IL86724A - Methods and kits for amplification and testing of nucleic acid sequences - Google Patents

Methods and kits for amplification and testing of nucleic acid sequences

Info

Publication number
IL86724A
IL86724A IL8672488A IL8672488A IL86724A IL 86724 A IL86724 A IL 86724A IL 8672488 A IL8672488 A IL 8672488A IL 8672488 A IL8672488 A IL 8672488A IL 86724 A IL86724 A IL 86724A
Authority
IL
Israel
Prior art keywords
subsegment
sequence
primer
dna
segment
Prior art date
Application number
IL8672488A
Other languages
English (en)
Hebrew (he)
Other versions
IL86724A0 (en
Original Assignee
Siska Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26744190&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL86724(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Siska Diagnostics Inc filed Critical Siska Diagnostics Inc
Publication of IL86724A0 publication Critical patent/IL86724A0/xx
Publication of IL86724A publication Critical patent/IL86724A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6867—Replicase-based amplification, e.g. using Q-beta replicase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
IL8672488A 1987-06-19 1988-06-13 Methods and kits for amplification and testing of nucleic acid sequences IL86724A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6414187A 1987-06-19 1987-06-19
US20297888A 1988-06-06 1988-06-06

Publications (2)

Publication Number Publication Date
IL86724A0 IL86724A0 (en) 1988-11-30
IL86724A true IL86724A (en) 1995-01-24

Family

ID=26744190

Family Applications (1)

Application Number Title Priority Date Filing Date
IL8672488A IL86724A (en) 1987-06-19 1988-06-13 Methods and kits for amplification and testing of nucleic acid sequences

Country Status (17)

Country Link
EP (2) EP0368906B2 (da)
JP (1) JP2843586B2 (da)
KR (1) KR960014107B1 (da)
AT (2) ATE196657T1 (da)
BR (1) BR8807097A (da)
DE (2) DE3856428T2 (da)
DK (1) DK175614B1 (da)
ES (1) ES2009286A6 (da)
FI (1) FI93743C (da)
GR (1) GR880100396A (da)
HU (1) HU216317B (da)
IE (1) IE65089B1 (da)
IL (1) IL86724A (da)
NO (1) NO303068B1 (da)
NZ (1) NZ225077A (da)
PT (1) PT87769B (da)
WO (1) WO1988010315A1 (da)

Families Citing this family (419)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356774A (en) * 1986-04-16 1994-10-18 The Trustees Of Columbia University In The City Of New York Replicative RNA-based amplification/detection systems
CA1340843C (en) * 1987-07-31 1999-12-07 J. Lawrence Burg Selective amplification of target polynucleotide sequences
WO1989006700A1 (en) * 1988-01-21 1989-07-27 Genentech, Inc. Amplification and detection of nucleic acid sequences
WO1989007149A1 (en) * 1988-01-28 1989-08-10 Mayo Foundation For Medical Education And Research Genomic amplification with direct sequencing
CA1340807C (en) * 1988-02-24 1999-11-02 Lawrence T. Malek Nucleic acid amplification process
US5130238A (en) * 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
WO1990002819A1 (en) * 1988-09-08 1990-03-22 The Salk Institute For Biological Studies Replicative rna-based amplification detection systems
CA1339991C (en) * 1988-09-08 1998-08-11 The Trustees Of Columbia University Replicative rna-based amplification/detection system
WO1990006376A1 (en) * 1988-12-05 1990-06-14 The Salk Institute For Biological Studies Target nucleic acid amplification/detection systems
AU4829690A (en) 1988-12-16 1990-07-10 Siska Diagnostics, Inc. Self-sustained, sequence replication system
US5237016A (en) * 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
EP0458909A1 (en) * 1989-02-14 1991-12-04 Biogen, Inc. Oligonucleotide primer pairs for sequence independent gene amplification and methods which employ them
IE66597B1 (en) * 1989-05-10 1996-01-24 Akzo Nv Method for the synthesis of ribonucleic acid (RNA)
US5112734A (en) * 1989-05-26 1992-05-12 Gene-Trak Systems Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
US5683896A (en) 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
CA2020958C (en) * 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US7009041B1 (en) 1989-07-11 2006-03-07 Gen-Probe Incorporated Oligonucleotides for nucleic acid amplification and for the detection of Mycobacterium tuberculosis
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
US5766849A (en) * 1989-07-11 1998-06-16 Gen-Probe Incorporated Methods of amplifying nucleic acids using promoter-containing primer sequence
EP0731174B1 (en) * 1989-07-11 2004-11-17 Gen-Probe Incorporated Nucleic acid sequence amplification methods
US5219727A (en) * 1989-08-21 1993-06-15 Hoffmann-Laroche Inc. Quantitation of nucleic acids using the polymerase chain reaction
DE3929030A1 (de) * 1989-09-01 1991-03-07 Boehringer Mannheim Gmbh Verfahren zur vermehrung von nukleinsaeuren
US5545522A (en) * 1989-09-22 1996-08-13 Van Gelder; Russell N. Process for amplifying a target polynucleotide sequence using a single primer-promoter complex
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US5215899A (en) * 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
US7585512B1 (en) 1990-05-08 2009-09-08 Thomas Jefferson University Composition and method of using tumor cells
US5194370A (en) * 1990-05-16 1993-03-16 Life Technologies, Inc. Promoter ligation activated transcription amplification of nucleic acid sequences
US5645994A (en) * 1990-07-05 1997-07-08 University Of Utah Research Foundation Method and compositions for identification of species in a sample using type II topoisomerase sequences
JPH04141098A (ja) * 1990-09-29 1992-05-14 Shimadzu Corp Ｒｎａ検出用試薬及びそれを用いたｒｎａの検出方法
EP0557456A4 (en) * 1990-11-14 1995-11-15 Siska Diagnostics Inc Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
AU9165091A (en) 1990-12-31 1992-08-17 Promega Corporation Nucleic acid amplification with dna-dependent rna polymerase activity of rna replicases
US5518900A (en) * 1993-01-15 1996-05-21 Molecular Tool, Inc. Method for generating single-stranded DNA molecules
WO1992020820A1 (en) * 1991-05-15 1992-11-26 Vanderbilt University Method to determine metastatic potential of tumor cells
US5169766A (en) * 1991-06-14 1992-12-08 Life Technologies, Inc. Amplification of nucleic acid molecules
ES2092056T3 (es) * 1991-09-23 1996-11-16 Pfizer Procedimiento para detectar arnm y adn especificos en celulas.
DE4132133A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen herstellung von ribonukleinsaeuren
DE4213029A1 (de) * 1991-09-26 1993-04-01 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleins aeuresequenzen
US5981179A (en) * 1991-11-14 1999-11-09 Digene Diagnostics, Inc. Continuous amplification reaction
WO1993022461A1 (en) * 1992-05-06 1993-11-11 Gen-Probe Incorporated Nucleic acid sequence amplification method, composition and kit
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US5834202A (en) * 1992-08-04 1998-11-10 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
KR100316498B1 (ko) * 1992-08-04 2002-06-20 다니엘 엘. 캐시앙, 헨리 엘. 노르호프, 피터 알. 쉬어리 핵산서열증폭방법
US5614389A (en) * 1992-08-04 1997-03-25 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US5733733A (en) * 1992-08-04 1998-03-31 Replicon, Inc. Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
CA2159103C (en) 1993-03-26 2002-03-12 Sherrol H. Mcdonough Detection of human immunodeficiency virus type 1
AU689789B2 (en) * 1993-07-23 1998-04-09 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
DE69431240T2 (de) * 1993-12-01 2003-04-17 Toyo Boseki Verfahren zur ampflifizierung und zum nachweis bestimmter nukleinsäuresequenzen mittels thermostabiler enzyme
FR2714062B1 (fr) * 1993-12-22 1996-02-16 Bio Merieux Promoteur modifié pour ARN polymérase, sa préparation et ses applications.
