MX2009012789A - Composiciones farmaceuticas no acuosas estables. - Google Patents
Composiciones farmaceuticas no acuosas estables.Info
- Publication number
- MX2009012789A MX2009012789A MX2009012789A MX2009012789A MX2009012789A MX 2009012789 A MX2009012789 A MX 2009012789A MX 2009012789 A MX2009012789 A MX 2009012789A MX 2009012789 A MX2009012789 A MX 2009012789A MX 2009012789 A MX2009012789 A MX 2009012789A
- Authority
- MX
- Mexico
- Prior art keywords
- pharmaceutical compositions
- aqueous pharmaceutical
- stable non
- hyperglycaemia
- semi
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se relaciona con composiciones farmacéuticas no acuosas estables en almacenamiento, y al uso de las mismas en métodos de tratar diabetes e hiperglicemia, que comprende polipéptido activo deshidratado que comprende lo-loo aminoácidos y por lo menos un solvente orgánico prótico semipolar.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07109435 | 2007-06-01 | ||
EP07114524 | 2007-08-17 | ||
PCT/EP2008/056689 WO2008145730A1 (en) | 2007-06-01 | 2008-05-30 | Stable non-aqueous pharmaceutical compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009012789A true MX2009012789A (es) | 2009-12-10 |
Family
ID=39764679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009012789A MX2009012789A (es) | 2007-06-01 | 2008-05-30 | Composiciones farmaceuticas no acuosas estables. |
Country Status (11)
Country | Link |
---|---|
US (3) | US20100190706A1 (es) |
EP (4) | EP2164458A1 (es) |
JP (2) | JP5675347B2 (es) |
KR (1) | KR20100017667A (es) |
CN (1) | CN101677944A (es) |
AU (1) | AU2008257505B2 (es) |
BR (1) | BRPI0812354A2 (es) |
CA (1) | CA2716159A1 (es) |
MX (1) | MX2009012789A (es) |
RU (1) | RU2472492C2 (es) |
WO (2) | WO2008145730A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2663074A1 (en) | 2006-09-22 | 2008-03-27 | Novo Nordisk A/S | Protease resistant insulin analogues |
ES2563038T3 (es) | 2007-04-30 | 2016-03-10 | Novo Nordisk A/S | Método para secar una composición proteica, una composición proteica seca y una composición farmacéutica que comprende la proteína seca |
EP2164458A1 (en) * | 2007-06-01 | 2010-03-24 | Novo Nordisk A/S | Stable non-aqueous pharmaceutical compositions |
US9260502B2 (en) | 2008-03-14 | 2016-02-16 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
HUE032284T2 (en) | 2008-03-18 | 2017-09-28 | Novo Nordisk As | Protease-stabilized, acylated insulin analogues |
WO2011033019A1 (en) * | 2009-09-16 | 2011-03-24 | Novo Nordisk A/S | Stable non-aqueous liquid pharmaceutical compositions comprising an insulin |
US9445992B2 (en) | 2009-11-25 | 2016-09-20 | Arisgen Sa | Mucosal delivery compositions comprising a peptide complexed with a crown compound and/or a counter ion |
CA2786953A1 (en) * | 2010-01-12 | 2011-07-21 | Florian Anders Foeger | Pharmaceutical compositions for oral administration of insulin peptides |
US20120035103A1 (en) * | 2010-01-29 | 2012-02-09 | Pillion Dennis J | Method for administration of insulin and pharmaceutical composition thereof |
EP2608771B1 (en) * | 2010-08-23 | 2018-12-12 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | Compositions for gastric delivery of active agents |
EP2526971A1 (en) | 2011-05-25 | 2012-11-28 | ArisGen SA | Mucosal delivery of drugs |
ES2594303T3 (es) | 2012-04-11 | 2016-12-19 | Novo Nordisk A/S | Formulaciones de insulina |
US8853189B2 (en) | 2012-05-31 | 2014-10-07 | Prima Innovations, Llc | Antispasmodic 1,2-Diols and 1,2,3-triols |
WO2014124096A1 (en) * | 2013-02-06 | 2014-08-14 | Perosphere Inc. | Stable glucagon formulations |
PL3055325T3 (pl) | 2013-10-07 | 2018-06-29 | Novo Nordisk A/S | Nowa pochodna analogu insuliny |
EP2946788A1 (en) | 2014-05-23 | 2015-11-25 | Immundiagnostik AG | Method and composition for treating heart failure with preserved ejection fraction |
EP3154568A4 (en) | 2014-06-10 | 2018-01-24 | California Institute of Technology | Non-canonical insulins and their uses |
ES2841933T3 (es) | 2014-10-31 | 2021-07-12 | Univ Monash | Formulación en polvo |
IL300839B2 (en) | 2016-12-16 | 2024-04-01 | Novo Nordisk As | Pharmaceutical preparations containing insulin |
