TW202139863A - New formulation of a plant extract - Google Patents
New formulation of a plant extract Download PDFInfo
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- TW202139863A TW202139863A TW110104545A TW110104545A TW202139863A TW 202139863 A TW202139863 A TW 202139863A TW 110104545 A TW110104545 A TW 110104545A TW 110104545 A TW110104545 A TW 110104545A TW 202139863 A TW202139863 A TW 202139863A
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- maltodextrin
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- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 238000009472 formulation Methods 0.000 title claims abstract description 50
- 239000000419 plant extract Substances 0.000 title abstract description 4
- 240000000249 Morus alba Species 0.000 claims description 19
- 235000008708 Morus alba Nutrition 0.000 claims description 19
- 229920002774 Maltodextrin Polymers 0.000 claims description 17
- 239000005913 Maltodextrin Substances 0.000 claims description 17
- 229940035034 maltodextrin Drugs 0.000 claims description 17
- 239000000284 extract Substances 0.000 claims description 14
- 239000004615 ingredient Substances 0.000 claims description 8
- 235000015872 dietary supplement Nutrition 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 239000006052 feed supplement Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000002245 particle Substances 0.000 description 6
- LXBIFEVIBLOUGU-JGWLITMVSA-N duvoglustat Chemical compound OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O LXBIFEVIBLOUGU-JGWLITMVSA-N 0.000 description 5
- 235000000346 sugar Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- LXBIFEVIBLOUGU-UHFFFAOYSA-N Deoxymannojirimycin Natural products OCC1NCC(O)C(O)C1O LXBIFEVIBLOUGU-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 125000001841 imino group Chemical group [H]N=* 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 101000959414 Bacillus thermoamyloliquefaciens Alpha-glucosidase 2 Proteins 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- YZNNBIPIQWYLDM-HSUXUTPPSA-N Fagomine Chemical compound OC[C@H]1NCC[C@@H](O)[C@@H]1O YZNNBIPIQWYLDM-HSUXUTPPSA-N 0.000 description 1
- YZNNBIPIQWYLDM-ZLUOBGJFSA-N Fagomine Natural products OC[C@@H]1NCC[C@H](O)[C@H]1O YZNNBIPIQWYLDM-ZLUOBGJFSA-N 0.000 description 1
- 206010056465 Food craving Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- YZNNBIPIQWYLDM-UHFFFAOYSA-N L-fagomine Natural products OCC1NCCC(O)C1O YZNNBIPIQWYLDM-UHFFFAOYSA-N 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- AAKDPDFZMNYDLR-XZBKPIIZSA-N N-methyl-1-deoxynojirimycin Chemical compound CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO AAKDPDFZMNYDLR-XZBKPIIZSA-N 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000019788 craving Nutrition 0.000 description 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 108010050669 glucosidase I Proteins 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000037219 healthy weight Effects 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- -1 imino sugars Chemical class 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000003061 melanogenesis Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000003359 percent control normalization Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Description
本發明涉及一種特定植物萃取物之新調配物。The present invention relates to a new formulation of specific plant extracts.
該特定植物萃取物係白桑樹之葉萃取物。The specific plant extract is the leaf extract of the white mulberry tree.
白桑(拉丁名為Morus alba)係一快速生長且小型至中等尺寸之桑樹，其可生長至10-20公尺高。 此物種最初原產於中國北部，而現今已於許多其他國家被廣泛地栽培與歸化，諸如美國、墨西哥、澳大利亞、吉爾吉斯、阿根廷、土耳其、伊朗等。White mulberry (Latin name Morus alba) is a fast-growing small to medium-sized mulberry tree that can grow to a height of 10-20 meters. This species was originally native to northern China, and now it has been widely cultivated and naturalized in many other countries, such as the United States, Mexico, Australia, Kyrgyzstan, Argentina, Turkey, Iran, etc.
桑葉在亞洲國家具有很長的藥用歷史，特別是中國。近年來，植物化學家已自桑葉分離出許多亞胺糖組成分，諸如1-去氧野尻黴素(1-deoxynojirimycin)(DNJ)、蕎麥鹼(fagomine)及N-甲基-DNJ。亞胺糖的化學結構與單醣的化學結構相似，其主要是具有5至6員環的多羥基雜環。Mulberry leaves have a long history of medicinal use in Asian countries, especially China. In recent years, phytochemists have isolated many imino sugar components from mulberry leaves, such as 1-deoxynojirimycin (DNJ), fagomine and N-methyl-DNJ. The chemical structure of imino sugars is similar to that of monosaccharides, which are mainly polyhydroxy heterocycles with 5- to 6-membered rings.