KR100230718B1 (ko) 1994-03-16 1999-11-15 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 등온 가닥 변위 핵산 증폭법
US5863724A (en) * 1994-04-13 1999-01-26 Baylor College Of Medicine Methods of screening for persistent hyperinsulinemic hypoglycemia of infancy
FR2724934B1 (fr) * 1994-09-26 1997-01-24 Bio Merieux Oligonucleotide chimere et son utilisation dans l'obtention de transcrits d'un acide nucleique
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
FR2726277B1 (fr) 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
US5606043A (en) * 1994-11-03 1997-02-25 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5789169A (en) * 1994-11-03 1998-08-04 Regents Of The University Of California Methods for the diagnosis of glaucoma
US5849879A (en) * 1994-11-03 1998-12-15 The Regents Of The University Of California Methods for the diagnosis of glaucoma
US5654141A (en) * 1994-11-18 1997-08-05 Thomas Jefferson University Amplification based detection of bacterial infection
US6001610A (en) * 1994-11-23 1999-12-14 Roche Diagnostics, Gmbh Method for the particularly sensitive detection of nucleic acids
DE4441626A1 (de) * 1994-11-23 1996-05-30 Boehringer Mannheim Gmbh Verfahren zum besonders sensitiven Nachweis von Nukleinsäuren
US5739311A (en) * 1995-06-07 1998-04-14 Gen-Probe Incorporated Enzymatic synthesis of phosphorothioate oligonucleotides using restriction endonucleases
US5652126A (en) * 1995-06-07 1997-07-29 Gen-Probe Incorporated Use of restriction endonuclease sequences for cleaving phosphorothioate oligonucleotides
US5916777A (en) * 1995-06-07 1999-06-29 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using 3'-ribonucleotide primers
US5932450A (en) * 1995-06-07 1999-08-03 Gen-Probe Incorporated Enzymatic synthesis of oligonucleotides using digestible templates
WO1997044488A2 (en) 1996-05-22 1997-11-27 Gen-Probe Incorporated Compositions and methods for the detection of mycobacterium kansasii
US5914229A (en) * 1996-06-14 1999-06-22 Sarnoff Corporation Method for amplifying a polynucleotide
JPH1028585A (ja) * 1996-07-16 1998-02-03 Toyobo Co Ltd 耐熱性リボヌクレアーゼｈを用いる核酸増幅法
US6132954A (en) * 1996-08-20 2000-10-17 Baylor College Of Medicine Methods of screening for agents that delay a cell cycle and compositions comprising era and an analogue of wild-type era
US6071493A (en) * 1996-09-20 2000-06-06 Baylor College Of Medicine Method of screening for an agent that inhibits mononuclear phagocyte-plaque component complex formation
US6043283A (en) * 1996-09-20 2000-03-28 Baylor College Of Medicine Tyramine compounds and their neuronal effects
US6379929B1 (en) 1996-11-20 2002-04-30 The Regents Of The University Of Michigan Chip-based isothermal amplification devices and methods
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
JP3968810B2 (ja) * 1997-01-24 2007-08-29 東ソー株式会社 核酸配列分析方法
US6475724B1 (en) 1997-01-28 2002-11-05 The Regents Of The University Of California Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6171788B1 (en) 1997-01-28 2001-01-09 The Regents Of The University Of California Methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US7138511B1 (en) 1997-01-28 2006-11-21 The Regents Of The University Of California Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders
US6262242B1 (en) 1997-01-30 2001-07-17 Board Of Regents, The University Of Texas System Tumor suppressor designated TS10Q23.3
US6482795B1 (en) 1997-01-30 2002-11-19 Myriad Genetics, Inc. Tumor suppressor designated TS10q23.3
GB9703146D0 (en) 1997-02-14 1997-04-02 Innes John Centre Innov Ltd Methods and means for gene silencing in transgenic plants
US6713300B1 (en) 1997-02-27 2004-03-30 University Of Utah Research Foundation Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter
ATE364718T1 (de) 1997-04-01 2007-07-15 Solexa Ltd Verfahren zur vervielfältigung von nukleinsäure
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
DE69836012T2 (de) 1997-05-02 2007-04-05 Gen-Probe Inc., San Diego Zwei-schritt hybridisierung und einfang von einem polynukleotid
JP3689333B2 (ja) 1997-08-08 2005-08-31 アクゾ・ノベル・エヌ・ベー Ｈｉｖ−１の全てのサブタイプを増幅及び検出するためにプライマー及びプローブとして使用できる核酸配列
ATE335822T1 (de) 1997-12-18 2006-09-15 Monsanto Technology Llc Insekten-resistante transgene pflanzen und verfahren zur verbesserung von der aktivität von delta-endotoxine gegen insekte
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
EP1049806B1 (en) * 1998-01-27 2002-07-10 Cytocell Limited Method for detection of nucleic acid target sequences involving in vitro transcription from an rna promoter
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
WO1999057561A2 (en) 1998-05-01 1999-11-11 Gen-Probe Incorporated Automated diagnostic analyzer and method
DE19834948A1 (de) * 1998-08-03 2000-02-17 Monika Jecht Verfahren zur spezifischen Detektion von RNA
US6207379B1 (en) 1998-09-11 2001-03-27 One Lambda Method for amplification of DNA
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
CN1230444C (zh) 1998-11-16 2005-12-07 德克萨斯州立大学董事会 含有hiv细胞毒t淋巴细胞表位的hiv多肽或肽或其多聚核苷酸表达构建体的用途
US6156515A (en) 1999-02-09 2000-12-05 Urocor, Inc. Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
AU4807400A (en) 1999-04-30 2000-11-17 University Of Florida Adeno-associated virus-delivered ribozyme compositions and methods of use
CA2375106C (en) 1999-06-01 2014-08-19 Huda Y. Zoghbi Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
CA2377707A1 (en) 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
DK1218542T3 (da) 1999-09-13 2004-08-02 Nugen Technologies Inc Fremgangsmåder og sammensætninger til lineær isotermisk amplifikation af polynukleotidsekvenser
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
US20040002068A1 (en) 2000-03-01 2004-01-01 Corixa Corporation Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
US20030175700A1 (en) 2000-04-21 2003-09-18 Ajay Bhatia Compounds and methods for treatment and diagnosis of chlamydial infection
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
CN1498274A (zh) 2000-06-26 2004-05-19 Ŧب������˾ 基于转录的核酸扩增方法和组合物
ATE396265T1 (de) 2000-06-28 2008-06-15 Corixa Corp Zusammensetzungen und verfahren für therapie und diagnose von lungenkrebs
ATE414794T1 (de) 2000-09-01 2008-12-15 Gen Probe Inc Amplifizierung von hiv-1 sequenzen zur detektion von sequenzen, die mit wirkstoff-resistenz mutationen einhergehen
