AP2005003292A0 - Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof - Google Patents
Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereofInfo
- Publication number
- AP2005003292A0 AP2005003292A0 AP2005003292A AP2005003292A AP2005003292A0 AP 2005003292 A0 AP2005003292 A0 AP 2005003292A0 AP 2005003292 A AP2005003292 A AP 2005003292A AP 2005003292 A AP2005003292 A AP 2005003292A AP 2005003292 A0 AP2005003292 A0 AP 2005003292A0
- Authority
- AP
- ARIPO
- Prior art keywords
- cystic fibrosis
- protein inhibitors
- fibrosis transmembrane
- conductance regulator
- transmembrane conductance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/262,573 US20040063695A1 (en) | 2002-09-30 | 2002-09-30 | Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof |
US48025303P | 2003-06-20 | 2003-06-20 | |
PCT/US2003/031005 WO2004028480A2 (en) | 2002-09-30 | 2003-09-30 | Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AP2005003292A0 true AP2005003292A0 (en) | 2005-06-30 |
Family
ID=32044981
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2005003292A AP2005003292A0 (en) | 2002-09-30 | 2003-09-30 | Cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1549321A4 (en) |
JP (1) | JP4977319B2 (en) |
KR (1) | KR20050061501A (en) |
CN (1) | CN100356922C (en) |
AP (1) | AP2005003292A0 (en) |
AU (1) | AU2003277162C1 (en) |
BR (1) | BR0314943A (en) |
CA (1) | CA2500498C (en) |
EA (1) | EA009847B1 (en) |
MX (1) | MXPA05003366A (en) |
NZ (1) | NZ538809A (en) |
PL (1) | PL376147A1 (en) |
WO (1) | WO2004028480A2 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
HUE027630T2 (en) | 2006-04-07 | 2016-10-28 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
EP2142498A2 (en) | 2007-04-02 | 2010-01-13 | Institute for Oneworld Health | Cftr inhibitor compounds and uses thereof |
NZ583420A (en) * | 2007-08-24 | 2012-06-29 | Vertex Pharma | Isothiazolopyridinones useful for the treatment of (inter alia) cystic fibrosis |
JP5646338B2 (en) | 2007-11-16 | 2014-12-24 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Isoquinoline regulator of ATP binding cassette transporter |
LT3170818T (en) | 2007-12-07 | 2020-05-25 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
JP2011517674A (en) * | 2008-03-25 | 2011-06-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Water-soluble small molecule inhibitor of cystic fibrosis membrane conductance regulator |
CN103951614A (en) | 2008-03-31 | 2014-07-30 | 沃泰克斯药物股份有限公司 | Pyridyl derivatives as CFTR modulators |
WO2009131957A2 (en) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
US8236838B2 (en) | 2008-04-21 | 2012-08-07 | Institute For Oneworld Health | Compounds, compositions and methods comprising isoxazole derivatives |
EP2341776A4 (en) * | 2008-09-19 | 2012-05-30 | Inst Oneworld Health | Compounds, compositions and methods comprising imidazole and triazole derivatives |
US8343976B2 (en) | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
US20120219543A1 (en) * | 2009-10-20 | 2012-08-30 | Raphael Scharfmann | Methods and pharmaceutical compositions for the treatment of disorders of glucose homeostasis |
CA2794559C (en) | 2010-03-25 | 2019-07-23 | Vertex Pharmaceuticals Incorporated | Solid forms of (r)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
AU2011237494C1 (en) | 2010-04-07 | 2016-05-26 | Vertex Pharmaceuticals Incorporated | Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid |
NZ708598A (en) | 2010-04-07 | 2017-05-26 | Vertex Pharma | Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d](1,3)dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof |
CA3108488A1 (en) | 2010-04-22 | 2011-10-27 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
US8563593B2 (en) | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
AU2011293658B2 (en) | 2010-08-23 | 2015-03-05 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxy propyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof |
CN102133402B (en) * | 2011-03-24 | 2013-06-12 | 首都医科大学附属北京同仁医院 | Application of cystic fibrosis transmembrane transduction regulating factor inhibitor to preparation of medicaments for treating diabetes |
JP6014816B2 (en) | 2011-05-10 | 2016-10-26 | 国立大学法人神戸大学 | Thioxothiazolidine derivative having Ras function inhibitory action |
RU2640420C2 (en) | 2011-11-08 | 2018-01-09 | Вертекс Фармасьютикалз Инкорпорейтед | Modulators of atp-binding cartridge transporters |