已證實來自桑葉之亞胺糖組成分對α-葡萄糖苷酶I與II展現出一定的抑制活性，其中DNJ顯示出最強的活性。進一步的藥理學實驗揭示DNJ作用於黑素細胞而抑制TYR的成熟過程，其導致黑色素的生成低減。(Genji Imokawa，藉由差異式碳水化合物加工抑制作用對培養惡性黑素瘤細胞的TYR中黑色素生成所必要之碳水化合物性質分析。The Journal of Investigative dermatodiy，1990，95(1)：39-49；Ju Young Park，Hyunjung Choi，Jae Sung Hwang，Junoh Kim，Ih-Seop Chang，藉由pH敏感性脂質體遞送至HM3KO黑素瘤細胞之N-醣化抑制劑的增強脫色效果，Journal of Cosmetic Science，2008，59:139-150。)It has been confirmed that the imino sugar component from mulberry leaves exhibits certain inhibitory activity on α-glucosidase I and II, and DNJ shows the strongest activity. Further pharmacological experiments revealed that DNJ acts on melanocytes to inhibit the maturation process of TYR, which leads to a decrease in the production of melanin. (Genji Imokawa, analysis of carbohydrate properties necessary for melanogenesis in TYR cultured malignant melanoma cells by differential carbohydrate processing inhibition. The Journal of Investigative dermatodiy, 1990, 95(1): 39-49; Ju Young Park, Hyunjung Choi, Jae Sung Hwang, Junoh Kim, Ih-Seop Chang, Enhanced decolorization effect of N-glycation inhibitor delivered to HM3KO melanoma cells by pH-sensitive liposomes, Journal of Cosmetic Science, 2008 , 59:139-150.)
有許多含有白桑葉萃取物的市售補充劑(呈各種形式)。There are many commercially available supplements (in various forms) containing white mulberry leaf extract.
已知白桑葉萃取物會： ․支持健康糖位準與血液循環 ․改善整體消化健康 ․透過管理食慾與減少嗜食渴求來降低葡萄糖位準及穩定體內血糖 ․透過幫助控制您的食慾、嗜糖渴求及其吸收來支持健康減重。White mulberry leaf extract is known to: ․ Supports healthy sugar levels and blood circulation ․ Improve overall digestive health ․ Reduce glucose level and stabilize blood sugar in the body by managing appetite and reducing cravings ․ Support healthy weight loss by helping control your appetite, sugar cravings and absorption.
為了生產此等補充劑，必須提供一白桑葉萃取物之調配物，其再併入至所欲之最終市場產品。In order to produce these supplements, it is necessary to provide a blend of white mulberry leaf extract, which is then incorporated into the desired final market product.
亦有市售的白桑葉萃取物之調配物(諸如，來自DSM營養品有限公司的Reducose® 1%與Reducose® 5%)。There are also commercially available white mulberry leaf extract formulations (such as Reduceose ® 1% and Reduceose ® 5% from DSM Nutrition Co., Ltd.).
由於白桑之葉萃取物的重要性，存在此一萃取物之經改良調配物的需求。Due to the importance of the white mulberry leaf extract, there is a need for an improved formulation of this extract.
白桑葉萃取物的問題在於強吸濕性。此係例如對調配物的流動性有負面影響。流動性係粉末狀調配物之一相當重要的性質。The problem with white mulberry leaf extract is its strong hygroscopicity. This system, for example, has a negative impact on the fluidity of the formulation. Flowability is one of the very important properties of powdered formulations.
現今發現當白桑之葉萃取物與特定(高用量)之麥芽糊精(及任擇其他成分)一起調配時，所得之粉末的流動性係顯著改善。It has now been found that when the white mulberry leaf extract is blended with specific (high dosage) maltodextrin (and optional other ingredients), the fluidity of the resulting powder is significantly improved.