AU2002230545B2 (en) 2000-10-23 2006-09-21 Gen-Probe Incorporated Compositions and methods for detecting human immunodeficiency virus 2 (HIV-2)
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
JP2005503755A (ja) 2000-12-13 2005-02-10 ニューゲン テクノロジーズ， インコーポレイテッド 核酸配列の複数コピーを作製するための方法および組成物、ならびにそれらを検出する方法
KR20030088035A (ko) * 2001-03-07 2003-11-15 바이오메리욱스 비.브이. 전사 기초한 증폭을 이용하는 ｄｎａ의 증폭 및 검출 방법
AU2002252279B2 (en) 2001-03-09 2005-05-12 Nugen Technologies, Inc. Methods and compositions for amplification of RNA sequences
WO2002089747A2 (en) 2001-05-09 2002-11-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
EP1399541A4 (en) 2001-05-22 2005-04-13 Univ Chicago RNA POLYMERASE DEPENDENT ON SINGLE VIBRATION N4 DNA
EP1908851A3 (en) 2001-09-19 2008-06-25 Intergenetics Incorporated Genetic analysis for stratification of cancer risk
EP2135960A1 (en) 2001-09-19 2009-12-23 Intergenetics Incorporated Genetic analysis for stratification of cancer risk by determining the allelic profile of the VDR-ApaI and CYP11B2 genes
JP2005504281A (ja) 2001-09-24 2005-02-10 ワン ラムダ 診断用プローブ検出システム
US20030165859A1 (en) 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
DK1581119T3 (da) 2001-12-17 2013-05-13 Corixa Corp Sammensætninger og fremgangsmåder til terapi og diagnose af inflammatoriske tarmsygdomme
DE60337040D1 (de) 2002-02-01 2011-06-16 Life Technologies Corp Oligonukleotid-Zusammensetzungen mit verbesserter Wirksamkeit
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
CN1653338A (zh) 2002-05-17 2005-08-10 贝克顿·迪金森公司 用于分离、放大和检测目标核酸序列的自动化系统
ES2370169T3 (es) 2002-06-14 2011-12-13 Gen-Probe Incorporated Composiciones y métodos para detectar el virus de la hepatitis b.
US7504215B2 (en) 2002-07-12 2009-03-17 Affymetrix, Inc. Nucleic acid labeling methods
AU2003304195B8 (en) 2002-07-15 2008-08-28 Board Of Regents, The University Of Texas System Combinatorial protein library screening by periplasmic expression
WO2004014314A2 (en) 2002-08-12 2004-02-19 David Kirn Methods and compositions concerning poxviruses and cancer
AU2002951411A0 (en) 2002-09-16 2002-09-26 The University Of Sydney Genotype screen
US7115374B2 (en) 2002-10-16 2006-10-03 Gen-Probe Incorporated Compositions and methods for detecting West Nile virus
US7074561B2 (en) 2002-10-22 2006-07-11 Biomerieux, Inc. Isothermal amplification based assay for the detection and quantitation of alpha-fetoprotein mRNA
RU2544850C2 (ru) 2003-01-06 2015-03-20 Корикса Корпорейшн Некоторые аминоалкилглюкозаминидфосфатные производные и их применение
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
US6852494B2 (en) 2003-01-10 2005-02-08 Linden Technologies, Inc. Nucleic acid amplification
JP2007525151A (ja) 2003-01-29 2007-09-06 ４５４ コーポレーション 一本鎖ｄｎａライブラリーの調製方法
WO2004081225A2 (en) 2003-03-07 2004-09-23 Rubicon Genomics, Inc. Amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization process
EP2390352A1 (en) 2003-03-18 2011-11-30 Quantum Genetics Ireland Limited Systems and methods for improving protein and milk production of dairy herds
WO2004092418A2 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
CA3084542A1 (en) 2003-06-10 2005-01-06 The Trustees Of Boston University Gene expression analysis of airway epithelial cells for diagnosing lung cancer
JP4871722B2 (ja) 2003-07-25 2012-02-08 アプライド バイオシステムズ リミテッド ライアビリティー カンパニー 固定試料からｒｎａを調製するための方法および組成物
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
JP2007511738A (ja) 2003-08-08 2007-05-10 ジーンニュース インコーポレーテッド 変形性関節症のバイオマーカー及びその使用
CA2538222A1 (en) 2003-09-12 2005-03-24 Stephen Bryant Liggett Methods for risk assessment, survival prediction and treatment of heart failure and other conditions based on adrenergic receptor polymorphisms
US8173785B2 (en) 2003-11-26 2012-05-08 Advandx, Inc. Peptide nucleic acid probes for analysis of certain Staphylococcus species
CA2547750C (en) 2003-12-19 2014-04-08 Gen-Probe Incorporated Compositions, methods and kits for detecting the nucleic acids of hiv-1 and hiv-2
CA2497324A1 (en) 2004-02-17 2005-08-17 Affymetrix, Inc. Methods for fragmenting and labelling dna
AU2005244673B2 (en) 2004-02-19 2009-12-10 The Governors Of The University Of Alberta Leptin promoter polymorphisms and uses thereof
EP1598428A1 (en) 2004-05-18 2005-11-23 Georg Dewald Methods and kits to detect Hereditary angioedema type III
CN101133157A (zh) 2004-06-03 2008-02-27 阿什洛米克斯控股有限公司 诊断应激的药物和方法
EP2412830B1 (en) 2004-07-13 2014-11-19 Gen-Probe Incorporated Compositions and methods for detection of Hepatitis A virus nucleic acid
EP1970454B1 (en) 2004-08-27 2012-09-19 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
US7713697B2 (en) 2004-08-27 2010-05-11 Gen-Probe Incorporated Methods and kits for amplifying DNA
EP1630236A3 (de) 2004-08-30 2006-05-03 FBF- Förderverein Biologieforschung der Deutschen Schweineproduktion e.V. Hernia inguinalis/scrotalis assozieerte Genomregionen
ATE469245T1 (de) 2004-09-14 2010-06-15 Univ Colorado Auf genetischem targeting basierendes verfahren zur behandlung mit bucindolol
EP1647600A3 (en) 2004-09-17 2006-06-28 Affymetrix, Inc. (A US Entity) Methods for identifying biological samples by addition of nucleic acid bar-code tags
AU2005291899A1 (en) 2004-09-30 2006-04-13 Gen-Probe Incorporated Assay for detecting and quantifying HIV-1
US20060073511A1 (en) 2004-10-05 2006-04-06 Affymetrix, Inc. Methods for amplifying and analyzing nucleic acids
JP2006126204A (ja) 2004-10-29 2006-05-18 Affymetrix Inc ポリマーアレイを製造するための自動化方法
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
CA2587670A1 (en) 2004-11-01 2006-05-11 George Mason University Compositions and methods for diagnosing colon disorders
AU2005333163B2 (en) 2004-11-09 2011-06-16 Gen-Probe Incorporated Compositions and methods for detecting Group A streptococci
JP4874999B2 (ja) 2005-02-07 2012-02-15 ジェン−プローブ・インコーポレーテッド Ｂ群連鎖球菌属を検出するための組成物及び方法
JP5265923B2 (ja) 2005-02-07 2013-08-14 ジーンニュース インコーポレーテッド 軽度の変形性関節症のバイオマーカーおよびその使用
DE602006019203D1 (de) 2005-02-18 2011-02-10 Gen Probe Inc Probenherstellungsverfahren mit einem alkali-stoss
EP1874955A4 (en) 2005-02-28 2009-05-06 Bioquest Inc METHODS FOR EXECUTING DIRECT ENZYMATIC REACTIONS USING NUCLEIC ACID MOLECULES
WO2006095981A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