EP3644964B1 (en) * | 2017-06-28 | 2024-04-10 | Children's Medical Center Corporation | Promoting lung growth |
CN114432424B (zh) * | 2021-12-27 | 2023-06-27 | 南通联亚药业股份有限公司 | 一种稳定的铝塑包装去氨加压素片剂 |
WO2024123214A1 (ru) * | 2022-12-04 | 2024-06-13 | Общество С Ограниченной Ответственностью "Герофарм" | Композиция инсулина аспарта (варианты) |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6074A (en) | 1849-01-30 | Machine fob making suspender-buckles | ||
US3003A (en) * | 1843-03-17 | Improvement in the method of propelling vessels by means of continuous streams of water | ||
US221A (en) | 1837-06-03 | Steam-boii | ||
US4468A (en) | 1846-04-25 | Improvement in casting spoons | ||
US2832685A (en) * | 1952-05-24 | 1958-04-29 | Crest Foods Co Inc | Solubilization of milk proteins |
US3528960A (en) * | 1968-10-07 | 1970-09-15 | Lilly Co Eli | N-carboxyaroyl insulins |
US3950517A (en) * | 1970-05-08 | 1976-04-13 | National Research Development Corporation | Insulin derivatives |
US3869437A (en) * | 1970-05-08 | 1975-03-04 | Nat Res Dev | Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin |
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4033941A (en) * | 1975-12-17 | 1977-07-05 | Eli Lilly And Company | Process for purifying glucagon |
JPS6030650B2 (ja) * | 1979-10-26 | 1985-07-17 | 日本油脂株式会社 | 座薬基剤組成物 |
US4468221A (en) | 1981-04-10 | 1984-08-28 | Parker-Hannifin Corporation | Medication infusion pump |
US4839341A (en) * | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
US4719655A (en) * | 1986-01-21 | 1988-01-19 | Dean S Brooks | Invalid transfer device |
US4849227A (en) * | 1986-03-21 | 1989-07-18 | Eurasiam Laboratories, Inc. | Pharmaceutical compositions |
US5266310A (en) * | 1987-09-17 | 1993-11-30 | Boehringer Ingelheim International Gmbh | Stabilization of therapeutically active proteins in pharmaceutical preparations |
DE3837825A1 (de) | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
WO1990007522A1 (en) | 1988-12-23 | 1990-07-12 | Novo Nordisk A/S | Human insulin analogues |
DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
NZ232375A (en) | 1989-02-09 | 1992-04-28 | Lilly Co Eli | Insulin analogues modified at b29 |
US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
AU628674B2 (en) * | 1989-10-19 | 1992-09-17 | Nippon Oil And Fats Company, Limited | Polymer complexes of a sugar response type |
US5179189A (en) * | 1990-01-19 | 1993-01-12 | Nova Pharmaceutical Corporation | Fatty acid terminated polyanhydrides |
US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5206219A (en) * | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
AU5171293A (en) * | 1992-10-14 | 1994-05-09 | Regents Of The University Of Colorado, The | Ion-pairing of drugs for improved efficacy and delivery |
RU2143889C1 (ru) * | 1993-02-23 | 2000-01-10 | Генентек, Инк. | Способ стабилизации полипептида, способы получения композиций полипептида и композиции |
US5359030A (en) * | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
DE122006000015I1 (de) | 1993-06-21 | 2006-06-29 | Novo Nordisk As | Asp-B28-Insulinkristalle |
US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
US6869930B1 (en) * | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
US6011007A (en) | 1993-09-17 | 2000-01-04 | Novo Nordisk A/S | Acylated insulin |
CN1056618C (zh) | 1993-09-17 | 2000-09-20 | 诺沃挪第克公司 | 酰化的胰岛素和含有这种胰岛素的药物组合物 |
US5504188A (en) | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
US6500645B1 (en) * | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
US6251856B1 (en) * | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
US20030104981A1 (en) * | 1995-11-03 | 2003-06-05 | Jelena Mandic | Human insulin analogues |
US5858001A (en) | 1995-12-11 | 1999-01-12 | Elan Medical Technologies Limited | Cartridge-based drug delivery device |
US6451970B1 (en) * | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
US5981489A (en) * | 1996-07-18 | 1999-11-09 | Alza Corporation | Non-aqueous protic peptide formulations |
