030B1 (ko) * | 2007-08-23 | 2009-06-18 | 주식회사 안지오랩 | 멜리사엽 추출물 분획 및 이를 포함하는 조성물 |
| ES2561330T3 (es) | 2007-10-17 | 2016-02-25 | Rudolf Wild Gmbh & Co. Kg | Composición que comprende extractos de toronjil |
| JP5503125B2 (ja) * | 2008-08-08 | 2014-05-28 | 静岡県公立大学法人 | 内臓脂肪蓄積抑制剤 |
| CN101361774B (zh) * | 2008-09-01 | 2012-01-25 | 北京世纪博康医药科技有限公司 | 一种含有褐藻多糖硫酸酯和人参的组合物和其应用 |
| KR101108376B1 (ko) | 2009-04-08 | 2012-01-30 | 바이오스펙트럼 주식회사 | 아테미신 산을 함유하는 항비만, 항지방용 조성물 |
| KR101326932B1 (ko) | 2009-11-26 | 2013-11-11 | (주)아모레퍼시픽 | 퍼옥시좀 증식체 활성화 수용체 델타의 활성촉진 조성물 |
| US20130052284A1 (en) * | 2011-08-29 | 2013-02-28 | Carolyn J. Harrington | Palm kernel oil-based intranasal composition and use |
| CN107281490B (zh) * | 2012-05-29 | 2021-08-20 | 尤妮金公司 | 用于控制体重的组合物和方法 |
| KR101539289B1 (ko) * | 2013-08-16 | 2015-07-24 | 한국국제대학교 산학협력단 | 개똥쑥 추출물을 함유하는 지방간 또는 비만의 예방 또는 치료용 조성물 |
| JP2014097987A (ja) * | 2013-12-17 | 2014-05-29 | Shizuokaken Koritsu Daigaku Hojin | 内臓脂肪蓄積抑制剤 |
| CN105899208A (zh) | 2014-01-10 | 2016-08-24 | 雀巢产品技术援助有限公司 | 对孕产妇施用维生素b6 预防后代发胖、超重或肥胖的增加 |
| EP3091988B1 (en) | 2014-01-10 | 2020-09-02 | Société des Produits Nestlé S.A. | Maternal vitamin b12 administration for the prevention of increased adiposity, overweight or obesity in the offspring especially offspring of overweight and/or obese mothers |
| JP6338113B2 (ja) * | 2015-03-31 | 2018-06-06 | 株式会社東洋新薬 | 除脂肪体重の増加剤 |
| KR20160118552A (ko) | 2015-04-02 | 2016-10-12 | 계명대학교 산학협력단 | 칡잎 추출물을 유효성분으로 함유하는 비만 예방 또는 치료용 약학조성물 |
| KR101885949B1 (ko) * | 2015-12-24 | 2018-08-06 | 오좌섭 | 광대나물 추출물을 이용한 항비만용 조성물 |
| KR101915071B1 (ko) | 2016-12-01 | 2018-11-20 | 주식회사 코시스바이오 | 커피 로부스타 발효 추출물을 유효성분으로 포함하는 비만 예방 및 개선용 식품 조성물 |
| KR101802696B1 (ko) | 2017-02-15 | 2017-11-28 | 계명대학교 산학협력단 | 칡잎 추출물을 유효성분으로 함유하는 비만 예방 또는 치료용 약학조성물 |
| CN108902939A (zh) * | 2018-06-23 | 2018-11-30 | 袁维寨 | 一种用于减肥的组合物 |
| KR20200053344A (ko) | 2018-11-08 | 2020-05-18 | 충남대학교산학협력단 | 펙티넥스를 처리한 뽕나무 잎 추출물을 유효성분으로 포함하는 비만 예방 또는 치료용 약학 조성물 |
| CN109511848A (zh) * | 2018-12-11 | 2019-03-26 | 北京康比特体育科技股份有限公司 | 一种具有减肥功能的代餐组合物 |
| KR102125244B1 (ko) * | 2018-12-14 | 2020-06-23 | 주식회사 휴앤코스메틱 | 지방 분해용 조성물 |
| KR102036186B1 (ko) * | 2019-03-25 | 2019-10-24 | 임재선 | 레몬밤 추출물을 유효성분으로 포함하는 지방 분해용 주사제 조성물 |
| WO2020197041A1 (ko) * | 2019-03-25 | 2020-10-01 | 임재선 | 레몬밤 추출물을 유효성분으로 포함하는 주사제 및 화장료 조성물 |
| JP2020164486A (ja) * | 2019-03-29 | 2020-10-08 | 丸善製薬株式会社 | 抗老化剤、抗酸化剤、抗炎症剤、及び美白剤、並びに、化粧料 |
| KR20200135621A (ko) | 2019-05-23 | 2020-12-03 | 주식회사 하람 | 퀘르세틴-3-o-글루쿠로니드를 유효성분으로 하는 비만 예방 및 치료소재 |
