WO2021156184A1 - New formulation of a plant extract - Google Patents
New formulation of a plant extract Download PDFInfo
- Publication number
- WO2021156184A1 WO2021156184A1 PCT/EP2021/052268 EP2021052268W WO2021156184A1 WO 2021156184 A1 WO2021156184 A1 WO 2021156184A1 EP 2021052268 W EP2021052268 W EP 2021052268W WO 2021156184 A1 WO2021156184 A1 WO 2021156184A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formulation
- powderous
- formulation according
- present
- maltodextrin
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 55
- 238000009472 formulation Methods 0.000 title claims abstract description 51
- 239000000419 plant extract Substances 0.000 title abstract description 5
- 240000000249 Morus alba Species 0.000 claims description 19
- 235000008708 Morus alba Nutrition 0.000 claims description 19
- 239000000284 extract Substances 0.000 claims description 14
- 239000005913 Maltodextrin Substances 0.000 claims description 13
- 229940035034 maltodextrin Drugs 0.000 claims description 13
- 229920002774 Maltodextrin Polymers 0.000 claims description 12
- 239000004615 ingredient Substances 0.000 claims description 8
- 235000015872 dietary supplement Nutrition 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 239000006052 feed supplement Substances 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002245 particle Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 235000000346 sugar Nutrition 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 125000001841 imino group Chemical group [H]N=* 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- YZNNBIPIQWYLDM-HSUXUTPPSA-N Fagomine Chemical compound OC[C@H]1NCC[C@@H](O)[C@@H]1O YZNNBIPIQWYLDM-HSUXUTPPSA-N 0.000 description 1
- YZNNBIPIQWYLDM-ZLUOBGJFSA-N Fagomine Natural products OC[C@@H]1NCC[C@H](O)[C@H]1O YZNNBIPIQWYLDM-ZLUOBGJFSA-N 0.000 description 1
- 206010056465 Food craving Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229940121672 Glycosylation inhibitor Drugs 0.000 description 1
- YZNNBIPIQWYLDM-UHFFFAOYSA-N L-fagomine Natural products OCC1NCCC(O)C1O YZNNBIPIQWYLDM-UHFFFAOYSA-N 0.000 description 1
- 230000004988 N-glycosylation Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000019788 craving Nutrition 0.000 description 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- LXBIFEVIBLOUGU-JGWLITMVSA-N duvoglustat Chemical compound OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O LXBIFEVIBLOUGU-JGWLITMVSA-N 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000037219 healthy weight Effects 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- -1 imino sugars Chemical class 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000008099 melanin synthesis Effects 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000003061 melanogenesis Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a new formulation of a specific plant extract.
- the specific plant extract is the leaf extract of the white mulberry tree.
- White mulberry (Latin name is Morus alba), is a fast-growing, small to medium-sized mul berry tree which grows to 10-20 m tall.
- the species is originally native to northern China, and is now widely cultivated and natu ralized in many other countries (such as i.e. United States, Mexico, Australia, Kyrgyzstan, Argentina, Turkey, Iran, etc.)/
- Mulberry leaves have a long history of medicinal use in Asian countries, in particular China.
- phytochemists have isolated a number of imino sugar constituents from mulberry leaves, such as 1 -deoxynojirimycin (DNJ), fagomine, and N- methyl-DNJ.
- DNJ 1 -deoxynojirimycin
- fagomine fagomine
- N- methyl-DNJ The chemical structures of the imino sugars are similar to that of monosaccharides, being mostly polyhydroxyl heterocyclics with a 5 to 6-membered ring.
- white mulberry leaf extracts such as i.e. Reducose ® 1% and Reducose ® 5% from DSM Nutritional Products Ltd.
- the problem of the white mulberry leaf extracts is the strong hygroscopicity. This has for example a negative effect on the flowability property of the formulation.
- the flowability is a very important property of a powderous formulation.
