JP2007518712A - コンパニオンアニマルのためのプロバイオティクビフィズス菌の使用方法 - Google Patents
コンパニオンアニマルのためのプロバイオティクビフィズス菌の使用方法 Download PDFInfo
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Abstract
Description
配列番号1 − ビフィドバクテリア・グロボーサム(Bifidobacteria globosum)AHCF由来の16s−23s遺伝子間スペーサヌクレオチド配列(NCIMB41198)。
配列番号2 − ビフィドバクテリア・シュードロンガム(Bifidobacteria pseudolongum)AHC7由来の16s−23s遺伝子間スペーサヌクレオチド配列(NCIMB41199)。
配列番号3 − 配列分析用の16s−23s左PCRプライマー配列。
配列番号4 − 配列分析用の16s−23s右PCRプライマー配列。
以下の表に、本発明で有用な、切除及び洗浄された哺乳類の胃腸管から単離することによって得られるプロバイオティクビフィズス菌について、種、菌株番号、及び寄託番号を記載する。細菌株は、英国工業・食品・海洋細菌収集機関(NCIMB:National Collections of Industrial Food and Marine Bacteria)(英国アバディーン(Aberdeen))に寄託されている。
特異的細胞毒性(%)=100×{1−[(ターゲット細胞及びエフェクター細胞のOD−エフェクター細胞のOD)/(ターゲット細胞のOD)]}
a)脱毛指数(Shedding index):標準ブラッシングセッションの間に生じた毛を収集することによって、各被験体に脱毛指数を割り当てる。毛を保管して計量し、対照と被験体とを比較する。
b)皮膚/被毛の主観的評価:訓練を受けた官能試験員が、脱毛、ふけ、光沢、均一性、柔軟性、及び密度を評価することによって、皮膚及び被毛の状態を主観的に評価する。
c)皮膚機能評価:アセトンを染み込ませたガーゼで皮膚表面を拭うことによって、皮膚のバリア機能を評価することができる。この手法は、単一の細胞層及び関連した角質層の脂質画分を除去することによって皮膚バリアを効果的に破壊する。当業者に既知の方法を使用して、経表皮水分損失(TEWL:transepidermal water loss)の増加及び被術部位の赤色度を測定することによって、バリアの破壊を定量化する。前述のカメラ及び照明システムを使用して、発赤(紅斑)スコアを得る。破壊の直前及び直後、並びに5時間及び24時間エンドポイントにおいて、TEWLの読み値及び発赤スコアを獲得して、皮膚の保護及び治癒特性を評価する。
この大便は、硬く、表面にくっつかない。大便は、押されると転がる。大便を拾い上げたときに、くぼみができない。大便は、完全な単一体ではなく、個別の大便の集団として排泄されることが多い。大便は、収集後に元の形状を維持している。
この大便は、硬く、形が良く、円筒状である。この大便は、拾い上げたときに容易にはばらばらにならない。この大便は、表面及び手袋に残留物を残すことがある。この大便は、単一体として排泄されることが多い。大便は、収集後に元の形状を維持している。
この大便は、柔らかいが、明確な形がある。この大便は、容易にばらばらになり、表面及び手袋に確実に残留物を残す。大便は、収集後に元の形状を失うことが多い。この大便は、しばしば別のスコアと共に存在するが、大便試料丸ごとを含むことができる。
この大便は、柔らかく、円筒状の形をもたない。「2」にしばしば関連した形状は、「牛肉パティ(cow patty)」形である。この大便は、収集されると元の形状を失い、表面及び手袋に確実に残留物を残す。この大便スコアは、しばしば別のスコアと共に存在するが、大便試料丸ごとを含むことができる。この大便試料は、数インチ(5〜15センチ)の面積に広げることができる。
この大便スコアは、常に液体様であり、粒子状物質が存在することもしないこともある。この大便は、完全な単一体ではなく、集合体(groups of piles)として排泄されることが多い。この大便試料と共に粘液が存在することが多い。この大便試料は、収集が非常に困難であり、常に表面及び手袋に残留物が残る。この大便試料は、数インチ(5〜15センチ)の面積に広げることができる。
Claims (15)
- コンパニオンアニマルにおける免疫系の調節、コンパニオンアニマルにおける皮膚及び/又は被毛系の健康の維持又は改善、コンパニオンアニマルにおける老化の影響の改善又は低減、コンパニオンアニマルにおける感染中及び感染後の体重減少の予防、コンパニオンアニマルにおける尿路疾患の治療又は予防、コンパニオンアニマルにおける繊維消化の向上、コンパニオンアニマルにおける胃腸管の感染症の予防又は治療、コンパニオンアニマルにおける消化の改善、コンパニオンアニマルにおけるストレスレベルの低下あるいはこれらの組み合わせから選択される、コンパニオンアニマルの処置のための薬剤の製造における、切除及び洗浄された哺乳類の胃腸管から単離することによって得られるビフィズス菌のプロバイオティク菌株を含む、組成物の使用。
- 前記コンパニオンアニマルが、イヌ科動物及びネコ科動物からなる群から選択される、請求項1に記載の使用。
- 前記ビフィズス菌のプロバイオティク菌株が、ヒト、イヌ科動物又はネコ科動物から得られる、切除及び洗浄された胃腸組織から単離される、請求項1又は請求項2に記載の使用。
- 前記プロバイオティクビフィズス菌が、コンパニオンアニマルの胃腸管で生存してコロニーを形成する能力で選択される、請求項1〜3のいずれか一項に記載の使用。
- 前記プロバイオティクビフィズス菌は、0.5%胆汁酸塩の存在下で培養すると少なくとも33%増殖する、請求項1〜4のいずれか一項に記載の使用。
- 前記プロバイオティクビフィズス菌が、pH2.5において1時間置かれた後で生存能力を維持することが可能である、請求項1〜5のいずれか一項に記載の使用。
- 前記プロバイオティクビフィズス菌が、ビフィドバクテリア・ロンガム(Bifidobacteria longum)、ビフィドバクテリア・シュードロンガム(Bifidobacteria pseudolongum)、ビフィドバクテリア・インファンティス(Bifidobacteria infantis)、ビフィドバクテリア・グロボーサム(Bifidobacteria globosum)又はこれらの組み合わせからなる群から選択される、請求項1〜6のいずれか一項に記載の使用。
- 前記プロバイオティクビフィズス菌が、NCIMB41050、NCIMB41051、NCIMB41052、NCIMB41053、NCIMB41099、NCIMB41100、NCIMB41003、NCIMB41198、NCIMB41199、これらの突然変異体及びこれらの組み合わせからなる群から選択される、請求項1〜7のいずれか一項に記載の使用。
- コンパニオンアニマルにおける免疫系の調節用の薬剤の製造のための請求項1に記載の使用であって、前記調節が、コンパニオンアニマルにおける自己免疫疾患の治療又は予防、コンパニオンアニマルにおける炎症の治療又は予防あるいはこれらの組み合わせを含む、使用。
- コンパニオンアニマルにおける皮膚及び/又は被毛系の健康の維持又は改善用の薬剤の製造のための請求項1に記載の使用であって、コンパニオンアニマルにおけるアトピー性皮膚疾患の治療又は予防を含む、使用。
- コンパニオンアニマルにおける尿路疾患の治療又は予防用の薬剤の製造のための請求項1に記載の使用であって、前記尿路疾患が、尿路感染症、腎臓結石又はこれらの組み合わせを含む、使用。
- 前記プロバイオティクビフィズス菌が、インビトロにてシュウ酸の分解を増進する、請求項11に記載の使用。
- 胃腸管の感染症の予防又は治療用の薬剤の製造のための請求項1に記載の使用であって、前記予防又は治療が、前記コンパニオンアニマルにおける微生物生態系の改善、前記コンパニオンアニマルにおける糞便中に見られる病原菌の数の低減又はこれらの組み合わせを含む、使用。
- 前記病原菌が、クロストリジウム属(Clostridia)、エシェリキア属(Escherichia)、サルモネラ属(Salmonella)及びこれらの組み合わせからなる群から選択される、請求項13に記載の使用。
- コンパニオンアニマルにおけるストレスレベルを低下する薬剤の製造のための請求項1に記載の使用であって、前記ストレスレベルが、エピネフリン、ノルエピネフリン、ドーパミン、コルチゾール、C反応性タンパク質及びこれらの組み合わせからなる群から選択されるストレスホルモンの、前記コンパニオンアニマルにおける血中レベルを決定することによって測定される、使用。
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007523634A (ja) * | 2003-12-19 | 2007-08-23 | ザ・アイムス・カンパニー | イヌ科動物のプロバイオティク・ビフィドバクテリア・グロボーサム |
JP2013500020A (ja) * | 2009-07-31 | 2013-01-07 | ザ・アイムス・カンパニー | 低い水分活性を有する動物フード |
JP2013509204A (ja) * | 2009-11-11 | 2013-03-14 | アリメンタリー、ヘルス、リミテッド | ビフィズス菌株 |
JP2014500007A (ja) * | 2010-11-05 | 2014-01-09 | ネステク ソシエテ アノニム | プロバイオティクス微生物を含有するペットフード調製物 |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060116330A1 (en) * | 1997-07-08 | 2006-06-01 | The Iams Company | Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose |
US8563522B2 (en) * | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
US20020035071A1 (en) * | 1997-07-08 | 2002-03-21 | Josef Pitha | Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites |
US7785635B1 (en) | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
US8894991B2 (en) * | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
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US20050158294A1 (en) * | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
AU2006253007B2 (en) * | 2005-05-31 | 2012-12-20 | Alimentary Health Ltd | Feline probiotic Bifidobacteria |
AU2006253006B8 (en) * | 2005-05-31 | 2011-09-15 | Alimentary Health Ltd | Feline probiotic Lactobacilli |
US7682619B2 (en) * | 2006-04-06 | 2010-03-23 | Cornell Research Foundation, Inc. | Canine influenza virus |
JP5799299B2 (ja) | 2007-02-01 | 2015-10-21 | ザ・アイムス・カンパニーThe Iams Company | ブドウ糖代謝拮抗物質、アボカド又はアボカド抽出物を使用する、哺乳動物における炎症及びストレスの低下方法 |
JP2008195635A (ja) * | 2007-02-09 | 2008-08-28 | Crossfield Bio Inc | 馬用乳酸菌製剤 |
CN101679938B (zh) * | 2007-03-28 | 2014-03-19 | 营养健康有限公司 | 益生双歧杆菌菌株 |
US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
MX2011002735A (es) * | 2008-09-11 | 2011-04-12 | Iams Company | Alimento granulado para animales que tiene un nucleo basado en proteinas y metodos relacionados. |
WO2010138372A2 (en) | 2009-05-28 | 2010-12-02 | The Iams Company | Pet food in the form of a coated kibble |
US9173423B2 (en) | 2009-07-31 | 2015-11-03 | The Iams Company | Animal food kibble with electrostatically adhered dusting |
US20110027417A1 (en) * | 2009-07-31 | 2011-02-03 | Patrick Joseph Corrigan | Process for Dusting Animal Food |
US8691303B2 (en) | 2009-07-31 | 2014-04-08 | The Iams Company | Dusted animal food |
US10104903B2 (en) | 2009-07-31 | 2018-10-23 | Mars, Incorporated | Animal food and its appearance |
FI122247B (fi) | 2009-08-12 | 2011-10-31 | Vetcare Oy | Probioottinen valmiste koiran maha- ja suolistokanavassa ilmenevien häiriöiden ennaltaehkäisemiseksi tai hoitamiseksi |
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US20120052013A1 (en) | 2010-08-27 | 2012-03-01 | Susan Hart Chapman | Methods of Measuring Activities of Daily Living |
US9259019B2 (en) | 2010-11-11 | 2016-02-16 | Mars, Incorporated | Bifidobacteriumstrain |
US20130295227A1 (en) | 2012-05-01 | 2013-11-07 | Robbert H. ter Haar | Composition Comprising a Sensitive Ingredient |
WO2016133909A1 (en) | 2015-02-16 | 2016-08-25 | Mars, Incorporated | Interlocking kibble |
MX2017013715A (es) | 2015-04-28 | 2018-03-02 | Mars Inc | Proceso de preparacion de un producto de alimento para mascotas humedo esterilizado. |
WO2019113086A1 (en) * | 2017-12-05 | 2019-06-13 | The Regents Of The University Of California | Methods of treating dog urinary tract infections |
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TWI701034B (zh) * | 2018-05-28 | 2020-08-11 | 豐華生物科技股份有限公司 | 用於改善腎病及抑制發炎之乳酸菌菌株的醫藥組合物及食品組合物 |
WO2020051379A1 (en) | 2018-09-05 | 2020-03-12 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases |
US11980647B2 (en) | 2018-09-05 | 2024-05-14 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
TWI726429B (zh) * | 2019-09-27 | 2021-05-01 | 寶耕生技股份有限公司 | 用於皮膚傷口癒合之用途的大豆醱酵組合物 |
CN115305210A (zh) * | 2021-05-06 | 2022-11-08 | 江苏恒丰强生物技术有限公司 | 一种鸡源假长双歧杆菌培养方法及其应用 |
AU2022391767A1 (en) | 2021-11-22 | 2024-07-04 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
