IT1270216B - Metodo di stabilizzazione di composti biologicamente attivi mediante microgranuli ricoperti sospendibili in fluidi alimentari - Google Patents

Metodo di stabilizzazione di composti biologicamente attivi mediante microgranuli ricoperti sospendibili in fluidi alimentari

Info

Publication number
IT1270216B
IT1270216B ITMI941231A ITMI941231A IT1270216B IT 1270216 B IT1270216 B IT 1270216B IT MI941231 A ITMI941231 A IT MI941231A IT MI941231 A ITMI941231 A IT MI941231A IT 1270216 B IT1270216 B IT 1270216B
Authority
IT
Italy
Prior art keywords
suspendable
stabilization
biologically active
active compounds
microgranules
Prior art date
Application number
ITMI941231A
Other languages
English (en)
Inventor
Giancarlo Santus
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of ITMI941231A0 publication Critical patent/ITMI941231A0/it
Priority to ITMI941231A priority Critical patent/IT1270216B/it
Priority to EP95919607A priority patent/EP0762873B1/en
Priority to DE69505374T priority patent/DE69505374T2/de
Priority to MX9606452A priority patent/MX9606452A/es
Priority to AT95919607T priority patent/ATE172110T1/de
Priority to AU25371/95A priority patent/AU694227B2/en
Priority to PCT/IB1995/000471 priority patent/WO1995034292A2/en
Priority to CA002192333A priority patent/CA2192333C/en
Priority to NZ285848A priority patent/NZ285848A/en
Priority to KR1019960707136A priority patent/KR970703754A/ko
Priority to ES95919607T priority patent/ES2122612T3/es
Priority to JP50188696A priority patent/JP2002504065A/ja
Publication of ITMI941231A1 publication Critical patent/ITMI941231A1/it
Application granted granted Critical
Publication of IT1270216B publication Critical patent/IT1270216B/it
Priority to US08/941,730 priority patent/US5952021A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
    • A23C9/1206—Lactose hydrolysing enzymes, e.g. lactase, beta-galactosidase
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
    • A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/06—Enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/065—Microorganisms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
    • A23L9/10—Puddings; Dry powder puddings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/22—Agglomeration or granulation with pulverisation of solid particles, e.g. in a free-falling curtain
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C2220/00—Biochemical treatment
    • A23C2220/20—Treatment with microorganisms
    • A23C2220/204—Use of bacteria which are encapsulated, entrapped or immobilised; Fermentation with these bacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/113—Acidophilus
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/51—Bifidobacterium
    • A23V2400/533—Longum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Viene descritto un metodo per la stabilizzazione di composti biologicamente attivi, quali enzimi e microorganismi, basato su una composizione microgranulare sospendibile nelle sostanze alimentari fluide o semifluide. Il metodo, consentendo una protezione dei composti stessi dagli agenti inattivanti presenti nell'ambiente di veicolazione o nell'ambiente gastrico, permette di minimizzarne la degradazione prolungando il loro tempo di conservazione ed aumentandone l'efficacia.
ITMI941231A 1994-06-14 1994-06-14 Metodo di stabilizzazione di composti biologicamente attivi mediante microgranuli ricoperti sospendibili in fluidi alimentari IT1270216B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ITMI941231A IT1270216B (it) 1994-06-14 1994-06-14 Metodo di stabilizzazione di composti biologicamente attivi mediante microgranuli ricoperti sospendibili in fluidi alimentari
PCT/IB1995/000471 WO1995034292A2 (en) 1994-06-14 1995-06-12 Stabilized biologically active compounds contained in coated microgranules which can be suspended in alimentary fluids
NZ285848A NZ285848A (en) 1994-06-14 1995-06-12 Stabilised microcapsulated additives for food
MX9606452A MX9606452A (es) 1994-06-14 1995-06-12 Compuestos biologicamente activos estabilizados contenidos en microgranulos revestidos que pueden ser suspendidos en fluidos alimenticios.
AT95919607T ATE172110T1 (de) 1994-06-14 1995-06-12 In überzogenen mikrogranulaten enthaltene, stabilisierte biologisch aktive verbindungen, die in lebensmittelflüssigkeiten suspendiert werden können
AU25371/95A AU694227B2 (en) 1994-06-14 1995-06-12 Stabilized biologically active compounds contained in coated microgranules which can be suspended in alimentary fluids
EP95919607A EP0762873B1 (en) 1994-06-14 1995-06-12 Stabilized biologically active compounds contained in coated microgranules which can be suspended in alimentary fluids
CA002192333A CA2192333C (en) 1994-06-14 1995-06-12 Stabilized biologically active compounds contained in coated microgranules which can be suspended in alimentary fluids
DE69505374T DE69505374T2 (de) 1994-06-14 1995-06-12 In überzogenen mikrogranulaten enthaltene, stabilisierte biologisch aktive verbindungen, die in lebensmittelflüssigkeiten suspendiert werden können
KR1019960707136A KR970703754A (ko) 1994-06-14 1995-06-12 음식물 유체에서 현탁 가능한 코팅된 소립자에 함유된 안정화된 생리적 활성 화합물(starbilized biologically active compounds contained incoated microgranules which can be suspended in alimentary fluids)
ES95919607T ES2122612T3 (es) 1994-06-14 1995-06-12 Compuestos estabilizados, biologicamente activos, contenidos en microgranulos dotados de recubrimiento, que pueden ser suspendidos en fluidos alimenticios.
JP50188696A JP2002504065A (ja) 1994-06-14 1995-06-12 栄養流体中に懸濁されうる被覆された顆粒に含まれ安定化された生物学的に活性の化合物
US08/941,730 US5952021A (en) 1994-06-14 1997-10-01 Stabilized biologically active compounds contained in coated microgranules which can be suspended in alimentary fluids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941231A IT1270216B (it) 1994-06-14 1994-06-14 Metodo di stabilizzazione di composti biologicamente attivi mediante microgranuli ricoperti sospendibili in fluidi alimentari