- the present invention relates to a powderous formulation (PF) comprising
- the powderous formulation according to the present invention comprises at least 55wt-% of maltodextrin.
- the present invention relates to a powderous formulation (PF1), which is pow derous formulation (PF), wherein the powderous formulation comprises at least 55 wt-%, based on the total weight of the powderous formulation of maltodextrin.
- the formulation according to the present invention comprises up to 99 wt-% of maltodextrin.
- the present invention relates to a powderous formulation (PF2), which is pow derous formulation (PF) or (PF1), wherein the powderous formulation comprises up to 99 wt-%, based on the total weight of the powderous formulation of maltodextrin.
- the present invention relates to a powderous formulation (PF3), which powder ous formulation (PF), (PF1) or (PF3) comprising 50 to 99 wt-%, based on the total weight of the powderous formulation of maltodextrin.
- the formulation according to the present invention can optionally comprise further ingreists, which could added to such formulation, but which are not essential for the excellent property of the powderous formulation according to the present invention.
- ingredi ents can be vitamins, minerals, fillers, dyestuff, flavours, fibers, etc.
- the present invention relates to a powderous formulation (PF4) comprising
- composition according to the present invention can be used as such (as dietary sup plement, food supplement, feed, feed supplement or any further possible use).
- the formulation according to the present invention can also be used to be formulated into other product forms. This means the powderous formulation according to the present in vention can serve as a premix.
- the present invention also related to the use of a powderous formulation (PF5), (PF1), (PF2), (PF3) or (P4) as dietary supplement, food supplement, feed, feed supple ment.
- the present invention also related to the use of a powderous formulation (PF5’), (PF1), (PF2), (PF3) or (P4) as premix.
- the formulation according to the present invention can be produced according to com monly known methods.
- the powderous formulation according to the present invention is single particle. This means that all components (i), (ii) and (iii) are part of one particle.
- the size and the shape of such a particle is not essential to the invention. It should be in a suitable form to be used for the desired use.
- the powderous formulation according to the present invention is a mixture of more than one specific particle. This means that components (i), (ii) and (iii) are all different particles, which are then mixed together.
- ingredients of the powderous formulation according to the present invention are mixed the sequence of mixing is no essential. All ingredients can be added all at once and the mixed or they can be added one after the other, or in any possible combination.
- a preferred method is that the leaf extract of the white mulberry tree is produced (usually by spray drying and the mixed and then mix it with component (ii) and optionally with (iii)/ As stated the sequence of mixing is not essential for the invention. It is also possible to use commercially available leaf extract of the white mulberry tree such as Reducose ® 1% or Reducose® 5% or a mixture of them, (these products are available from DSM Nutritional Products Ltd) and mix it with Maltodextrin and optionally and other ingredients (component (iii).
- the mixing time was 5 min and the temperature was 20°C (humidity: 50% RH).
- the so obtained powderous formulation was then tested in view of flowability. This was done by determining the desorption as well as the adsorption. This was done by the Dynamic Vapor Sorption (DVS) test Performed using Aqualab Vapor Sorption Analyzer.
- DVD Dynamic Vapor Sorption
- the DVS method for static or equilibrium isotherms consists of tracking sample weight change as the sample is exposed to deferent controlled humidities.
- the sample is held at each humidity for a preset time interval or until a steady state weight change is achieved, the goal being to achieve equilibrium between the sample water ac tivity and the controlled humidity.
- eight change versus time data is recorded allowing for determining kinetics of sorption for each humidity level.
Abstract
The present invention relates to a new formulation of a specific plant extract.
Description
NEW FORMULATION OF A PLANT EXTRACT
The present invention relates to a new formulation of a specific plant extract.
The specific plant extract is the leaf extract of the white mulberry tree.
White mulberry (Latin name is Morus alba), is a fast-growing, small to medium-sized mul berry tree which grows to 10-20 m tall.