| KR102143084B1 (ko) * | 2019-10-08 | 2020-08-11 | 주식회사 뉴트라코어 | 비만, 당뇨, 고지혈증 및 지방간을 포함하는 대사증후군의 예방, 개선 또는 치료용 조성물 |
| CN113115881A (zh) * | 2019-12-31 | 2021-07-16 | 南京宿根花卉植物园有限公司 | 一种具有减肥功能的固体饮料 |
| WO2021156184A1 (en) * | 2020-02-07 | 2021-08-12 | Dsm Ip Assets B.V. | New formulation of a plant extract |
| CN115397449A (zh) * | 2020-04-08 | 2022-11-25 | 血管实验室公司 | 香蜂花叶的分步提取物以及包含该提取物的新的药物组合物 |
| JP6923065B1 (ja) * | 2020-11-25 | 2021-08-18 | 大正製薬株式会社 | 経口固形組成物 |
| CN116634882A (zh) * | 2020-12-22 | 2023-08-22 | 希尔氏宠物营养品公司 | 宠物食品组合物 |
| KR20210019051A (ko) | 2021-02-10 | 2021-02-19 | 충남대학교산학협력단 | 펙티넥스를 처리한 뽕나무 잎 추출물을 유효성분으로 포함하는 비만 예방 또는 치료용 약학 조성물 |
| CN113712206A (zh) * | 2021-09-16 | 2021-11-30 | 湖南希尔天然药业有限公司 | 一种含有桑叶dnj和桑叶肽的组合物及其制备方法 |
| CN113826799A (zh) * | 2021-09-26 | 2021-12-24 | 山东森健生物科技发展有限公司 | 减肥用食品 |
| CN113875952A (zh) * | 2021-10-09 | 2022-01-04 | 江西邦泰绿色生物合成生态产业园发展有限公司 | 一种减肥复合制剂及其制备方法 |
| KR20230098421A (ko) | 2021-12-24 | 2023-07-04 | 주식회사 앤드메이드 | 체중 감량용 조성물 및 그 제조방법 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2442633A1 (fr) | 1978-11-28 | 1980-06-27 | Kitasato Inst | Inducteurs d'interferon et leur procede de fabrication |
| JPS6140763A (ja) * | 1984-08-02 | 1986-02-27 | Osaka Chem Lab | 抗肥満食品 |
| FR2622110A1 (fr) | 1987-10-26 | 1989-04-28 | Marty Georges | Pile prevue pour l'utilisation du pouvoir radio-actif des plantes a des fins medicales |
| JPH02256621A (ja) | 1988-12-28 | 1990-10-17 | King Jozo Kk | 抗変異原剤 |
| CN1033945C (zh) * | 1992-12-09 | 1997-02-05 | 陈宗尧 | 一种保健花粉糖 |
| JPH06199647A (ja) | 1992-12-28 | 1994-07-19 | Noevir Co Ltd | 美白化粧料 |
| JPH07196526A (ja) | 1994-01-11 | 1995-08-01 | Takano Co Ltd | コラゲナーゼ阻害剤 |
| JPH08301779A (ja) | 1995-05-01 | 1996-11-19 | Sansho Seiyaku Co Ltd | アトピー性皮膚炎用外用剤 |
| JPH09241142A (ja) | 1996-03-06 | 1997-09-16 | Noevir Co Ltd | 皮膚外用剤 |
| FR2751878B1 (fr) | 1996-07-30 | 1998-09-04 | Oreal | Utilisation dans une composition d'un extrait d'au moins une labiee |
| KR19980021670U (ko) | 1996-10-22 | 1998-07-15 | 이영서 | 전자렌지 |
| KR100257448B1 (ko) | 1997-08-01 | 2000-07-01 | 박홍락 | 항암, 기관분화유도, 암세포전이 혈관형성억제, 항산화 및 숙취해소 작용을 하는 옻나무 추출물, 이의 제조방법 및 이를 포함하는 조성물 |
| ES2186199T3 (es) | 1997-09-12 | 2003-05-01 | Procter & Gamble | Articulo de limpieza y acondicionador para la piel o el pelo. |
| JP3796340B2 (ja) | 1997-11-18 | 2006-07-12 | 株式会社ノエビア | セリンプロテアーゼ阻害剤 |
| JPH11187843A (ja) * | 1997-12-25 | 1999-07-13 | Lotte Co Ltd | 肥満改善用の飲食組成物およびこれを含有する飲食物 |
| JPH11335285A (ja) * | 1998-05-25 | 1999-12-07 | Toyotama Koryo Kk | 整腸・便秘改善剤およびこれを含有する飲食物並びに動物用飼料 |