JP2015504920A (en) | 2012-01-25 | 2015-02-16 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Formulation of 3- (6- (1- (2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl) benzoic acid |
EP2872122A1 (en) | 2012-07-16 | 2015-05-20 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof |
MX368353B (en) | 2012-11-02 | 2019-09-30 | Vertex Pharma | Pharmaceutical compositions for the treatment of cftr mediated diseases. |
FR2999191B1 (en) | 2012-12-12 | 2016-02-05 | Lesaffre & Cie | PROBIOTIC STRAINS FOR THE TREATMENT AND / OR PREVENTION OF DIARRHEA |
IL266286B2 (en) | 2014-04-15 | 2023-11-01 | Vertex Pharma | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases |
RU2020134082A (en) | 2014-10-06 | 2020-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | MODULATORS OF THE TRANSMEMBRANE CONDUCTIVITY REGULATOR IN FLUISCIDOSIS |
CN104398509B (en) * | 2014-11-13 | 2017-01-11 | 四川大学华西第二医院 | Application of CFTR (cystic fibrosis transmembrane conductance regulator) inhibitor CFTRinh-172 in preparation of drug for prevention and treatment of leukemia cell mediated diseases |
CN104788423B (en) * | 2015-03-13 | 2016-10-26 | 成都理工大学 | A kind of new cystic fibrosis transmembrane conductance regulator inhibitor |
PL3394083T3 (en) * | 2015-12-24 | 2022-01-17 | The Regents Of The University Of California | N-[5-[(3,4-dimethoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]-2-methoxy-benzeneacetamide derivatives and related compounds as cftr activators for treating constipation or cholestasis |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA9010041B (en) * | 1989-12-21 | 1992-08-26 | Lilly Co Eli | Compounds for treating inflammatory bowel disease |
AU1090795A (en) * | 1993-11-12 | 1995-05-29 | Cell Therapeutics, Inc. | Method for preventing tissue injury from hypoxia |
US6423708B1 (en) * | 1996-09-30 | 2002-07-23 | Pfizer Inc | Aralkyl and aralkylidene heterocyclic lactams and imides |
UA56185C2 (en) * | 1996-09-30 | 2003-05-15 | Пфайзер Інк. | Aralkyl- and aralkylidene heterocyclic lactams and imids, a pharmaceutical composition and a treatment method |
IL141456A0 (en) * | 1998-08-21 | 2002-03-10 | Viropharma Inc | Rhodanine derivatives and pharmaceutical compositions containing the same |
US6484397B1 (en) * | 2000-07-11 | 2002-11-26 | Corning Incorporated | Method of assembling a catalytic converter for use in an internal combustion engine |
US20020052396A1 (en) * | 2001-04-23 | 2002-05-02 | Bailey Thomas R. | Compounds, compositions and methods for treating or preventing viral infections and associated diseases |
-
2003
- 2003-09-30 EA EA200500583A patent/EA009847B1/en not_active IP Right Cessation
- 2003-09-30 NZ NZ538809A patent/NZ538809A/en not_active IP Right Cessation
- 2003-09-30 WO PCT/US2003/031005 patent/WO2004028480A2/en active Application Filing
- 2003-09-30 CA CA2500498A patent/CA2500498C/en not_active Expired - Fee Related
- 2003-09-30 AP AP2005003292A patent/AP2005003292A0/en unknown
- 2003-09-30 JP JP2004540305A patent/JP4977319B2/en not_active Expired - Fee Related
- 2003-09-30 PL PL03376147A patent/PL376147A1/en not_active Application Discontinuation
- 2003-09-30 AU AU2003277162A patent/AU2003277162C1/en not_active Ceased
- 2003-09-30 MX MXPA05003366A patent/MXPA05003366A/en active IP Right Grant
- 2003-09-30 EP EP03798805A patent/EP1549321A4/en not_active Withdrawn
- 2003-09-30 KR KR1020057005551A patent/KR20050061501A/en active IP Right Grant
- 2003-09-30 CN CNB038233665A patent/CN100356922C/en not_active Expired - Fee Related
- 2003-09-30 BR BR0314943-9A patent/BR0314943A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PL376147A1 (en) | 2005-12-27 |
MXPA05003366A (en) | 2005-10-05 |
JP4977319B2 (en) | 2012-07-18 |
CN1684686A (en) | 2005-10-19 |
NZ538809A (en) | 2008-06-30 |
EA009847B1 (en) | 2008-04-28 |
EA200500583A1 (en) | 2005-12-29 |
JP2006503853A (en) | 2006-02-02 |
CN100356922C (en) | 2007-12-26 |
CA2500498C (en) | 2012-08-21 |
KR20050061501A (en) | 2005-06-22 |
AU2003277162B2 (en) | 2009-07-16 |
BR0314943A (en) | 2005-08-02 |
WO2004028480A2 (en) | 2004-04-08 |
AU2003277162C1 (en) | 2009-12-24 |
AU2003277162A1 (en) | 2004-04-19 |
CA2500498A1 (en) | 2004-04-08 |
EP1549321A4 (en) | 2007-05-23 |
EP1549321A2 (en) | 2005-07-06 |
WO2004028480A3 (en) | 2004-07-01 |
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