The species is originally native to northern China, and is now widely cultivated and natu ralized in many other countries (such as i.e. United States, Mexico, Australia, Kyrgyzstan, Argentina, Turkey, Iran, etc.)/
Mulberry leaves have a long history of medicinal use in Asian countries, in particular China. In recent years, phytochemists have isolated a number of imino sugar constituents from mulberry leaves, such as 1 -deoxynojirimycin (DNJ), fagomine, and N- methyl-DNJ. The chemical structures of the imino sugars are similar to that of monosaccharides, being mostly polyhydroxyl heterocyclics with a 5 to 6-membered ring.
It has been shown that the imino sugar constituents from mulberry leaves exhibit certain inhibitory activity on oglucosidase I and II, among which DNJ showed the strongest activ ity. Further pharmacological experiments revealed that DNJ acted on melanocyte inhibit ing the maturing process of TYR, which resulted in the reduction of melanin production. (Genji Imokawa, Analysis of Carbohydrate Properties Essential for Melanogenesis in TYRs of Cultured Malignant Melanoma Cells by Differential Carbohydrate Processing In hibition. The Journal of Investigative dermatology, 1990,
95(1 ):39-49; Ju Young Park, hyunjung Choi, Jae Sung hwang, Junoh Kim, Ih-Seop Chang, Enhanced depigmenting effects of N-glycosylation inhibitors delivered by pH-sen- sitive liposomes into HM3KO melanoma cells, Journal of Cosmetic Science, 2008, 59: ISO- ISO.)
There many commercially available supplements (in various forms) containing white mul berry leaf extract.
The white mulberry leaf extract is known
• to support healthy sugar levels and blood circulation
• to improve the overall digestive health
• to lower glucose levels and stabilizes blood sugar in the body by managing appe tite and reducing cravings
• to support healthy weight loss by helping to control your appetite, sugar cravings and its absorption.
To produce such supplements, it is necessary to provide a formulation of the white mul berry leaf extract, which is then incorporated into the desired end market product.
There are also commercially available formulations of white mulberry leaf extracts (such as i.e. Reducose® 1% and Reducose® 5% from DSM Nutritional Products Ltd).
Due to the importance of the leaf extract of the white mulberry, there is always a need for improved formulations of such an extract.
The problem of the white mulberry leaf extracts is the strong hygroscopicity. This has for example a negative effect on the flowability property of the formulation. The flowability is a very important property of a powderous formulation.
It was now found that the when the leaf extract of the white mulberry is formulated with a specific (high amount) of maltodextrin (and optionally other ingredients) the flowability of the obtained powder is improved significantly.
Therefore the present invention relates to a powderous formulation (PF) comprising
(i) a leaf extract of the white mulberry tree and
(ii) at least 50 weight-% (wt-%), based on the total weight of the powderous for mulation of maltodextrin.
It is clear that all the percentages always add up to 100.
Surprisingly such a powderous formulation has excellent flowability properties.
Preferably the powderous formulation according to the present invention comprises at least 55wt-% of maltodextrin.
Therefore the present invention relates to a powderous formulation (PF1), which is pow derous formulation (PF), wherein the powderous formulation comprises at least 55 wt-%, based on the total weight of the powderous formulation of maltodextrin.
Preferably, the formulation according to the present invention comprises up to 99 wt-% of maltodextrin.
Therefore the present invention relates to a powderous formulation (PF2), which is pow derous formulation (PF) or (PF1), wherein the powderous formulation comprises up to 99 wt-%, based on the total weight of the powderous formulation of maltodextrin.
Therefore the present invention relates to a powderous formulation (PF3), which powder ous formulation (PF), (PF1) or (PF3) comprising 50 to 99 wt-%, based on the total weight of the powderous formulation of maltodextrin.
The formulation according to the present invention can optionally comprise further ingre dients, which could added to such formulation, but which are not essential for the excellent property of the powderous formulation according to the present invention. Such ingredi ents can be vitamins, minerals, fillers, dyestuff, flavours, fibers, etc.
