IL130622A - Endothelin antagonists: n-[[2'-[[(4,5-dimethyl-3-isoxazolyl) amino] sulfonyl]-4-(2-oxazolyl) [1,1'-biphenyl]-2-yl] methyl]-n-3,3-trimethylbutanamide) and salts thereof and pharmaceutical compositions comprising them - Google Patents

Endothelin antagonists: n-[[2'-[[(4,5-dimethyl-3-isoxazolyl) amino] sulfonyl]-4-(2-oxazolyl) [1,1'-biphenyl]-2-yl] methyl]-n-3,3-trimethylbutanamide) and salts thereof and pharmaceutical compositions comprising them

Info

Publication number
IL130622A
IL130622A IL13062298A IL13062298A IL130622A IL 130622 A IL130622 A IL 130622A IL 13062298 A IL13062298 A IL 13062298A IL 13062298 A IL13062298 A IL 13062298A IL 130622 A IL130622 A IL 130622A
Authority
IL
Israel
Prior art keywords
trimethylbutanamide
isoxazolyl
oxazolyl
sulfonyl
biphenyl
Prior art date
Application number
IL13062298A
Other languages
English (en)
Other versions
IL130622A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to IL14384298A priority Critical patent/IL143842A0/xx
Publication of IL130622A0 publication Critical patent/IL130622A0/xx
Publication of IL130622A publication Critical patent/IL130622A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL13062298A 1997-01-30 1998-01-26 Endothelin antagonists: n-[[2'-[[(4,5-dimethyl-3-isoxazolyl) amino] sulfonyl]-4-(2-oxazolyl) [1,1'-biphenyl]-2-yl] methyl]-n-3,3-trimethylbutanamide) and salts thereof and pharmaceutical compositions comprising them IL130622A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL14384298A IL143842A0 (en) 1997-01-30 1998-01-26 N-(4,5-dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl) [1,1' biphenyl]-2-sulfonamide derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3583297P 1997-01-30 1997-01-30
PCT/US1998/001490 WO1998033780A1 (en) 1997-01-30 1998-01-26 Endothelin antagonists: n-[[2'-[ [(4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4-(2-oxazolyl) [1,1'-biphenyl]-2-yl]methyl] -n,3,3-trimethylbutanamide and n-(4,5-dimethyl-3-isoxazolyl) -2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl) methyl] -4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide and salts thereof

Publications (2)

Publication Number Publication Date
IL130622A0 IL130622A0 (en) 2000-06-01
IL130622A true IL130622A (en) 2003-01-12

Family

ID=21885049

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13062298A IL130622A (en) 1997-01-30 1998-01-26 Endothelin antagonists: n-[[2'-[[(4,5-dimethyl-3-isoxazolyl) amino] sulfonyl]-4-(2-oxazolyl) [1,1'-biphenyl]-2-yl] methyl]-n-3,3-trimethylbutanamide) and salts thereof and pharmaceutical compositions comprising them

Country Status (22)

Country Link
US (1) US6043265A (pt)
EP (1) EP0996618B1 (pt)
JP (1) JP2002513397A (pt)
KR (1) KR20000070584A (pt)
CN (1) CN1117738C (pt)
AR (1) AR015358A1 (pt)
AT (1) ATE254115T1 (pt)
AU (1) AU730111B2 (pt)
BR (1) BR9807098A (pt)
CA (1) CA2279178A1 (pt)
CZ (1) CZ236299A3 (pt)
DE (1) DE69819729T2 (pt)
ES (1) ES2205451T3 (pt)
HU (1) HUP0001310A3 (pt)
IL (1) IL130622A (pt)
NO (1) NO313142B1 (pt)
NZ (1) NZ336380A (pt)
PL (1) PL334773A1 (pt)
RU (1) RU2183632C2 (pt)
TW (1) TW536540B (pt)
WO (1) WO1998033780A1 (pt)
ZA (1) ZA98759B (pt)

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EP0996618B1 (en) 2003-11-12
AU6134998A (en) 1998-08-25
DE69819729T2 (de) 2004-09-23
PL334773A1 (en) 2000-03-13
HUP0001310A2 (hu) 2001-06-28
CN1244862A (zh) 2000-02-16
NO313142B1 (no) 2002-08-19
EP0996618A1 (en) 2000-05-03
EP0996618A4 (en) 2000-05-03
NZ336380A (en) 2001-04-27
CN1117738C (zh) 2003-08-13
BR9807098A (pt) 2000-04-18
IL130622A0 (en) 2000-06-01
NO993691L (no) 1999-07-29
AR015358A1 (es) 2001-05-02
US6043265A (en) 2000-03-28
WO1998033780A1 (en) 1998-08-06
CA2279178A1 (en) 1998-08-06
CZ236299A3 (cs) 1999-11-17
NO993691D0 (no) 1999-07-29
RU2183632C2 (ru) 2002-06-20
TW536540B (en) 2003-06-11
ES2205451T3 (es) 2004-05-01
KR20000070584A (ko) 2000-11-25
DE69819729D1 (de) 2003-12-18
JP2002513397A (ja) 2002-05-08
AU730111B2 (en) 2001-02-22
ATE254115T1 (de) 2003-11-15
ZA98759B (en) 1999-07-29

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