WO2006095941A1 (en) 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
EP1712557A1 (en) 2005-04-14 2006-10-18 RWTH Aachen New s-adenosyl-L-methionine analogues with extended activated groups for transfer by methyltransferases
EP3211093A1 (en) 2005-04-14 2017-08-30 The Trustees of Boston University Diagnostic for lung disorders using class prediction
WO2006121773A2 (en) 2005-05-06 2006-11-16 Gen-Probe Incorporated Compositions and assays to detect influenza virus a and b nucleic acids
CN101175852B (zh) 2005-05-13 2013-02-13 和光纯药工业株式会社 堪萨斯分枝杆菌检测用的引物和探针、以及使用它们检测堪萨斯分枝杆菌的方法
WO2006122354A1 (en) 2005-05-17 2006-11-23 Ozgene Pty Ltd Sequential cloning system
US20090264305A1 (en) 2005-07-07 2009-10-22 Athlomics Pty Ltd. Polynucleotide Marker Genes and their Expression, for Diagnosis of Endotoxemia
US7494788B2 (en) 2005-07-11 2009-02-24 Molecular Kinetics, Inc. Entropic bristle domain sequences and their use in recombinant protein production
US7838646B2 (en) 2005-08-18 2010-11-23 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
WO2007030759A2 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
EP1937847A2 (en) 2005-10-17 2008-07-02 Gen-Probe Incorporated Compositions and methods to detect legionella pneumophila nucleic acid
EP2319941A3 (en) 2005-10-21 2011-08-17 GeneNews Inc. Method and apparatus for correlating levels of biomarker products with disease
US7989395B2 (en) 2005-10-28 2011-08-02 Glaxosmithkline Llc Methods for identifying compounds of interest using encoded libraries
EP1785434A1 (en) 2005-11-11 2007-05-16 Ludwig-Maximilians-Universität München Targeting and tracing of antigens in living cells
ATE504044T1 (de) 2005-11-14 2011-04-15 Gen Probe Inc Parametrisches kalibrationsverfahren
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
CA2645310A1 (en) 2006-03-09 2007-09-13 The Trustees Of Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
WO2007105673A1 (ja) 2006-03-13 2007-09-20 Wako Pure Chemical Industries, Ltd. 変異遺伝子の検出方法
EP2007905B1 (en) 2006-03-15 2012-08-22 Micronics, Inc. Integrated nucleic acid assays
EP2011871A4 (en) 2006-05-02 2010-01-27 Wako Pure Chem Ind Ltd PRIMER AND PROBE FOR THE DETECTION OF MYCOBACTERIUM INTRACELLULARE AND METHOD FOR THE DETECTION OF MYCOBACTERIUM INTRACELLULARE USING THE PRIMER AND THE PROBE
AU2007249286B2 (en) 2006-05-12 2013-06-13 Gen-Probe Incorporated Compositions and methods to detect enterococci nucleic acid
AR061180A1 (es) 2006-05-25 2008-08-13 Monsanto Technology Llc Metodo para identificar loci de caracteristicas cuantitativas de resistencia a enfermedades en soja y composiciones de los mismos
CA2654266A1 (en) 2006-06-12 2007-12-27 Oncomethylome Sciences S.A. Methylation markers for early detection and prognosis of colon cancers
CA2660286A1 (en) 2006-08-09 2008-02-21 Homestead Clinical Corporation Organ-specific proteins and methods of their use
CA2921048C (en) 2006-09-15 2018-06-05 Ottawa Hospital Research Institute Oncolytic rhabdovirus
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
US8026065B2 (en) 2006-11-02 2011-09-27 Yale University Assessment of oocyte competence
US8293684B2 (en) 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
ATE555128T1 (de) 2006-11-30 2012-05-15 Res Dev Foundation Verbesserte immunglobulin-bibliotheken
JPWO2008075520A1 (ja) 2006-12-18 2010-04-08 和光純薬工業株式会社 マイコバクテリウム・アビウム検出用プライマー及びプローブ、並びにこれを用いたマイコバクテリウム・アビウムの検出方法
JP2010514692A (ja) 2006-12-20 2010-05-06 バイエル ヘルスケア リミティド ライアビリティ カンパニー 癌の治療に有用なヒドロキシメチルフェニルピラゾリル尿素化合物
US8198027B2 (en) * 2006-12-21 2012-06-12 Gen-Probe Incorporated Methods and compositions for nucleic acid amplification
US7794937B2 (en) 2006-12-22 2010-09-14 Quest Diagnostics Investments Incorporated Cystic fibrosis transmembrane conductance regulator gene mutations
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
WO2008093098A2 (en) 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
US8183359B2 (en) 2007-03-01 2012-05-22 Gen-Probe Incorporated Kits for amplifying DNA
EP2623605B1 (en) 2007-04-09 2018-11-28 University of Florida Research Foundation, Inc. RAAV vector compositions having tyrosine-modified capsid proteins and methods for use
AU2008239594B2 (en) 2007-04-13 2013-10-24 Beth Israel Deaconess Medical Center Methods for treating cancer resistant to ErbB therapeutics
EP2155789B1 (en) 2007-05-01 2013-07-24 Research Development Foundation Immunoglobulin fc libraries
WO2009085704A2 (en) 2007-12-26 2009-07-09 Gen-Probe Incorporated Compositions and methods to detect candida albicans nucleic acid
EP2251422B1 (en) 2008-02-08 2013-04-10 Wako Pure Chemical Industries, Ltd. Primer and probe for detecting chlamydophilia caviae, as well as chlamydophilia caviae detection method using the same
US8034568B2 (en) 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
EP2677041A3 (en) 2008-02-19 2014-04-09 MDxHealth SA Detection and prognosis of lung cancer
US7846666B2 (en) 2008-03-21 2010-12-07 Nugen Technologies, Inc. Methods of RNA amplification in the presence of DNA
WO2009115615A2 (en) 2008-03-21 2009-09-24 Oncomethylome Sciences S.A. Detection and prognosis of cervical cancer
EP2281070B1 (en) 2008-04-21 2015-01-21 Gen-Probe Incorporated Method for detecting chikungunya virus
CN102046788B (zh) 2008-05-28 2013-07-10 和光纯药工业株式会社 胞内分枝杆菌检测用引物和探针、以及使用该引物和探针检测胞内分枝杆菌的方法
EP2151502A1 (en) 2008-07-30 2010-02-10 Lohmann Tierzucht GmbH Genetic variations associated with feather pecking behaviour in avians
CA2679750A1 (en) 2008-09-23 2010-03-23 Nexus Dx, Inc. Methods for detecting nucleic acids in a sample
US8728764B2 (en) 2008-10-02 2014-05-20 Illumina Cambridge Limited Nucleic acid sample enrichment for sequencing applications
EP2210944A1 (en) 2009-01-22 2010-07-28 ATG:biosynthetics GmbH Methods for generation of RNA and (poly)peptide libraries and their use
EP3301446B1 (en) 2009-02-11 2020-04-15 Caris MPI, Inc. Molecular profiling of tumors
US8921039B2 (en) 2009-02-26 2014-12-30 Gen-Probe Incorporated Assay for detection of human parvovirus nucleic acid
JP5642769B2 (ja) 2009-04-22 2014-12-17 インディアナ ユニバーシティ リサーチ アンド テクノロジー コーポレイション 慢性閉塞性肺疾患及び喘息を治療するための組成物及び方法
WO2010126913A1 (en) 2009-04-27 2010-11-04 Gen-Probe Incorporated Methods and kits for use in the selective amplification of target sequences
