JPS6442427A - Sialidase inhibitor - Google Patents
Sialidase inhibitorInfo
- Publication number
- JPS6442427A JPS6442427A JP19819487A JP19819487A JPS6442427A JP S6442427 A JPS6442427 A JP S6442427A JP 19819487 A JP19819487 A JP 19819487A JP 19819487 A JP19819487 A JP 19819487A JP S6442427 A JPS6442427 A JP S6442427A
- Authority
- JP
- Japan
- Prior art keywords
- solvent
- sialidase inhibitor
- luteolin
- afford
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE:To obtain a sialidase inhibitor, containing formononetin, luteolin or luteolin-7-O-glucoside as active ingredients, applicable to medicines, such as anti-inflammatory agent and having high safety with low toxicity. CONSTITUTION:A sialidase inhibitor obtained by extracting Dalbergia odorifera T. CHEN which is heart wood of dried root of a leguminous plant or Chrysanthemum indicum L. which is a dried flower part of a composite plant as a raw material with a solvent, such as methanol, by heating at 0 deg.C- the boiling point temperature of the solvent or using ultrasonic waves to provide an extract solution, directly or concentrating or drying the extract solution and subjected the resultant substance to column chromatography with an adsorbent, such as silica gel, to afford a fraction, recrystallizing the obtained fraction from a solvent, such as water or methanol, to afford the aimed compound which is an active ingredient. The resultant substance can be prepared in the form of a pharmaceutical by a conventional method and the dose thereof as an oral agent is 100-450mg in several divided portion a day for an adult.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19819487A JPS6442427A (en) | 1987-08-10 | 1987-08-10 | Sialidase inhibitor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP19819487A JPS6442427A (en) | 1987-08-10 | 1987-08-10 | Sialidase inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6442427A true JPS6442427A (en) | 1989-02-14 |
Family
ID=16387034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP19819487A Pending JPS6442427A (en) | 1987-08-10 | 1987-08-10 | Sialidase inhibitor |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6442427A (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0633022A2 (en) | 1993-07-09 | 1995-01-11 | Kureha Chemical Industry Co., Ltd. | Chondroprotective flavones |
US6599536B1 (en) | 1998-03-26 | 2003-07-29 | Novogen Research Pty Ltd | Therapy of estrogen-associated disorders |
US6987098B2 (en) | 1992-05-19 | 2006-01-17 | Novogen Research Pty. Ltd. | Health supplement |
US7033621B1 (en) | 1997-04-28 | 2006-04-25 | Novogen, Inc. | Isoflavone compositions produced from legumes |
WO2006135084A1 (en) * | 2005-06-14 | 2006-12-21 | Kurume University | Prophylactic or therapeutic agent for steatohepatitis or fatty liver |
US7202273B2 (en) | 1996-08-30 | 2007-04-10 | Novogen Research Pty Ltd | Therapeutic methods and compositions involving isoflavones |
US7312344B2 (en) | 2001-03-08 | 2007-12-25 | Novogen Research Pty Limited | Dimeric isoflavones |
US7488494B2 (en) | 1999-09-06 | 2009-02-10 | Novogen Research Pty Ltd. | Compositions and therapeutic methods involving isoflavones and analogues thereof |
CN102250172A (en) * | 2011-07-13 | 2011-11-23 | 长沙华诚生物科技有限公司 | Method for extracting Buddleoside from wild chrysanthemum flowers |
JP2013060460A (en) * | 2012-12-17 | 2013-04-04 | Kao Corp | Nfat signal inhibitor and nfat signal-inhibiting method |
CN104558071A (en) * | 2013-10-16 | 2015-04-29 | 浙江中医药大学 | Method for extracting and purifying effective part or linarin monomer from chrysantheum indici flos |
-
1987
- 1987-08-10 JP JP19819487A patent/JPS6442427A/en active Pending
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7045155B2 (en) | 1992-05-19 | 2006-05-16 | Novogen Research Pty Ltd. | Dietary supplements comprising soy hypocotyls containing at least one isoflavone |
USRE40792E1 (en) | 1992-05-19 | 2009-06-23 | Novogen Research Pty Ltd | Health supplements containing phyto-oestrogens, analogues or metabolites thereof |
US6987098B2 (en) | 1992-05-19 | 2006-01-17 | Novogen Research Pty. Ltd. | Health supplement |
EP0633022A2 (en) | 1993-07-09 | 1995-01-11 | Kureha Chemical Industry Co., Ltd. | Chondroprotective flavones |
US7202273B2 (en) | 1996-08-30 | 2007-04-10 | Novogen Research Pty Ltd | Therapeutic methods and compositions involving isoflavones |
US7033621B1 (en) | 1997-04-28 | 2006-04-25 | Novogen, Inc. | Isoflavone compositions produced from legumes |
US6599536B1 (en) | 1998-03-26 | 2003-07-29 | Novogen Research Pty Ltd | Therapy of estrogen-associated disorders |
US7488494B2 (en) | 1999-09-06 | 2009-02-10 | Novogen Research Pty Ltd. | Compositions and therapeutic methods involving isoflavones and analogues thereof |
US7312344B2 (en) | 2001-03-08 | 2007-12-25 | Novogen Research Pty Limited | Dimeric isoflavones |
WO2006135084A1 (en) * | 2005-06-14 | 2006-12-21 | Kurume University | Prophylactic or therapeutic agent for steatohepatitis or fatty liver |
CN102250172A (en) * | 2011-07-13 | 2011-11-23 | 长沙华诚生物科技有限公司 | Method for extracting Buddleoside from wild chrysanthemum flowers |
JP2013060460A (en) * | 2012-12-17 | 2013-04-04 | Kao Corp | Nfat signal inhibitor and nfat signal-inhibiting method |
CN104558071A (en) * | 2013-10-16 | 2015-04-29 | 浙江中医药大学 | Method for extracting and purifying effective part or linarin monomer from chrysantheum indici flos |
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