EA201492064A1 - Варианты фактора роста фибробластов 21 - Google Patents
Варианты фактора роста фибробластов 21Info
- Publication number
- EA201492064A1 EA201492064A1 EA201492064A EA201492064A EA201492064A1 EA 201492064 A1 EA201492064 A1 EA 201492064A1 EA 201492064 A EA201492064 A EA 201492064A EA 201492064 A EA201492064 A EA 201492064A EA 201492064 A1 EA201492064 A1 EA 201492064A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- growth factor
- fibroblast growth
- options
- variants
- fgf21
- Prior art date
Links
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title abstract 3
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title abstract 3
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- 101000846529 Homo sapiens Fibroblast growth factor 21 Proteins 0.000 abstract 1
- 208000017170 Lipid metabolism disease Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 102000056713 human FGF21 Human genes 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/813—Carrier is a saccharide
- Y10S530/814—Cellulose or derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Настоящее изобретение относится к фармакологически активным и стабильным вариантам фактора роста фибробластов 21 (FGF21) человека, фармацевтическим композициям, содержащим варианты FGF21, и способам лечения диабета 2-го типа, ожирения, дислипидемии и/или метаболического синдрома с применением таких вариантов.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261658110P | 2012-06-11 | 2012-06-11 | |
PCT/US2013/044192 WO2013188182A1 (en) | 2012-06-11 | 2013-06-05 | Fibroblast growth factor 21 variants |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201492064A1 true EA201492064A1 (ru) | 2015-02-27 |
Family
ID=48626674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201492064A EA201492064A1 (ru) | 2012-06-11 | 2013-06-05 | Варианты фактора роста фибробластов 21 |
Country Status (12)
Country | Link |
---|---|
US (1) | US9422353B2 (ru) |
EP (1) | EP2859014B1 (ru) |
JP (1) | JP6181752B2 (ru) |
KR (1) | KR20150006059A (ru) |
CN (1) | CN104364261B (ru) |
AU (1) | AU2013274639A1 (ru) |
CA (1) | CA2871656A1 (ru) |
EA (1) | EA201492064A1 (ru) |
ES (1) | ES2632078T3 (ru) |
MX (1) | MX2014015258A (ru) |
WO (1) | WO2013188182A1 (ru) |
ZA (1) | ZA201407938B (ru) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012279237B2 (en) | 2011-07-01 | 2016-09-29 | Ngm Biopharmaceuticals, Inc. | Compositions, uses and methods for treatment of metabolic disorders and diseases |
US9290557B2 (en) | 2012-11-28 | 2016-03-22 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants and fusions of FGF19 polypeptides |
WO2014085365A2 (en) | 2012-11-28 | 2014-06-05 | Ngm Biopharmaceuticals, Inc. | Compositions and methods for treatment of metabolic disorders and diseases |
JP6403685B2 (ja) | 2012-12-27 | 2018-10-17 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | 胆汁酸ホメオスタシス調整並びに胆汁酸障害及び疾患の治療の方法 |
US9273107B2 (en) | 2012-12-27 | 2016-03-01 | Ngm Biopharmaceuticals, Inc. | Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
NZ718962A (en) | 2013-10-28 | 2019-12-20 | Ngm Biopharmaceuticals Inc | Cancer models and associated methods |
US9738716B2 (en) | 2014-01-24 | 2017-08-22 | Ngm Biopharmaceuticals, Inc. | Beta klotho binding proteins and methods of use thereof |
US10398758B2 (en) | 2014-05-28 | 2019-09-03 | Ngm Biopharmaceuticals, Inc. | Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions |
AU2015277438B2 (en) | 2014-06-16 | 2020-02-27 | Ngm Biopharmaceuticals, Inc. | Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases |
RU2729161C2 (ru) | 2014-10-23 | 2020-08-04 | ЭнДжиЭм БАЙОФАРМАСЬЮТИКАЛЗ, ИНК. | Фармацевтические композиции, содержащие варианты пептидов, и способы их применения |
US10434144B2 (en) | 2014-11-07 | 2019-10-08 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders |
US10800843B2 (en) | 2015-07-29 | 2020-10-13 | Ngm Biopharmaceuticals, Inc. | Beta klotho-binding proteins |
US10744185B2 (en) | 2015-11-09 | 2020-08-18 | Ngm Biopharmaceuticals, Inc. | Methods of using variants of FGF19 polypeptides for the treatment of pruritus |
TW201731867A (zh) | 2015-12-02 | 2017-09-16 | 賽諾菲公司 | Fgf21變異體 |
CN109689079A (zh) | 2016-08-22 | 2019-04-26 | 伊兰科美国公司 | 牛成纤维细胞生长因子21和乳畜中的酮病 |
US11370841B2 (en) | 2016-08-26 | 2022-06-28 | Ngm Biopharmaceuticals, Inc. | Methods of treating fibroblast growth factor 19-mediated cancers and tumors |
RU2019122785A (ru) | 2016-12-22 | 2021-01-22 | Санофи | Комбинации соединения на основе fgf21/агониста glp-1r с оптимизированным соотношением активности |
US20220127322A1 (en) | 2017-03-14 | 2022-04-28 | Sunshine Lake Pharma Co., Ltd. | Dual-target fusion proteins comprising the fc portion of an immunoglobulin |
CN107056925B (zh) * | 2017-04-28 | 2022-01-14 | 中国科学院合肥物质科学研究院 | 人fgf21突变体、其制备方法及用途 |
EP3749683A4 (en) | 2018-02-08 | 2022-03-16 | Sunshine Lake Pharma Co., Ltd. | FGF21 VARIANT, FUSION PROTEIN AND USE THEREOF |
KR102094184B1 (ko) | 2018-05-18 | 2020-03-27 | 고려대학교 산학협력단 | Crtc 2의 간 특이적 조절에 의한 지방간 및 비만 제어용 조성물 |
EP3935075A4 (en) * | 2019-03-05 | 2023-01-18 | Sunshine Lake Pharma Co., Ltd. | POLYPEPTIDIC MOLECULE AND ITS APPLICATION |
CN114853908B (zh) | 2019-05-16 | 2024-06-07 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的融合蛋白 |
CN115109137A (zh) * | 2021-03-19 | 2022-09-27 | 广东东阳光药业有限公司 | Fgf21多肽及其融合多肽的应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US7459540B1 (en) | 1999-09-07 | 2008-12-02 | Amgen Inc. | Fibroblast growth factor-like polypeptides |
WO2003011213A2 (en) | 2001-07-30 | 2003-02-13 | Eli Lilly And Company | Method for treating diabetes and obesity |
EA200601121A1 (ru) | 2003-12-10 | 2006-10-27 | Эли Лилли Энд Компани | Мутеины фактора роста фибробластов 21 |
US7576190B2 (en) | 2004-05-13 | 2009-08-18 | Eli Lilly And Company | FGF-21 fusion proteins |
EP2161281A1 (en) | 2004-09-02 | 2010-03-10 | Eli Lilly & Company | Muteins of fibroblast growth factor 21 |
BRPI0809583B1 (pt) | 2007-03-30 | 2022-02-22 | Ambrx, Inc | Polipeptídeo fgf-21 modificado, composição compreendendo o mesmo, método para produzir o referido polipetídeo fgf-21 e célula compreendendo um polinucleotídeo |
JOP20190083A1 (ar) * | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
EA032727B1 (ru) | 2008-10-10 | 2019-07-31 | Амген Инк. | Мутантный резистентный к протеолизу полипептид fgf21 и его применение |
WO2010065439A1 (en) | 2008-12-05 | 2010-06-10 | Eli Lilly And Company | Variants of fibroblast growth factor 21 |
CN102361647B (zh) | 2009-01-23 | 2018-02-16 | 诺沃-诺迪斯克有限公司 | 具有白蛋白结合剂a‑b‑c‑d‑e‑的fgf21衍生物及其应用 |
CN101520547B (zh) * | 2009-04-17 | 2011-05-18 | 东南大学 | 挠曲柱面反射式聚光镜制造方法 |
US20120052069A1 (en) * | 2009-05-05 | 2012-03-01 | Amgen Inc | Fgf21 mutants and uses thereof |
SG10201402038WA (en) | 2009-05-05 | 2014-07-30 | Amgen Inc | FGF21 Mutants And Uses Thereof |
WO2011154349A2 (en) * | 2010-06-08 | 2011-12-15 | Novo Nordisk A/S | Fgf21 analogues and derivatives |
US20120171125A1 (en) | 2009-08-07 | 2012-07-05 | Ucb Pharma, S.A. | Methods for Enhancing the Cognitive Function |
AR087973A1 (es) * | 2011-10-04 | 2014-04-30 | Lilly Co Eli | Variantes del factor 21 del crecimiento de fibroblastos |