US20230190834A1 (en) | 2021-12-21 | 2023-06-22 | Solarea Bio, Inc. | Immunomodulatory compositions comprising microbial entities |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06166626A (ja) * | 1992-05-12 | 1994-06-14 | Taiyo Kagaku Co Ltd | 生菌粉末 |
JP2002255853A (ja) * | 2001-03-01 | 2002-09-11 | Biofuerumin Seiyaku Kk | 免疫賦活組成物 |
JP2002534113A (ja) * | 1999-01-15 | 2002-10-15 | エンタープライズ・アイルランド(トレイディング・アズ・バイオリサーチ・アイルランド) | 炎症性疾患治療におけるビフィドバクテリウム(Bifidobacterium) |
WO2003010297A1 (en) * | 2001-07-26 | 2003-02-06 | Alimentary Health Limited | Probiotic bifidobacterium strains |
JP2003534003A (ja) * | 2000-05-25 | 2003-11-18 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | ペットフード用新規プロバイオチックス |
Family Cites Families (398)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US571521A (en) | 1896-11-17 | Package for powders | ||
US1086936A (en) | 1913-05-15 | 1914-02-10 | Malcolm Pounder | Dental massage implement. |
US1503094A (en) | 1923-09-15 | 1924-07-29 | Cramerton Mills Inc | Warp condenser |
US2473773A (en) | 1945-11-16 | 1949-06-21 | Eleanor Kushmaul | Toothbrush |
US2540979A (en) | 1948-04-24 | 1951-02-06 | Smith Kline French Lab | Enteric coating |
US2641548A (en) | 1950-04-06 | 1953-06-09 | Helen W Heinrich | Method of preserving avocados |
BE634858A (ja) | 1962-07-19 | 1900-01-01 | ||
US3398001A (en) | 1963-04-26 | 1968-08-20 | Air Reduction | Process of preparing and packaging frozen avocados |
DE1204363B (de) | 1963-09-10 | 1965-11-04 | Hoffmann La Roche | Verfahren zur Herstellung einer oralen Arzneizubereitung, die ihren Wirkstoff erst im Ileum abgibt |
GB1190387A (en) | 1966-05-24 | 1970-05-06 | Green Cross Corp | Enteric Coated Medicaments |
DE1536074A1 (de) | 1966-06-28 | 1969-11-13 | Hoefliger & Karg | Tiefziehpackung |
US3677898A (en) | 1969-01-31 | 1972-07-18 | Ajinomoto Kk | Acid protease and method of preparing the same |
US3898132A (en) | 1972-08-24 | 1975-08-05 | Int Feed Improvement Ass Inc | Method of preparing stowable, dormant bacteria |
US3931885A (en) | 1973-04-30 | 1976-01-13 | Nahill Edmond P | Medicine dispensing system |
US3897572A (en) | 1973-05-16 | 1975-07-29 | Star Kist Foods | Formed meat product |
US3989822A (en) | 1974-02-14 | 1976-11-02 | Purdue Research Foundation | Weight control compound |
US3984576A (en) | 1974-09-09 | 1976-10-05 | The Quaker Oats Company | Meatless marbled, semi-moist pet food |
US3957974A (en) | 1974-11-05 | 1976-05-18 | Seikenkai | Method for deodorization of excrements |
JPS6038372B2 (ja) * | 1975-04-09 | 1985-08-31 | 日清製粉株式会社 | 犬の下痢予防および治療方法 |
JPS52102419A (en) | 1976-02-23 | 1977-08-27 | Seikenkai | Lactic acid producing bacillus preparation |
US4132137A (en) * | 1977-03-14 | 1979-01-02 | Q Corporation | Apparatus for trimming electrical component leads |
GB1595054A (en) | 1977-11-14 | 1981-08-05 | Metal Box Co Ltd | Capsules containing micro-organisms |
US4160745A (en) * | 1977-12-01 | 1979-07-10 | Exxon Research & Engineering Co. | Method of preparing highly active nickel catalysts and catalysts prepared by said method |
IL58649A (en) | 1978-11-10 | 1982-04-30 | Beecham Group Ltd | Pharmaceutical dispensing container |
CH637297A5 (fr) | 1978-12-05 | 1983-07-29 | Nestle Sa | Microbille comprenant un microorganisme et son procede de fabrication. |
US4338346A (en) | 1978-12-21 | 1982-07-06 | The Procter & Gamble Company | Non-nutritive sweetener |
FR2453215A1 (fr) | 1979-04-05 | 1980-10-31 | Rhone Poulenc Ind | Procede d'inclusion de micro-organismes dans une matrice de polymere |
US4248857A (en) | 1979-08-09 | 1981-02-03 | American Home Products Corporation | Sustained release pharmaceutical compositions |
US4411925A (en) | 1980-01-21 | 1983-10-25 | Pfizer Inc. | Branched amides of L-aspartyl-d-amino acid dipeptides |
US4399163A (en) | 1980-11-05 | 1983-08-16 | Pfizer Inc. | Branched amides of L-aspartyl-D-amino acid dipeptides |
US4423029A (en) | 1981-06-25 | 1983-12-27 | The Procter & Gamble Company | (S)-3-Amino-4-[(S,S)-1-(1-hydroxyethyl)alkyl amino]-4-oxo-butyric acid compounds suitable as non-nutritive sweetners |
US4403623A (en) | 1981-11-16 | 1983-09-13 | Colgate-Palmolive Company | Combined toothbrush and gum massage device |
DE3221425A1 (de) | 1982-06-07 | 1983-12-08 | Boehringer Ingelheim KG, 6507 Ingelheim | Hydrolyseempfindlichen wirkstoff enthaltende, lagerstabile tablette |
US4518696A (en) | 1983-01-11 | 1985-05-21 | Chr. Hansen's Laboratory, Inc. | Stabilized liquid bacterial suspension for oral administration to animals |
JPS59213368A (ja) | 1983-05-17 | 1984-12-03 | Hanamaruki Kk | 果実食品およびその製造法 |
JPS6024153A (ja) | 1983-07-18 | 1985-02-06 | Kagome Kk | アボカドを含有するスプレツド |
US4736849A (en) | 1983-12-19 | 1988-04-12 | Leonard Walter G | Calendar-oriented pill dispenser |
US4592748A (en) | 1984-05-18 | 1986-06-03 | Vortex Research Corp. | Yoghurt based douche kit and assembly therefor |
CA1276394C (en) | 1984-07-13 | 1990-11-13 | John M. Janusz | Alpha-l-aspartyl-d-phenylglycine esters and amides useful as high intensity sweeteners |
US4647453A (en) | 1984-10-18 | 1987-03-03 | Peritain, Ltd. | Treatment for tissue degenerative inflammatory disease |
JPS61109729A (ja) | 1984-11-05 | 1986-05-28 | Advance Res & Dev Co Ltd | コレステロ−ル低下剤 |
SE463598B (sv) | 1984-11-08 | 1990-12-17 | Chemical Dynamics Sweden Ab | Preparat, avsett att oeka vidhaeftningen av bakterier till mag-tarmkanalen hos maenniskor och djur, samt ett framstaellningsfoerfarande foer detta |
US4839281A (en) | 1985-04-17 | 1989-06-13 | New England Medical Center Hospitals, Inc. | Lactobacillus strains and methods of selection |
DE3678643D1 (de) | 1985-08-16 | 1991-05-16 | Procter & Gamble | Partikel mit konstanter wirkstofffreisetzung. |
EP0212747B1 (en) | 1985-08-16 | 1991-04-10 | The Procter & Gamble Company | Drug particles having constant release and immediate release |
JPS62201823A (ja) | 1986-02-28 | 1987-09-05 | Freunt Ind Co Ltd | 腸内有用細菌含有物およびその製造方法 |
US4764389A (en) | 1986-04-24 | 1988-08-16 | Labarge Universal Ripener, Inc. | Method of accelerating fruit respiration |
US5160745A (en) | 1986-05-16 | 1992-11-03 | The University Of Kentucky Research Foundation | Biodegradable microspheres as a carrier for macromolecules |
CA1300538C (en) | 1986-08-01 | 1992-05-12 | Robert Charley | Maintenance of the viability of microorganisms for use in microbial inoculants |
US4808626A (en) | 1986-09-23 | 1989-02-28 | Monell Chemical Senses Center | Use of 2,5-anhydro-D-mannitol as a food intake modifier |
US4781939A (en) | 1986-10-28 | 1988-11-01 | Nestec, S.A. | Layered meat emulsion product and method of producing same |
US4816259A (en) | 1987-02-12 | 1989-03-28 | Chase Chemical Company, L.P. | Process for coating gelatin capsules |
US4797289A (en) | 1987-03-09 | 1989-01-10 | Reddy Malireddy S | Enhancement of lactobacillus acidophilus growth and viability in yogurt and other cultured dairy products |
EP0698347B1 (en) | 1987-05-01 | 2006-07-12 | Biogaia Biologics Ab | Food composition containing reuterin |
US5413960A (en) | 1987-05-01 | 1995-05-09 | Biogaia Ab | Antibiotic reuterin |
DE3715070A1 (de) | 1987-05-06 | 1988-11-17 | Kneipp Werke Kneipp Mittel Zen | Verfahren zur herstellung von pflanzenauszuegen, insbesondere von pflanzensaeften |
FI77573C (fi) | 1987-05-08 | 1989-04-10 | Orion Yhtymae Oy | Ny konsistens. |
FR2615203B1 (fr) | 1987-05-12 | 1989-08-18 | Agronomique Inst Nat Rech | Inoculum dans lequel les micro-organismes sont conditionnes sous la forme de granules biodegradables, son procede de preparation et ses applications |
GB8713601D0 (en) | 1987-06-10 | 1987-07-15 | Unilever Plc | Fermentation |
US4859377A (en) | 1987-07-10 | 1989-08-22 | The United States Of America, As Represented By The Secretary Of Agriculture | Starch encapsulation of entomopathogens |
