BR9807098A - Antagonistas de endotelina: n[[2'-[[(4,5-dimetil-3-isoxazolil)amino]sulfonil]-4-(2-oxa zolil)[1,1'-bi-fenil]-2-il]-n,3,3-trimetilbutanamida e n-(4,5-dimetil-3-isoxazolil)-2'-[(3,3-dimetil-2-oxo-1-pirro lidinil) metil]-4'-2-oxazolil)[1,1' -bifenil]-2-sulfonamida e sais dos mesmos - Google Patents

Antagonistas de endotelina: n[[2'-[[(4,5-dimetil-3-isoxazolil)amino]sulfonil]-4-(2-oxa zolil)[1,1'-bi-fenil]-2-il]-n,3,3-trimetilbutanamida e n-(4,5-dimetil-3-isoxazolil)-2'-[(3,3-dimetil-2-oxo-1-pirro lidinil) metil]-4'-2-oxazolil)[1,1' -bifenil]-2-sulfonamida e sais dos mesmos

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Publication number
BR9807098A
BR9807098A BR9807098-3A BR9807098A BR9807098A BR 9807098 A BR9807098 A BR 9807098A BR 9807098 A BR9807098 A BR 9807098A BR 9807098 A BR9807098 A BR 9807098A
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BR
Brazil
Prior art keywords
dimethyl
oxazolyl
isoxazolyl
sulfonamide
biphenyl
Prior art date
Application number
BR9807098-3A
Other languages
English (en)
Inventor
Natesan Murugesan
Joel C Barrish
Zhengxiang Gu
Richard A Morrison
Original Assignee
Bristol Myers Squibb Co
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Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BR9807098A publication Critical patent/BR9807098A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

''ANTAGONISTAS DE ENDOTELINA: N-[ [2' - [ [ (4,5-DIMETIL-3-ISOXAZOLIL)AMINO]SULFONIL]-4-(2-OXAZOLIL [1,1'-BI-FENIL]-2-IL]METIL]-N,3,3-TRIMETILBUTANAMIDA E N-(4,5-DIME-TIL-3-ISOXAZOLIL)-2'- [ (3,3-DIMETIL-2-OXO-PIRROLIDINIL) METIL] -4'- (2-OXAZOLIL) [1,1'- BOFENIL -2-SULFONAMIDA E SAIS DOS MESMOS''. Compostos N-[ [ 2'- [ [ (4,5-dimetil-3-isoxazolil)amino]sulfonil] -4- (2-oxazolil) [1,1'-bifenil -2-il]metil] -N,3,3-trimetilbutanamida e N-(4,5-dimetil-3-sioxazolil)-2'- [ (3,30dimetil-2-oxo-1-pirrolidinil)metil-4'- (2-oxazolil) [ 1,1'-bifenil -2-sulfonamida e sais dos mesmos, que são úteis como antagonistas de endotelina.
BR9807098-3A 1997-01-30 1998-01-26 Antagonistas de endotelina: n[[2'-[[(4,5-dimetil-3-isoxazolil)amino]sulfonil]-4-(2-oxa zolil)[1,1'-bi-fenil]-2-il]-n,3,3-trimetilbutanamida e n-(4,5-dimetil-3-isoxazolil)-2'-[(3,3-dimetil-2-oxo-1-pirro lidinil) metil]-4'-2-oxazolil)[1,1' -bifenil]-2-sulfonamida e sais dos mesmos BR9807098A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3583297P 1997-01-30 1997-01-30
PCT/US1998/001490 WO1998033780A1 (en) 1997-01-30 1998-01-26 Endothelin antagonists: n-[[2'-[ [(4,5-dimethyl-3-isoxazolyl) amino]sulfonyl]-4-(2-oxazolyl) [1,1'-biphenyl]-2-yl]methyl] -n,3,3-trimethylbutanamide and n-(4,5-dimethyl-3-isoxazolyl) -2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl) methyl] -4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide and salts thereof

Publications (1)

Publication Number Publication Date
BR9807098A true BR9807098A (pt) 2000-04-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807098-3A BR9807098A (pt) 1997-01-30 1998-01-26 Antagonistas de endotelina: n[[2'-[[(4,5-dimetil-3-isoxazolil)amino]sulfonil]-4-(2-oxa zolil)[1,1'-bi-fenil]-2-il]-n,3,3-trimetilbutanamida e n-(4,5-dimetil-3-isoxazolil)-2'-[(3,3-dimetil-2-oxo-1-pirro lidinil) metil]-4'-2-oxazolil)[1,1' -bifenil]-2-sulfonamida e sais dos mesmos

Country Status (22)

Country Link
US (1) US6043265A (pt)
EP (1) EP0996618B1 (pt)
JP (1) JP2002513397A (pt)
KR (1) KR20000070584A (pt)
CN (1) CN1117738C (pt)
AR (1) AR015358A1 (pt)
AT (1) ATE254115T1 (pt)
AU (1) AU730111B2 (pt)
BR (1) BR9807098A (pt)
CA (1) CA2279178A1 (pt)
CZ (1) CZ236299A3 (pt)
DE (1) DE69819729T2 (pt)
ES (1) ES2205451T3 (pt)
HU (1) HUP0001310A3 (pt)
IL (1) IL130622A (pt)
NO (1) NO313142B1 (pt)
NZ (1) NZ336380A (pt)
PL (1) PL334773A1 (pt)
RU (1) RU2183632C2 (pt)
TW (1) TW536540B (pt)
WO (1) WO1998033780A1 (pt)
ZA (1) ZA98759B (pt)

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JP2002513397A (ja) 2002-05-08
AU6134998A (en) 1998-08-25
US6043265A (en) 2000-03-28
EP0996618A4 (en) 2000-05-03
HUP0001310A3 (en) 2001-07-30
NO993691D0 (no) 1999-07-29
AR015358A1 (es) 2001-05-02
DE69819729T2 (de) 2004-09-23
ZA98759B (en) 1999-07-29
EP0996618B1 (en) 2003-11-12
CN1117738C (zh) 2003-08-13
ES2205451T3 (es) 2004-05-01
CA2279178A1 (en) 1998-08-06
CZ236299A3 (cs) 1999-11-17
ATE254115T1 (de) 2003-11-15
EP0996618A1 (en) 2000-05-03
CN1244862A (zh) 2000-02-16
NO313142B1 (no) 2002-08-19
WO1998033780A1 (en) 1998-08-06
IL130622A0 (en) 2000-06-01
NO993691L (no) 1999-07-29
DE69819729D1 (de) 2003-12-18
HUP0001310A2 (hu) 2001-06-28
IL130622A (en) 2003-01-12
KR20000070584A (ko) 2000-11-25
NZ336380A (en) 2001-04-27
PL334773A1 (en) 2000-03-13
TW536540B (en) 2003-06-11
AU730111B2 (en) 2001-02-22
RU2183632C2 (ru) 2002-06-20

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