EP3450573B1 (en) 2009-06-23 2022-01-26 Gen-Probe Incorporated Compositions and methods for detecting nucleic acid from mollicutes
JP5785942B2 (ja) 2009-06-29 2015-09-30 ルミネックス コーポレーション ヘアピンコンフォメーションを有するキメラプライマーおよびその使用法
CA2766391C (en) 2009-07-01 2021-04-20 Gen-Probe Incorporated Methods and compositions for multiplex nucleic acid amplification
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
US10174368B2 (en) 2009-09-10 2019-01-08 Centrillion Technology Holdings Corporation Methods and systems for sequencing long nucleic acids
US10072287B2 (en) 2009-09-10 2018-09-11 Centrillion Technology Holdings Corporation Methods of targeted sequencing
WO2011032088A1 (en) 2009-09-11 2011-03-17 Arca Biopharma, Inc. Polymorphisms in the pde3a gene
EP2477499B1 (en) 2009-09-14 2018-04-11 SillaJen Biotherapeutics, Inc. Oncolytic vaccinia virus combination cancer therapy
US8182994B2 (en) 2009-09-15 2012-05-22 Illumina Cambridge Limited Centroid markers for image analysis of high denisty clusters in complex polynucleotide sequencing
WO2011036173A1 (en) 2009-09-24 2011-03-31 Oncomethylome Sciences S.A. Detection and prognosis of cervical cancer
WO2011056688A2 (en) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Molecular profiling for personalized medicine
KR20110050327A (ko) 2009-11-07 2011-05-13 주식회사 씨젠 Ｔｈｄ 프라이머 타겟 검출
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
WO2011070440A2 (en) 2009-12-10 2011-06-16 Ottawa Hospital Research Institute Oncolytic rhabdovirus
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
WO2011078441A1 (en) 2009-12-21 2011-06-30 Seegene, Inc. Tsg primer target detection
EP2515899B1 (en) 2009-12-23 2016-05-25 ARCA biopharma, Inc. Methods and compositions for cardiovascular diseases and conditions
EP2529026B1 (en) 2010-01-25 2013-11-13 Rd Biosciences Inc. Self-folding amplification of target nucleic acid
KR101851117B1 (ko) 2010-01-29 2018-04-23 마이크로닉스 인코포레이티드. 샘플-투-앤서 마이크로유체 카트리지
EP3604558B1 (en) 2010-02-17 2022-10-12 Gen-Probe Incorporated Compositions and methods to detect atopobium vaginae nucleic acid
CN102918155B (zh) 2010-03-23 2015-12-16 和光纯药工业株式会社 沙眼衣原体检测用引物和探针、以及使用该引物和探针的沙眼衣原体的检测方法
DK2558577T3 (da) 2010-04-16 2019-04-01 Nuevolution As Bi-funktionelle komplekser og fremgangsmåder til fremstilling og anvendelse af sådanne komplekser
WO2011130728A1 (en) 2010-04-17 2011-10-20 Bayer Healthcare Llc Synthetic metabolites of fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention diseases and conditions
CA3074551C (en) 2010-04-21 2021-05-04 Gen-Probe Incorporated Compositions, methods and kits to detect herpes simplex virus nucleic acids
JP5454338B2 (ja) 2010-04-28 2014-03-26 株式会社島津製作所 液滴操作によるリアルタイム核酸増幅法
KR101223660B1 (ko) 2010-05-20 2013-01-17 광주과학기술원 ＨＩＦ－２α 억제제를 유효성분으로 포함하는 관절염 예방 또는 치료용 약제학적 조성물
KR101176139B1 (ko) 2010-05-20 2012-08-22 광주과학기술원 관절염 동물모델로서 연골 특이적 ＨＩＦ?２α 형질전환 마우스 및 이의 용도
US9234249B2 (en) 2010-07-12 2016-01-12 Gen-Probe Incorporated Compositions and assays to detect swine H1N1 influenza A virus, seasonal H1 influenza A virus and seasonal H3 influenza A virus nucleic acids
JP2013535193A (ja) 2010-07-23 2013-09-12 ベックマン コールター， インコーポレイテッド 分析装置を含むシステムおよび方法
WO2012030856A2 (en) 2010-08-30 2012-03-08 Gen-Probe Incorporated Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
JP5904501B2 (ja) 2010-09-02 2016-04-13 国立研究開発法人理化学研究所 ２型糖尿病の検出方法
WO2012046219A2 (en) 2010-10-04 2012-04-12 Gen-Probe Prodesse, Inc. Compositions, methods and kits to detect adenovirus nucleic acids
WO2012054639A2 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CN103269787B9 (zh) 2010-12-21 2016-07-20 株式会社岛津制作所 用于在管内操作对象成分的器件和方法
WO2012090073A2 (en) 2010-12-30 2012-07-05 The Netherlands Cancer Institute Methods and compositions for predicting chemotherapy sensitivity
WO2012094386A1 (en) 2011-01-04 2012-07-12 Jennerex Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
US8952132B2 (en) 2011-02-07 2015-02-10 Research Development Foundation Engineered immunoglobulin FC polypeptides
EP2673380B1 (en) 2011-02-09 2018-12-12 Bio-Rad Laboratories, Inc. Analysis of nucleic acids
ES2590263T3 (es) 2011-02-24 2016-11-21 Hill's Pet Nutrition, Inc. Composiciones y métodos para el diagnóstico de trastornos renales en un felino
US20140057295A1 (en) 2011-02-28 2014-02-27 Barbara J. Stegmann Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
WO2012120377A2 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
WO2012122571A1 (en) 2011-03-10 2012-09-13 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
US20120252682A1 (en) 2011-04-01 2012-10-04 Maples Corporate Services Limited Methods and systems for sequencing nucleic acids
US20140296248A1 (en) 2011-04-04 2014-10-02 Stichting het Nederlands Kanker Instiuut-Antoni van Leeuwenhoek ziekenhuis Methods and compositions for predicting resistance to anticancer treatment
AU2012240246A1 (en) 2011-04-04 2013-05-09 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
KR101291668B1 (ko) 2011-04-21 2013-08-01 서울대학교산학협력단 미코박테리아―대장균용 셔틀 벡터 및 이의 용도
EP3604559A1 (en) 2011-04-25 2020-02-05 Gen-Probe Incorporated Compositions and methods for detecting bv-associated bacterial nucleic acid
AP2013007180A0 (en) 2011-04-25 2013-10-31 Advanced Bioscience Lab Inc Truncated HIV envelope proteins (ENV), methods andcompositions related thereto
CA2872045A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
RU2593952C2 (ru) 2011-06-15 2016-08-10 Хилл'С Пет Ньютришн, Инк. Композиции и способы для диагностики и мониторинга гипертиреоза у животных семейства кошачьих
WO2012177595A1 (en) 2011-06-21 2012-12-27 Oncofactor Corporation Compositions and methods for the therapy and diagnosis of cancer
EP2723865B1 (en) 2011-06-21 2019-03-27 Alnylam Pharmaceuticals, Inc. METHODS FOR DETERMINING ACTIVITY OF RNAi IN A SUBJECT
WO2013012708A1 (en) 2011-07-15 2013-01-24 Gen-Probe Incorporated Compositions and method for detecting human parvovirus nucleic acid and for detecting hepatitis a virus nucleic acids in single-plex or multiplex assays
WO2013024173A1 (en) 2011-08-17 2013-02-21 Technische Universität München Computer implemented method for identifying regulatory regions or regulatory variations
AU2012304327B2 (en) 2011-09-08 2015-07-09 Gen-Probe Incorporated Compositions and methods for detecting BV-associated bacterial nucleic acid