US4806368A (en) | 1987-09-16 | 1989-02-21 | Reddy Malireddy S | Shelf life and subsequent growth of lactobacillus acidophilus, propionibacterium shermanii and leuconostoc citrovorum in dietary fiber based supplement preparation |
US4937077A (en) | 1987-09-21 | 1990-06-26 | Eastman Kodak Company | Method for improving feed conversion of meat-producing animals by oral administration of 2-deoxy-D-hexose |
DK686187D0 (da) | 1987-12-23 | 1987-12-23 | Hansens Chr Bio Syst | Veterinaert praeparat |
US4814193A (en) | 1988-04-06 | 1989-03-21 | General Foods Corporation | Reduction of microbial population on surface of food materials |
JPH01278781A (ja) | 1988-05-02 | 1989-11-09 | Nec Corp | 不揮発性半導体記憶装置 |
US5126153A (en) | 1988-05-13 | 1992-06-30 | Basic American Foods, Inc. | Compositions and methods for inhibiting browning of processed produce |
DE68928665T2 (de) | 1988-08-02 | 1998-11-12 | Gastro Services Pty Ltd | Behandlung von gastro-intestinalen krankheiten |
IT1227154B (it) | 1988-08-05 | 1991-03-19 | A Tosi Farmaceutici S R L Nova | Composizioni farmaceutiche per uso ginecologico a base di lattobacilli |
IT1230576B (it) | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
US4889238A (en) | 1989-04-03 | 1989-12-26 | The Procter & Gamble Company | Medicament package for increasing compliance with complex therapeutic regimens |
AU5254790A (en) | 1989-04-06 | 1990-10-11 | Chugai Seiyaku Kabushiki Kaisha | Process for preparing a therapeutic agent for rotavirus infection |
US5540945A (en) | 1989-05-11 | 1996-07-30 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical preparations for oral administration that are adapted to release the drug at appropriate sites in the intestines |
PT94108A (pt) | 1989-05-24 | 1991-02-08 | Asahi Chemical Ind | Preparacao de microorganismos viaveis contendo esporos estabilizada,sua producao e pilulas respectivas |
JPH06101994B2 (ja) | 1989-08-16 | 1994-12-14 | ユニコロイド株式会社 | 耐消化性腸内有用細菌及びその製法 |
PH27186A (en) | 1989-09-07 | 1993-04-16 | Ciba Geigy Ag | Double-coated granules of disodium pamidronate |
DE3933528C1 (ja) | 1989-10-04 | 1990-12-06 | Effem Gmbh, 2810 Verden, De | |
SE465206B (sv) | 1989-12-22 | 1991-08-12 | Eva Grahn | Farmaceutisk beredning foer bekaempning av patogena tarmbakterier |
US5198227A (en) | 1990-01-22 | 1993-03-30 | Mcneil-Ppc, Inc. | Dual subcoated simulated capsule medicament |
US5344824A (en) | 1990-02-02 | 1994-09-06 | Matsutani Chemical Industries Co., Ltd. | Method for reducing insulin secretion |
US6451341B1 (en) | 1990-02-05 | 2002-09-17 | Thomas J. Slaga | Time release formulation of vitamins, minerals and other beneficial supplements |
DK203090A (da) | 1990-02-28 | 1991-08-29 | Sitia Yomo Spa | Maelkeagtig mousse, dens tilberedning og anvendelse |
FI88856C (fi) | 1990-05-18 | 1997-07-01 | Alko Yhtioet Oy | Foerfarande foer framstaellning av ett fermenterat, huvudsakligen pao havrekli baserat, levande mikroorganismer innehaollande livsmedel |
DE4018392A1 (de) | 1990-06-08 | 1991-12-12 | Kaysan Rolf Dipl Kaufm | Verfahren zur gewinnung von pflanzen-hydrolysaten insbesondere fuer biokosmetische und pharmazeutische zwecke |
FR2663198B1 (fr) | 1990-06-14 | 1993-09-17 | Xeda International | Utilisation de composes antioxydants pour augmenter la resistance des fruits et legumes contre les infections fongiques. |
IE61651B1 (en) | 1990-07-04 | 1994-11-16 | Zambon Spa | Programmed release oral solid pharmaceutical dosage form |
FR2668081B1 (fr) | 1990-10-19 | 1994-11-18 | Lvmh Rech | Procede et appareil de fabrication de particules solides a partir d'un materiau solidifiable en presence d'un agent de solidification en de bons rendements. |
US5292657A (en) | 1990-12-31 | 1994-03-08 | Pioneer Hi-Bred International, Inc. | Process for preparing rotary disc fatty acid microspheres of microorganisms |
IT1244691B (it) | 1991-01-29 | 1994-08-08 | Sitia Yomo Spa | Mousse lattea, suo impiego per preparare dessert e dessert cosi' ottenuti |
GB9107305D0 (en) | 1991-04-08 | 1991-05-22 | Unilever Plc | Probiotic |
US5488964A (en) * | 1991-05-08 | 1996-02-06 | Tokyo Electron Limited | Washing apparatus, and washing method |
FR2678166B1 (fr) | 1991-06-27 | 1993-10-22 | Bioeurope | Compositions cosmetiques contenant des glucooligosaccharides. |
SE469875C (sv) | 1991-07-25 | 1997-04-14 | Probi Ab | Stam av tarmkoloniserande Lactobacillus samt komposition för profylax eller behandling av infektioner i magtarmkanalen |
WO1993002558A1 (en) | 1991-08-01 | 1993-02-18 | Biogaia Biologics Ab | Method and formulation for reducing microbial populations |
GB2261372A (en) | 1991-11-15 | 1993-05-19 | Gregor Reid | Lactobacillus and skim milk compositions for prevention of urogenital infection |
EP0563934A1 (de) | 1992-04-03 | 1993-10-06 | Dr. Karl Thomae GmbH | Blisterstreifen aus Kunststoff-Folien mit Doppel-bzw. Mehrfachdosierung. |
US5286495A (en) | 1992-05-11 | 1994-02-15 | University Of Florida | Process for microencapsulating cells |
DK0768375T4 (da) | 1992-07-06 | 2002-09-16 | Nestle Sa | Mælkesyrebakterier |
EP0577903B1 (fr) | 1992-07-06 | 1997-12-17 | Societe Des Produits Nestle S.A. | Agent antigastrite |
US5501857A (en) | 1992-07-24 | 1996-03-26 | Midwestern Bio-Ag Products & Services, Inc. | Oral nutritional and dietary composition |
HU220103B (hu) | 1992-08-20 | 2001-10-28 | Schering-Plough Corp. | IL-10 új alkalmazása |
US5403799A (en) | 1992-12-21 | 1995-04-04 | W. R. Grace & Co.-Conn. | Process upset-resistant inorganic supports for bioremediation |
JP3347381B2 (ja) | 1993-01-27 | 2002-11-20 | 協和醗酵工業株式会社 | ペットフード |
JP3472317B2 (ja) | 1993-02-26 | 2003-12-02 | 味の素ファルマ株式会社 | 被覆製剤 |
JPH08509965A (ja) | 1993-03-15 | 1996-10-22 | ファーマ・パシフィック・ピーティーワイ・リミテッド | 治療剤および治療方法 |
CA2156486C (en) | 1993-03-16 | 2002-11-12 | Norman J. Stern | Mucosal competitive exclusion flora |
IT1265092B1 (it) | 1993-05-31 | 1996-10-30 | Giuliani Spa | Preparato per uso come integratore alimentare, o dietetico,a rilascio mirato nel colon |
GB9315846D0 (en) | 1993-07-30 | 1993-09-15 | Isis Innovation | Tumour inhibitors |
GB9318439D0 (en) | 1993-09-06 | 1993-10-20 | Zeneca Ltd | Probiotics |
US5501868A (en) | 1993-09-21 | 1996-03-26 | Colgate Palmolive Company | Extruded dog treat food product having improved resistance to breakage |
DE4336050C2 (de) | 1993-10-22 | 1995-11-16 | Onken Gmbh | Tierfutter, insbesondere Alleinfutter für Katzen und Hunde |
US5733568A (en) | 1993-12-03 | 1998-03-31 | Lafor Laboratories Limited | Micro-encapsulated lactobacilli for medical applications |
JP3559790B2 (ja) | 1993-12-20 | 2004-09-02 | 松谷化学工業株式会社 | 食品にビフィズス菌の増殖促進作用を付与する方法 |
US5486507A (en) | 1994-01-14 | 1996-01-23 | Fuisz Technologies Ltd. | Porous particle aggregate and method therefor |
JPH07232049A (ja) | 1994-02-25 | 1995-09-05 | Freunt Ind Co Ltd | 遠心転動造粒コーティング装置および粉粒体の遠心転動造粒コーティング方法ならびにその方法を用いた粉粒体の造粒方法とコーティング方法 |
JP2992945B2 (ja) | 1994-03-11 | 1999-12-20 | カルピス株式会社 | ラクトバチルス・アシドフィルス乳酸菌 |
US5894029A (en) | 1994-03-21 | 1999-04-13 | Purebred Pet Products, Inc. | Method of making pet snack food |
SE9401738D0 (sv) | 1994-05-19 | 1994-05-19 | Ewos Ab | Bioactive feed |
IT1270216B (it) | 1994-06-14 | 1997-04-29 | Recordati Chem Pharm | Metodo di stabilizzazione di composti biologicamente attivi mediante microgranuli ricoperti sospendibili in fluidi alimentari |
GB2290965A (en) | 1994-07-11 | 1996-01-17 | Therapicon Srl | Multiple layer capsules for drugs |
US5849327A (en) | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
US5531988A (en) | 1994-10-28 | 1996-07-02 | Metagenics, Inc. | Bacteria and immunoglobulin-containing composition for human gastrointestinal health |
AU4214596A (en) | 1995-01-23 | 1996-08-01 | Glenda Julieanne Wilkinson | Processing avocado |
US5733540A (en) | 1995-03-08 | 1998-03-31 | Lee; Peter Poon-Hang | Protection from viral infection via colonization of mucosal membranes with genetically modified bacteria |