Therefore the present invention relates to a powderous formulation (PF4) comprising
(i) a leaf extract of the white mulberry tree and
(ii) at least 50 wt-%, based on the total weight of the formulation of maltodextrin and
(iii) at least one further ingredient.
The formulation according to the present invention can be used as such (as dietary sup plement, food supplement, feed, feed supplement or any further possible use).
The formulation according to the present invention can also be used to be formulated into other product forms. This means the powderous formulation according to the present in vention can serve as a premix.
Therefore the present invention also related to the use of a powderous formulation (PF5), (PF1), (PF2), (PF3) or (P4) as dietary supplement, food supplement, feed, feed supple ment.
Therefore the present invention also related to the use of a powderous formulation (PF5’), (PF1), (PF2), (PF3) or (P4) as premix.
The formulation according to the present invention can be produced according to com monly known methods.
It is possible that the powderous formulation according to the present invention is single particle. This means that all components (i), (ii) and (iii) are part of one particle. The size and the shape of such a particle is not essential to the invention. It should be in a suitable form to be used for the desired use.
It is possible that the powderous formulation according to the present invention is a mixture of more than one specific particle. This means that components (i), (ii) and (iii) are all different particles, which are then mixed together.
This means that components (i) and (ii) form one particle, which is mixed with (iii) or any other variation thereof.
When the ingredients of the powderous formulation according to the present invention are mixed the sequence of mixing is no essential. All ingredients can be added all at once and the mixed or they can be added one after the other, or in any possible combination.
A preferred method is that the leaf extract of the white mulberry tree is produced (usually by spray drying and the mixed and then mix it with component (ii) and optionally with (iii)/ As stated the sequence of mixing is not essential for the invention.
It is also possible to use commercially available leaf extract of the white mulberry tree such as Reducose ® 1% or Reducose® 5% or a mixture of them, (these products are available from DSM Nutritional Products Ltd) and mix it with Maltodextrin and optionally and other ingredients (component (iii).
The following examples serve to illustrate the invention.
Examples Example 1
200 g of Reducose 5% (from DSM Nutritional Products Ltd) and 1800 g Maltodextrin were mixed in a double action tumbler (sieve: 0.5 mm).
The mixing time was 5 min and the temperature was 20°C (humidity: 50% RH).
The so obtained powderous formulation was then tested in view of flowability. This was done by determining the desorption as well as the adsorption. This was done by the Dynamic Vapor Sorption (DVS) test Performed using Aqualab Vapor Sorption Analyzer.
The DVS method for static or equilibrium isotherms consists of tracking sample weight change as the sample is exposed to deferent controlled humidities.
The sample is held at each humidity for a preset time interval or until a steady state weight change is achieved, the goal being to achieve equilibrium between the sample water ac tivity and the controlled humidity. eight change versus time data is recorded allowing for determining kinetics of sorption for each humidity level.
Effective Relative Humidity = aw X 100 (i.e 0.1 aw = 10% RH)
In the following table the results can be seen
Claims
1. Powderous formulation comprising
(i) a leaf extract of the white mulberry tree and
(ii) at least 50 wt-%, based on the total weight of the formulation, of maltodex- trin.
2. Powerdous formulation according to claim 1 , which comprises at least 55wt-%, based on the total weight of the formulation, of maltodextrin.
3. Powerdous formulation according to claim 1 or 2, which comprises up to 99 wt-%, based on the total weight of the formulation, of maltodextrin.
4. Powerdous formulation according to any of the preceding claims, wherein the formu lation comprises further ingredients.
5. Use of a powderous formulation according to any of claims 1 - 4 as dietary supple ment, food supplement, feed, feed supplement or any further possible use).