Publications (3)

Publication Number Publication Date
ITMI941231A0 ITMI941231A0 (it) 1994-06-14
ITMI941231A1 ITMI941231A1 (it) 1995-12-14
IT1270216B true IT1270216B (it) 1997-04-29

Family

ID=11369106

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941231A IT1270216B (it) 1994-06-14 1994-06-14 Metodo di stabilizzazione di composti biologicamente attivi mediante microgranuli ricoperti sospendibili in fluidi alimentari

Country Status (13)

Country Link
US (1) US5952021A (it)
EP (1) EP0762873B1 (it)
JP (1) JP2002504065A (it)
KR (1) KR970703754A (it)
AT (1) ATE172110T1 (it)
AU (1) AU694227B2 (it)
CA (1) CA2192333C (it)
DE (1) DE69505374T2 (it)
ES (1) ES2122612T3 (it)
IT (1) IT1270216B (it)
MX (1) MX9606452A (it)
NZ (1) NZ285848A (it)
WO (1) WO1995034292A2 (it)

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Also Published As

Publication number Publication date
DE69505374T2 (de) 1999-05-12
ES2122612T3 (es) 1998-12-16
JP2002504065A (ja) 2002-02-05
CA2192333C (en) 2002-02-19
EP0762873B1 (en) 1998-10-14
CA2192333A1 (en) 1995-12-21
AU2537195A (en) 1996-01-05
ITMI941231A1 (it) 1995-12-14
ITMI941231A0 (it) 1994-06-14
KR970703754A (ko) 1997-08-09
ATE172110T1 (de) 1998-10-15
WO1995034292A2 (en) 1995-12-21
WO1995034292A3 (en) 2001-12-06
AU694227B2 (en) 1998-07-16
EP0762873A1 (en) 1997-03-19
MX9606452A (es) 1997-03-29
DE69505374D1 (de) 1998-11-19
US5952021A (en) 1999-09-14
NZ285848A (en) 1998-07-28

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