JPH08242763A (ja) | 1995-03-10 | 1996-09-24 | Morishita Jintan Kk | カプセル化された腸内有用細菌を含有するヨーグルト |
CR5278A (es) | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
IT1276783B1 (it) | 1995-06-23 | 1997-11-03 | Bracco Spa | Formulazioni farmaceutiche e dietetiche per la profilassi e la cura di affezioni gastrointestinali |
US5785990A (en) | 1995-07-10 | 1998-07-28 | Merrick's, Inc. | Feed fortifier and enhancer for preruminant calves and method of using same |
SG80553A1 (en) | 1995-07-20 | 2001-05-22 | Tanabe Seiyaku Co | Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract |
FI102298B1 (fi) | 1995-09-07 | 1998-11-13 | Oulutech Oy | Menetelmä maitohappobakteerilajien määrittämiseksi ja menetelmään soveltuvia oligonukleotideja |
US5702679A (en) | 1995-10-06 | 1997-12-30 | Kerr-Mcgee Chemical Corp. | Method of preparing Li1+X- Mn2-X O4 for use as secondary battery |
US6506389B2 (en) | 1995-10-20 | 2003-01-14 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek (Tno) | Adherence factors of non pathogenic microorganisms and applications thereof for screening microorganisms for specific probiotic properties; novel pharmaceutical compositions and food additives comprising such microorganisms and adherence factors |
US5853697A (en) | 1995-10-25 | 1998-12-29 | The United States Of America, As Represented By The Department Of Health & Human Services | Methods of treating established colitis using antibodies against IL-12 |
AT405235B (de) | 1995-11-02 | 1999-06-25 | Helmut Dr Viernstein | Probiotisch wirksame formulierung |
AUPN698495A0 (en) | 1995-12-06 | 1996-01-04 | Pharma Pacific Pty Ltd | Improved therapeutic formulation and method |
US5858356A (en) | 1995-12-21 | 1999-01-12 | Abbott Laboratories | Lactobacillus acidophilus to inhibit cryptosporidiosis in mammals |
US5854067A (en) | 1996-01-19 | 1998-12-29 | Board Of Regents, The University Of Texas System | Hexokinase inhibitors |
US5962043A (en) | 1996-02-29 | 1999-10-05 | Seal Rock Technologies Incorporated | Weight reduction method for dogs and other pets |
GB2311027B (en) | 1996-03-15 | 1999-10-27 | Johnson & Johnson Medical | Coated bioabsorbable beads for wound treatment |
RU2086248C1 (ru) * | 1996-04-02 | 1997-08-10 | Всероссийский государственный научно-исследовательский институт контроля, стандартизации и сертификации ветеринарных препаратов | Пробиотический препарат "стрептобифид" для животных |
US5824779A (en) | 1996-04-26 | 1998-10-20 | Wisconsin Alumni Research Foundation | Phytase-protein-pigmenting concentrate derived from green plant juice |
US5766520A (en) | 1996-07-15 | 1998-06-16 | Universal Preservation Technologies, Inc. | Preservation by foam formation |
US6440464B1 (en) | 1996-06-10 | 2002-08-27 | Viva Life Science | Nutritive composition for cardiovascular health containing fish oil, garlic, rutin, capsaicin, selenium, vitamins and juice concentrates |
ATE298363T1 (de) | 1996-07-09 | 2005-07-15 | Nestle Sa | Verfahren zur sprühtrocknung |
US5871794A (en) | 1996-08-07 | 1999-02-16 | Brito; Jorge Issac | Stabilized guacamole and method for making same |
US5660790A (en) | 1996-08-13 | 1997-08-26 | Litmus Concepts, Inc. | PH and amine test elements |
JP2002511777A (ja) | 1996-10-28 | 2002-04-16 | ゼネラル ミルズ,インコーポレイテッド | 調放性粒子の埋包およびカプセル化 |
ATE271379T1 (de) | 1996-11-06 | 2004-08-15 | Wockhardt Europ Ltd | System zur verzögerten freisetzung säurelabiler substanzen |
ES2283027T3 (es) | 1996-11-29 | 2007-10-16 | Bio K + International Inc. | Fermento lactico que comprende una cepa particular de lactobacilus acidofilus y utilizacion del mismo. |
AU5310898A (en) | 1996-12-20 | 1998-07-17 | Dumex-Alpharma A/S | Release-controlled coated tablets |
US5952033A (en) | 1996-12-24 | 1999-09-14 | Nestec S.A. | Gelatinized cereal product containing oligosaccharide and processes of preparing and using same |
EP0862863B9 (en) | 1997-01-09 | 2009-08-12 | Societe Des Produits Nestle S.A. | Cereal product containing probiotics |
WO1998035014A2 (en) | 1997-02-11 | 1998-08-13 | Enterprise Ireland Trading As Bioresearch Ireland | Probiotic strains from lactobacillus salivarius and antimicrobial agents obtained therefrom |
AU2809899A (en) | 1997-03-18 | 1999-07-22 | Mendel Institute For Nutraceutical Research Inc, The | Dosing beverage with a bacteria formulation |
US6133323A (en) | 1997-04-09 | 2000-10-17 | The Iams Company | Process for enhancing immune response in animals using β-carotene as a dietary supplement |
ATE493139T1 (de) | 1997-04-18 | 2011-01-15 | Ganeden Biotech Inc | Oberflächige verwendung von probiotischen bacillussporen zur verhinderung oder bekämpfung von mikrobiellen infektionen |
US8486389B2 (en) | 1997-05-23 | 2013-07-16 | Oxthera, Inc. | Compositions and methods for treating or preventing oxalate-related disease |
US6355242B1 (en) | 1997-05-23 | 2002-03-12 | Ixion Biotechnology, Inc. | Materials and methods for treating or preventing oxalate-related disease |
EP0986314B1 (en) | 1997-06-03 | 2008-09-10 | Ganeden Biotech, Inc. | Probiotic lactic acid bacterium to treat bacterial infections associated with sids |
IT1292636B1 (it) | 1997-06-20 | 1999-02-08 | Ascor Chimici Srl | Composizione a rilascio controllato di sostanze biologicamente attive ad uso zootecnico. |
RU2123343C1 (ru) | 1997-06-26 | 1998-12-20 | Алин Борис Иннокентьевич | Способ получения капсул, содержащих бактерии b.bifidum (бифидумбактерин сухой в капсулах) |
US5976579A (en) | 1997-07-03 | 1999-11-02 | Mclean; Linsey | Nutritional supplement for the prevention and treatment of excessive intestinal permeability |
ATE208205T1 (de) | 1997-07-05 | 2001-11-15 | Nestle Sa | Lactobacilli zur erhöhung der mineralienabsorption durch darmzellen |
US20020035071A1 (en) | 1997-07-08 | 2002-03-21 | Josef Pitha | Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites |
US20060116330A1 (en) | 1997-07-08 | 2006-06-01 | The Iams Company | Methods of mimicking the metabolic effects of caloric restriction by administration of mannoheptulose |
US8563522B2 (en) | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
US20180000880A9 (en) | 1997-07-08 | 2018-01-04 | The Iams Company | Methods of treating or preventing overweight and obsesity in mammals by administering a composition comprising mannoheptulose |
US6077530A (en) | 1997-07-28 | 2000-06-20 | Weinstein; Robert | Analgesic dosage units for coordinated administration |
SE510753C2 (sv) | 1997-08-05 | 1999-06-21 | Probi Ab | Användning av en stam av Lactobacillus för tillverkning av ett läkemedel för reduktion av fibrinogenhalten i blod |
US5939117A (en) | 1997-08-11 | 1999-08-17 | Mantrose-Haeuser Co., Inc. | Methods for preserving fresh fruit and product thereof |
US6063414A (en) | 1997-08-18 | 2000-05-16 | Seal Rock Technologies Incorporated | Combination container and dry pet food for increased shelf life, freshness, palatability, and nutritional value |
FI108512B (fi) | 1997-08-22 | 2002-02-15 | Danisco Finland Oy | Tahnamainen nautittavaksi tarkoitettu koostumus, sen käyttö ja sitä sisältävät tuotteet |
NZ503086A (en) | 1997-08-29 | 2002-03-01 | Upjohn Co | An orally administrable pharmaceutical composition comprising an inner core and two outer layers, which render it substantially free of unpleasant tastes |
JP3400685B2 (ja) | 1997-09-04 | 2003-04-28 | 矢崎総業株式会社 | インサート成形によるターミナルの製造方法 |
SE511025C2 (sv) | 1997-10-03 | 1999-07-26 | Probi Ab | Foderprodukt för häst omfattande Lactobacillus plantarum JI:1 samt Lactobacillus plantarum JI:1 och användning därav |
KR100387245B1 (ko) | 1997-10-17 | 2003-08-19 | 일양약품주식회사 | 유산균의안정화를위한미세장용성코팅과립 |
US5871802A (en) | 1997-12-16 | 1999-02-16 | Moorman Manufacturing Co. | Animal feed pelleting process and animal feed pellets produced therefrom |
