IL194576A - Modulators of caste transporters atp - Google Patents

Modulators of caste transporters atp

Info

Publication number
IL194576A
IL194576A IL194576A IL19457608A IL194576A IL 194576 A IL194576 A IL 194576A IL 194576 A IL194576 A IL 194576A IL 19457608 A IL19457608 A IL 19457608A IL 194576 A IL194576 A IL 194576A
Authority
IL
Israel
Prior art keywords
cassete
transporters
atp
modulators
binding
Prior art date
Application number
IL194576A
Other languages
English (en)
Hebrew (he)
Other versions
IL194576A0 (en
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of IL194576A0 publication Critical patent/IL194576A0/en
Publication of IL194576A publication Critical patent/IL194576A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
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IL194576A 2006-04-07 2008-10-06 Modulators of caste transporters atp IL194576A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79045906P 2006-04-07 2006-04-07
PCT/US2007/008975 WO2007117715A2 (en) 2006-04-07 2007-04-09 Modulators of atp-binding cassette transporters

Publications (2)

Publication Number Publication Date
IL194576A0 IL194576A0 (en) 2009-08-03
IL194576A true IL194576A (en) 2016-12-29

Family

ID=38477342

Family Applications (1)

Application Number Title Priority Date Filing Date
IL194576A IL194576A (en) 2006-04-07 2008-10-06 Modulators of caste transporters atp

Country Status (22)

Country Link
US (9) US7776905B2 (OSRAM)
EP (5) EP3327016B1 (OSRAM)
JP (3) JP5420395B2 (OSRAM)
CN (2) CN103254177A (OSRAM)
AU (1) AU2007235260B2 (OSRAM)
BR (1) BRPI0710965B8 (OSRAM)
CA (2) CA2648719C (OSRAM)
CY (3) CY1116979T1 (OSRAM)
DK (3) DK2007756T3 (OSRAM)
ES (4) ES2580803T3 (OSRAM)
HU (4) HUE026145T2 (OSRAM)
IL (1) IL194576A (OSRAM)
IN (1) IN2014KN02423A (OSRAM)
LT (1) LT3091011T (OSRAM)
MX (1) MX2008012945A (OSRAM)
NZ (3) NZ571803A (OSRAM)
PL (4) PL2674428T3 (OSRAM)
PT (3) PT2007756E (OSRAM)
RU (1) RU2451018C2 (OSRAM)
SI (4) SI2674428T1 (OSRAM)
WO (1) WO2007117715A2 (OSRAM)
ZA (1) ZA200809290B (OSRAM)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060088537A (ko) 2003-09-06 2006-08-04 버텍스 파마슈티칼스 인코포레이티드 Ａｔｐ-결합 카세트 수송체의 조절자
WO2005049018A1 (en) * 2003-11-14 2005-06-02 Vertex Pharmaceuticals Incorporated Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
AU2005210474B2 (en) * 2004-01-30 2011-07-07 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding cassette transporters
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ES2882684T3 (es) 2021-12-02
BRPI0710965A2 (pt) 2012-01-31
DK3091011T3 (en) 2018-02-26
US20240092766A1 (en) 2024-03-21
CA2869945A1 (en) 2007-10-18
EP3327016A1 (en) 2018-05-30
MX2008012945A (es) 2009-01-15
WO2007117715A2 (en) 2007-10-18
SI3091011T1 (en) 2018-06-29
PT2674428T (pt) 2016-07-14
EP3091011A1 (en) 2016-11-09
JP2014031384A (ja) 2014-02-20
PL3327016T3 (pl) 2021-10-04
CA2869945C (en) 2018-01-23
CY1117731T1 (el) 2017-05-17
US20220411410A1 (en) 2022-12-29
CY1116979T1 (el) 2017-04-05
SI2007756T1 (sl) 2015-11-30
DK2674428T3 (en) 2016-04-18
HUE036165T2 (hu) 2018-06-28
US20180162842A1 (en) 2018-06-14
US10975061B2 (en) 2021-04-13
BRPI0710965B8 (pt) 2021-05-25
JP5827297B2 (ja) 2015-12-02
CA2648719C (en) 2015-02-24
US20150119441A1 (en) 2015-04-30
NZ611485A (en) 2014-09-26
EP2674428B1 (en) 2016-04-06
ZA200809290B (en) 2009-10-28
NZ596889A (en) 2013-06-28
US20160332997A1 (en) 2016-11-17
US8912199B2 (en) 2014-12-16
AU2007235260B2 (en) 2013-05-30
PL2674428T3 (pl) 2017-01-31
PL2007756T3 (pl) 2016-01-29
WO2007117715A3 (en) 2008-01-10
US7776905B2 (en) 2010-08-17
BRPI0710965B1 (pt) 2020-08-18
ES2554353T3 (es) 2015-12-18
HUE055205T2 (hu) 2021-11-29
RU2008144124A (ru) 2010-05-20
IL194576A0 (en) 2009-08-03
PT3091011T (pt) 2018-03-07
JP2015120762A (ja) 2015-07-02
JP5420395B2 (ja) 2014-02-19
IN2014KN02423A (OSRAM) 2015-05-01
SI3327016T1 (sl) 2021-09-30
NZ571803A (en) 2011-12-22
US10239867B2 (en) 2019-03-26
EP2674428A1 (en) 2013-12-18
CY1120045T1 (el) 2018-12-12
ES2659364T3 (es) 2018-03-15
EP2007756A2 (en) 2008-12-31
US9758510B2 (en) 2017-09-12
US8598181B2 (en) 2013-12-03
SI2674428T1 (sl) 2016-07-29
US20070244159A1 (en) 2007-10-18
EP3882245A1 (en) 2021-09-22
AU2007235260A1 (en) 2007-10-18
EP3327016B1 (en) 2021-06-16
CN103254177A (zh) 2013-08-21
HUE026145T2 (en) 2016-05-30
US11639347B2 (en) 2023-05-02
JP2009533351A (ja) 2009-09-17
RU2451018C2 (ru) 2012-05-20
CN101460489A (zh) 2009-06-17

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