PT2217572E - Moduladores de isoquinolina de transportadores de cassete de ligação a atp - Google Patents

Moduladores de isoquinolina de transportadores de cassete de ligação a atp Download PDF

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Publication number
PT2217572E
PT2217572E PT08849242T PT08849242T PT2217572E PT 2217572 E PT2217572 E PT 2217572E PT 08849242 T PT08849242 T PT 08849242T PT 08849242 T PT08849242 T PT 08849242T PT 2217572 E PT2217572 E PT 2217572E
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PT
Portugal
Prior art keywords
isoquinoline
atp
modulators
binding cassette
cassette transporters
Prior art date
Application number
PT08849242T
Other languages
English (en)
Inventor
Mark Miller
Peter D J Grootenhuis
Brian Bear
Jinglan Zhou
Sara Hadida Ruah
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PT2217572E publication Critical patent/PT2217572E/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
PT08849242T 2007-11-16 2008-11-14 Moduladores de isoquinolina de transportadores de cassete de ligação a atp PT2217572E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98855907P 2007-11-16 2007-11-16

Publications (1)

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PT2217572E true PT2217572E (pt) 2014-02-17

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Family Applications (2)

Application Number Title Priority Date Filing Date
PT08849242T PT2217572E (pt) 2007-11-16 2008-11-14 Moduladores de isoquinolina de transportadores de cassete de ligação a atp
PT121813703T PT2578571E (pt) 2007-11-16 2008-11-14 Moduladores de transportadores de atp-binding cassette

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PT121813703T PT2578571E (pt) 2007-11-16 2008-11-14 Moduladores de transportadores de atp-binding cassette

Country Status (17)

Country Link
US (4) US8507524B2 (pt)
EP (3) EP2578571B1 (pt)
JP (3) JP5646338B2 (pt)
CN (2) CN101952254B (pt)
AU (1) AU2008322616B2 (pt)
CA (1) CA2705562C (pt)
CY (1) CY1115318T1 (pt)
DK (2) DK2217572T3 (pt)
ES (3) ES2445447T3 (pt)
HK (3) HK1148006A1 (pt)
HR (2) HRP20140103T1 (pt)
HU (1) HUE026334T2 (pt)
NZ (2) NZ598941A (pt)
PL (2) PL2578571T3 (pt)
PT (2) PT2217572E (pt)
SI (2) SI2578571T1 (pt)
WO (1) WO2009064959A1 (pt)

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CN1925854A (zh) * 2003-11-14 2007-03-07 沃泰克斯药物股份有限公司 可用作atp－结合弹夹转运蛋白调控剂的噻唑和噁唑
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
ES2791303T3 (es) * 2004-01-30 2020-11-03 Vertex Pharma Compuesto intermedio de moduladores de transportadores de casete de unión a ATP
US7495103B2 (en) 2004-06-24 2009-02-24 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
EP1912983B1 (en) 2005-08-11 2011-06-08 Vertex Pharmaceuticals, Inc. Modulators of cystic fibrosis transmembrane conductance regulator
DK2395002T3 (da) 2005-11-08 2014-09-08 Vertex Pharma Farmaceutisk sammensætning indeholdende en heterocyclisk modulator af ATP-bindende kassettetransportører
EP2016065B1 (en) 2005-12-28 2012-09-19 Vertex Pharmaceuticals Incorporated 1-(benzo[d][1,3]dioxol-5-yl)-n-(phenyl)cyclopropane-carboxamide derivatives and related compounds as modulators of atp-binding cassette transporters for the treatment of cystic fibrosis
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
PT1993360T (pt) 2005-12-28 2017-05-25 Vertex Pharma Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
DK2674428T3 (en) * 2006-04-07 2016-04-18 Vertex Pharma Modulators of ATP binding cassette transporters
US8563573B2 (en) * 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US7754739B2 (en) * 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8969386B2 (en) 2007-05-09 2015-03-03 Vertex Pharmaceuticals Incorporated Modulators of CFTR
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JP2015205936A (ja) 2015-11-19
SI2578571T1 (sl) 2016-01-29
PT2578571E (pt) 2015-11-30
US9012473B2 (en) 2015-04-21
EP2578571A1 (en) 2013-04-10
US9522145B2 (en) 2016-12-20
HRP20140103T1 (hr) 2014-05-09
JP5646338B2 (ja) 2014-12-24
CN102743385B (zh) 2014-09-17
AU2008322616A1 (en) 2009-05-22
CY1115318T1 (el) 2017-01-04
EP2578571B1 (en) 2015-09-16
US20090143381A1 (en) 2009-06-04
CN101952254A (zh) 2011-01-19
EP2217572B1 (en) 2013-11-06
JP5885359B2 (ja) 2016-03-15
NZ585980A (en) 2012-04-27
HK1177137A1 (en) 2013-08-16
NZ598941A (en) 2013-06-28
CN101952254B (zh) 2012-09-05
JP2011505338A (ja) 2011-02-24
EP2217572A1 (en) 2010-08-18
ES2556080T3 (es) 2016-01-12
JP2014077021A (ja) 2014-05-01
EP3012250B1 (en) 2017-11-08
HK1148006A1 (en) 2011-08-26
US8507524B2 (en) 2013-08-13
HUE026334T2 (en) 2016-06-28
ES2445447T3 (es) 2014-03-03
US20130296364A1 (en) 2013-11-07
SI2217572T1 (sl) 2014-05-30
WO2009064959A1 (en) 2009-05-22
EP3012250A1 (en) 2016-04-27
DK2217572T3 (da) 2014-02-03
PL2578571T3 (pl) 2016-03-31
CA2705562A1 (en) 2009-05-22
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US20150190390A1 (en) 2015-07-09
DK2578571T3 (en) 2015-10-05

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