| FR2788438B1 (fr) * | 1999-01-14 | 2003-10-03 | Arkopharma Laboratoires | Composition pour le traitement de l'obesite et procede de traitement esthetique |
| US20010024664A1 (en) | 1999-03-19 | 2001-09-27 | Obukowicz Mark G. | Selective COX-2 inhibition from edible plant extracts |
| US6485756B1 (en) | 1999-04-06 | 2002-11-26 | Collaborative Technologies, Inc. | Stable, homogeneous natural product extracts containing polar and apolar fractions |
| US6261566B1 (en) | 1999-10-22 | 2001-07-17 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Cosmetic compositions containing mulberry extract and retinoids |
| KR100455222B1 (ko) * | 1999-12-31 | 2004-11-06 | 주식회사 한국인삼공사 | 다이어트 인삼복합제품 및 그 제조방법 |
| US6416769B1 (en) | 2000-03-03 | 2002-07-09 | Australian Importers, Ltd. | Cosmetic compositions comprising exfoliating enzymes and uses thereof |
| EP1349558B1 (en) * | 2000-12-12 | 2011-06-15 | Angiolab, Inc. | Composition comprising melissa leaf extract for anti-angiogenic and matrix metalloproteinase inhibitory activity |
| DE10065832A1 (de) * | 2000-12-21 | 2002-06-27 | Bettina Kater | Mittel zur Gewichtsreduktion auf der Basis Minze, Melisse und Fenchel |
| KR100451962B1 (ko) | 2001-07-18 | 2004-10-08 | 주식회사 대창중기계 | 지중 물막이 연속벽 구축 공법 및 장치 |
| ATE451928T1 (de) * | 2001-08-31 | 2010-01-15 | Univ Rutgers | Verfahren zur behandlung von krankheiten mit pflanzenextrakten |
| JP5127104B2 (ja) * | 2001-09-29 | 2013-01-23 | 小林製薬株式会社 | 便意を増進する香料組成物及び付香製品 |
| KR100496622B1 (ko) * | 2002-04-29 | 2005-06-29 | (주) 김형민한약연구소 | 비만 억제를 위한 알콜 발효 식품 또는 약학적 조성물 및그의 제조방법 |
| KR100828519B1 (ko) | 2002-07-12 | 2008-05-13 | 삼성전자주식회사 | 액정 패널과 이를 갖는 액정 표시 장치 |
| AU2003256104A1 (en) * | 2002-08-14 | 2004-03-03 | Bionutrigen Co., Ltd | Powder or extracts of plant leaves with anti-obesity effects and anti-obesity food comprising them |
| JP2004217532A (ja) * | 2003-01-10 | 2004-08-05 | Maruzen Pharmaceut Co Ltd | 桑葉抽出物及びその製造方法、並びに血糖値上昇抑制用組成物及び肥満防止用組成物 |
| KR100569792B1 (ko) | 2003-01-14 | 2006-04-10 | 학교법인 인제학원 | 인진쑥올리고당 aip1을 함유한 항비만성 바이오헬스 소재 |
| KR20030026939A (ko) * | 2003-01-27 | 2003-04-03 | 최미회 | 구아바잎을 주성분으로한 당뇨병치료용, 비만개선용,노화방지용차의 효과적인 조성물 및 이를 함유한 건강식품 |
| US6908573B2 (en) | 2003-04-17 | 2005-06-21 | General Electric | Polymeric resin blends and methods of manufacture thereof |
| JP2005008572A (ja) * | 2003-06-19 | 2005-01-13 | Yakult Honsha Co Ltd | リパーゼ阻害剤 |
| KR100549698B1 (ko) | 2003-07-12 | 2006-02-08 | 영 욱 김 | 활성탄 섬유를 이용한 발열구조 및 이를 적용한 전열기구 |
| KR100521582B1 (ko) | 2003-07-15 | 2005-10-17 | 현대자동차주식회사 | 차량 시트의 사이드 팽창장치 |