AR014129A1 (es) | 1997-12-17 | 2001-02-07 | Nutrasweet Co | Bebida que comprende fundamentalmente un ester n-[n-(3,3-dimetilbutil)-l- alfa-aspartil]-l-fenilamina 1 - metilico, bebida sin alcohol carbonatada,bebida de jugo, bebida envasada caliente y bebida deportiva de bajas calorias. |
PT931543E (pt) | 1997-12-19 | 2002-09-30 | Merck Patent Gmbh | Comprimidos de varias camadas contendo microorganismos probioticos como por exemplo lactobacilus ou bifidobacterias |
IT1298918B1 (it) | 1998-02-20 | 2000-02-07 | Mendes Srl | Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche |
US6117477A (en) | 1998-03-18 | 2000-09-12 | Kal Kan Foods, Inc. | Multicomponent food product and methods of making and using the same |
DE69941212D1 (de) | 1998-03-23 | 2009-09-17 | Gen Mills Inc | Verkapselung von komponenten in essbaren produkten |
US7201923B1 (en) | 1998-03-23 | 2007-04-10 | General Mills, Inc. | Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles |
FI104405B (fi) | 1998-03-27 | 2000-01-31 | Valtion Teknillinen | Mikro-organismeja sisältävät tärkkelyskapselit ja niiden valmistusmenetelmä |
US5932258A (en) | 1998-04-06 | 1999-08-03 | The Iams Company | Composition and process for improving glucose metabolism in companion animals |
PT956858E (pt) | 1998-04-30 | 2002-04-29 | Renata Maria Anna Caval Vesely | Composicoes farmaceuticas contendo lactobacilos para o tratamento de infeccoes vaginais |
DE19819475A1 (de) | 1998-04-30 | 1999-11-04 | Basf Ag | Trockene Mikroorganismen-Kulturen und Verfahren zu deren Herstellung |
WO2000006127A1 (en) | 1998-07-30 | 2000-02-10 | Warner-Lambert Company | Centerfill delivery system for nutraceuticals |
SE9803871D0 (sv) | 1998-11-11 | 1998-11-11 | Pharmacia & Upjohn Ab | Therapeutic method and formulation |
US6156355A (en) | 1998-11-02 | 2000-12-05 | Star-Kist Foods, Inc. | Breed-specific canine food formulations |
US6080401A (en) * | 1998-11-19 | 2000-06-27 | Reddy; Malireddy S. | Herbal and pharmaceutical drugs enhanced with probiotics |
IT1304170B1 (it) | 1998-12-15 | 2001-03-08 | Novartis Nutrition Ag | Composti organici |
JP2000191519A (ja) | 1998-12-25 | 2000-07-11 | Nippon Kayaku Co Ltd | 薬効成分の不快な官能的性質が隠蔽された速放性粒状物 |
DE19860375A1 (de) | 1998-12-28 | 2000-07-06 | Aventis Res & Tech Gmbh & Co | Alpha Amylase-resistente Stärke zur Herstellung von Nahrungs- und Arzneimittel |
US6767573B1 (en) | 1999-03-10 | 2004-07-27 | Nestec S.A. | Fried pet treats |
EP1034788A1 (en) | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactic acid bacteria strains capable of preventing diarrhea |
EP1034787A1 (en) | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactobacillus strains preventing diarrhea caused by pathogenic bacteria |
US6692779B2 (en) | 1999-03-26 | 2004-02-17 | The Pillsbury Company | Food products with biocontrol preservation |
US6358555B1 (en) | 1999-03-31 | 2002-03-19 | Hideyuki Takahashi | Process for producing frozen avocados |
US20040161422A1 (en) | 1999-04-30 | 2004-08-19 | Natarajan Ranganathan | Nutritional compositions comprising probiotics |
HUP0201437A2 (en) | 1999-05-27 | 2002-08-28 | Iams Company | Process and product for enhancing immune response in companion animal using a combination of antioxidants |
IT1309427B1 (it) | 1999-05-28 | 2002-01-23 | Mendes S U R L | Composizione dietetica o farmaceutica utile per la prevenzione o iltrattamento dell'iperossaluria e suo uso |
US6375956B1 (en) | 1999-07-22 | 2002-04-23 | Drugtech Corporation | Strip pack |
DE19937361A1 (de) | 1999-08-12 | 2001-02-22 | Merck Patent Gmbh | Orale Darreichungsform |
US6737089B2 (en) | 1999-08-27 | 2004-05-18 | Morinda, Inc. | Morinda citrifolia (Noni) enhanced animal food product |
NZ511870A (en) | 1999-09-22 | 2004-02-27 | Nestle Sa | Method for increasing pet activity |
US6500463B1 (en) | 1999-10-01 | 2002-12-31 | General Mills, Inc. | Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles |
CN1281220C (zh) | 1999-10-26 | 2006-10-25 | 雀巢制品公司 | 乳酸菌在制备治疗和/或预防贾第鞭毛虫病药物中的应用 |
US6394803B1 (en) | 1999-12-09 | 2002-05-28 | Ivoclar Ag | Mixing arrangement |
US6406853B1 (en) | 1999-12-23 | 2002-06-18 | The Regents Of The University Of California | Interventions to mimic the effects of calorie restriction |
AU2461201A (en) | 1999-12-23 | 2001-07-03 | Regents Of The University Of California, The | Interventions to mimic the effects of calorie restriction |
EP1251747B1 (en) | 2000-01-18 | 2012-01-25 | Société des Produits Nestlé S.A. | Pet food composition for treating helicobacter species in pets |
US20010036488A1 (en) | 2000-01-18 | 2001-11-01 | Syuichi Hayashi | Anti-obestic composition |
US20030060503A1 (en) | 2000-01-25 | 2003-03-27 | Juvenon, Inc. | Nutritional supplements for mature pets |
JP3888064B2 (ja) | 2000-01-27 | 2007-02-28 | 田辺製薬株式会社 | 徐放性製剤およびその製法 |
US7115297B2 (en) | 2000-02-22 | 2006-10-03 | Suzanne Jaffe Stillman | Nutritionally fortified liquid composition with added value delivery systems/elements/additives |
JP2001309753A (ja) | 2000-04-28 | 2001-11-06 | Natl Fedelation Of Agricult Coop Assoc | 犬特有の感染症の予防・治療用ドッグフード |
US20030104090A1 (en) | 2000-05-05 | 2003-06-05 | Levy Pedro E. | Supplements containing annatto extracts and carotenoids and methods for using the same |
FR2809312B1 (fr) | 2000-05-25 | 2002-07-12 | Gervais Danone Sa | Utilisation de l. casei dans des compositions immunostimulantes |
US6571229B1 (en) | 2000-05-31 | 2003-05-27 | Motorola, Inc. | Method and apparatus for inerative training of a classification system |
DE10029079B4 (de) | 2000-06-13 | 2006-04-20 | Mars Inc. | Probiotische Mikroorganismen enthaltendes Nahrungsmittelerzeugnis |
WO2001098516A2 (en) | 2000-06-19 | 2001-12-27 | Regents Of The University Of Minnesota | Siderophores-producing bifidobacteria thereby and uses thereof |
WO2002005829A2 (en) | 2000-07-17 | 2002-01-24 | Chr. Hansen A/S | Methods and formultations with probiotic microorganisms and medicaments |
DE60135760D1 (de) | 2000-08-01 | 2008-10-23 | Oryza Oil & Fat Chem | Nachtkerzensamenextrakte als inhibitoren der zuckerabsorption und deren herstellungsprozess |
US6592863B2 (en) | 2000-08-22 | 2003-07-15 | Nestec S.A. | Nutritional composition |
WO2002016554A1 (fr) | 2000-08-25 | 2002-02-28 | Wakamoto Pharmaceutical Co.,Ltd. | Produits probiotiques contenant une bacterie de l'acide lactique |
RU2294366C2 (ru) | 2000-09-25 | 2007-02-27 | Сосьете Де Продюи Нестле С.А. | Трансформированные молочно-кислые бактерии, снижающие склонность к проявлению аллергических реакций, и их применение |
AU2002220587B2 (en) | 2000-10-06 | 2006-06-29 | Societe Des Produits Nestle S.A. | Use of probiotic lactic acid bacteria for balancing the skin's immune system |
CA2359812C (en) | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
US6802422B2 (en) | 2000-12-12 | 2004-10-12 | Multi-Comp, Inc. | Sealed blister assembly |
IL156490A0 (en) | 2000-12-18 | 2004-01-04 | Probiohealth | Probiotic compounds derived from lactobacillus casei strain ke01 |
KR20020050048A (ko) | 2000-12-20 | 2002-06-26 | 박흥재 | Lactobacillus sp.DW-1 동정 시스템 |
US20020119237A1 (en) | 2000-12-22 | 2002-08-29 | Hevey Maurice O. | Medium and method for delivery of edible materials subject to degradation by oxidation and hydrolysis |
AUPR272901A0 (en) | 2001-01-25 | 2001-02-22 | Gainful Plan Limited | Method of preparing biological materials and preparations produced using same |
EP1227152A1 (en) | 2001-01-30 | 2002-07-31 | Société des Produits Nestlé S.A. | Bacterial strain and genome of bifidobacterium |
US20030190314A1 (en) | 2001-01-30 | 2003-10-09 | The Lauridsen Group | Methods and compositions of treatment for modulating the immune system of animals |
US6588180B2 (en) | 2001-02-02 | 2003-07-08 | R. P. Scherer Technologies, Inc. | Constricted neck blister pack and apparatus and method for making the same |
JP2004531477A (ja) | 2001-02-06 | 2004-10-14 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 乳酸菌及びビフィズス菌による内毒素結合 |
