IL92222A - History of insulin, its use and the pharmaceutical preparations containing it - Google Patents

History of insulin, its use and the pharmaceutical preparations containing it

Info

Publication number
IL92222A
IL92222A IL9222289A IL9222289A IL92222A IL 92222 A IL92222 A IL 92222A IL 9222289 A IL9222289 A IL 9222289A IL 9222289 A IL9222289 A IL 9222289A IL 92222 A IL92222 A IL 92222A
Authority
IL
Israel
Prior art keywords
insulin
formula
physiologically tolerated
tolerated salts
arg
Prior art date
Application number
IL9222289A
Other languages
English (en)
Hebrew (he)
Other versions
IL92222A0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6366698&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL92222(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL92222A0 publication Critical patent/IL92222A0/xx
Publication of IL92222A publication Critical patent/IL92222A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL9222289A 1988-11-08 1989-11-06 History of insulin, its use and the pharmaceutical preparations containing it IL92222A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3837825A DE3837825A1 (de) 1988-11-08 1988-11-08 Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Publications (2)

Publication Number Publication Date
IL92222A0 IL92222A0 (en) 1990-07-26
IL92222A true IL92222A (en) 1999-09-22

Family

ID=6366698

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9222289A IL92222A (en) 1988-11-08 1989-11-06 History of insulin, its use and the pharmaceutical preparations containing it

Country Status (22)

Country Link
US (2) US5656722A (no)
EP (1) EP0368187B1 (no)
JP (1) JP2680145B2 (no)
KR (1) KR0158197B1 (no)
AT (1) ATE93868T1 (no)
AU (1) AU621680B2 (no)
CA (1) CA1339044C (no)
DE (3) DE3837825A1 (no)
DK (1) DK173196B1 (no)
ES (1) ES2059676T4 (no)
FI (1) FI100185B (no)
HK (1) HK1006171A1 (no)
HU (2) HU213018B (no)
IE (1) IE63338B1 (no)
IL (1) IL92222A (no)
LU (1) LU90614I2 (no)
NL (1) NL300019I2 (no)
NO (2) NO177963C (no)
NZ (1) NZ231272A (no)
PH (1) PH30695A (no)
PT (1) PT92220B (no)
ZA (1) ZA898456B (no)

Families Citing this family (128)