因此本發明涉及一種粉末狀調配物(PF)，包含 (i) 一白桑樹之葉萃取物及 (ii)以該粉末狀調配物的總重量計至少50重量%(wt-%)的麥芽糊精。Therefore the present invention relates to a powdered formulation (PF) comprising (i) Leaf extract of a white mulberry tree and (ii) At least 50% by weight (wt-%) of maltodextrin based on the total weight of the powdered formulation.
很清楚的是所有百分比加總皆為100。It is clear that all percentages add up to 100.
出乎意料地，此一粉末狀調配物具有優良的流動性。Unexpectedly, this powdery formulation has excellent fluidity.
優選地，本發明之粉末狀調配物包含至少55wt-%的麥芽糊精。Preferably, the powdered formulation of the present invention contains at least 55 wt-% maltodextrin.
因此本發明涉及一種粉末狀調配物(PF1)，其為粉末狀調配物(PF)，其中該粉末狀調配物包含以該粉末狀調配物的總重量計至少55wt-%的麥芽糊精。The present invention therefore relates to a powdered formulation (PF1), which is a powdered formulation (PF), wherein the powdered formulation contains at least 55 wt-% maltodextrin based on the total weight of the powdered formulation.
優選地，本發明之調配物包含高達99wt-%的麥芽糊精。Preferably, the formulation of the present invention contains up to 99wt-% maltodextrin.
因此本發明涉及一種粉末狀調配物(PF2)，其為粉末狀調配物(PF)或(PF1)，其中該粉末狀調配物包含以該粉末狀調配物的總重量計高達99wt-%的麥芽糊精。Therefore, the present invention relates to a powdered formulation (PF2), which is a powdered formulation (PF) or (PF1), wherein the powdered formulation contains up to 99wt-% wheat based on the total weight of the powdered formulation Buddextrin.
因此本發明涉及一種粉末狀調配物(PF3)，其為粉末狀調配物(PF)、(PF1)或(PF3)，包含以該粉末狀調配物的總重量計50至99wt-%的麥芽糊精。Therefore, the present invention relates to a powdered formulation (PF3), which is a powdered formulation (PF), (PF1) or (PF3), comprising 50 to 99wt-% malt based on the total weight of the powdered formulation dextrin.
本發明之調配物可任擇包含進一步成分，其可添加至此等調配物，但其對於本發明之粉末狀調配物的優良特性來說並非必要的。此等成分可為維生素、礦物質、填料、染料、香料及纖維等。The formulations of the present invention may optionally contain further ingredients, which can be added to these formulations, but they are not necessary for the excellent properties of the powdered formulations of the present invention. These ingredients can be vitamins, minerals, fillers, dyes, fragrances and fibers.
因此本發明涉及一種粉末狀調配物(PF4)，包含 (i) 一白桑樹之葉萃取物及 (ii)以調配物的總重量計至少50wt-%的麥芽糊精，以及 (iii)至少一個進一步成分。Therefore the present invention relates to a powdered formulation (PF4) comprising (i) Leaf extract of a white mulberry tree and (ii) At least 50 wt-% maltodextrin based on the total weight of the formulation, and (iii) At least one further ingredient.
本發明之調配物可用作此等用途(作為膳食補充劑、食品補充劑、飼料、飼料補充劑或任何進一步可能的用途)。The formulation of the present invention can be used for these purposes (as a dietary supplement, food supplement, feed, feed supplement or any further possible use).
本發明之調配物也可用於調配成其他產品形式。此意謂著本發明之粉末狀調配物可作為一預混物。The formulation of the present invention can also be used for formulation into other product forms. This means that the powdered formulation of the present invention can be used as a premix.
因此本發明也涉及粉末狀調配物(PF5)、(PF1)、(PF2)、(PF3)或(P4)作為膳食補充劑、食品補充劑、飼料及飼料補充劑的用途。Therefore, the present invention also relates to the use of powdered formulations (PF5), (PF1), (PF2), (PF3) or (P4) as dietary supplements, food supplements, feed and feed supplements.
因此，本發明也涉及粉末狀調配物(PF5')、(PF1)、(PF2)、(PF3)或(P4)作為預混物的用途。Therefore, the present invention also relates to the use of powdered formulations (PF5'), (PF1), (PF2), (PF3) or (P4) as premixes.
本發明之調配物可以依照普遍已知的方法生產。The formulation of the present invention can be produced according to generally known methods.