ES2218622T3 (es) * | 1996-07-26 | 2004-11-16 | Aventis Pharma Deutschland Gmbh | Derivados de insulina con actividad de union al zinc incrementada. |
US5898067A (en) * | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
US5957895A (en) | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
TW570805B (en) * | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
US7030083B2 (en) * | 1998-09-09 | 2006-04-18 | University Of Washington | Treatment of eclampsia and preeclampsia |
US6660715B2 (en) * | 1998-11-19 | 2003-12-09 | Massachusetts Institute Of Technology | Nonaqueous solutions and suspensions of macromolecules for pulmonary delivery |
US7425541B2 (en) * | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
AU2879100A (en) * | 1999-02-12 | 2000-08-29 | Miles A. Libbey Iii | Formulation and system for intra-oral delivery of pharmaceutical agents |
CN1141974C (zh) * | 2000-06-07 | 2004-03-17 | 张昊 | 结肠定位释放的口服生物制剂 |
US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6867183B2 (en) * | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
CN1160122C (zh) * | 2001-04-20 | 2004-08-04 | 清华大学 | 一种制备口服胰岛素油相制剂的方法 |
US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
EP1423136A4 (en) * | 2001-08-10 | 2007-07-25 | Epix Pharm Inc | POLYPEPTIDE CONJUGATES HAVING INCREASED CIRCULATION HALF-VIES |
US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
US6770625B2 (en) * | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
EP1456371A1 (en) * | 2001-12-05 | 2004-09-15 | Dow Global Technologies Inc. | Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications |
UA46669C2 (uk) * | 2001-12-29 | 2005-12-15 | Товариство З Обмеженою Відповідальністю "Мако" | Спосіб приготування готової лікарської форми інсуліну пролонгованої дії |
WO2003078538A1 (en) | 2002-03-18 | 2003-09-25 | Bespak Plc | Seal material for a dispensing apparatus |
WO2003105768A2 (en) * | 2002-06-13 | 2003-12-24 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
US7563807B2 (en) * | 2002-09-17 | 2009-07-21 | Merck & Co. Inc. | Removal of aldehyde impurity by reactive polystyrene resini |
PL1633391T3 (pl) * | 2003-06-03 | 2012-03-30 | Novo Nordisk As | Stabilizowane farmaceutycznie kompozycje peptydowe |
WO2005012347A2 (en) * | 2003-08-05 | 2005-02-10 | Novo Nordisk A/S | Novel insulin derivatives |
RU2421238C2 (ru) * | 2003-11-20 | 2011-06-20 | Ново Нордиск А/С | Пептидная композиция, содержащая пропиленгликоль, являющаяся оптимальной для изготовления и применения в инъекционных устройствах |
CN102816228A (zh) | 2003-12-03 | 2012-12-12 | 诺和诺德公司 | 单链胰岛素 |
WO2005058961A2 (en) * | 2003-12-12 | 2005-06-30 | Amgen Inc. | Antibodies specific for human galanin, and uses thereof |
CN101084016A (zh) * | 2004-04-15 | 2007-12-05 | 克艾思马有限公司 | 能够容易穿透生物学障碍的组合物 |
JP2007537274A (ja) * | 2004-05-10 | 2007-12-20 | ナステック ファーマスーティカル カンパニー インク. | 副甲状腺ホルモンの粘膜送達を増強するための組成物及び方法 |
PL1773878T3 (pl) * | 2004-07-19 | 2015-07-31 | Biocon Ltd | Koniugaty insulina-oligomer, ich formulacje i zastosowania |
EP1781324A2 (en) | 2004-08-20 | 2007-05-09 | Novo Nordisk A/S | Pharmaceutically active insulin receptor-modulating molecules |
US20080200383A1 (en) * | 2005-04-08 | 2008-08-21 | Amylin Pharmaceuticals, Inc. | Pharmaceutical Formulations Comprising Incretin Peptide and Aprotic Polar Solvent |
CN101212947A (zh) * | 2005-06-30 | 2008-07-02 | 阿斯利康(瑞典)有限公司 | 环境检测器 |
KR20080064171A (ko) * | 2005-10-20 | 2008-07-08 | 나스텍 파마수티컬 컴퍼니 인코포레이티드 | 속효성 인슐린의 비강내 투여 |
CA2663074A1 (en) | 2006-09-22 | 2008-03-27 | Novo Nordisk A/S | Protease resistant insulin analogues |
EP2164458A1 (en) * | 2007-06-01 | 2010-03-24 | Novo Nordisk A/S | Stable non-aqueous pharmaceutical compositions |
US20090087484A1 (en) * | 2007-09-28 | 2009-04-02 | Alza Corporation | Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules |
WO2010060667A1 (en) * | 2008-11-28 | 2010-06-03 | Novo Nordisk A/S | Pharmaceutical compositions suitable for oral administration of derivatized insulin peptides |
-
2008
- 2008-05-30 EP EP08760278A patent/EP2164458A1/en not_active Withdrawn
- 2008-05-30 JP JP2010509835A patent/JP5675347B2/ja not_active Expired - Fee Related
- 2008-05-30 EP EP12159415A patent/EP2497462A1/en not_active Withdrawn