* Cited by examiner, † Cited by third party
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DE19825447A1 (de) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh Neue Insulinanaloga mit erhöhter Zinkbildung
DE19838097A1 (de) 1998-08-24 2000-03-02 Hoechst Marion Roussel De Gmbh Verfahren zur chromatographischen Reinigung von Insulinen
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
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US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
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FR2822834B1 (fr) * 2001-04-02 2005-02-25 Flamel Tech Sa Suspension colloidale de nanoparticules a base de copolymeres amphiphile pour la vectorisation de principes actifs et leur mode de preparation
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CN104688677B (zh) * 2015-02-05 2018-02-09 通化东宝药业股份有限公司 一种稳定的甘精胰岛素注射液及其制备方法
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TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
AR107560A1 (es) 2016-02-24 2018-05-09 Lilly Co Eli Compuesto que disminuye la glucosa en la sangre
FR3052072A1 (fr) 2016-06-07 2017-12-08 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
ES2932498T3 (es) 2016-12-05 2023-01-20 Nuritas Ltd Composiciones que comprenden el péptido WKDEAGKPLVK
EP3329930A1 (en) 2016-12-05 2018-06-06 Nuritas Limited Pharmaceuctical compositions
KR20190122706A (ko) 2017-03-09 2019-10-30 다이어메디카 인코포레이티드 조직 칼리크레인 1의 투약 형태
FR3070264A1 (fr) 2017-08-24 2019-03-01 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris de 5,8 a 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
WO2019110625A1 (fr) 2017-12-06 2019-06-13 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
FR3083088B1 (fr) 2018-06-29 2020-10-02 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
FR3083089A1 (fr) 2018-06-29 2020-01-03 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
EP3723728A1 (fr) 2017-12-07 2020-10-21 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
MX2020005913A (es) 2017-12-07 2020-10-19 Adocia Solución inyectable a ph 7 que comprende al menos una insulina basal que tiene un pi de entre 5.8 y 8.5 y un copoliaminoácido con cargas de carboxilato y radicales hidrofóbicos.
TWI813604B (zh) 2017-12-07 2023-09-01 法商阿道洽公司 包含至少一具有pi從5.8至8.5之基礎胰島素以及一帶有羧酸鹽電荷及疏水基之共聚胺基酸的可注射ph7溶液
CN112423741A (zh) * 2018-04-16 2021-02-26 犹他大学研究基金会 葡萄糖反应性胰岛素
WO2019243628A1 (fr) 2018-06-22 2019-12-26 Adocia Composition injectable a ph 7 comprenant un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes et au moins une insuline basale presentant au moins un effet prandial et un effet basal
FR3084585B1 (fr) 2018-08-03 2020-11-06 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un compose amphiphile porteur de radicaux hydrophobes
KR102666154B1 (ko) 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
WO2020115334A1 (fr) 2018-12-07 2020-06-11 Adocia Procede de preparation d'une composition stable sous forme d'une solution aqueuse injectable
US20200179489A1 (en) 2018-12-07 2020-06-11 Adocia Injectable solution at ph 7 comprising at least one basal insulin which pi is from 5.8 to 8.5 and a co-polyamino-acid bearing carboxylate charges and hydrophobic radicals and a limited amount of m-cresol
KR20200080747A (ko) 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
KR20200080748A (ko) 2018-12-27 2020-07-07 주식회사 폴루스 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법
KR20200082618A (ko) 2018-12-31 2020-07-08 주식회사 폴루스 인슐린 과발현용 램프 태그 및 이를 이용한 인슐린의 제조방법
WO2020245470A1 (fr) 2019-06-07 2020-12-10 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5, du liraglutide et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
TWI844709B (zh) 2019-07-31 2024-06-11 美商美國禮來大藥廠 鬆弛素(relaxin)類似物及其使用方法
CN113105536B (zh) 2020-09-11 2023-07-18 美药星（南京）制药有限公司 一种新甘精胰岛素原及其制备甘精胰岛素的方法
CN114805610B (zh) * 2022-06-23 2022-10-04 北京惠之衡生物科技有限公司 一种高表达甘精胰岛素前体的重组基因工程菌及其构建方法

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DE10075022I2 (de) 2002-07-04
PH30695A (en) 1997-09-16
KR900007435A (ko) 1990-06-01
PT92220B (pt) 1995-07-06
HK1006171A1 (en) 1999-02-12
ZA898456B (en) 1990-06-27
HU895678D0 (en) 1990-01-28
CA1339044C (en) 1997-04-01
NO177963C (no) 1995-12-27
EP0368187A2 (de) 1990-05-16
NO177963B (no) 1995-09-18
AU621680B2 (en) 1992-03-19
JPH02218696A (ja) 1990-08-31
DE58905456D1 (de) 1993-10-07
AU4441289A (en) 1990-05-17
LU90614I2 (fr) 2000-09-26
DK554789D0 (da) 1989-11-07
NL300019I1 (nl) 2000-12-01
FI100185B (fi) 1997-10-15
KR0158197B1 (ko) 1998-12-01
EP0368187B1 (de) 1993-09-01
ATE93868T1 (de) 1993-09-15
HU210800A9 (en) 1995-07-28
NO2001023I1 (no) 2001-12-17
NO894424D0 (no) 1989-11-07
NO894424L (no) 1990-05-09
NZ231272A (en) 1992-11-25
DK173196B1 (da) 2000-03-13
HUT52549A (en) 1990-07-28
ES2059676T3 (es) 1994-11-16
HU213018B (en) 1997-01-28
US6100376A (en) 2000-08-08
IE63338B1 (en) 1995-04-19
FI895259A0 (fi) 1989-11-06
EP0368187A3 (de) 1991-07-03
PT92220A (pt) 1990-05-31
DE3837825A1 (de) 1990-05-10
DK554789A (da) 1990-05-09
IL92222A0 (en) 1990-07-26
US5656722A (en) 1997-08-12
ES2059676T4 (es) 2012-03-13
DE10075022I1 (de) 2000-10-05
IE893576L (en) 1990-05-08
NL300019I2 (nl) 2001-02-01
JP2680145B2 (ja) 1997-11-19

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