ZA898456B - New insulin derivatives,the use thereof,and a pharmaceutical composition containing them - Google Patents

New insulin derivatives,the use thereof,and a pharmaceutical composition containing them

Info

Publication number
ZA898456B
ZA898456B ZA898456A ZA898456A ZA898456B ZA 898456 B ZA898456 B ZA 898456B ZA 898456 A ZA898456 A ZA 898456A ZA 898456 A ZA898456 A ZA 898456A ZA 898456 B ZA898456 B ZA 898456B
Authority
ZA
South Africa
Prior art keywords
insulin derivatives
amino acid
genetically encodable
pharmaceutical composition
formula
Prior art date
Application number
ZA898456A
Other languages
English (en)
Inventor
Michael Dorschug
Dorschug Michael
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6366698&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA898456(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of ZA898456B publication Critical patent/ZA898456B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA898456A 1988-11-08 1989-11-07 New insulin derivatives,the use thereof,and a pharmaceutical composition containing them ZA898456B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3837825A DE3837825A1 (de) 1988-11-08 1988-11-08 Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung

Publications (1)

Publication Number Publication Date
ZA898456B true ZA898456B (en) 1990-06-27

Family

ID=6366698

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA898456A ZA898456B (en) 1988-11-08 1989-11-07 New insulin derivatives,the use thereof,and a pharmaceutical composition containing them

Country Status (22)

Country Link
US (2) US5656722A (xx)
EP (1) EP0368187B1 (xx)
JP (1) JP2680145B2 (xx)
KR (1) KR0158197B1 (xx)
AT (1) ATE93868T1 (xx)
AU (1) AU621680B2 (xx)
CA (1) CA1339044C (xx)
DE (3) DE3837825A1 (xx)
DK (1) DK173196B1 (xx)
ES (1) ES2059676T4 (xx)
FI (1) FI100185B (xx)
HK (1) HK1006171A1 (xx)
HU (2) HU213018B (xx)
IE (1) IE63338B1 (xx)
IL (1) IL92222A (xx)
LU (1) LU90614I2 (xx)
NL (1) NL300019I2 (xx)
NO (2) NO177963C (xx)
NZ (1) NZ231272A (xx)
PH (1) PH30695A (xx)
PT (1) PT92220B (xx)
ZA (1) ZA898456B (xx)

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* Cited by examiner, † Cited by third party
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KR20200106892A (ko) 2017-12-07 2020-09-15 아도시아 pI가 5.8 내지 8.5인 적어도 1종의 기저 인슐린, 및 카복실산염 전하 및 소수성 라디칼을 보유하는 코-폴리아미노산을 포함하는 pH 7의 주사용 용액
JP2021505607A (ja) 2017-12-07 2021-02-18 アドシア ５．８〜８．５のｐＩを有する少なくとも１つの基礎インスリンならびにカルボキシレート電荷および疎水性ラジカルを有するコポリアミノ酸を含むｐＨ７の注射溶液
KR20210005630A (ko) * 2018-04-16 2021-01-14 유니버시티 오브 유타 리서치 파운데이션 글루코스-반응성 인슐린
WO2019243628A1 (fr) 2018-06-22 2019-12-26 Adocia Composition injectable a ph 7 comprenant un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes et au moins une insuline basale presentant au moins un effet prandial et un effet basal
FR3084585B1 (fr) 2018-08-03 2020-11-06 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un compose amphiphile porteur de radicaux hydrophobes
KR102666154B1 (ko) 2018-08-08 2024-05-20 주식회사 대웅제약 지속형 인슐린 아날로그 및 그 복합체
WO2020115334A1 (fr) 2018-12-07 2020-06-11 Adocia Procede de preparation d'une composition stable sous forme d'une solution aqueuse injectable
US20200179489A1 (en) 2018-12-07 2020-06-11 Adocia Injectable solution at ph 7 comprising at least one basal insulin which pi is from 5.8 to 8.5 and a co-polyamino-acid bearing carboxylate charges and hydrophobic radicals and a limited amount of m-cresol
KR20200080748A (ko) 2018-12-27 2020-07-07 주식회사 폴루스 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법
KR20200080747A (ko) 2018-12-27 2020-07-07 주식회사 폴루스 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법
KR20200082618A (ko) 2018-12-31 2020-07-08 주식회사 폴루스 인슐린 과발현용 램프 태그 및 이를 이용한 인슐린의 제조방법
WO2020245470A1 (fr) 2019-06-07 2020-12-10 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5, du liraglutide et un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes
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DE3837825A1 (de) 1990-05-10
KR0158197B1 (ko) 1998-12-01
NO2001023I1 (no) 2001-12-17
HK1006171A1 (en) 1999-02-12
KR900007435A (ko) 1990-06-01
NO177963C (no) 1995-12-27
NL300019I2 (nl) 2001-02-01
NO177963B (no) 1995-09-18
EP0368187B1 (de) 1993-09-01
JP2680145B2 (ja) 1997-11-19
NL300019I1 (nl) 2000-12-01
ES2059676T3 (es) 1994-11-16
PT92220A (pt) 1990-05-31
HU213018B (en) 1997-01-28
AU4441289A (en) 1990-05-17
US6100376A (en) 2000-08-08
DE58905456D1 (de) 1993-10-07
HU210800A9 (en) 1995-07-28
HUT52549A (en) 1990-07-28
JPH02218696A (ja) 1990-08-31
AU621680B2 (en) 1992-03-19
DK554789D0 (da) 1989-11-07
NO894424L (no) 1990-05-09
DE10075022I1 (de) 2000-10-05
HU895678D0 (en) 1990-01-28
IL92222A (en) 1999-09-22
EP0368187A3 (de) 1991-07-03
PT92220B (pt) 1995-07-06
EP0368187A2 (de) 1990-05-16
ES2059676T4 (es) 2012-03-13
PH30695A (en) 1997-09-16
DE10075022I2 (de) 2002-07-04
DK173196B1 (da) 2000-03-13
IE893576L (en) 1990-05-08
ATE93868T1 (de) 1993-09-15
FI100185B (fi) 1997-10-15
DK554789A (da) 1990-05-09
IL92222A0 (en) 1990-07-26
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US5656722A (en) 1997-08-12
NZ231272A (en) 1992-11-25
IE63338B1 (en) 1995-04-19
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FI895259A0 (fi) 1989-11-06
NO894424D0 (no) 1989-11-07

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