JP2001500480A - イソフラボン類を含有する治療方法及び組成物 - Google Patents
イソフラボン類を含有する治療方法及び組成物Info
- Publication number
- JP2001500480A JP2001500480A JP10511105A JP51110598A JP2001500480A JP 2001500480 A JP2001500480 A JP 2001500480A JP 10511105 A JP10511105 A JP 10511105A JP 51110598 A JP51110598 A JP 51110598A JP 2001500480 A JP2001500480 A JP 2001500480A
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 本発明を特定する請求項は以下の通りである: 1.式Iの一以上の化合物の治療有効量を患者に投与することからなる、体熱感 、不安、鬱病、気分動揺、寝汗、頭痛及び尿失禁を含む閉経期症候群、骨粗鬆症 、閉経前症候群、体液貯留、月経困難、レイノー症候群、レイノー現象、ブエル ガー病、冠動脈痙縮、片頭痛、骨粗鬆症、高血圧、良性前立腺肥大、乳癌、子宮 癌、卵巣癌、精巣癌、大腸癌、子宮内膜癌、前立腺癌、周期的乳房痛、子宮癌、 動脈硬化、アルツハイマー病、炎症性腸病、潰瘍性大腸炎、クローン病を含む炎 症性疾患、関節リウマチを含むリウマチ病、アクネ、男性型禿頭症(遺伝性脱毛 症)を含む禿頭、乾せん、および癌、心筋梗塞、発作、関節炎、日光誘導皮膚傷 害、若しくは白内障を含む酸化ストレスと関連する病気の予防、改善、防御及び /若しくは防止する治療方法: ここで、ZはH, R1はH,若しくはRACO、ここでRAはC1-10のアルキル基若しくはアミノ酸 、 R2はH、OH若しくはORBここでRBはアミノ酸若しくはCORA、ここでRA は前記定義と同じ、 WはH,AはH若しくはOH、Bは以下から選択される、 WはH,及びAとBが一緒になり以下から選択される6員環を形成するWとAとBがそれらが結合している官能基と一緒に以下を構成する WとAがそれらが結合している官能基と一緒になり以下を構成し、 及びBは ここでR3はH、CORA、ここでRAは上記定義と同じ、C O2RCここでRCはC1-10アルキル基、若しくはCORBここでRBは上記定義と 同じ、 R4はH,CORDここでRDはH,OH、C1-10アルキル基若しくはアミノ酸、 CO2RCここでRCは上記定義と同じ、 COREここでREはH,C1-10アルキル基若しくはアミノ酸、COOH,CORC ここでRCは上記定義と同じ、又はCONHREここでREは上記定義と同じ、 R5はH,CO2RCここでRCは上記定義と同じ、若しくはCORCOREここでRC とREは上記定義と同じ、そして2個のR5はそれらが同じ若しくは異なる同じ 官能基に結合している、 R6はH若しくはヒドロキシC1-10アルキル基、 Xは好ましくはO、しかしN若しくはSでもよい、そして Yは ここでR7はH若しくはC1-10アルキル基 2.好ましくは式Iの化合物は以下から選択される請求項1記載の方法: ここで R8はCORここでRDは前記定義と同じ R9はCO2RC若しくはCOREここでRCとREは前記定義と同じ R10はCORC若しくはCORCOREここでRCとREは前記定義と同じ R11はH若しくはOH R12はH,COOH,CO2RCここでRCは前記定義と同じ、若しくはCONH REここでREは前記定義と同じ R13はOH,ORBここでRBは前記定義と同じ、若しくはCORAここでRAは前 記定義と同じ R14はH、若しくはCORAここでRAは前記定義と同じ R15はCORAここでRAは前記定義と同じ R16はH,CORB若しくはCO2RCここでRBとRCは前記定義と同じ R17はH若しくはヒドロキシC1-10アルキル基 そして、”=”は単結合、若しくは2重結合を示す。 3.式1、3、8、10、11、13、若しくは14の化合物の一つ以上が薬理 学的に許容される担体若しくは賦形剤と一緒に、治療の必要な患者に投与される 閉経期症候群、高血圧、動脈硬化、男性性不能、閉経前症候群若しくは周期的乳 房痛を治療する方法である請求項2記載の方法。 4.式1、3、8、10、11、13、若しくは14の化合物の一以上が薬理学 的に許容される担体若しくは賦形剤と一緒に、 治療の必要な患者に投与される乳癌、卵巣癌、精巣癌、大腸癌、白血病、子宮内 膜癌、若しくは前立腺癌を治療する方法である請求項2記載の方法。 5.式1、3、8、10、11、13、若しくは14の化合物の一以上が薬理学 的に許容される担体若しくは賦形剤と一緒に、治療の必要な患者に投与される癌 、心筋梗塞、発作、関節炎、白内障を治療する方法である請求項2記載の方法 6.式Iの化合物を、請求項1記載の治療適応症の一以上の治療、改善、防御、 予防及び/若しくは防止の薬剤の製造のためにする使用。 7.式Iの当該化合物が請求項2で特定される化合物1〜19までの化合物から 選択される請求項6記載の使用。 8.請求項1記載の治療適応症の一以上の治療、改善、防御、予防及び/若しく は防止に式Iの化合物の使用。 9.当該式Iの化合物が請求項2で特定される化合物1〜19から選択される請 求項8記載の使用。 10.請求項1記載の治療適応症の一以上の治療、予防、改善、防御及び/若し くは治療のための薬剤。 11.式Iの当該化合物が請求項2で特定される化合物1〜19から選択される 請求項10記載の薬剤。 12.式Iの化合物の一以上と一以上の薬理学的に許容できる担体及び/若しく は賦形剤とからなる組成物。 13.式I化合物の一以上と生理学的及び/若しくは化粧品学的に許容できる担 体及び/若しくは賦形剤とからなる抗酸化剤組成物。 14.式Iの化合物の一以上とビタミンE、任意的には薬理学的に許容できる担 体及び/若しくは賦形剤とからなる抗酸化剤組成物。 15.式Iの当該化合物の一以上が請求項2で特定される化合 物の一以上からなる請求項14記載の抗酸化剤組成物。 16.請求項2で特定される化合物1〜19の一以上を含有するスキンクリーム 、若しくはゲルからなる請求項13記載の組成物。 17.請求項2で特定される化合物1〜19の一以上を含有する固体投与単位組 成物からなる請求項13記載の組成物。 18.式Iの当該化合物が請求項2で特定される化合物1〜19から選択される 請求項12記載の組成物。 19.式Iの化合物の一以上を含有する食品若しくは飲料。 20.当該式Iの化合物が請求項2で特定される化合物1〜19から選択される 請求項17記載の食品、若しくは飲料。 21.微生物が式Iの化合物の一以上を産生する一以上の微生物種を含有する微 生物培養物、若しくは食品。 22.当該式Iの化合物が請求項2で特定される化合物1〜19から選択される 請求項21記載の微生物培養物。 23.式Iの化合物の一以上を産生する微生物、又は式Iの化合物の一以上を産 生する微生物の混合物。 24.当該式Iの化合物が請求項2で特定される化合物1〜19から選択される 請求項23記載の微生物。
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AUPO2039A AUPO203996A0 (en) | 1996-08-30 | 1996-08-30 | Therapeutic uses |
PCT/AU1997/000563 WO1998008503A1 (en) | 1996-08-30 | 1997-08-29 | Therapeutic methods and compositions involving isoflavones |
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