EP1408760B1 (en) | 2001-02-19 | 2009-04-01 | Société des Produits Nestlé S.A. | Consumable product containing probiotics |
US6586027B2 (en) | 2001-02-23 | 2003-07-01 | T.F.H. Publications, Inc. | Health chew toy |
EP1239032A1 (en) | 2001-03-02 | 2002-09-11 | Société des Produits Nestlé S.A. | Lactic acid bacteria as agents for treating and preventing allergy |
JP2004519241A (ja) | 2001-03-09 | 2004-07-02 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | 高齢化に伴う生理的障害を改善し寿命を延ばす組成物 |
WO2002074285A1 (en) | 2001-03-16 | 2002-09-26 | Andrx Corporation | Controlled release sulfonylurea formulation |
EP1243273A1 (en) | 2001-03-22 | 2002-09-25 | Societe Des Produits Nestle S.A. | Composition comprising a prebiotic for decreasing infammatory process and abnormal activation of non-specific immune parameters |
AU2002249531A1 (en) | 2001-04-02 | 2002-10-28 | Alimentary Health Limited | Immunotherapy based on dendritic cells |
WO2002085415A1 (en) | 2001-04-17 | 2002-10-31 | Biomatrix, Inc | Non-digestible sugar-coated products and process |
EP1260227A1 (en) | 2001-05-23 | 2002-11-27 | Societe Des Produits Nestle S.A. | Lipoteichoic acid from lactic acid bacteria and its use to modulate immune responses mediated by gram-negative bacteria, potential pathogenic gram-positive bacteria |
US7081478B2 (en) | 2001-06-29 | 2006-07-25 | Chrysantis, Inc. | Mixed zeaxanthin ester concentrate and uses thereof |
EP1277412A1 (en) | 2001-07-17 | 2003-01-22 | Societe Des Produits Nestle S.A. | Pet food composition for regulating body weight and preventing obesity and related disorders in pets |
PE20030283A1 (es) | 2001-07-26 | 2003-05-01 | Alimentary Health Ltd | Cepas de lactobacillus casei |
PE20030274A1 (es) | 2001-07-26 | 2003-05-08 | Alimentary Health Ltd | Cepas de lactobacillus salivarius |
US7666459B2 (en) | 2001-09-12 | 2010-02-23 | The Procter & Gamble Company | Pet food compositions |
US7842329B2 (en) | 2001-09-18 | 2010-11-30 | Nestec S.A. | Pet food product and method of manufacture |
US20070098784A1 (en) | 2001-09-28 | 2007-05-03 | Nutraceutix, Inc. | Delivery system for biological component |
US6624162B2 (en) | 2001-10-22 | 2003-09-23 | Pfizer Inc. | Imidazopyridine compounds as 5-HT4 receptor modulators |
US6896914B2 (en) | 2001-10-26 | 2005-05-24 | David I. Chapnick | Method for normalizing insulin levels |
US20050164978A1 (en) | 2001-10-26 | 2005-07-28 | Chapnick David I. | Method for normalizing insulin levels |
AU2002339112B2 (en) | 2001-11-12 | 2007-10-11 | Mars, Incorporated | Foodstuff |
US7008648B2 (en) | 2001-11-16 | 2006-03-07 | Novartis Nutrition Ag | Plant derived or derivable material with appetite suppressing activity |
BRPI0117180B8 (pt) | 2001-11-23 | 2021-05-25 | Procter & Gamble | composição farmacêutica em uma forma de unidade sólida de dosagem para a administração oral a um ser humano ou animal inferior |
EP1319410A1 (en) | 2001-12-11 | 2003-06-18 | Société des Produits Nestlé S.A. | Use of micro-organisms for a directed delivery of substances to specific parts of the gut |
EP1471797B1 (en) | 2002-01-15 | 2008-03-05 | Mars Incorporated | Methods and products produced thereby to stabilize multi-layer food products |
US20030143293A1 (en) | 2002-01-31 | 2003-07-31 | Sergei Shushunov | Compositions and methods for treating diarrhea |
ES2297181T3 (es) | 2002-02-21 | 2008-05-01 | Societe Des Produits Nestle S.A. | Una composicion fotoprotectora para la piel, de administracion oral. |
EP1344458A1 (en) | 2002-03-12 | 2003-09-17 | Société des Produits Nestlé S.A. | Probiotic delivery system |
DE10217970A1 (de) | 2002-04-22 | 2003-11-13 | Henkel Kgaa | Durchdrückverpackung |
DE10213280A1 (de) | 2002-03-25 | 2003-10-23 | Mars Inc | Proteinhaltiges Nahrungsmittelerzeugnis und Verfahren zu seiner Herstellung |
US6681935B1 (en) | 2002-04-02 | 2004-01-27 | Graham L. Lewis | Method of providing a therapeutic regimen and prefabricated container therefor |
ATE492166T1 (de) | 2002-04-05 | 2011-01-15 | Nestle Sa | Zusammensetzungen und verfahren zur verbesserung von lipidassimilation in haustieren |
US20030194423A1 (en) | 2002-04-15 | 2003-10-16 | Mars, Inc. | Composition for enhancing nutritional content of food |
US20040001817A1 (en) | 2002-05-14 | 2004-01-01 | Giampapa Vincent C. | Anti-aging nutritional supplement |
EP1364586A1 (en) | 2002-05-24 | 2003-11-26 | Nestec S.A. | Probiotics and oral tolerance |
US8142810B2 (en) | 2002-05-30 | 2012-03-27 | The Procter & Gamble Company | Dietary method for modulating glucose metabolism and associated conditions and increasing longevity |
GB0212975D0 (en) | 2002-06-06 | 2002-07-17 | Mars Uk Ltd | Mammalian animal composition |
US6733795B2 (en) | 2002-07-30 | 2004-05-11 | Laboratoires Expanscience | Method for producing an avocado leaf extract rich in furanic lipids |
US20050208163A1 (en) | 2002-07-31 | 2005-09-22 | Brovelli Ernesto A | Compositions containing avocado leaf extract for lowering cholesterol levels |
KR20040024774A (ko) | 2002-09-16 | 2004-03-22 | 이성표 | 혈액형별 체질에 적합하도록 제조한 생약 조성물 |
JP2004173675A (ja) | 2002-10-02 | 2004-06-24 | Takayuki Hirano | 耐化学剤性を有する菌封入物および製造方法 |
BR0315629A (pt) | 2002-11-15 | 2005-08-23 | Warner Lambert Co | Método para baixar a cpr e reduzir a inflamação sistêmica |
WO2004051219A2 (en) | 2002-11-27 | 2004-06-17 | Molecular Nanosystems, Inc. | Nanotube chemical sensor based on work function of electrodes |
US7179460B2 (en) | 2002-12-05 | 2007-02-20 | Danisco A/S | Bacterial composition and its use |
US6835397B2 (en) | 2002-12-23 | 2004-12-28 | Balchem Corporation | Controlled release encapsulated bioactive substances |
KR20050098244A (ko) | 2003-01-10 | 2005-10-11 | 쓰레솔드 파마슈티컬스, 인코포레이티드 | 2-데옥시글루코오스를 사용한 암 치료 방법 |
US7122370B2 (en) | 2003-01-14 | 2006-10-17 | Randolph Stanley Porubcan | Formulations to increase in vivo survival of probiotic bacteria and extend their shelf-life |
GB0303716D0 (en) | 2003-02-18 | 2003-03-19 | Mars Uk Ltd | Food product and process |
EP1613338A4 (en) | 2003-03-21 | 2009-06-24 | Madeleine M Joullie | TAMANDARIN ANALOGUES, FRAGMENTS THEREOF AND METHODS OF MAKING AND USING THE SAME |
DK1610617T3 (da) | 2003-03-25 | 2009-03-30 | Gen Mills Inc | Fremgangsmåde til behandling af avocadoer og fremgangsmåde til fremstilling af guacomole deraf |
GB0308104D0 (en) | 2003-04-08 | 2003-05-14 | Novartis Nutrition Ag | Organic compounds |
US20040265279A1 (en) | 2003-05-08 | 2004-12-30 | Timothy Dinan | Probiotics in the treatment of atypical depression and other disorders characterized by hypothalamic pitiuitary-adrenal axis over-activity |
US20040234579A1 (en) | 2003-05-22 | 2004-11-25 | Mark D. Finke, Inc. | Dietary supplements and methods of preparing and administering dietary supplements |
FR2855374B1 (fr) | 2003-05-26 | 2007-06-01 | Roquette Freres | Procede de drageification dure ameliore |
US20060147962A1 (en) | 2003-06-16 | 2006-07-06 | Mars, Inc. | Genotype test |
ES2416287T3 (es) | 2003-06-23 | 2013-07-31 | Nestec S.A. | Empleo de una fórmula nutritiva para la función óptima de la barrera intestinal |
EP2236131A3 (en) | 2003-07-01 | 2011-03-02 | President and Fellows of Harvard College | Sirt1 modulators for manipulating cell/organism lifespan/stress response |
US7235276B2 (en) | 2003-09-24 | 2007-06-26 | General Mills Ip Holdings Ii, Llc | High protein puffed food product and method of preparation |
US20050074519A1 (en) | 2003-10-01 | 2005-04-07 | Sensient Flavors Inc. | Method for the production of natural botanical extracts |
GB0323668D0 (en) | 2003-10-09 | 2003-11-12 | Nestec Sa | Fat-based confectionery product coated with a film forming agent making it resistant to heat and shape stable to heat |
US20050100559A1 (en) | 2003-11-07 | 2005-05-12 | The Procter & Gamble Company | Stabilized compositions comprising a probiotic |
CN103636926A (zh) | 2003-11-26 | 2014-03-19 | 希尔氏宠物营养品公司 | 减少伴侣动物粪便气味的方法 |