6. Use of a powderous formulation according to any of claims 1 - 4 as a premix.
7. Process of production of a powderous formulation according to any of claims 1 - 4 wherein the components (i) and (ii) and optionally (iii) are mixed.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10202001110VA SG10202001110VA (en) | 2020-02-07 | 2020-02-07 | New Formulation Of A Plant Extract |
| SG10202001110V | 2020-02-07 | ||
| CH7562020 | 2020-06-23 | ||
| CH00756/20 | 2020-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2021156184A1 true WO2021156184A1 (en) | 2021-08-12 |
Family
ID=74595256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2021/052268 WO2021156184A1 (en) | 2020-02-07 | 2021-02-01 | New formulation of a plant extract |
Country Status (2)
| Country | Link |
|---|---|
| TW (1) | TW202139863A (en) |
| WO (1) | WO2021156184A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023165856A1 (en) * | 2022-03-02 | 2023-09-07 | Société des Produits Nestlé S.A. | Use of a composition for managing postprandial glucose response and associated disorders |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5618527A (en) * | 1992-09-30 | 1997-04-08 | Ascent Pediatrics Inc. | Calcium polycarbophil sprinkle |
| WO2007040377A1 (en) * | 2005-10-05 | 2007-04-12 | Angiolab., Inc. | Antiobesity composition |
| KR20180063390A (en) * | 2016-11-25 | 2018-06-12 | 부안군(관리부서: 부안군 농업기술센터) | Method for Preparing Mulberry Leaf Extracts |
-
2021
- 2021-02-01 WO PCT/EP2021/052268 patent/WO2021156184A1/en active Application Filing
- 2021-02-05 TW TW110104545A patent/TW202139863A/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5618527A (en) * | 1992-09-30 | 1997-04-08 | Ascent Pediatrics Inc. | Calcium polycarbophil sprinkle |
| WO2007040377A1 (en) * | 2005-10-05 | 2007-04-12 | Angiolab., Inc. | Antiobesity composition |
| KR20180063390A (en) * | 2016-11-25 | 2018-06-12 | 부안군(관리부서: 부안군 농업기술센터) | Method for Preparing Mulberry Leaf Extracts |
Non-Patent Citations (4)
| Title |
|---|
| GENJI IMOKAWA: "Analysis of Carbohydrate Properties Essential for Melanogenesis in TYRs of Cultured Malignant Melanoma Cells by Differential Carbohydrate Processing Inhibition", THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 95, no. 1, 1990, pages 39 - 49 |
| JU YOUNG PARKHYUNJUNG CHOIJAE SUNG HWANGJUNOH KIMIH-SEOP CHANG: "Enhanced depigmenting effects of N-glycosylation inhibitors delivered by pH-sensitive liposomes into HM3KO melanoma cells", JOURNAL OF COSMETIC SCIENCE, vol. 59, 2008, pages 139 - 150 |
| TCHABO WILLIAM ET AL: "Process Analysis of Mulberry (Morus alba) Leaf Extract Encapsulation: Effects of Spray Drying Conditions on Bioactive Encapsulated Powder Quality", FOOD AND BIOPROCESS TECHNOLOGY ; AN INTERNATIONAL JOURNAL, SPRINGER-VERLAG, NEW YORK, vol. 12, no. 1, 20 October 2018 (2018-10-20), pages 122 - 146, XP036665297, ISSN: 1935-5130, [retrieved on 20181020], DOI: 10.1007/S11947-018-2194-2 * |
| WU CHENG-TIEN ET AL: "Genotoxicity and 28-day oral toxicity studies of a functional food mixture containing maltodextrin, white kidney bean extract, mulberry leaf extract, and niacin-bound chromium complex", REGULATORY TOXICOLOGY AND PHARMACOLOGY, vol. 92, 1 February 2018 (2018-02-01), US, pages 67 - 74, XP055796900, ISSN: 0273-2300, DOI: 10.1016/j.yrtph.2017.11.008 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023165856A1 (en) * | 2022-03-02 | 2023-09-07 | Société des Produits Nestlé S.A. | Use of a composition for managing postprandial glucose response and associated disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| TW202139863A (en) | 2021-11-01 |
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