- 2008-05-30 BR BRPI0812354-3A2A patent/BRPI0812354A2/pt not_active Application Discontinuation
- 2008-05-30 EP EP12159419A patent/EP2514407A1/en not_active Withdrawn
- 2008-05-30 CN CN200880017599A patent/CN101677944A/zh active Pending
- 2008-05-30 US US12/601,345 patent/US20100190706A1/en not_active Abandoned
- 2008-05-30 CA CA2716159A patent/CA2716159A1/en not_active Abandoned
- 2008-05-30 EP EP08760287A patent/EP2164459A1/en not_active Withdrawn
- 2008-05-30 US US12/601,884 patent/US20100144592A1/en not_active Abandoned
- 2008-05-30 WO PCT/EP2008/056689 patent/WO2008145730A1/en active Application Filing
- 2008-05-30 MX MX2009012789A patent/MX2009012789A/es active IP Right Grant
- 2008-05-30 KR KR1020097025474A patent/KR20100017667A/ko not_active IP Right Cessation
- 2008-05-30 RU RU2009146883/15A patent/RU2472492C2/ru not_active IP Right Cessation
- 2008-05-30 WO PCT/EP2008/056699 patent/WO2008145732A1/en active Application Filing
- 2008-05-30 JP JP2010509834A patent/JP5628026B2/ja not_active Expired - Fee Related
- 2008-05-30 AU AU2008257505A patent/AU2008257505B2/en not_active Ceased
-
2014
- 2014-07-21 US US14/336,562 patent/US20140349924A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20100144592A1 (en) | 2010-06-10 |
WO2008145732A1 (en) | 2008-12-04 |
KR20100017667A (ko) | 2010-02-16 |
BRPI0812354A2 (pt) | 2015-01-27 |
JP5628026B2 (ja) | 2014-11-19 |
EP2497462A1 (en) | 2012-09-12 |
AU2008257505B2 (en) | 2013-05-16 |
RU2009146883A (ru) | 2011-07-20 |
RU2472492C2 (ru) | 2013-01-20 |
CN101677944A (zh) | 2010-03-24 |
EP2164459A1 (en) | 2010-03-24 |
US20100190706A1 (en) | 2010-07-29 |
EP2164458A1 (en) | 2010-03-24 |
WO2008145730A1 (en) | 2008-12-04 |
EP2514407A1 (en) | 2012-10-24 |
CA2716159A1 (en) | 2008-12-04 |
JP2010529956A (ja) | 2010-09-02 |
JP5675347B2 (ja) | 2015-02-25 |
AU2008257505A1 (en) | 2008-12-04 |
US20140349924A1 (en) | 2014-11-27 |
JP2010529004A (ja) | 2010-08-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009012789A (es) | Composiciones farmaceuticas no acuosas estables. | |
MX2014015257A (es) | Proteinas del factor 21 de crecimiento de fibroblasto. | |
EA201492064A1 (ru) | Варианты фактора роста фибробластов 21 | |
UA104605C2 (uk) | Аналоги глюкагону | |
GEP20146056B (en) | Acylated glucagon analogues | |
WO2013006486A3 (en) | Compositions, uses and methods for treatment of metabolic disorders and diseases | |
MY158890A (en) | Pegylated insulin lispro compounds | |
BR112012017345A2 (pt) | "composições e métodos de pgl para a produção aumentada de isopreno e outros produtos com 6-fosfogliconolactonase (pgl)" | |
BRPI0916515B8 (pt) | polipeptídeo de fator estimulante de colônias de granulócitos bovino (bg-csf), formulação farmacêutica e composição compreendendo o mesmo | |
NZ596037A (en) | Fgf21 mutants and uses thereof | |
EA201590525A1 (ru) | Слитые белки для лечения метаболического синдрома | |
AR092076A1 (es) | Proteinas homodimericas | |
CA2818969A1 (en) | Improved n-terminal capping modules for designed ankyrin repeat proteins | |
WO2009073618A3 (en) | Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure | |
EA201490521A1 (ru) | Варианты фактора роста фибробластов 21 | |
MX355457B (es) | Fsh recombinante que incluye alfa, 2-3- y alfa 2,6-sialilacion. | |
WO2009126292A3 (en) | Biologically active peptidomimetic macrocycles | |
WO2011008823A3 (en) | Peptide-mediated non-covalent delivery of active agents across the blood brain barrier | |
EA201170878A1 (ru) | Полипептиды с ксиланазной активностью | |
WO2011008495A3 (en) | Arginase formulations and methods | |
EP2502618A3 (en) | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein | |
MX342039B (es) | Composiciones y usos de materiales con actividad antimicrobiana elevada y toxicidad baja referencia cruzada a solicitudes previas. | |
WO2006138099A3 (en) | Bone morphogenetic protein formulations | |
PH12015502102A1 (en) | Reducing proinflammatory response | |
WO2011069037A3 (en) | Stabilization and storage of biological pharmaceutical compositions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |