JPS6442427A - Sialidase inhibitor - Google Patents

Sialidase inhibitor

Info

Publication number
JPS6442427A
JPS6442427A JP19819487A JP19819487A JPS6442427A JP S6442427 A JPS6442427 A JP S6442427A JP 19819487 A JP19819487 A JP 19819487A JP 19819487 A JP19819487 A JP 19819487A JP S6442427 A JPS6442427 A JP S6442427A
Authority
JP
Japan
Prior art keywords
solvent
sialidase inhibitor
luteolin
afford
methanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP19819487A
Other languages
Japanese (ja)
Inventor
Akishiro Yamada
Soutetsu Chiyou
Takao Otsuka
Takayuki Nagai
Iwao Sakakibara
Hiroshi Mihashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tsumura and Co
Kitasato Institute
Original Assignee
Tsumura and Co
Kitasato Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsumura and Co, Kitasato Institute filed Critical Tsumura and Co
Priority to JP19819487A priority Critical patent/JPS6442427A/en
Publication of JPS6442427A publication Critical patent/JPS6442427A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE:To obtain a sialidase inhibitor, containing formononetin, luteolin or luteolin-7-O-glucoside as active ingredients, applicable to medicines, such as anti-inflammatory agent and having high safety with low toxicity. CONSTITUTION:A sialidase inhibitor obtained by extracting Dalbergia odorifera T. CHEN which is heart wood of dried root of a leguminous plant or Chrysanthemum indicum L. which is a dried flower part of a composite plant as a raw material with a solvent, such as methanol, by heating at 0 deg.C- the boiling point temperature of the solvent or using ultrasonic waves to provide an extract solution, directly or concentrating or drying the extract solution and subjected the resultant substance to column chromatography with an adsorbent, such as silica gel, to afford a fraction, recrystallizing the obtained fraction from a solvent, such as water or methanol, to afford the aimed compound which is an active ingredient. The resultant substance can be prepared in the form of a pharmaceutical by a conventional method and the dose thereof as an oral agent is 100-450mg in several divided portion a day for an adult.
JP19819487A 1987-08-10 1987-08-10 Sialidase inhibitor Pending JPS6442427A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP19819487A JPS6442427A (en) 1987-08-10 1987-08-10 Sialidase inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19819487A JPS6442427A (en) 1987-08-10 1987-08-10 Sialidase inhibitor

Publications (1)

Publication Number Publication Date
JPS6442427A true JPS6442427A (en) 1989-02-14

Family

ID=16387034

Family Applications (1)

Application Number Title Priority Date Filing Date
JP19819487A Pending JPS6442427A (en) 1987-08-10 1987-08-10 Sialidase inhibitor

Country Status (1)

Country Link
JP (1) JPS6442427A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633022A2 (en) 1993-07-09 1995-01-11 Kureha Chemical Industry Co., Ltd. Chondroprotective flavones
US6599536B1 (en) 1998-03-26 2003-07-29 Novogen Research Pty Ltd Therapy of estrogen-associated disorders
US6987098B2 (en) 1992-05-19 2006-01-17 Novogen Research Pty. Ltd. Health supplement
US7033621B1 (en) 1997-04-28 2006-04-25 Novogen, Inc. Isoflavone compositions produced from legumes
WO2006135084A1 (en) * 2005-06-14 2006-12-21 Kurume University Prophylactic or therapeutic agent for steatohepatitis or fatty liver
US7202273B2 (en) 1996-08-30 2007-04-10 Novogen Research Pty Ltd Therapeutic methods and compositions involving isoflavones
US7312344B2 (en) 2001-03-08 2007-12-25 Novogen Research Pty Limited Dimeric isoflavones
US7488494B2 (en) 1999-09-06 2009-02-10 Novogen Research Pty Ltd. Compositions and therapeutic methods involving isoflavones and analogues thereof
CN102250172A (en) * 2011-07-13 2011-11-23 长沙华诚生物科技有限公司 Method for extracting Buddleoside from wild chrysanthemum flowers
JP2013060460A (en) * 2012-12-17 2013-04-04 Kao Corp Nfat signal inhibitor and nfat signal-inhibiting method
CN104558071A (en) * 2013-10-16 2015-04-29 浙江中医药大学 Method for extracting and purifying effective part or linarin monomer from chrysantheum indici flos

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7045155B2 (en) 1992-05-19 2006-05-16 Novogen Research Pty Ltd. Dietary supplements comprising soy hypocotyls containing at least one isoflavone
USRE40792E1 (en) 1992-05-19 2009-06-23 Novogen Research Pty Ltd Health supplements containing phyto-oestrogens, analogues or metabolites thereof
US6987098B2 (en) 1992-05-19 2006-01-17 Novogen Research Pty. Ltd. Health supplement
EP0633022A2 (en) 1993-07-09 1995-01-11 Kureha Chemical Industry Co., Ltd. Chondroprotective flavones
US7202273B2 (en) 1996-08-30 2007-04-10 Novogen Research Pty Ltd Therapeutic methods and compositions involving isoflavones
US7033621B1 (en) 1997-04-28 2006-04-25 Novogen, Inc. Isoflavone compositions produced from legumes
US6599536B1 (en) 1998-03-26 2003-07-29 Novogen Research Pty Ltd Therapy of estrogen-associated disorders
US7488494B2 (en) 1999-09-06 2009-02-10 Novogen Research Pty Ltd. Compositions and therapeutic methods involving isoflavones and analogues thereof
US7312344B2 (en) 2001-03-08 2007-12-25 Novogen Research Pty Limited Dimeric isoflavones
WO2006135084A1 (en) * 2005-06-14 2006-12-21 Kurume University Prophylactic or therapeutic agent for steatohepatitis or fatty liver
CN102250172A (en) * 2011-07-13 2011-11-23 长沙华诚生物科技有限公司 Method for extracting Buddleoside from wild chrysanthemum flowers
JP2013060460A (en) * 2012-12-17 2013-04-04 Kao Corp Nfat signal inhibitor and nfat signal-inhibiting method
CN104558071A (en) * 2013-10-16 2015-04-29 浙江中医药大学 Method for extracting and purifying effective part or linarin monomer from chrysantheum indici flos

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