本發明之粉末狀調配物有可能是單一顆粒。此意謂著所有組分(i)、(ii)及(iii)皆為一個顆粒的一部分。此一顆粒的尺寸與形狀對本發明來說並非必要的。它應呈用於所欲用途之合適形式。The powdered formulation of the present invention may be a single particle. This means that all components (i), (ii) and (iii) are part of one particle. The size and shape of this particle are not essential to the present invention. It should be in a suitable form for the intended use.
本發明之粉末狀調配物有可能為多於一個特定顆粒的混合物。此意謂著組分(i)、(ii)及(iii)皆為不同顆粒，其等再混合在一起。The powdered formulation of the present invention may be a mixture of more than one specific particle. This means that the components (i), (ii) and (iii) are all different particles, which are then mixed together.
此意謂著組分(i)與(ii)形成一個顆粒，該顆粒與(iii)或其任何其他變化混合。This means that components (i) and (ii) form a particle, which is mixed with (iii) or any other variation thereof.
當本發明之粉末狀調配物的成分被混合時，混合的順序並非必要的。所有成分可以一次全部加入然後混合、或者它們可以一個接著一個或以任何可能的組合加入。When the ingredients of the powdered formulation of the present invention are mixed, the order of mixing is not necessary. All ingredients can be added all at once and then mixed, or they can be added one after another or in any possible combination.
一優選的方法係生產白桑樹之葉萃取物(通常藉由噴霧乾燥及混合物，然後將其與組分(ii)及任擇與(iii)混合。 如前述，混合的順序對本發明來說並非必要的。A preferred method is to produce white mulberry leaf extract (usually by spray drying and mixing, and then mixing it with component (ii) and optional and (iii). As mentioned above, the order of mixing is not essential to the present invention.
也可以使用市售的白桑樹葉萃取物，諸如Reducose® 1%或Reducose® 5%、或它們的混合物(此等產品可從DSM營養品有限公司獲得)，並將其與麥芽糊精及任擇其他成分(組分(iii))混合。It is also possible to use commercially available white mulberry leaf extracts, such as Reduceose® 1% or Reduceose® 5%, or their mixtures (these products are available from DSM Nutrition Co., Ltd.), and combine them with maltodextrin and Optional mixing of other ingredients (component (iii)).
以下範例用於例示本發明。 範例 範例1The following examples are used to illustrate the invention. example Example 1
200克的Reducose 5%(來自DSM營養品有限公司)與1800克的麥芽糊精在雙作用式轉鼓機(篩子:0.5毫米)中混合。200 g of Reduceose 5% (from DSM Nutrition Co., Ltd.) was mixed with 1800 g of maltodextrin in a double-acting drum machine (sieve: 0.5 mm).
混合時間為5分鐘且溫度為20°C(濕度：50%RH)。The mixing time is 5 minutes and the temperature is 20°C (humidity: 50%RH).
然後所得的粉末狀調配物就流動性進行測試。此係透過測定脫附與吸附來完成。此係使用Aqualab蒸氣吸附分析儀執行動態蒸氣吸附(DVS)測試來完成。The resulting powdered formulation was then tested for fluidity. This is done by measuring desorption and adsorption. This system uses Aqualab vapor adsorption analyzer to perform dynamic vapor adsorption (DVS) test to complete.
靜態或平衡等溫的DVS方法係由下述構成：在樣品暴露於不同控制濕度下追蹤樣品重量變化。The static or equilibrium isothermal DVS method consists of the following: the change in sample weight is tracked when the sample is exposed to different controlled humidity.
將樣品在每個濕度下保持一預設的時間區間、或直到已達穩態重量變化，其目標係該樣品水活性與該控制濕度之間達到平衡。The sample is maintained at each humidity for a preset time interval, or until a steady-state weight change has been reached, the goal is to reach a balance between the water activity of the sample and the controlled humidity.
記錄重量變化對時間的資料，允許來測定每個濕度位準的吸附動力學。 有效相對濕度 = aw X 100 (即0.1 aw = 10% RH)Recording the weight change versus time data allows to determine the adsorption kinetics of each humidity level. Effective relative humidity = aw X 100 (i.e. 0.1 aw = 10% RH)
從下表中可得知結果
(無)(none)
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| CHCH00756/20 | 2020-06-23 |
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