US7687077B2 (en) | 2003-11-26 | 2010-03-30 | Hill's Pet Nutrition, Inc. | Method to reduce stool odor of companion animals |
BRPI0417723A (pt) | 2003-12-18 | 2007-04-03 | Nestec Sa | composição para melhorar a saúde da pele, cabelo e tegumento contendo flavanonas |
US8894991B2 (en) | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
US7785635B1 (en) | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
US20050152884A1 (en) | 2003-12-19 | 2005-07-14 | The Procter & Gamble Company | Canine probiotic Bifidobacteria globosum |
US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
TW200524539A (en) | 2003-12-23 | 2005-08-01 | Rohm & Haas | A method to reverse ethylene inhibitor responses in plants |
GB0330009D0 (en) | 2003-12-24 | 2004-01-28 | Ferrosan As | Probiotic tablet formulations |
DE102004004030A1 (de) | 2004-01-27 | 2005-08-18 | Mars Inc. | Nahrungsmittelerzeugnis und Verfahren zu dessen Herstellung |
US20050266438A1 (en) | 2004-03-16 | 2005-12-01 | The Regents Of The University Of California | Genetic networks regulated by attenuated GH/IGF1 signaling and caloric restriction |
GB0406654D0 (en) | 2004-03-24 | 2004-04-28 | Mars Inc | Foodstuff |
CA2563702A1 (en) | 2004-04-20 | 2005-12-01 | The University Of Chicago | Probiotic compounds from lactobacillus gg and uses therefor |
FR2869541B1 (fr) | 2004-04-30 | 2007-12-28 | Expanscience Sa Lab | Utilisation d'une composition comprenant du d-mannoheptulose et/ou du perseitol dans le traitement et la prevention des maladies liees a une modification de l'immunite innee |
US9089576B2 (en) | 2004-04-30 | 2015-07-28 | Laboratoires Expanscience | Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency or oxidative stress or skin ageing or dry skin |
FR2869543B1 (fr) | 2004-04-30 | 2006-07-28 | Expanscience Laboratoires Sa | Medicament comprenant un extrait peptidique d'avocat destine au traitement et la prevention des maladies liees a une deficience du systeme immunitaire |
US20090252834A1 (en) | 2004-05-10 | 2009-10-08 | Michael Griffin Hayek | Compositions comprising glucose anti-metabolites |
CA2569249C (en) | 2004-05-10 | 2012-08-14 | The Iams Company | Processes for preparing plant matter extracts and pet food compositions |
US20050249837A1 (en) | 2004-05-10 | 2005-11-10 | The Procter & Gamble Company | Processes for preparing plant matter extracts and pet food compositions |
EP1750674A4 (en) | 2004-05-27 | 2012-05-23 | Advanced Bionutrition Corp | MICROPARTICLES FOR THE ORAL LEVY |
JP2005348698A (ja) | 2004-06-14 | 2005-12-22 | Yonezawa Biru System Service:Kk | ケフィア粒から分離された微生物とこの微生物あるいはそれを含む微生物群を培養して得られる微生物培養物ならびにそれらを用いた製品 |
AU2005258021B2 (en) | 2004-06-17 | 2008-12-18 | Wisconsin Alumni Research Foundation | Compounds and methods for treating seizure and paroxysmal disorders |
MXPA06015203A (es) | 2004-07-01 | 2007-03-27 | Nestec Sa | Formulacion de dieta para osteoartritis canina. |
US20080305210A1 (en) | 2004-07-01 | 2008-12-11 | General Mills, Inc. | Cultures Encapsulated With Compound Fat Breakfast Cereals Coated With Compound Fat and Methods of Preparation |
US7935334B2 (en) | 2005-07-07 | 2011-05-03 | Imagilin Technologies, LLC | Probiotics as alternative medicines against infectious diseases |
US20060008511A1 (en) | 2004-07-08 | 2006-01-12 | Jhy-Jhu Lin | Probiotic products for pet applications |
US20060029685A1 (en) | 2004-07-30 | 2006-02-09 | Henderson Todd R | Combination of unsaponifiable lipids combined with polyphenols and/or catechins for the protection, treatment and repair of cartilage in joints of humans and animals |
US20060070895A1 (en) | 2004-08-16 | 2006-04-06 | Faisal Khawaja | Drug administration kit |
JP2006055145A (ja) | 2004-08-19 | 2006-03-02 | Kosshi:Kk | ペットフード及びペットフードの提供方法 |
DE602004013441T2 (de) | 2004-09-21 | 2009-06-04 | Nestec S.A. | Verbesserung der Lebensdauer alter Katzen |
US20070286935A1 (en) | 2004-10-07 | 2007-12-13 | Nestec S.A. | Bioactive Compositions, Natural Methods of Producing Them and Computational Methods for Designing Natural Production Processes |
FR2876876B1 (fr) | 2004-10-22 | 2007-02-16 | Gervais Danone Sa | Protection d'ingredients alimentaires bioactifs par l'utilisation de microorganismes presentant une capacite de metabolisation reduite |
FR2876875B1 (fr) | 2004-10-22 | 2007-02-02 | Gervais Danone Sa | Protection d'ingredients alimentaires bioactifs par encapsulation |
WO2006066244A2 (en) | 2004-12-17 | 2006-06-22 | Cash Alan B | Method for extending lifespan and delaying the onset of age-related disease |
CN101111164B (zh) | 2005-02-10 | 2013-05-29 | 弗门尼舍有限公司 | 具有封装香料包衣的加热食品 |
US20100233312A9 (en) | 2005-04-11 | 2010-09-16 | The Procter & Gamble Company | Compositions comprising probiotic and sweetener components |
US20060228459A1 (en) | 2005-04-11 | 2006-10-12 | The Iams Company | Compositions comprising a cocoa butter component and an animal-derived fat component |
US20060228448A1 (en) | 2005-04-11 | 2006-10-12 | The Iams Company | Pet food compositions comprising two components |
RU2379944C2 (ru) | 2005-05-11 | 2010-01-27 | Хилл`С Пет Ньютришн, Инк. | Улучшающая вкус композиция для кормления собак, способ ее получения, продукт способа, набор, способ усиления вкуса корма для собак и способ увеличения приема или частоты приема корма |
WO2006124675A2 (en) | 2005-05-13 | 2006-11-23 | Hill's Pet Nutrition, Inc. | Dry food compositions having enhanced palatability |
US9480275B2 (en) | 2005-05-20 | 2016-11-01 | Mars Incorporated | Coated pet food products |
RU2372794C2 (ru) | 2005-05-20 | 2009-11-20 | Хилл`С Пет Ньютришн, Инк. | Способы укрепления здоровья или общего состояния взрослых животных |
AU2006253006B8 (en) | 2005-05-31 | 2011-09-15 | Alimentary Health Ltd | Feline probiotic Lactobacilli |
AU2006253007B2 (en) * | 2005-05-31 | 2012-12-20 | Alimentary Health Ltd | Feline probiotic Bifidobacteria |
US20080280274A1 (en) | 2005-06-01 | 2008-11-13 | Kim Gene Friesen | Methods For Enhancing Palatability of Compositions for Animal Consumption |
AT501919B1 (de) | 2005-06-14 | 2008-09-15 | Erber Ag | Probiotischer, gesundheits- bzw. leistungsfördernder futtermittel- und/oder trinkwasserzusatz für tiere sowie seine verwendung |
US20070009577A1 (en) | 2005-07-05 | 2007-01-11 | Mankovitz Roy J | Probiotic compositions and methods |
US20070149466A1 (en) | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
BRPI0613000A2 (pt) | 2005-07-14 | 2012-12-04 | Hills Pet Nutrition Inc | método para aumentar a longevidade de um animal, artigo de fabricação, kit, e, meio de comunicação de informação acerca de ou instruções para a administração a um animal velho de uma composição |
US20070122531A1 (en) | 2005-09-01 | 2007-05-31 | Wellmark International | Methods for Selecting a Pet-Appropriate Product |
US8865197B2 (en) | 2005-09-06 | 2014-10-21 | Israel Oceanographic And Limnological Research Ltd. | Food formulation for aquatic animals with integrated targeted delivery of bioactive agents |
GB0519164D0 (en) | 2005-09-20 | 2005-10-26 | Mars Inc | Composition |
JP4198728B2 (ja) | 2005-09-30 | 2008-12-17 | 株式会社グローバルエンジニアリング | 動物用免疫活性調整剤、及びその調整剤を含有する動物用飼料 |
RU2388320C2 (ru) | 2005-09-30 | 2010-05-10 | Хилл'С Пет Ньютришн, Инк. | Способы увеличения срока хранения пищевых композиций, содержащих полиненасыщенные жирные кислоты |
US20070098744A1 (en) | 2005-10-06 | 2007-05-03 | Nestec S.A. | Probiotic enterococci for improved immunity |
US20070280964A1 (en) | 2005-10-06 | 2007-12-06 | Ruth Knorr | Compositions and methods useful for modulating immunity, enhancing vaccine efficacy, decreasing morbidity associated with chronic FHV-1 infections, and preventing or treating conjunctivitis |
US20070082107A1 (en) | 2005-10-07 | 2007-04-12 | Aimutis William R Jr | Compositions and methods for reducing food intake and controlling weight |