TWI513705B (zh) * | 2012-06-11 | 2015-12-21 | Lilly Co Eli | 纖維母細胞生長因子21蛋白質 |
-
2013
- 2013-06-05 KR KR1020147034365A patent/KR20150006059A/ko active IP Right Grant
- 2013-06-05 CN CN201380030829.XA patent/CN104364261B/zh not_active Expired - Fee Related
- 2013-06-05 AU AU2013274639A patent/AU2013274639A1/en not_active Abandoned
- 2013-06-05 CA CA2871656A patent/CA2871656A1/en not_active Abandoned
- 2013-06-05 EP EP13729210.8A patent/EP2859014B1/en active Active
- 2013-06-05 ES ES13729210.8T patent/ES2632078T3/es active Active
- 2013-06-05 JP JP2015517298A patent/JP6181752B2/ja active Active
- 2013-06-05 EA EA201492064A patent/EA201492064A1/ru unknown
- 2013-06-05 US US14/400,809 patent/US9422353B2/en active Active
- 2013-06-05 WO PCT/US2013/044192 patent/WO2013188182A1/en active Application Filing
- 2013-06-05 MX MX2014015258A patent/MX2014015258A/es unknown
-
2014
- 2014-10-30 ZA ZA2014/07938A patent/ZA201407938B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2013274639A1 (en) | 2014-11-06 |
EP2859014A1 (en) | 2015-04-15 |
US9422353B2 (en) | 2016-08-23 |
WO2013188182A1 (en) | 2013-12-19 |
CN104364261A (zh) | 2015-02-18 |
JP6181752B2 (ja) | 2017-08-16 |
CA2871656A1 (en) | 2013-12-19 |
US20150141327A1 (en) | 2015-05-21 |
CN104364261B (zh) | 2017-04-05 |
ZA201407938B (en) | 2016-08-31 |
ES2632078T3 (es) | 2017-09-08 |
KR20150006059A (ko) | 2015-01-15 |
EP2859014B1 (en) | 2017-04-26 |
MX2014015258A (es) | 2015-03-05 |
JP2015521596A (ja) | 2015-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201492064A1 (ru) | Варианты фактора роста фибробластов 21 | |
EA201492053A1 (ru) | Белки фактора роста фибробластов 21 | |
EA201490521A1 (ru) | Варианты фактора роста фибробластов 21 | |
UA114710C2 (uk) | Похідне оксинтомодуліну та фармацевтична композиція для запобігання або лікування ожиріння, яка його містить | |
EA201290964A1 (ru) | Пептидные конъюгаты агонистов рецептора glp-1 и их применение | |
EA201590525A1 (ru) | Слитые белки для лечения метаболического синдрома | |
EA201391236A1 (ru) | Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов | |
EA201400772A1 (ru) | Варианты полипептидов ph20, композиции на их основе и их применение | |
UY33739A (es) | Metodos de tratamiento de trastornos asociados con el fgf21 | |
MY161088A (en) | Agonists of gpr40 | |
EA201390409A1 (ru) | Составы с низкой дозой панкрелипазы и кишечно-растворимым покрытием | |
EA201692007A1 (ru) | Соединения изоиндолинона в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных с ними нарушений | |
EA201300471A1 (ru) | Замещенные 6-аминоникотинамиды в качестве модуляторов kcnq2/3 | |
EA201491856A1 (ru) | Терапевтическое применение белков фактора роста фибробластов 21 | |
EA201200570A1 (ru) | Соединения и композиции в качестве модуляторов активности gpr119 | |
EA201490688A1 (ru) | 2-тиопиримидиноны | |
EA201590562A1 (ru) | Бензамиды | |
EA201692008A1 (ru) | Замещенные сконденсированные гетероциклы в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных нарушений | |
EA201201623A1 (ru) | Лечение диабета 2 типа | |
CY1116158T1 (el) | Υποκατεστημενα 2-οξο- και 2-θειοξο-διυδροκινολινο-3-καρβοξαμιδια σαν διαμορφωτες kcnq2/3 | |
EA201591123A1 (ru) | Комбинации агониста glp1r и метформина, а также способ их применения при лечении диабета 2 типа и прочих расстройств | |
EA201290485A1 (ru) | Производные бензамида | |
UA112981C2 (uk) | Варіант людського gdnf | |
EA201270547A1 (ru) | Фармацевтическая композиция | |
EA201500446A1 (ru) | Фармацевтическая композиция для снижения уровня n-оксида триметиламина |