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
FR2981088B1 (fr) 2011-10-06 2013-11-29 Biomerieux Sa Arn polymerases mutees
WO2013064163A1 (en) 2011-11-01 2013-05-10 Academisch Medisch Centrum Methylation markers for colorectal cancer
KR20140092378A (ko) 2011-11-07 2014-07-23 베크만 컬터, 인코포레이티드 샘플을 처리하기 위한 시스템 및 방법
JP6190380B2 (ja) 2011-11-07 2017-08-30 ベックマン コールター， インコーポレイテッド 等分機システムおよびワークフロー
EP2776847A1 (en) 2011-11-07 2014-09-17 Beckman Coulter, Inc. Magnetic damping for specimen transport system
EP2776844B1 (en) 2011-11-07 2020-09-30 Beckman Coulter, Inc. Specimen container detection
KR102040996B1 (ko) 2011-11-07 2019-11-05 베크만 컬터, 인코포레이티드 로봇식 아암
EP2776843B1 (en) 2011-11-07 2019-03-27 Beckman Coulter, Inc. Centrifuge system and workflow
RU2622082C2 (ru) 2011-11-14 2017-06-09 Нестек С.А. Анализы и способы выбора режима лечения пациента с депрессией
DE102011120550B4 (de) 2011-12-05 2013-11-07 Gen-Probe Prodesse, Inc. Zusammensetzungen, Verfahren und Kits zur Detektion von Adenovirusnukleinsäuren
CN104039823A (zh) 2011-12-19 2014-09-10 希尔氏宠物营养品公司 用于诊断和治疗伴侣动物的甲状腺机能亢进的组合物和方法
WO2013093629A2 (en) 2011-12-20 2013-06-27 Netherlands Cancer Institute Modular vaccines, methods and compositions related thereto
JP5807542B2 (ja) 2011-12-22 2015-11-10 株式会社島津製作所 対象成分を操作するためのチップデバイス及びそれを用いた方法
ES2645418T3 (es) 2011-12-22 2017-12-05 Ibis Biosciences, Inc. Amplificación de una secuencia de un ácido ribonucleico
WO2013116698A2 (en) 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
EP2817416B1 (en) 2012-02-24 2018-10-31 Gen-Probe Prodesse Inc. Detection of shiga toxin genes in bacteria
GB2513024B (en) 2012-02-27 2016-08-31 Cellular Res Inc A clonal amplification method
ES2776673T3 (es) 2012-02-27 2020-07-31 Univ North Carolina Chapel Hill Métodos y usos para etiquetas moleculares
US9879314B2 (en) 2012-02-29 2018-01-30 Riken Method for detecting HLA-A*31:01 allele
EP3095879B1 (en) 2012-04-19 2018-09-19 Life Technologies Corporation Nucleic acid amplification
CN116064734A (zh) 2012-04-19 2023-05-05 生命技术公司 核酸扩增
AU2013205110B2 (en) 2012-04-24 2016-10-13 Gen-Probe Incorporated Compositions, Methods and Kits to Detect Herpes Simplex Virus Nucleic Acids
AU2013205064B2 (en) 2012-06-04 2015-07-30 Gen-Probe Incorporated Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid
AU2013205087B2 (en) 2012-07-13 2016-03-03 Gen-Probe Incorporated Method for detecting a minority genotype
EP2877952B1 (en) 2012-07-27 2023-04-12 Gen-Probe Incorporated Dual reference calibration method and system for quantifying polynucleotides
AU2013202808B2 (en) 2012-07-31 2014-11-13 Gen-Probe Incorporated System and method for performing multiplex thermal melt analysis
US9139870B2 (en) 2012-08-30 2015-09-22 Gen-Probe Incorporated Multiphase nucleic acid amplification
EP2895620B1 (en) 2012-09-11 2017-08-02 Life Technologies Corporation Nucleic acid amplification
WO2014043143A1 (en) 2012-09-11 2014-03-20 Life Technologies Corporation Nucleic acid amplification
WO2014055746A1 (en) 2012-10-04 2014-04-10 The Board Of Trustees Of The Leland Stanford Junior University Methods and reagents for detection, quantitation, and serotyping of dengue viruses
AU2013205122B2 (en) 2012-10-11 2016-11-10 Gen-Probe Incorporated Compositions and Methods for Detecting Human Papillomavirus Nucleic Acid
ES2730690T3 (es) 2012-12-07 2019-11-12 Suppremol Gmbh Estratificación y tratamiento de pacientes que padecen púrpura trombocitopénica idiopática
AU2013205090B2 (en) 2012-12-07 2016-07-28 Gen-Probe Incorporated Compositions and Methods for Detecting Gastrointestinal Pathogen Nucleic Acid
JP2016509206A (ja) 2012-12-21 2016-03-24 マイクロニクス， インコーポレイテッド 携帯型蛍光検出システムおよびマイクロアッセイカートリッジ
EP2935908B1 (en) 2012-12-21 2019-08-14 PerkinElmer Health Sciences, Inc. Fluidic circuits and related manufacturing methods
US10518262B2 (en) 2012-12-21 2019-12-31 Perkinelmer Health Sciences, Inc. Low elasticity films for microfluidic use
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
US20140213471A1 (en) 2013-01-24 2014-07-31 California Institute Of Technology Chromophore-based characterization and detection methods
US10077475B2 (en) 2013-01-24 2018-09-18 California Institute Of Technology FRET-based analytes detection and related methods and systems
RU2019107976A (ru) 2013-02-21 2019-08-23 Тёрнстоун Лимитед Партнершип Композиция вакцины
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
CN105264090B (zh) 2013-03-15 2020-04-07 简·探针公司 校准方法、设备和计算机程序产品
US9255265B2 (en) 2013-03-15 2016-02-09 Illumina, Inc. Methods for producing stranded cDNA libraries
KR101403507B1 (ko) 2013-03-21 2014-06-09 주식회사 현일바이오 결핵균 및 비결핵 마이코박테리아의 선택적 검출 방법, 그리고 이를 이용한 키트
US9340817B2 (en) 2013-03-27 2016-05-17 Sample6 Technologies, Inc. Methods of making recombinant phage, compositions and articles of manufacture of same for bacterial detection
KR101507505B1 (ko) 2013-04-18 2015-04-07 사회복지법인 삼성생명공익재단 제 1 형 근긴장성 이영양증의 진단 방법
US10190153B2 (en) 2013-05-07 2019-01-29 Micronics, Inc. Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions
EP2994750B1 (en) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
JP6484222B2 (ja) 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド 核酸の調製および分析のためのデバイス
US20160186263A1 (en) 2013-05-09 2016-06-30 Trustees Of Boston University Using plexin-a4 as a biomarker and therapeutic target for alzheimer's disease
WO2014205221A2 (en) 2013-06-19 2014-12-24 Sample6 Technologies, Inc. Phage-based bacterial detection assay
US9547006B2 (en) 2013-08-08 2017-01-17 Institut Pasteur Correlation of disease activity with clonal expansions of human papillomavirus 16-specific CD8+ T-cells in patients with severe erosive oral lichen planus
EP4299767A3 (en) 2013-08-14 2024-03-27 Gen-Probe Incorporated Compositions and methods for detecting hev nucleic acid
GB2546833B (en) 2013-08-28 2018-04-18 Cellular Res Inc Microwell for single cell analysis comprising single cell and single bead oligonucleotide capture labels
EP3052193B1 (en) 2013-10-03 2018-01-31 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
BR112016011046A2 (pt) 2013-11-15 2019-01-29 Centre Nat Rech Scient método para genotipagem, método para a detecção de uma infecção, kit para detectar uma infecção e método para detectar em uma amostra biológica.