| KR100624488B1 (ko) * | 2004-02-03 | 2006-09-19 | 제일약품주식회사 | 비만의 예방 및 치료용 조성물 |
| KR100716066B1 (ko) | 2004-02-21 | 2007-05-08 | 변상요 | 두충엽 추출물 및 상엽 추출물을 포함하는 비만억제 식품 |
| JP4929611B2 (ja) * | 2004-04-09 | 2012-05-09 | 大正製薬株式会社 | リパーゼ阻害剤 |
| KR20060070254A (ko) * | 2004-12-20 | 2006-06-23 | 김정훈 | 비만조절용 건강보조식품 및 그 제조방법 |
| US20060280700A1 (en) * | 2005-06-08 | 2006-12-14 | Isler Stuart L | Oral hygiene system to fight the effects of aging on the mouth, gums, and teeth |
-
2005
- 2005-10-05 KR KR1020050093577A patent/KR100645385B1/ko not_active Expired - Lifetime
-
2006
- 2006-10-09 ES ES06799129.9T patent/ES2581336T3/es active Active
- 2006-10-09 EP EP06799129.9A patent/EP1951275B8/en active Active
- 2006-10-09 CN CN200680036456.7A patent/CN101277710B/zh not_active Expired - Fee Related
- 2006-10-09 AU AU2006297973A patent/AU2006297973A1/en not_active Abandoned
- 2006-10-09 BR BRPI0617988-6A patent/BRPI0617988A2/pt not_active Application Discontinuation
- 2006-10-09 JP JP2008534469A patent/JP5284097B2/ja active Active
- 2006-10-09 WO PCT/KR2006/004049 patent/WO2007040377A1/en not_active Ceased
- 2006-10-09 CA CA2624929A patent/CA2624929C/en not_active Expired - Fee Related
-
2008
- 2008-03-31 US US12/059,611 patent/US9155773B2/en not_active Expired - Fee Related
-
2011
- 2011-03-22 AU AU2011201268A patent/AU2011201268B2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5284097B2 (ja) | 抗肥満組成物 | |
| JP2009511468A5 (enExample) | ||
| CN1058614C (zh) | 植物制剂组合物 | |
| JP2008094754A (ja) | 糖尿病または血糖コントロール用栄養組成物 | |
| KR101511364B1 (ko) | 복합 생약재를 이용한 비만 및 대사증후군의 예방 또는치료용 조성물 | |
| KR100500373B1 (ko) | 숙취해소용 조성물 | |
| CN104857154A (zh) | 一种治疗“三高”症的中药组合物及其制备方法 | |
| KR20110105627A (ko) | 누에 체액을 함유하는 항비만 조성물 | |
| KR20200016608A (ko) | 체중조절용 건강식품 조성물 | |
| CN106999532A (zh) | 含有复合提取物的运动执行能力增强及体力增进用组合物 | |
| WO2004045605A1 (en) | Use of flavonoid for the treatment of overweight and the reduction of the mammalian appetite | |
| KR20070113460A (ko) | 체중조절용 건강식품 조성물 | |
| CN102178798A (zh) | 一种用于降低血脂、防治心脑血管疾病的制剂 | |
| KR100595459B1 (ko) | 비만 억제용 조성물 | |
| JP7602875B2 (ja) | 腎臓機能改善剤 | |
| JP6378926B2 (ja) | 血糖値低下用組成物 | |
| KR20210047897A (ko) | 대사증후군을 치료하는 중약 조성물 및 그 제제 | |
| KR100573590B1 (ko) | 비만치료ㆍ억제용 생약 조성물 | |
| KR20040089258A (ko) | 솔잎, 녹차 및 홍차 추출물을 유효성분으로 함유하는 비만및 변비 치료용 조성물 | |
| KR20070090835A (ko) | 지각 추출물을 함유하는 당뇨병 치료 조성물 및 이를유효성분으로 하는 건강보조식품 | |
| JP4465963B2 (ja) | 高脂血症の予防または改善用組成物 | |
| CN101143203A (zh) | 一种具有护肝养胃功能的复方口服液 | |
| CN104524276B (zh) | 降血脂组合物及其制剂和制备方法 | |
| JP2025023248A (ja) | 脂質排泄促進剤 | |
| JP2004359606A (ja) | 糖とアルコールの吸収を抑制する組成物 |