BRPI0617479A2 (pt) | 2005-10-19 | 2016-11-08 | Hills Pet Nutrition Inc | método e composição útil para manter ou melhorar a saúde gastrintestiinal de um animal, kit, meio para comunicação de informações ou instruções, e, uso de uma composição |
US7647098B2 (en) | 2005-10-31 | 2010-01-12 | New York University | System and method for prediction of cognitive decline |
CN101299926B (zh) | 2005-11-04 | 2014-03-05 | 希尔氏宠物营养品公司 | 改善粪便质量的方法和组合物 |
FR2893628B1 (fr) | 2005-11-18 | 2008-05-16 | Expanscience Laboratoires Sa | Procede d'obtention d'une huile d'avocat raffinee riche en triglycerides et huile susceptible d'etre obtenue par un tel procede |
US8524304B2 (en) | 2005-11-23 | 2013-09-03 | The Coca-Cola Company | High-potency sweetener composition with probiotics/prebiotics and compositions sweetened therewith |
WO2007060539A2 (en) | 2005-11-28 | 2007-05-31 | Jorrocks Pty Ltd. | Methods for preparation of animal feeds |
RU2390342C2 (ru) | 2005-12-02 | 2010-05-27 | Хилл`С Пет Ньютришн, Инк. | Способы изменения качества стула и/или частоты стула |
ATE541469T1 (de) | 2005-12-29 | 2012-02-15 | Hills Pet Nutrition Inc | Verfahren zum modifizieren der darmflora bei tieren |
DE102006001554A1 (de) | 2006-01-05 | 2007-07-12 | Ipc Process-Center Gmbh & Co. | Micropellets für die Herstellung von Tiernahrungspellets |
DE102006001553A1 (de) | 2006-01-05 | 2007-07-19 | Ipc Process-Center Gmbh & Co. | Teilchen mit darin enthaltener empfindlicher Komponente |
EP1993384A2 (en) | 2006-01-11 | 2008-11-26 | Attune Foods | Probiotic food, process for its preparation and dietary regimen |
US20070166295A1 (en) | 2006-01-13 | 2007-07-19 | Vet Solutions L.P. | Anti-Diarrhea Preparations for Small Domestic Animals |
US8057840B2 (en) | 2006-01-25 | 2011-11-15 | Tate & Lyle Ingredients Americas Llc | Food products comprising a slowly digestible or digestion resistant carbohydrate composition |
MX2008009574A (es) | 2006-02-01 | 2008-09-04 | Nestec Sa | Sistema y metodos nutricionales para aumentar la longevidad. |
PL1986669T3 (pl) | 2006-02-15 | 2012-09-28 | Nestec Sa | Zastosowanie Bifidobacterium longum do zapobiegania i leczenia zapalenia |
US7960605B2 (en) | 2006-03-17 | 2011-06-14 | BioMaker Pharmaceuticals, Inc. | Methods for testing for caloric restriction (CR) mimetics |
PL2004201T3 (pl) | 2006-03-29 | 2019-02-28 | Nestec S.A. | Suplementy diety zawierające probiotyki |
US20070231414A1 (en) | 2006-03-29 | 2007-10-04 | Kaneka Corporation | Composition having bone resorption inhibition-related effect and method for inhibiting bone resorption |
WO2007137808A1 (en) | 2006-05-29 | 2007-12-06 | University College Dublin, National University Of Ireland, Dublin | Compositions comprising oligosaccharides for treating prion disease |
EA200870545A1 (ru) | 2006-05-31 | 2009-12-30 | Глэксо Груп Лимитед | Новые гетероциклические соединения |
WO2008019887A2 (en) | 2006-08-18 | 2008-02-21 | Organobalance Gmbh | Probiotic microorganisms for the reduction of manure odor |
US20080053490A1 (en) | 2006-09-01 | 2008-03-06 | Bausch & Lomb Incorporated | Method for hydrating a contact lens |
US20080107699A1 (en) | 2006-10-25 | 2008-05-08 | Mark Spigelman | Method of using topical probiotics for the inhibition of surface contamination by a pathogenic microorganism and composition therefor |
US20090175838A1 (en) | 2007-01-26 | 2009-07-09 | Newell Rogers M Karen | Methods of modulating immune function |
RU2429853C2 (ru) | 2007-02-01 | 2011-09-27 | Дзе Иамс Компани | Способ уменьшения воспаления и окислительного стресса у млекопитающих |
JP5799299B2 (ja) | 2007-02-01 | 2015-10-21 | ザ・アイムス・カンパニーThe Iams Company | ブドウ糖代謝拮抗物質、アボカド又はアボカド抽出物を使用する、哺乳動物における炎症及びストレスの低下方法 |
RU2407401C2 (ru) | 2007-02-13 | 2010-12-27 | Общество С Ограниченной Ответственностью "Марс" | Способ кормления собак |
CN101636173A (zh) | 2007-03-27 | 2010-01-27 | 宝洁公司 | 施用益生菌剂的方法及试剂盒 |
US9771199B2 (en) | 2008-07-07 | 2017-09-26 | Mars, Incorporated | Probiotic supplement, process for making, and packaging |
US9232813B2 (en) | 2008-07-07 | 2016-01-12 | The Iams Company | Probiotic supplement, process for making, and packaging |
MX2011002735A (es) | 2008-09-11 | 2011-04-12 | Iams Company | Alimento granulado para animales que tiene un nucleo basado en proteinas y metodos relacionados. |
EP2199792B1 (de) | 2008-12-18 | 2012-08-08 | F. Hoffmann-La Roche AG | Verfahren zur Überprüfung der Qualität der thermischen Ankopplung einer Messzelle |
US8691303B2 (en) | 2009-07-31 | 2014-04-08 | The Iams Company | Dusted animal food |
WO2011069051A1 (en) | 2009-12-04 | 2011-06-09 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions |
US20120115798A1 (en) | 2010-11-04 | 2012-05-10 | Stefan Patrick Massimino | Method for improving the immunity of a companion animal |
FR2969496B1 (fr) | 2010-12-22 | 2013-11-08 | Expanscience Lab | Extrait de pulpe et/ou de peau d'avocat riche en polyphenols et compositions cosmetiques, dermatologiques et nutraceutiques le comprenant |
US20120282373A1 (en) | 2011-05-02 | 2012-11-08 | Ashok Premchand Luhadiya | Compositions Comprising a Glucose Anti-Metabolite and Selenium |
US20120283197A1 (en) | 2011-05-02 | 2012-11-08 | Ashok Premchand Luhadiya | Compositions Comprising a Glucose Anti-Metabolite, BHA, and/or BHT |
CA2879784C (en) | 2012-07-25 | 2020-09-15 | Agrofresh Inc. | Methods of handling avocados and system |
US20140349002A1 (en) | 2013-05-23 | 2014-11-27 | The Iams Company | Ingestible Compositions Containing Criollo Avocado Component |
US20140348986A1 (en) | 2013-05-23 | 2014-11-27 | The Iams Company | Avocado Processing |
PL2805721T3 (pl) | 2013-05-23 | 2019-01-31 | Iams Europe B V | Naśladowanie metabolicznego wpływu restrykcji kalorycznej przez podawanie antymetabolitów glukozy dla zwiększenia pozytywnej odpowiedzi u ssaka |
EP3068238A4 (en) | 2013-11-11 | 2017-07-12 | The Iams Company | Processes for preparing a carbohydrate extract comprising mannoheptulose and compositions comprising same |
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06166626A (ja) * | 1992-05-12 | 1994-06-14 | Taiyo Kagaku Co Ltd | 生菌粉末 |
JP2002534113A (ja) * | 1999-01-15 | 2002-10-15 | エンタープライズ・アイルランド(トレイディング・アズ・バイオリサーチ・アイルランド) | 炎症性疾患治療におけるビフィドバクテリウム(Bifidobacterium) |
JP2003534003A (ja) * | 2000-05-25 | 2003-11-18 | ソシエテ デ プロデユイ ネツスル ソシエテ アノニム | ペットフード用新規プロバイオチックス |
JP2002255853A (ja) * | 2001-03-01 | 2002-09-11 | Biofuerumin Seiyaku Kk | 免疫賦活組成物 |
WO2003010297A1 (en) * | 2001-07-26 | 2003-02-06 | Alimentary Health Limited | Probiotic bifidobacterium strains |
Non-Patent Citations (1)
Title |
---|
JPN6009054547, Antonie van Leeuwenhoek, 1999, Vol.76, pp.279−292 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007523634A (ja) * | 2003-12-19 | 2007-08-23 | ザ・アイムス・カンパニー | イヌ科動物のプロバイオティク・ビフィドバクテリア・グロボーサム |
JP2013500020A (ja) * | 2009-07-31 | 2013-01-07 | ザ・アイムス・カンパニー | 低い水分活性を有する動物フード |
JP2013509204A (ja) * | 2009-11-11 | 2013-03-14 | アリメンタリー、ヘルス、リミテッド | ビフィズス菌株 |
JP2014500007A (ja) * | 2010-11-05 | 2014-01-09 | ネステク ソシエテ アノニム | プロバイオティクス微生物を含有するペットフード調製物 |
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BRPI0417823A (pt) | 2007-04-27 |
JP5172151B2 (ja) | 2013-03-27 |
CA2550296C (en) | 2012-02-28 |
AU2004305122A1 (en) | 2005-07-07 |
DK1718155T3 (da) | 2011-10-03 |
ATE513898T1 (de) | 2011-07-15 |
WO2005060709A3 (en) | 2005-09-15 |
ES2368333T3 (es) | 2011-11-16 |
AU2009200529A1 (en) | 2009-03-05 |
EP1718155A4 (en) | 2007-05-16 |
US9821015B2 (en) | 2017-11-21 |
AR047067A1 (es) | 2006-01-04 |
EP1718155A2 (en) | 2006-11-08 |
EP1718155B1 (en) | 2011-06-22 |
CA2550296A1 (en) | 2005-07-07 |
US20150190437A1 (en) | 2015-07-09 |
WO2005060709A2 (en) | 2005-07-07 |
AU2009200529B2 (en) | 2011-02-10 |
US20050175598A1 (en) | 2005-08-11 |
EP2261322A1 (en) | 2010-12-15 |
US8877178B2 (en) | 2014-11-04 |
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