EP3102691B1 (en) 2014-02-03 2019-09-11 Thermo Fisher Scientific Baltics UAB Method for controlled dna fragmentation
CN106795473A (zh) 2014-06-11 2017-05-31 精密公司 用于核酸分析的具有集成的测定对照的微流体盒及设备
GB201415349D0 (en) 2014-08-29 2014-10-15 Univ Leuven Kath Cofactor analogues for methyltransferases
WO2016086227A2 (en) 2014-11-26 2016-06-02 The Regents Of The University Of California Therapeutic compositions comprising transcription factors and methods of making and using the same
WO2016094425A1 (en) 2014-12-08 2016-06-16 Berg Llc Use of markers including filamin a in the diagnosis and treatment of prostate cancer
EP3736346B1 (en) 2015-01-09 2023-12-20 Gen-Probe Incorporated Methods and compositions for diagnosing bacterial vaginosis
KR101718800B1 (ko) 2015-01-21 2017-03-24 주식회사 디알나노 약물 및 ｓｉＲＮＡ의 공동―운반용 나노복합체 및 이의 용도
US10457737B2 (en) 2015-02-09 2019-10-29 Research Development Foundation Engineered immunoglobulin Fc polypeptides displaying improved complement activation
EP3064592A1 (en) 2015-03-06 2016-09-07 Brigitte König Methods for the qualitative and quantitative detection of microbes in a sample
JP6796593B2 (ja) 2015-03-16 2020-12-09 ジェン−プローブ・インコーポレーテッド 細菌核酸を検出し細菌性膣炎を診断するための方法および組成物
JP6698708B2 (ja) 2015-06-09 2020-05-27 ライフ テクノロジーズ コーポレーション 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体
JP2018527947A (ja) 2015-07-17 2018-09-27 プレジデント アンド フェローズ オブ ハーバード カレッジ 核酸配列増幅方法
WO2017040380A2 (en) 2015-08-28 2017-03-09 Research Development Foundation Engineered antibody fc variants
RU2706203C1 (ru) 2015-10-18 2019-11-14 Эффиметрикс, Инк. Мультиаллельное генотипирование однонуклеотидных полиморфизмов и индел-мутаций
KR101651817B1 (ko) 2015-10-28 2016-08-29 대한민국 Ngs 라이브러리 제작용 프라이머 세트 및 이를 이용한 ngs 라이브러리 제작방법 및 키트
EP3387147A1 (en) 2015-12-09 2018-10-17 Life Technologies Corporation Detection and quantification of nucleic acid molecules associated with a surface
EP4249610A3 (en) 2016-01-04 2023-12-20 Gen-Probe Incorporated Methods and compositions for detecting candida species
EP3402880B1 (en) 2016-01-15 2024-01-03 Thermo Fisher Scientific Baltics UAB Thermophilic dna polymerase mutants
EP3405559B1 (en) 2016-01-21 2021-11-17 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
KR101845957B1 (ko) 2016-02-23 2018-04-05 전남대학교기술지주회사(주) 프로히비틴 유전자 타깃 백혈병 진단용 키트 및 이를 이용한 진단 방법
US20210002715A1 (en) 2016-04-14 2021-01-07 T2 Biosystems, Inc. Methods and systems for amplification in complex samples
US20200185063A1 (en) 2016-06-05 2020-06-11 Berg Llc Systems and methods for patient stratification and identification of potential biomarkers
EP3469103B1 (en) 2016-06-10 2021-10-06 Gen-Probe Incorporated Compositions and methods for detecting zika virus nucleic acid
ES2919927T3 (es) 2016-08-10 2022-07-29 Pasteur Institut Métodos y reactivos para la detección del paludismo por Plasmodium falciparum resistente a la piperaquina
WO2018071522A1 (en) 2016-10-11 2018-04-19 Life Technologies Corporation Rapid amplification of nucleic acids
WO2018075633A2 (en) 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
WO2018094171A1 (en) 2016-11-21 2018-05-24 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis b virus
KR102651626B1 (ko) 2016-12-29 2024-03-26 주식회사 씨젠 프라이머 다이머 형성을 감소시키고 증폭 효율을 증가시키는 방법
KR101936799B1 (ko) 2017-01-09 2019-01-11 주식회사 엠이티라이프사이언스 구강전암의 치료용 약학 조성물 및 구강전암 또는 구강암의 예측 또는 진단 방법
US20190390278A1 (en) 2017-01-26 2019-12-26 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
WO2018146162A1 (en) 2017-02-07 2018-08-16 Academisch Medisch Centrum Molecular biomarker for prognosis of sepsis patients
EP3601617B3 (en) 2017-03-24 2024-03-20 Gen-Probe Incorporated Compositions and methods for detecting or quantifying parainfluenza virus
EP4219771A3 (en) 2017-03-24 2023-08-16 Gen-Probe Incorporated Compositions and methods for multiplex detection of viral pathogens in samples
EP3631008A1 (en) 2017-06-02 2020-04-08 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
US11441174B2 (en) 2017-06-02 2022-09-13 Affymetrix, Inc. Array-based methods for analysing mixed samples using differently labelled allele-specific probes
EP4276201A3 (en) 2017-06-07 2024-01-17 Gen-Probe Incorporated Detecting babesia species nucleic acid in a sample
GB2578038B (en) 2017-06-16 2022-11-23 Life Technologies Corp Control nucleic acids, and compositions, kits, and uses thereof
US11618891B2 (en) 2017-06-26 2023-04-04 Thermo Fisher Scientific Baltics Uab Thermophilic DNA polymerase mutants
WO2019014239A1 (en) 2017-07-10 2019-01-17 Gen-Probe Incorporated ANALYTICAL SYSTEMS AND METHODS FOR AMPLIFICATION OF NUCLEIC ACIDS USING SAMPLE ASSIGNMENT PARAMETERS
WO2019017680A2 (ko) 2017-07-19 2019-01-24 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miRNA 및 이를 이용한 진단키트
KR101956315B1 (ko) 2017-07-19 2019-03-08 국민대학교 산학협력단 파킨슨병 바이오마커로서의 miR494 및 이를 이용한 진단키트
EP4219766A3 (en) 2017-08-11 2023-10-11 Gen-Probe Incorporated Compositions and methods for detecting staphylococcus aureus
WO2019094578A1 (en) 2017-11-09 2019-05-16 Alnylam Pharmaceuticals Inc. Assays and methods for determining expression of the lect2 gene
EP3710595A1 (en) 2017-11-17 2020-09-23 Gen-Probe Incorporated Compositions and methods for detecting c1orf43 nucleic acid
CN111902213B (zh) 2018-01-29 2022-12-06 简·探针公司 分析系统和方法
GB2597567B (en) 2018-06-13 2022-11-23 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
EP3820616A1 (en) 2018-07-10 2021-05-19 Gen-Probe Incorporated Methods and systems for detecting and quantifying nucleic acids
EP3830302B1 (en) 2018-08-01 2022-10-05 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
CN109306376B (zh) * 2018-08-03 2022-06-24 国家卫生计生委科学技术研究所 检验核酸扩增均一性的质量控制标准品及其制备方法
CA3108105A1 (en) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
AU2019326462A1 (en) 2018-08-21 2021-03-25 Gen-Probe Incorporated Compositions and methods for amplifying, detecting or quantifying human cytomegalovirus
WO2020041671A1 (en) 2018-08-24 2020-02-27 Gen-Probe Incorporated Compositions and methods for detecting bacterial nucleic acid and diagnosing bacterial vaginosis
WO2020053808A1 (en) 2018-09-12 2020-03-19 Georg Dewald Method of diagnosing vasoregulatory disorders
CA3112651A1 (en) 2018-09-27 2020-04-02 Gen-Probe Incorporated Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
JP2022508954A (ja) 2018-10-22 2022-01-19 ジェン－プローブ・インコーポレーテッド ヒトポリオーマウイルスｂｋウイルスを増幅、検出または定量化するための組成物および方法
WO2020089841A1 (en) 2018-10-31 2020-05-07 Garcia Joe G N Biomarkers and methods of use for radiation-induced lung injury
MX2021006234A (es) 2018-11-30 2021-09-10 Caris Mpi Inc Perfilado molecular de proxima generacion.
TW202030333A (zh) 2018-12-20 2020-08-16 美商簡 探針公司 用於檢測瘧原蟲物種核酸之組成物及方法
WO2020142347A2 (en) 2018-12-31 2020-07-09 Gen-Probe Incorporated Systems and methods for filling multi-well cartridges with solid reagents
WO2020212580A1 (en) 2019-04-17 2020-10-22 Igenomix, S.L. Improved methods for the early diagnosis of uterine leiomyomas and leiomyosarcomas
CN114127312A (zh) 2019-04-30 2022-03-01 拉利玛生物医药公司 用于测定共济蛋白替代疗法的疗效的共济蛋白敏感性标志物
CA3176703A1 (en) 2019-05-03 2020-11-12 Gen-Probe Incorporated Receptacle transport system for an analytical system
AU2020291343A1 (en) 2019-06-14 2021-12-02 Seegene, Inc. Computer-implemented method for collaborative development of reagents for detection of target nucleic acids
CN114096683A (zh) 2019-07-03 2022-02-25 简·探针公司 用于确定样品中阴道毛滴虫的存在的寡核苷酸
CA3152309A1 (en) 2019-08-23 2021-03-04 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
JP2022553489A (ja) 2019-09-05 2022-12-23 ジェン－プローブ・インコーポレーテッド Ｃｈｌａｍｙｄｉａ ｔｒａｃｈｏｍａｔｉｓ変異体の核酸の検出
AU2020397802A1 (en) 2019-12-02 2022-06-16 Caris Mpi, Inc. Pan-cancer platinum response predictor
US20230067123A1 (en) 2019-12-09 2023-03-02 Gen-Probe Incorporated Quantification of polynucleotide analytes from dried samples
JP2023516683A (ja) 2020-03-04 2023-04-20 ジェン－プローブ・インコーポレーテッド ＳＡＲＳ－ＣｏＶ－２核酸を検出するための組成物および方法
US20230220499A1 (en) 2020-05-07 2023-07-13 Grifols Diagnostic Solutions Inc. Methods and compositions for detecting sars-cov-2 nucleic acid
EP4163397A1 (en) 2020-06-05 2023-04-12 Seegene, Inc. Specimen transport kit for detecting respiratory pathogens and methods for detecting respiratory pathogens using same
EP4172370A1 (en) 2020-06-30 2023-05-03 Lunglife Ai, Inc. Methods for detecting lung cancer
WO2022047359A1 (en) 2020-08-31 2022-03-03 Berg Llc Protein biomarkers for pancreatic cancer
CN116323440A (zh) 2020-10-21 2023-06-23 简·探针公司 流体容器管理系统
EP4320443A1 (en) 2021-04-06 2024-02-14 BPGbio, Inc. Protein markers for the prognosis of breast cancer progression
IL307531A (en) 2021-04-06 2023-12-01 Bpgbio Inc Protein markers for estrogen receptor (ER)-like and estrogen receptor (ER)-negative breast cancer
IL307530A (en) 2021-04-06 2023-12-01 Bpgbio Inc Estrogen receptor-like (ER) breast cancer protein markers LUMINAL A (LA) and LUMINAL B1 (LB1)
WO2023003402A1 (ko) 2021-07-21 2023-01-26 주식회사 씨젠 조립형 분석 시스템, 방법 및 컴퓨터 판독가능한 기록 매체
WO2023010008A1 (en) 2021-07-27 2023-02-02 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2023196937A1 (en) 2022-04-06 2023-10-12 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring frataxin replacement therapy
EP4282980A1 (en) 2022-05-23 2023-11-29 Mobidiag Oy Methods for amplifying a nucleic acid
WO2023230531A1 (en) 2022-05-24 2023-11-30 Lunglife Ai, Inc. Methods for detecting circulating genetically abnormal cells
WO2023240201A1 (en) 2022-06-08 2023-12-14 Larimar Therapeutics, Inc. Frataxin-sensitive markers for monitoring progression and treatment of leigh syndrome
US20240010742A1 (en) 2022-06-10 2024-01-11 Research Development Foundation Engineered fcriib selective igg1 fc variants and uses thereof
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0128042A3 (en) 1983-06-06 1985-01-16 Genentech, Inc. A process for indentifying or isolating a dna sequence, and a dna hybridization probe therefor
CA1288073C (en) 1985-03-07 1991-08-27 Paul G. Ahlquist Rna transformation vector
ES8706823A1 (es) * 1985-03-28 1987-06-16 Cetus Corp Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
AU606043B2 (en) * 1985-03-28 1991-01-31 F. Hoffmann-La Roche Ag Detection of viruses by amplification and hybridization
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
CA1339653C (en) * 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
FI76119C (fi) 1986-02-27 1988-09-09 Orion Yhtymae Oy Kvantitativ bestaemning av nukleinsyramolekyler och reagensfoerpackning som anvaends vid foerfarandet.

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